Purified amyloid fibrils from three separate spleens obtained from patients with primary and secondary disease were used to determine the relation between human amyloid fibrils and human γ-globulin and its subunits. Results demonstrated no reaction a) when solubilized amyloid fibrils were tested against specific antisera to whole human γ-globulin and some of its components; b) when specific components of human γ-globulin were tested against antiserum to solubilized amyloid fibrils and c) when intact lyophilized amyloid fibrils were tested against specific antisera to whole human γ-globulin and some of its components. The probable nonspecific relation of amyloid fibrils to γ-globulin was discussed.

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Grants in support of these investigations have been received in part from United States Public Health Service Grants Nos. AM-05589, AM-04599 and T1-AM-5285.

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