Allergic encephalomyelitis (AE) is suppressed in rats given whole body x-irradiation prior to sensitization with spinal cord plus adjuvant. Suppression of the disease is paralleled by reduced production of complement-fixing antibrain antibodies. There is little, if any, suppression of delayed-type immunologic reactivity, based on tuberculin skin testing. X-irradiation after sensitization does not suppress AE. The meaning of these findings with respect to pathogenesis of AE is discussed.

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This study supported by USPHS Grant B-3104 from the National Institute of Allergy and Infectious Diseases and Grant B-1127 from the National Institute of Neurological Diseases and Blindness, National Institutes of Health, Bethesda, Maryland. The initial phase of work was supported by contract with Laboratory of Immunology, National Institute of Allergy and Infectious Diseases.

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