1. Guinea-pigs sensitized to egg white, receiving peptone intracardially thirty minutes before the shocking dose of egg white, showed no protection against anaphylactic shock in comparison with sensitized guinea-pigs not treated with peptone.

  2. Guinea-pigs sensitized to egg white and receiving thereafter serial intracardial peptone injections were similarly found to be unprotected against anaphylactic shock.

  3. Peptone in weak concentration did not prevent the specific reaction of the uterine muscle strip to egg white in the Dale experiment.

  4. Peptone in strong concentrations produced inhibition of the of the specific reaction of the uterine muscle strip to egg white in the Dale experiment. Inhibition of rhythmic contractions and loss of tone were also observed in the normal unsensitized muscle under the conditions of the Dale experiment when the concentration of peptone was sufficiently strong.

  5. Clinically, the use of peptone intravenously in bronchial asthma according to the method of Auld has been disappointing and is considered dangerous.

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From the Second Medical (Cornell) Division, Bellevue Hospital; Department of Medicine and Clinic of the Cornell University Medical School; and Pathological Laboratories, Bellevue Hospital.

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