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Volume 145, Issue 9
1 November 1990
Issue Cover
ISSN 0022-1767
EISSN 1550-6606
In this Issue

PRESIDENTIAL ADDRESS

Focusing: the dilemma of interpreting sharp images on a blurred background.
G J Thorbecke
J Immunol (1990) 145 (9): 2779–2790.
View articletitled, Focusing: the dilemma of interpreting sharp images on a blurred background.
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ARTICLES

Phenotypic and functional characteristics of in vivo-activated Langerhans cells.
S Aiba; S I Katz
J Immunol (1990) 145 (9): 2791–2796.
View articletitled, Phenotypic and functional characteristics of in vivo-activated Langerhans cells.
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In vitro differentiation from a pluripotent human CD4+CD8+ thymic cloned cell into four phenotypically distinct subsets.
L Boumsell; M Schmid; H Dastot; C Gouttefangeas; D Mathieu-Mahul; A Bensussan
J Immunol (1990) 145 (9): 2797–2802.
View articletitled, In vitro differentiation from a pluripotent human CD4+CD8+ thymic cloned cell into four phenotypically distinct subsets.
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Heterogeneity of helper/inducer T lymphocytes. III. Responses of IL-2- and IL-4-producing (Th1 and Th2) clones to antigens presented by different accessory cells.
T L Chang; C M Shea; S Urioste; R C Thompson; W H Boom; A K Abbas
J Immunol (1990) 145 (9): 2803–2808.
View articletitled, Heterogeneity of helper/inducer T lymphocytes. III. Responses of IL-2- and IL-4-producing (Th1 and Th2) clones to antigens presented by different accessory cells.
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Expression of functional alpha beta T cell receptor gene rearrangements in suppressor T cell hybridomas correlates with antigen binding, but not with suppressor cell function.
M Collins; V K Kuchroo; M J Whitters; R M O'Hara, Jr; K Kelleher; R T Kubo; M E Dorf
J Immunol (1990) 145 (9): 2809–2819.
View articletitled, Expression of functional alpha beta T cell receptor gene rearrangements in suppressor T cell hybridomas correlates with antigen binding, but not with suppressor cell function.
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Freshly isolated spleen dendritic cells and epidermal Langerhans cells undergo similar phenotypic and functional changes during short-term culture.
G Girolomoni; J C Simon; P R Bergstresser; P D Cruz, Jr
J Immunol (1990) 145 (9): 2820–2826.
View articletitled, Freshly isolated spleen dendritic cells and epidermal Langerhans cells undergo similar phenotypic and functional changes during short-term culture.
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Human cytotoxic lymphocytes. V. Frequency and specificity of gamma delta+ cytotoxic lymphocyte precursors activated by allogeneic or autologous stimulator cells.
D Kabelitz; A Bender; S Schondelmaier; M L da Silva Lobo; O Janssen
J Immunol (1990) 145 (9): 2827–2832.
View articletitled, Human cytotoxic lymphocytes. V. Frequency and specificity of gamma delta+ cytotoxic lymphocyte precursors activated by allogeneic or autologous stimulator cells.
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Evidence that cutaneous antigen-presenting cells migrate to regional lymph nodes during contact sensitization.
M L Kripke; C G Munn; A Jeevan; J M Tang; C Bucana
J Immunol (1990) 145 (9): 2833–2838.
View articletitled, Evidence that cutaneous antigen-presenting cells migrate to regional lymph nodes during contact sensitization.
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Functional epitope analysis of the human CD4 molecule. The MHC class II-dependent activation of resting T cells is inhibited by monoclonal antibodies to CD4 regardless whether or not they recognize epitopes involved in the binding of MHC class II or HIV gp120.
M Merkenschlager; D Buck; P C Beverley; Q J Sattentau
J Immunol (1990) 145 (9): 2839–2845.
View articletitled, Functional epitope analysis of the human CD4 molecule. The MHC class II-dependent activation of resting T cells is inhibited by monoclonal antibodies to CD4 regardless whether or not they recognize epitopes involved in the binding of MHC class II or HIV gp120.
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Cloned suppressor T cells derived from mice tolerized with conjugates of antigen and monomethoxypolyethylene glycol. Relationship between monoclonal T suppressor factor and the T cell receptor.
M Takata; P K Maiti; R T Kubo; Y H Chen; V Holford-Strevens; E S Rector; A H Sehon
J Immunol (1990) 145 (9): 2846–2853.
View articletitled, Cloned suppressor T cells derived from mice tolerized with conjugates of antigen and monomethoxypolyethylene glycol. Relationship between monoclonal T suppressor factor and the T cell receptor.
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In vivo ultraviolet-exposed human epidermal cells activate T suppressor cell pathways that involve CD4+CD45RA+ suppressor-inducer T cells.
O Baadsgaard; B Salvo; A Mannie; B Dass; D A Fox; K D Cooper
J Immunol (1990) 145 (9): 2854–2861.
View articletitled, In vivo ultraviolet-exposed human epidermal cells activate T suppressor cell pathways that involve CD4+CD45RA+ suppressor-inducer T cells.
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Intact antigen receptor-mediated generation of inositol phosphates and increased intracellular calcium in CD4 CD8 T lymphocytes from MRL lpr mice.
R C Budd; G Winslow; S Inokuchi; J B Imboden
J Immunol (1990) 145 (9): 2862–2872.
View articletitled, Intact antigen receptor-mediated generation of inositol phosphates and increased intracellular calcium in CD4 CD8 T lymphocytes from MRL lpr mice.
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Human severe combined immunodeficiency disease: phenotypic and functional characteristics of peripheral B lymphocytes.
M L Gougeon; G Drean; F Le Deist; M Dousseau; M Fevrier; A Diu; J Theze; C Griscelli; A Fischer
J Immunol (1990) 145 (9): 2873–2879.
View articletitled, Human severe combined immunodeficiency disease: phenotypic and functional characteristics of peripheral B lymphocytes.
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HLA-DR2a is the dominant restriction molecule for the cytotoxic T cell response to myelin basic protein in DR2Dw2 individuals.
D Jaraquemada; R Martin; S Rosen-Bronson; M Flerlage; H F McFarland; E O Long
J Immunol (1990) 145 (9): 2880–2885.
View articletitled, HLA-DR2a is the dominant restriction molecule for the cytotoxic T cell response to myelin basic protein in DR2Dw2 individuals.
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IL-4 acts synergistically with IL-1 beta to promote lymphocyte adhesion to microvascular endothelium by induction of vascular cell adhesion molecule-1.
B Masinovsky; D Urdal; W M Gallatin
J Immunol (1990) 145 (9): 2886–2895.
View articletitled, IL-4 acts synergistically with IL-1 beta to promote lymphocyte adhesion to microvascular endothelium by induction of vascular cell adhesion molecule-1.
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Resistance to infection by HIV-1 of peripheral blood mononuclear cells from HIV-1-infected patients is probably mediated by neutralizing antibodies.
M Tremblay; K Numazaki; X G Li; M Gornitsky; J Hiscott; M A Wainberg
J Immunol (1990) 145 (9): 2896–2901.
View articletitled, Resistance to infection by HIV-1 of peripheral blood mononuclear cells from HIV-1-infected patients is probably mediated by neutralizing antibodies.
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Vascular hyperpermeability induced by tumor necrosis factor and its augmentation by IL-1 and IFN-gamma is inhibited by selective depletion of neutrophils with a monoclonal antibody.
Y Abe; S Sekiya; T Yamasita; F Sendo
J Immunol (1990) 145 (9): 2902–2907.
View articletitled, Vascular hyperpermeability induced by tumor necrosis factor and its augmentation by IL-1 and IFN-gamma is inhibited by selective depletion of neutrophils with a monoclonal antibody.
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Synergistic interactions between tumor necrosis factor and inhibitors of DNA topoisomerase I and II.
Z Baloch; S Cohen; F D Coffman
J Immunol (1990) 145 (9): 2908–2913.
View articletitled, Synergistic interactions between tumor necrosis factor and inhibitors of DNA topoisomerase I and II.
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Regulation of IFN-gamma-receptor expression in human monocytes by granulocyte-macrophage colony-stimulating factor.
T Fischer; K Wiegmann; H Böttinger; K Morens; G Burmester; K Pfizenmaier
J Immunol (1990) 145 (9): 2914–2919.
View articletitled, Regulation of IFN-gamma-receptor expression in human monocytes by granulocyte-macrophage colony-stimulating factor.
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The role of IFN-gamma in the pathology of experimental endotoxemia.
F P Heinzel
J Immunol (1990) 145 (9): 2920–2924.
View articletitled, The role of IFN-gamma in the pathology of experimental endotoxemia.
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Induction of the heat shock response protects cells from lysis by tumor necrosis factor.
D I Kusher; C F Ware; L R Gooding
J Immunol (1990) 145 (9): 2925–2931.
View articletitled, Induction of the heat shock response protects cells from lysis by tumor necrosis factor.
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Cytokine regulation of IL-1 beta gene expression in the human polymorphonuclear leukocyte.
P T Marucha; R A Zeff; D L Kreutzer
J Immunol (1990) 145 (9): 2932–2937.
View articletitled, Cytokine regulation of IL-1 beta gene expression in the human polymorphonuclear leukocyte.
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Isolation of monoclonal antibodies specific for IL-4, IL-5, IL-6, and a new Th2-specific cytokine (IL-10), cytokine synthesis inhibitory factor, by using a solid phase radioimmunoadsorbent assay.
T R Mosmann; J H Schumacher; D F Fiorentino; J Leverah; K W Moore; M W Bond
J Immunol (1990) 145 (9): 2938–2945.
View articletitled, Isolation of monoclonal antibodies specific for IL-4, IL-5, IL-6, and a new Th2-specific cytokine (IL-10), cytokine synthesis inhibitory factor, by using a solid phase radioimmunoadsorbent assay.
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Expression of the human IL-2 receptor on lymphocytes involves rapid turnover of its p55 alpha-subunit (Tac).
D Sayar; M Ketzinel; L Gerez; C Silberberg; A Reshef; R Kaempfer
J Immunol (1990) 145 (9): 2946–2949.
View articletitled, Expression of the human IL-2 receptor on lymphocytes involves rapid turnover of its p55 alpha-subunit (Tac).
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Effects of IFN on human eosinophils in comparison with other cytokines. A novel class of eosinophil activators with delayed onset of action.
T Valerius; R Repp; J R Kalden; E Platzer
J Immunol (1990) 145 (9): 2950–2958.
View articletitled, Effects of IFN on human eosinophils in comparison with other cytokines. A novel class of eosinophil activators with delayed onset of action.
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Characterization of the CD45 molecule on murine intestinal intraepithelial lymphocytes.
T G Goodman; H L Chang; W J Esselman; R LeCorre; L Lefrancois
J Immunol (1990) 145 (9): 2959–2966.
View articletitled, Characterization of the CD45 molecule on murine intestinal intraepithelial lymphocytes.
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The lymphocyte-specific protein LSP1 is associated with the cytoskeleton and co-caps with membrane IgM.
D P Klein; S Galea; J Jongstra
J Immunol (1990) 145 (9): 2967–2973.
View articletitled, The lymphocyte-specific protein LSP1 is associated with the cytoskeleton and co-caps with membrane IgM.
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A molecular and immunochemical characterization of mouse CR2. Evidence for a single gene model of mouse complement receptors 1 and 2.
H Molina; T Kinoshita; K Inoue; J C Carel; V M Holers
J Immunol (1990) 145 (9): 2974–2983.
View articletitled, A molecular and immunochemical characterization of mouse CR2. Evidence for a single gene model of mouse complement receptors 1 and 2.
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Platelet C1q receptor interactions with collagen- and C1q-coated surfaces.
E I Peerschke; B Ghebrehiwet
J Immunol (1990) 145 (9): 2984–2988.
View articletitled, Platelet C1q receptor interactions with collagen- and C1q-coated surfaces.
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Mouse Ig coded by VH families S107 or J606 bind to protein A.
I Seppälä; M Kaartinen; S Ibrahim; O Mäkelä
J Immunol (1990) 145 (9): 2989–2993.
View articletitled, Mouse Ig coded by VH families S107 or J606 bind to protein A.
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Analysis of the immune response to lipopolysaccharide. Existence of an interspecies cross-reactive idiotype associated with anti-lipid A antibodies.
S D Su; M M Ward; M A Apicella; R E Ward
J Immunol (1990) 145 (9): 2994–3001.
View articletitled, Analysis of the immune response to lipopolysaccharide. Existence of an interspecies cross-reactive idiotype associated with anti-lipid A antibodies.
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Two families of monoclonal antibodies to alpha(1----6)dextran, VH19.1.2 and VH9.14.7, show distinct patterns of J kappa and JH minigene usage and amino acid substitutions in CDR3.
D N Wang; H T Chen; J Liao; P N Akolkar; S K Sikder; F Gruezo; E A Kabat
J Immunol (1990) 145 (9): 3002–3010.
View articletitled, Two families of monoclonal antibodies to alpha(1----6)dextran, VH19.1.2 and VH9.14.7, show distinct patterns of J kappa and JH minigene usage and amino acid substitutions in CDR3.
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High level synthesis of immunoglobulins in Chinese hamster ovary cells.
C R Wood; A J Dorner; G E Morris; E M Alderman; D Wilson; R M O'Hara, Jr; R J Kaufman
J Immunol (1990) 145 (9): 3011–3016.
View articletitled, High level synthesis of immunoglobulins in Chinese hamster ovary cells.
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Priming of neutrophils by lipopolysaccharide for enhanced release of superoxide. Requirement for plasma but not for tumor necrosis factor-alpha.
Y Aida; M J Pabst
J Immunol (1990) 145 (9): 3017–3025.
View articletitled, Priming of neutrophils by lipopolysaccharide for enhanced release of superoxide. Requirement for plasma but not for tumor necrosis factor-alpha.
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Soluble and insoluble immune complexes activate human neutrophil NADPH oxidase by distinct Fc gamma receptor-specific mechanisms.
E Crockett-Torabi; J C Fantone
J Immunol (1990) 145 (9): 3026–3032.
View articletitled, Soluble and insoluble immune complexes activate human neutrophil NADPH oxidase by distinct Fc gamma receptor-specific mechanisms.
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Endothelial and leukocyte forms of IL-8. Conversion by thrombin and interactions with neutrophils.
C A Hébert; F W Luscinskas; J M Kiely; E A Luis; W C Darbonne; G L Bennett; C C Liu; M S Obin; M A Gimbrone, Jr; J B Baker
J Immunol (1990) 145 (9): 3033–3040.
View articletitled, Endothelial and leukocyte forms of IL-8. Conversion by thrombin and interactions with neutrophils.
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Inhibition by dexamethasone of histamine production in allergic inflammation in rats.
N Hirasawa; Y Funaba; Y Hirano; K Kawarasaki; M Omata; M Watanabe; S Mue; S Tsurufuji; K Ohuchi
J Immunol (1990) 145 (9): 3041–3046.
View articletitled, Inhibition by dexamethasone of histamine production in allergic inflammation in rats.
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Priming of the human neutrophil respiratory burst by granulocyte-macrophage colony-stimulating factor and tumor necrosis factor-alpha involves regulation at a post-cell surface receptor level. Enhancement of the effect of agents which directly activate G proteins.
S R McColl; D Beauseigle; C Gilbert; P H Naccache
J Immunol (1990) 145 (9): 3047–3053.
View articletitled, Priming of the human neutrophil respiratory burst by granulocyte-macrophage colony-stimulating factor and tumor necrosis factor-alpha involves regulation at a post-cell surface receptor level. Enhancement of the effect of agents which directly activate G proteins.
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Protein L. A bacterial Ig-binding protein that activates human basophils and mast cells.
V Patella; V Casolaro; L Björck; G Marone
J Immunol (1990) 145 (9): 3054–3061.
View articletitled, Protein L. A bacterial Ig-binding protein that activates human basophils and mast cells.
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The subcellular distribution of platelet-activating factor in stimulated human neutrophils.
D W Riches; S K Young; J F Seccombe; J E Henson; K L Clay; P M Henson
J Immunol (1990) 145 (9): 3062–3070.
View articletitled, The subcellular distribution of platelet-activating factor in stimulated human neutrophils.
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Immunogenicity of a Haemophilus influenzae polysaccharide-Neisseria meningitidis outer membrane protein complex conjugate vaccine.
J J Donnelly; R R Deck; M A Liu
J Immunol (1990) 145 (9): 3071–3079.
View articletitled, Immunogenicity of a Haemophilus influenzae polysaccharide-Neisseria meningitidis outer membrane protein complex conjugate vaccine.
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The adenovirus E3-14.7K protein is a general inhibitor of tumor necrosis factor-mediated cytolysis.
L R Gooding; I O Sofola; A E Tollefson; P Duerksen-Hughes; W S Wold
J Immunol (1990) 145 (9): 3080–3086.
View articletitled, The adenovirus E3-14.7K protein is a general inhibitor of tumor necrosis factor-mediated cytolysis.
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A large degree of functional diversity exists among helper T cells specific for the same antigenic site of influenza hemagglutinin.
A M Haberman; C Moller; D McCreedy; W U Gerhard
J Immunol (1990) 145 (9): 3087–3094.
View articletitled, A large degree of functional diversity exists among helper T cells specific for the same antigenic site of influenza hemagglutinin.
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Immune responses during human Schistosoma mansoni. XVII. Recognition by monoclonal anti-idiotypic antibodies of several idiotopes on a monoclonal anti-soluble schistosomal egg antigen antibody and anti-soluble schistosomal egg antigen antibodies from patients with different clinical forms of infection.
M A Montesano; G L Freeman, Jr; G Gazzinelli; D G Colley
J Immunol (1990) 145 (9): 3095–3099.
View articletitled, Immune responses during human Schistosoma mansoni. XVII. Recognition by monoclonal anti-idiotypic antibodies of several idiotopes on a monoclonal anti-soluble schistosomal egg antigen antibody and anti-soluble schistosomal egg antigen antibodies from patients with different clinical forms of infection.
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Immunologic responsiveness in American cutaneous leishmaniasis lesions.
C Pirmez; C Cooper; M Paes-Oliveira; A Schubach; V K Torigian; R L Modlin
J Immunol (1990) 145 (9): 3100–3104.
View articletitled, Immunologic responsiveness in American cutaneous leishmaniasis lesions.
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Identification of B-epitopes in the human papillomavirus 18 E7 open reading frame protein.
L A Selvey; R W Tindle; H M Geysen; C J Haller; J A Smith; I H Frazer
J Immunol (1990) 145 (9): 3105–3110.
View articletitled, Identification of B-epitopes in the human papillomavirus 18 E7 open reading frame protein.
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Cell specificity of granzyme gene expression.
J A Garcia-Sanz; H R MacDonald; D E Jenne; J Tschopp; M Nabholz
J Immunol (1990) 145 (9): 3111–3118.
View articletitled, Cell specificity of granzyme gene expression.
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Two divergent routes of evolution gave rise to the DRw13 haplotypes.
K W Lee; A H Johnson; C K Hurley
J Immunol (1990) 145 (9): 3119–3125.
View articletitled, Two divergent routes of evolution gave rise to the DRw13 haplotypes.
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Regulation of HLA class II molecule expressions by IFN-gamma. The signal transduction mechanism in glioblastoma cell lines.
N Nezu; K Ryu; Y Koide; T O Yoshida
J Immunol (1990) 145 (9): 3126–3135.
View articletitled, Regulation of HLA class II molecule expressions by IFN-gamma. The signal transduction mechanism in glioblastoma cell lines.
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Low doses of IL-4 injected perilymphatically in tumor-bearing mice inhibit the growth of poorly and apparently nonimmunogenic tumors and induce a tumor-specific immune memory.
M Bosco; M Giovarelli; M Forni; A Modesti; S Scarpa; L Masuelli; G Forni
J Immunol (1990) 145 (9): 3136–3143.
View articletitled, Low doses of IL-4 injected perilymphatically in tumor-bearing mice inhibit the growth of poorly and apparently nonimmunogenic tumors and induce a tumor-specific immune memory.
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Calcium-dependent natural killer and calcium-independent natural cytotoxic activities in an IL-2-dependent killer cell line.
A L Richards; J Y Djeu
J Immunol (1990) 145 (9): 3144–3149.
View articletitled, Calcium-dependent natural killer and calcium-independent natural cytotoxic activities in an IL-2-dependent killer cell line.
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LETTERS TO THE EDITOR

Nucleotide sequence for the murine CD14 cDNA and gene.
K Matsuura; M Setoguchi; N Nasu; S Yoshida; Y Higuchi; S Akizuki; S Yamamoto
J Immunol (1990) 145 (9): 3150.
View articletitled, Nucleotide sequence for the murine CD14 cDNA and gene.
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A genetically engineered murine/human chimeric antibody retains specificity for human tumor-associated antigen.
B G Sahagan
J Immunol (1990) 145 (9): 3150.
View articletitled, A genetically engineered murine/human chimeric antibody retains specificity for human tumor-associated antigen.
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ERRATA

T lymphocyte recognition of a celiae disease-associated cis- or trans-encoded HLA-DQ alpha/beta-heterodimer
KEA Lundin; LM Sollid; E Qvigstad; G Markussen; HA Gjertsen; J Ek; E Thorsby
J Immunol (1990) 145 (9): 3151.
View articletitled, T lymphocyte recognition of a celiae disease-associated cis- or trans-encoded HLA-DQ alpha/beta-heterodimer
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The in vivo generation of murine IgD-secreting cells is accompanied by deletion of the Cm gene and occasional deletion of the mistakenly identified as Cd1 domain
JD Mountz; JF Mushinski; JD Owens; FD Finkelman
J Immunol (1990) 145 (9): 3151.
View articletitled, The in vivo generation of murine IgD-secreting cells is accompanied by deletion of the Cm gene and occasional deletion of the mistakenly identified as Cd1 domain
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  • Online ISSN 1550-6606
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