During the course of the studies on endothelial permeability made with thoracic duct fistulas we have had occasion to study the effect of varying doses of peptone injected intravenously. The effect of peptone has been studied intensively; usually relatively large doses have been injected and it has been found that there undoubtedly follows an increase in the rate at which colloids (hemolysins, agglutinins, antitoxins, foreign serum, etc.) pass through from the capillary bed to the lymph stream. Yet there seems some doubt whether we are dealing with an actual alteration in the permeability of the endothelium or are dealing purely with an increased intraportal pressure, as Abe (1) suggests. Starling inclines to the view that both an increase in intraportal pressure and an increased permeability of the endothelium must take place (2).

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