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CUTTING EDGE

CD28-B7 costimulatory blockade by CTLA4Ig prevents actively induced experimental autoimmune encephalomyelitis and inhibits Th1 but spares Th2 cytokines in the central nervous system.

S J Khoury; E Akalin; A Chandraker; L A Turka; P S Linsley; M H Sayegh; W W Hancock

J Immunol (1995) 155 (10): 4521–4524.

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Functional glucocorticoid receptor expression is required for cAMP-mediated apoptosis in a human leukemic T cell line.

J Kiefer; S Okret; M Jondal; D J McConkey

J Immunol (1995) 155 (10): 4525–4528.

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Human DNA-activated protein kinase (DNA-PK) is homologous to phosphatidylinositol kinases.

V P Poltoratsky; X Shi; J D York; M R Lieber; T H Carter

J Immunol (1995) 155 (10): 4529–4533.

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ARTICLES

Cyclic AMP signaling pathways are important in IL-1 beta transcriptional regulation.

G Chandra; J P Cogswell; L R Miller; M M Godlevski; S W Stinnett; S L Noel; S H Kadwell; T A Kost; J G Gray

J Immunol (1995) 155 (10): 4535–4543.

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MHC class I-selected CD4-CD8-TCR-alpha beta+ T cells are a potential source of IL-4 during primary immune response.

M C Leite-de-Moraes; A Herbelin; F Machavoine; A Vicari; J M Gombert; M Papiernik; M Dy

J Immunol (1995) 155 (10): 4544–4550.

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Role of environmental antigen in the development of IgG+ cells in the bursa of fabricius.

S Ekino; B Riwar; F G Kroese; E H Schwander; G Koch; P Nieuwenhuis

J Immunol (1995) 155 (10): 4551–4558.

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Disturbed MHC regulation in the IFN-gamma knockout mouse. Evidence for three states of MHC expression with distinct roles for IFN-gamma.

N Goes; T Sims; J Urmson; D Vincent; V Ramassar; P F Halloran

J Immunol (1995) 155 (10): 4559–4566.

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Enhancement of VLA integrin receptor function on thymocytes by cAMP is dependent on the maturation stage of the thymocytes.

M J Halvorson; J E Coligan

J Immunol (1995) 155 (10): 4567–4574.

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Analysis of thymic subpopulations expressing the activation antigen GL7. Expression, genetics, and function.

K S Hathcock; C E Pucillo; G Laszlo; L Lai; R J Hodes

J Immunol (1995) 155 (10): 4575–4581.

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Activation of the signal transducer and transcription (STAT) signaling pathway in a primary T cell response. Critical role for IL-6.

T Henttinen; D E Levy; O Silvennoinen; M Hurme

J Immunol (1995) 155 (10): 4582–4587.

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CD40 function in nonhematopoietic cells. Nuclear factor kappa B mobilization and induction of IL-6 production.

S Hess; A Rensing-Ehl; R Schwabe; P Bufler; H Engelmann

J Immunol (1995) 155 (10): 4588–4595.

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Phosphorylated immunoreceptor signaling motifs (ITAMs) exhibit unique abilities to bind and activate Lyn and Syk tyrosine kinases.

S A Johnson; C M Pleiman; L Pao; J Schneringer; K Hippen; J C Cambier

J Immunol (1995) 155 (10): 4596–4603.

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Prostaglandin E2 at priming of naive CD4+ T cells inhibits acquisition of ability to produce IFN-gamma and IL-2, but not IL-4 and IL-5.

K Katamura; N Shintaku; Y Yamauchi; T Fukui; Y Ohshima; M Mayumi; K Furusho

J Immunol (1995) 155 (10): 4604–4612.

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Alterations in cytokine and antibody production following chemical sympathectomy in two strains of mice.

B Kruszewska; S Y Felten; J A Moynihan

J Immunol (1995) 155 (10): 4613–4620.

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Mucosal adjuvant effect of cholera toxin in mice results from induction of T helper 2 (Th2) cells and IL-4.

M Marinaro; H F Staats; T Hiroi; R J Jackson; M Coste; P N Boyaka; N Okahashi; M Yamamoto; H Kiyono; H Bluethmann; K Fujihashi; J R McGhee

J Immunol (1995) 155 (10): 4621–4629.

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Expression of ecto-adenosine deaminase and CD26 in human T cells triggered by the TCR-CD3 complex. Possible role of adenosine deaminase as costimulatory molecule.

M Martín; J Huguet; J J Centelles; R Franco

J Immunol (1995) 155 (10): 4630–4643.

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Bcl-2 blocks glucocorticoid- but not Fas- or activation-induced apoptosis in a T cell hybridoma.

S A Memon; M B Moreno; D Petrak; C M Zacharchuk

J Immunol (1995) 155 (10): 4644–4652.

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Stimulation of thymocytes before and after positive selection results in the induction of different NF-kappa B/Rel protein complexes.

N C Moore; J Girdlestone; G Anderson; J J Owen; E J Jenkinson

J Immunol (1995) 155 (10): 4653–4660.

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IL-12 as mediator and adjuvant for the induction of contact sensitivity in vivo.

G Müller; J Saloga; T Germann; G Schuler; J Knop; A H Enk

J Immunol (1995) 155 (10): 4661–4668.

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Induction of tolerance in freshly isolated alloreactive T cells by activated T cell stimulators is not due to the absence of CD28-B7 interaction.

E Satyaraj; S Rath; V Bal

J Immunol (1995) 155 (10): 4669–4675.

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Processing of exogenous heat-aggregated (denatured) and particulate (native) hepatitis B surface antigen for class I-restricted epitope presentation.

R Schirmbeck; W Böhm; K Melber; J Reimann

J Immunol (1995) 155 (10): 4676–4684.

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Regulation of IkB alpha phosphorylation by PKC- and Ca(2+)-dependent signal transduction pathways.

N M Steffan; G D Bren; B Frantz; M J Tocci; E A O'Neill; C V Paya

J Immunol (1995) 155 (10): 4685–4691.

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Early activation signal transduction pathways of Th1 and Th2 cell clones stimulated with anti-CD3. Roles of protein tyrosine kinases in the signal for IL-2 and IL-4 production.

T Tamura; H Nakano; H Nagase; T Morokata; O Igarashi; Y Oshimi; S Miyazaki; H Nariuchi

J Immunol (1995) 155 (10): 4692–4701.

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CD28 delivers costimulatory signals independently of its association with phosphatidylinositol 3-kinase.

K E Truitt; J Shi; S Gibson; L G Segal; G B Mills; J B Imboden

J Immunol (1995) 155 (10): 4702–4710.

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Differentiation to T helper cells in the thymus. Gradual acquisition of T helper cell function by CD3+CD4+ cells.

D Vanhecke; B Verhasselt; V Debacker; G Leclercq; J Plum; B Vandekerckhove

J Immunol (1995) 155 (10): 4711–4718.

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Mapping of receptor binding sites on IL-1 beta by reconstruction of IL-1ra-like domains.

D Boraschi; P Bossù; P Ruggiero; A Tagliabue; R Bertini; G Macchia; C Gasbarro; L Pellegrini; G Melillo; E Ulisse; U Visconti; C Bizzarri; E Del Grosso; A R Mackay; G Frascotti; F Frigerio; R Grifantini; G Grandi

J Immunol (1995) 155 (10): 4719–4725.

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TAP associates with a unique class I conformation, whereas calnexin associates with multiple class I forms in mouse and man.

B M Carreno; J C Solheim; M Harris; I Stroynowski; J M Connolly; T H Hansen

J Immunol (1995) 155 (10): 4726–4733.

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Non-sense and missense mutations in the structural genes of complement component C1q A and C chains are linked with two different types of complete selective C1q deficiencies.

F Petry; D T Le; M Kirschfink; M Loos

J Immunol (1995) 155 (10): 4734–4738.

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Identification of a mouse protein homologous to the human CD6 T cell surface protein and sequence of the corresponding cDNA.

W H Robinson; S S Prohaska; J C Santoro; H L Robinson; J R Parnes

J Immunol (1995) 155 (10): 4739–4748.

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Differences in MHC class I self peptide repertoires among HLA-A2 subtypes.

T Sudo; N Kamikawaji; A Kimura; Y Date; C J Savoie; H Nakashima; E Furuichi; S Kuhara; T Sasazuki

J Immunol (1995) 155 (10): 4749–4756.

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Interference of distinct invariant chain regions with superantigen contact area and antigenic peptide binding groove of HLA-DR.

A B Vogt; L J Stern; C Amshoff; B Dobberstein; G J Hämmerling; H Kropshofer

J Immunol (1995) 155 (10): 4757–4765.

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Identification of an HLA-A11-restricted epitope from the tandem repeat domain of the epithelial tumor antigen mucin.

N Doménech; R A Henderson; O J Finn

J Immunol (1995) 155 (10): 4766–4774.

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Induction of cell-mediated immune responses to human immunodeficiency virus type 1 Gag protein by using Listeria monocytogenes as a live vaccine vector.

F R Frankel; S Hegde; J Lieberman; Y Paterson

J Immunol (1995) 155 (10): 4775–4782.

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Expression of activated H-rasval12 in nontumorigenic and non-cross-reactive syngeneic cells induces tumor antigens cross-reactive with rat mammary adenocarcinoma 13762.

A B Frey; S Cestari

J Immunol (1995) 155 (10): 4783–4789.

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The role of monocyte chemotactic protein-1 (MCP-1) in the recruitment of monocytes and CD4+ T cells during a pulmonary Cryptococcus neoformans infection.

G B Huffnagle; R M Strieter; T J Standiford; R A McDonald; M D Burdick; S L Kunkel; G B Toews

J Immunol (1995) 155 (10): 4790–4797.

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IL-7 stimulates protective immunity in mice against the intracellular pathogen, Toxoplasma gondii.

L H Kasper; T Matsuura; I A Khan

J Immunol (1995) 155 (10): 4798–4804.

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Constitutive production of IL-2 by human carcinoma cells, expression of IL-2 receptor, and tumor cell growth.

W C Lin; S Yasumura; Y Suminami; M W Sung; S Nagashima; J Stanson; T L Whiteside

J Immunol (1995) 155 (10): 4805–4816.

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Nonviable bacterial antigens administered with IL-12 generate antigen-specific T cell responses and protective immunity against Listeria monocytogenes.

M A Miller; M J Skeen; H K Ziegler

J Immunol (1995) 155 (10): 4817–4828.

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Increased susceptibility of fas mutant MRL-lpr/lpr mice to staphylococcal enterotoxin B-induced septic shock.

J D Mountz; T J Baker; D R Borcherding; H Bluethmann; T Zhou; C K Edwards, 3rd

J Immunol (1995) 155 (10): 4829–4837.

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High level monocyte chemoattractant protein-1 expression in transgenic mice increases their susceptibility to intracellular pathogens.

B J Rutledge; H Rayburn; R Rosenberg; R J North; R P Gladue; C L Corless; B J Rollins

J Immunol (1995) 155 (10): 4838–4843.

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Early IL-4 production by non-CD4+ cells at the site of antigen deposition predicts the development of a T helper 2 cell response to Schistosoma mansoni eggs.

E A Sabin; E J Pearce

J Immunol (1995) 155 (10): 4844–4853.

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Parasite strain specificity of bovine cytotoxic T cell responses to Theileria parva is determined primarily by immunodominance.

E L Taracha; B M Goddeeris; A J Teale; S J Kemp; W I Morrison

J Immunol (1995) 155 (10): 4854–4860.

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Triggering of complement receptors CR1 (CD35) and CR3 (CD11b/CD18) induces nuclear translocation of NF-kappa B (p50/p65) in human monocytes and enhances viral replication in HIV-infected monocytic cells.

N Thieblemont; N Haeffner-Cavaillon; A Haeffner; B Cholley; L Weiss; M D Kazatchkine

J Immunol (1995) 155 (10): 4861–4867.

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Soluble CD23 directly activates monocytes to contribute to the antigen-independent stimulation of resting T cells.

M Armant; M Rubio; G Delespesse; M Sarfati

J Immunol (1995) 155 (10): 4868–4875.

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Neutrophil inhibitory factor prevents neutrophil-dependent lung injury.

J W Barnard; M G Biro; S K Lo; S Ohno; M A Carozza; M Moyle; H R Soule; A B Malik

J Immunol (1995) 155 (10): 4876–4881.

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Identification and characterization of the complement C5a anaphylatoxin receptor on human astrocytes.

P Gasque; P Chan; M Fontaine; A Ischenko; M Lamacz; O Götze; B P Morgan

J Immunol (1995) 155 (10): 4882–4889.

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A central role for IL-1 beta in the in vitro and in vivo regulation of hepatic inducible nitric oxide synthase. IL-1 beta induces hepatic nitric oxide synthesis.

D A Geller; M E de Vera; D A Russell; R A Shapiro; A K Nussler; R L Simmons; T R Billiar

J Immunol (1995) 155 (10): 4890–4898.

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Lipopolysaccharide-induced change of phosphorylation of two cytosolic proteins in human monocytes is prevented by inhibitors of ADP-ribosylation.

H Heine; A J Ulmer; H D Flad; S Hauschildt

J Immunol (1995) 155 (10): 4899–4908.

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Cyclic nucleotide phosphodiesterase type IV participates in the regulation of IL-10 and in the subsequent inhibition of TNF-alpha and IL-6 release by endotoxin-stimulated macrophages.

T Kambayashi; C O Jacob; D Zhou; N Mazurek; M Fong; G Strassmann

J Immunol (1995) 155 (10): 4909–4916.

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Stimulation of CD40 with purified soluble gp39 induces proinflammatory responses in human monocytes.

P A Kiener; P Moran-Davis; B M Rankin; A F Wahl; A Aruffo; D Hollenbaugh

J Immunol (1995) 155 (10): 4917–4925.

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TGF-beta enhances macrophage ability to produce IL-10 in normal and tumor-bearing mice.

H Maeda; H Kuwahara; Y Ichimura; M Ohtsuki; S Kurakata; A Shiraishi

J Immunol (1995) 155 (10): 4926–4932.

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Differential utilization of IFN-gamma-responsive elements in two maturationally distinct macrophage cell lines.

M A McDowell; D M Lucas; C M Nicolet; D M Paulnock

J Immunol (1995) 155 (10): 4933–4938.

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Identification of messenger RNA for IL-4 in human eosinophils with granule localization and release of the translated product.

R Moqbel; S Ying; J Barkans; T M Newman; P Kimmitt; M Wakelin; L Taborda-Barata; Q Meng; C J Corrigan; S R Durham; A B Kay

J Immunol (1995) 155 (10): 4939–4947.

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Differential effects of granulocyte-macrophage colony-stimulating factor on eosinophil and neutrophil superoxide anion generation.

M Nagata; J B Sedgwick; W W Busse

J Immunol (1995) 155 (10): 4948–4954.

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Classical complement pathway activation on nucleated cells. Role of factor H in the control of deposited C3b.

M W Ollert; K David; R Bredehorst; C W Vogel

J Immunol (1995) 155 (10): 4955–4962.

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p21ras links Fc epsilon RI to NF-AT family member in mast cells. The AP3-like factor in this cell type is an NF-AT family member.

E E Prieschl; G G Pendl; N E Harrer; T Baumruker

J Immunol (1995) 155 (10): 4963–4970.

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Follicular dendritic cells, interdigitating cells, and cells of the monocyte-macrophage lineage are the C1q-producing sources in the spleen. Identification of specific cell types by in situ hybridization and immunohistochemical analysis.

W Schwaeble; M K Schäfer; F Petry; T Fink; D Knebel; E Weihe; M Loos

J Immunol (1995) 155 (10): 4971–4978.

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Regulation of polymorphonuclear neutrophil CD16 and CD11b/CD18 expression by matrix proteins during hypoxia is VLA-5, VLA-6 dependent.

H Simms; R D'Amico

J Immunol (1995) 155 (10): 4979–4990.

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Whither clinical immunology?

R R Rich

J Immunol (1995) 155 (10): 4992–4995.

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Construction and characterization of a humanized anti-gamma-Ig receptor type I (Fc gamma RI) monoclonal antibody.

R F Graziano; P R Tempest; P White; T Keler; Y Deo; H Ghebremariam; K Coleman; L C Pfefferkorn; M W Fanger; P M Guyre

J Immunol (1995) 155 (10): 4996–5002.

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An important role for the chemokine macrophage inflammatory protein-1 alpha in the pathogenesis of the T cell-mediated autoimmune disease, experimental autoimmune encephalomyelitis.

W J Karpus; N W Lukacs; B L McRae; R M Strieter; S L Kunkel; S D Miller

J Immunol (1995) 155 (10): 5003–5010.

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Neuroantigen-specific Th2 cells are inefficient suppressors of experimental autoimmune encephalomyelitis induced by effector Th1 cells.

A Khoruts; S D Miller; M K Jenkins

J Immunol (1995) 155 (10): 5011–5017.

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Evidence for superantigen involvement in cardiovascular injury due to Kawasaki syndrome.

D Y Leung; R C Giorno; L V Kazemi; P A Flynn; J B Busse

J Immunol (1995) 155 (10): 5018–5021.

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Delineation of additional genetic bases for C8 beta deficiency. Prevalence of null alleles and predominance of C-->T transition in their genesis.

L Saucedo; L Ackermann; A E Platonov; A Gewurz; R M Rakita; P Densen

J Immunol (1995) 155 (10): 5022–5028.

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Elevated Th1- or Th0-like cytokine mRNA in peripheral circulation of patients with rheumatoid arthritis. Modulation by treatment with anti-ICAM-1 correlates with clinical benefit.

H Schulze-Koops; P E Lipsky; A F Kavanaugh; L S Davis

J Immunol (1995) 155 (10): 5029–5037.

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Effects of recombinant dimeric TNF receptor on human inflammatory responses following intravenous endotoxin administration.

A F Suffredini; D Reda; S M Banks; M Tropea; J M Agosti; R Miller

J Immunol (1995) 155 (10): 5038–5045.

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CD8highCD57+ T lymphocytes in normal, healthy individuals are oligoclonal and respond to human cytomegalovirus.

E C Wang; P A Moss; P Frodsham; P J Lehner; J I Bell; L K Borysiewicz

J Immunol (1995) 155 (10): 5046–5056.

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Localization of an Fc-binding reactivity to the constant region of human IgG4. Implications for the pathogenesis of rheumatoid arthritis.

D J Zack; M Stempniak; A L Wong; R H Weisbart

J Immunol (1995) 155 (10): 5057–5063.

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T cell epitope mapping of ragweed pollen allergen Ambrosia artemisiifolia (Amb a 5) and Ambrosia trifida (Amb t 5) and the role of free sulfhydryl groups in T cell recognition.

X Zhu; J L Greenstein; B L Rogers; M C Kuo

J Immunol (1995) 155 (10): 5064–5073.

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