Rabbit antisera prepared against guinea pig γ2-globulin digested by pepsin react with isolated H and L chains. They contain antibodies against part of the H chain, the Fd fragment, and not against the Fc fragment. These antisera, directed against L chains and Fd fragments from γ2-globulins, do not detect any differences between γ1- and γ2- guinea pig immunoglobulins, when double diffusion in gel techniques are used. These results show that not only L chains but also Fd fragments of these different classes of immunoglobulins have common antigenic determinants.

1

This study was supported by the United States Public Health Service Grants AI04983 and AI-2094, and by the Health Research Council of the City of New York under Contract I-138.

Wherever possible, a similar nomenclature to that suggested during the W.H.O. Meeting on Nomenclature of Human Immunoglobulins has been used (Bull. World Health Org., 30: 447, 1964). However, as some uncertainty remains concerning the relationship between the families of human and animal immunoglobulins, guinea pig 7S globulins have been termed γ1 and γ2 as previously suggested.

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Copyright © 1966 by The American Association of Immunologists, Inc.
1966
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