Evidence has been presented which indicates that opsonization of γ-globulin-coated bentonite is diminished in sera lacking C′1, C′2 and C′4, but not in sera lacking C′3. These observations provide additional evidence for the similarity of γ-globulin-coated particles and specific antigen-antibody complexes in their interactions with the complement system.

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Supported in part by USPHS Grant H-2622.

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