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CUTTING EDGE

Cutting Edge: Lipopolysaccharide Induces Physical Proximity Between CD14 and Toll-Like Receptor 4 (TLR4) Prior to Nuclear Translocation of NF-κB ¹

Qingqi Jiang; Sachiko Akashi; Kensuke Miyake; Howard R. Petty

J Immunol (2000) 165 (7): 3541–3544.

Abstract

View articletitled, Cutting Edge: Lipopolysaccharide Induces Physical Proximity Between CD14 and Toll-Like Receptor 4 (TLR4) Prior to Nuclear Translocation of NF-κB<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Cutting Edge: NK Cell Inhibitory Receptors Prevent Tyrosine Phosphorylation of the Activation Receptor 2B4 (CD244)¹

Carsten Watzl; Christopher C. Stebbins; Eric O. Long

J Immunol (2000) 165 (7): 3545–3548.

Abstract

View articletitled, Cutting Edge: NK Cell Inhibitory Receptors Prevent Tyrosine Phosphorylation of the Activation Receptor 2B4 (CD244)<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Cutting Edge: Defective NK Cell Activation in X-Linked Lymphoproliferative Disease ¹

Loralyn Benoit; Xiaoxia Wang; Henry F. Pabst; Jan Dutz; Rusung Tan

J Immunol (2000) 165 (7): 3549–3553.

Abstract

View articletitled, Cutting Edge: Defective NK Cell Activation in X-Linked Lymphoproliferative Disease<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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CELLULAR IMMUNOLOGY AND IMMUNE REGULATION

NK-Mediated Elimination of Mutant Lymphocytes that Have Lost Expression of MHC Class I Molecules ¹

Yoichiro Kusunoki; Seishi Kyoizumi; Masamitsu Honma; Yoshiko Kubo; Hisashi Ohnishi; Tomonori Hayashi; Toshio Seyama

J Immunol (2000) 165 (7): 3555–3563.

Abstract

View articletitled, NK-Mediated Elimination of Mutant Lymphocytes that Have Lost Expression of MHC Class I Molecules<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Ligation of the WC1 Receptor Induces γδ T Cell Growth Arrest Through Fumonisin B1-Sensitive Increases in Cellular Ceramide ¹

Paul A. Kirkham; Haru-Hisa Takamatsu; Eric W.-F. Lam; R. M. E. Parkhouse

J Immunol (2000) 165 (7): 3564–3570.

Abstract

View articletitled, Ligation of the WC1 Receptor Induces γδ T Cell Growth Arrest Through Fumonisin B1-Sensitive Increases in Cellular Ceramide<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Distinct Requirements for IFNs and STAT1 in NK Cell Function ¹

Chien-Kuo Lee; Dharma T. Rao; Rachel Gertner; Ramon Gimeno; Alan B. Frey; David E. Levy

J Immunol (2000) 165 (7): 3571–3577.

Abstract

View articletitled, Distinct Requirements for IFNs and STAT1 in NK Cell Function<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Differential Requirement of ZAP-70 for CD2-Mediated Activation Pathways of Mature Human T Cells ¹

Edgar Meinl; Doris Lengenfelder; Norbert Blank; Rainer Pirzer; Luis Barata; Claire Hivroz

J Immunol (2000) 165 (7): 3578–3583.

Abstract

View articletitled, Differential Requirement of ZAP-70 for CD2-Mediated Activation Pathways of Mature Human T Cells<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Monocyte-Derived CD1a⁺ and CD1a⁻ Dendritic Cell Subsets Differ in Their Cytokine Production Profiles, Susceptibilities to Transfection, and Capacities to Direct Th Cell Differentiation ¹

Chia-Chun J. Chang; Anne Wright; Juha Punnonen

J Immunol (2000) 165 (7): 3584–3591.

Abstract

View articletitled, Monocyte-Derived CD1a+ and CD1a− Dendritic Cell Subsets Differ in Their Cytokine Production Profiles, Susceptibilities to Transfection, and Capacities to Direct Th Cell Differentiation<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Prolonged Exposure to Lipopolysaccharide Inhibits Macrophage 5-Lipoxygenase Metabolism Via Induction of Nitric Oxide Synthesis ¹

Michael J. Coffey; Susan M. Phare; Marc Peters-Golden

J Immunol (2000) 165 (7): 3592–3598.

Abstract

View articletitled, Prolonged Exposure to Lipopolysaccharide Inhibits Macrophage 5-Lipoxygenase Metabolism Via Induction of Nitric Oxide Synthesis<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Role of Tolerogen Conformation in Induction of Oral Tolerance in Experimental Autoimmune Myasthenia Gravis ¹

Sin-Hyeog Im; Dora Barchan; Miriam C. Souroujon; Sara Fuchs

J Immunol (2000) 165 (7): 3599–3605.

Abstract

View articletitled, Role of Tolerogen Conformation in Induction of Oral Tolerance in Experimental Autoimmune Myasthenia Gravis<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Mutant Mouse Lysozyme Carrying a Minimal T Cell Epitope of Hen Egg Lysozyme Evokes High Autoantibody Response

Yoshiyuki Tsujihata; Takanori So; Yuki Chijiiwa; Yoshio Hashimoto; Masato Hirata; Tadashi Ueda; Taiji Imoto

J Immunol (2000) 165 (7): 3606–3611.

Abstract

View articletitled, Mutant Mouse Lysozyme Carrying a Minimal T Cell Epitope of Hen Egg Lysozyme Evokes High Autoantibody Response

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CD4 Help-Independent Induction of Cytotoxic CD8 Cells to Allogeneic P815 Tumor Cells Is Absolutely Dependent on Costimulation ¹

Yifan Zhan; Alexandra J. Corbett; Jamie L. Brady; Robyn M. Sutherland; Andrew M. Lew

J Immunol (2000) 165 (7): 3612–3619.

Abstract

View articletitled, CD4 Help-Independent Induction of Cytotoxic CD8 Cells to Allogeneic P815 Tumor Cells Is Absolutely Dependent on Costimulation<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Conventional, Naive CD4⁺ T Cells Provide an Initial Source of IL-4 During Th2 Differentiation

Nancy Noben-Trauth; Jane Hu-Li; William E. Paul

J Immunol (2000) 165 (7): 3620–3625.

Abstract

View articletitled, Conventional, Naive CD4+ T Cells Provide an Initial Source of IL-4 During Th2 Differentiation

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IL-10, But Not IL-4, Suppresses Infection-Stimulated Bone Resorption In Vivo ¹

Hajime Sasaki; Linda Hou; Anita Belani; Cun-Yu Wang; Toru Uchiyama; Ralph Müller; Philip Stashenko

J Immunol (2000) 165 (7): 3626–3630.

Abstract

View articletitled, IL-10, But Not IL-4, Suppresses Infection-Stimulated Bone Resorption In Vivo<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Effects of a Hexameric Deoxyriboguanosine Run Conjugation into CpG Oligodeoxynucleotides on Their Immunostimulatory Potentials ¹

Seung Woo Lee; Man Ki Song; Kwan Hyuck Baek; Yunji Park; Jong Kyung Kim; Chu Hee Lee; Hae-Kap Cheong; Chaejoon Cheong; Young Chul Sung

J Immunol (2000) 165 (7): 3631–3639.

Abstract

View articletitled, Effects of a Hexameric Deoxyriboguanosine Run Conjugation into CpG Oligodeoxynucleotides on Their Immunostimulatory Potentials<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Cellular Interactions Involved in Th Cell Memory ¹

Dominic van Essen; Per Dullforce; Thomas Brocker; David Gray

J Immunol (2000) 165 (7): 3640–3646.

Abstract

View articletitled, Cellular Interactions Involved in Th Cell Memory<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Bacterial Lipopolysaccharide, TNF-α, and Calcium Ionophore Under Serum-Free Conditions Promote Rapid Dendritic Cell-Like Differentiation in CD14⁺ Monocytes Through Distinct Pathways That Activate NF-κB

Lyudmila A. Lyakh; Gary K. Koski; William Telford; Ronald E. Gress; Peter A. Cohen; Nancy R. Rice

J Immunol (2000) 165 (7): 3647–3655.

Abstract

View articletitled, Bacterial Lipopolysaccharide, TNF-α, and Calcium Ionophore Under Serum-Free Conditions Promote Rapid Dendritic Cell-Like Differentiation in CD14+ Monocytes Through Distinct Pathways That Activate NF-κB

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Cross-Presentation of Tumor Antigens to Effector T Cells Is Sufficient to Mediate Effective Immunotherapy of Established Intracranial Tumors ¹

Gregory E. Plautz; Shigehiko Mukai; Peter A. Cohen; Suyu Shu

J Immunol (2000) 165 (7): 3656–3662.

Abstract

View articletitled, Cross-Presentation of Tumor Antigens to Effector T Cells Is Sufficient to Mediate Effective Immunotherapy of Established Intracranial Tumors<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Cytotoxic T Cells Specifically Induce Fas on Target Cells, Thereby Facilitating Exocytosis-Independent Induction of Apoptosis ¹

Markus M. Simon; Paul Waring; Mario Lobigs; Ahmed Nil; Thao Tran; Ron Tha Hla; Seow Chin; Arno Müllbacher

J Immunol (2000) 165 (7): 3663–3672.

Abstract

View articletitled, Cytotoxic T Cells Specifically Induce Fas on Target Cells, Thereby Facilitating Exocytosis-Independent Induction of Apoptosis<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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CD8⁺ T Cells Rapidly Acquire NK1.1 and NK Cell-Associated Molecules Upon Stimulation In Vitro and In Vivo ¹

Erika Assarsson; Taku Kambayashi; Johan K. Sandberg; Seokmann Hong; Masaru Taniguchi; Luc Van Kaer; Hans-Gustaf Ljunggren; Benedict J. Chambers

J Immunol (2000) 165 (7): 3673–3679.

Abstract

View articletitled, CD8+ T Cells Rapidly Acquire NK1.1 and NK Cell-Associated Molecules Upon Stimulation In Vitro and In Vivo<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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A Profound Deficiency in Thymic Progenitor Cells in Mice Lacking Jak3 ¹

Allison M. Baird; Julie A. Lucas; Leslie J. Berg

J Immunol (2000) 165 (7): 3680–3688.

Abstract

View articletitled, A Profound Deficiency in Thymic Progenitor Cells in Mice Lacking Jak3<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Differential Survival of Naive CD4 and CD8 T Cells ¹

Cristina Ferreira; Thomas Barthlott; Sylvie Garcia; Rose Zamoyska; Brigitta Stockinger

J Immunol (2000) 165 (7): 3689–3694.

Abstract

View articletitled, Differential Survival of Naive CD4 and CD8 T Cells<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Development of Dendritic Epidermal T Cells with a Skewed Diversity of γδTCRs in Vδ1-Deficient Mice ¹

Hiromitsu Hara; Kenji Kishihara; Goro Matsuzaki; Hiroaki Takimoto; Tadasuke Tsukiyama; Robert E. Tigelaar; Kikuo Nomoto

J Immunol (2000) 165 (7): 3695–3705.

Abstract

View articletitled, Development of Dendritic Epidermal T Cells with a Skewed Diversity of γδTCRs in Vδ1-Deficient Mice<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Thymocyte Maturation: Selection for In-Frame TCR α-Chain Rearrangement Is Followed by Selection for Shorter TCR β-Chain Complementarity-Determining Region 3 ¹

Maryam Yassai; Jack Gorski

J Immunol (2000) 165 (7): 3706–3712.

Abstract

View articletitled, Thymocyte Maturation: Selection for In-Frame TCR α-Chain Rearrangement Is Followed by Selection for Shorter TCR β-Chain Complementarity-Determining Region 3<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Effects of a Constitutively Active Form of Calcineurin on T Cell Activation and Thymic Selection ¹

Kristine Hayden-Martinez; Lawrence P. Kane; Stephen M. Hedrick

J Immunol (2000) 165 (7): 3713–3721.

Abstract

View articletitled, Effects of a Constitutively Active Form of Calcineurin on T Cell Activation and Thymic Selection<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Galectin-1 Induces Partial TCR ζ-Chain Phosphorylation and Antagonizes Processive TCR Signal Transduction ¹

Chan D. Chung; Viresh P. Patel; Miriana Moran; Linda A. Lewis; M. Carrie Miceli

J Immunol (2000) 165 (7): 3722–3729.

Abstract

View articletitled, Galectin-1 Induces Partial TCR ζ-Chain Phosphorylation and Antagonizes Processive TCR Signal Transduction<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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The Mechanism of Unresponsiveness to Circulating Tumor Antigen MUC1 Is a Block in Intracellular Sorting and Processing by Dendritic Cells ¹

Elizabeth M. Hiltbold; Anda M. Vlad; Pawel Ciborowski; Simon C. Watkins; Olivera J. Finn

J Immunol (2000) 165 (7): 3730–3741.

Abstract

View articletitled, The Mechanism of Unresponsiveness to Circulating Tumor Antigen MUC1 Is a Block in Intracellular Sorting and Processing by Dendritic Cells<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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The CD85/LIR-1/ILT2 Inhibitory Receptor Is Expressed by All Human T Lymphocytes and Down-Regulates Their Functions ¹

Daniele Saverino; Marina Fabbi; Fabio Ghiotto; Andrea Merlo; Silvia Bruno; Daniela Zarcone; Claudya Tenca; Micaela Tiso; Giuseppe Santoro; Giuseppe Anastasi; David Cosman; Carlo E. Grossi; Ermanno Ciccone

J Immunol (2000) 165 (7): 3742–3755.

Abstract

View articletitled, The CD85/LIR-1/ILT2 Inhibitory Receptor Is Expressed by All Human T Lymphocytes and Down-Regulates Their Functions<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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CD1d on Myeloid Dendritic Cells Stimulates Cytokine Secretion from and Cytolytic Activity of Vα24JαQ T Cells: A Feedback Mechanism for Immune Regulation ¹

Otto O. Yang; Frederick K. Racke; Phuong Thi Nguyen; Rudolf Gausling; Michael E. Severino; Heidi F. Horton; Michael C. Byrne; Jack L. Strominger; S. Brian Wilson

J Immunol (2000) 165 (7): 3756–3762.

Abstract

View articletitled, CD1d on Myeloid Dendritic Cells Stimulates Cytokine Secretion from and Cytolytic Activity of Vα24JαQ T Cells: A Feedback Mechanism for Immune Regulation<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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A Monoclonal Antibody Against the 66-kDa Protein Expressed in Mouse Spleen and Thymus Inhibits Ly-6A.2-Dependent Cell-Cell Adhesion ¹

Andrea English; Roman Kosoy; Rafel Pawlinski; Anil Bamezai

J Immunol (2000) 165 (7): 3763–3771.

Abstract

View articletitled, A Monoclonal Antibody Against the 66-kDa Protein Expressed in Mouse Spleen and Thymus Inhibits Ly-6A.2-Dependent Cell-Cell Adhesion<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Plasmid Vaccine Expressing Granulocyte-Macrophage Colony-Stimulating Factor Attracts Infiltrates Including Immature Dendritic Cells into Injected Muscles ¹

Diana Haddad; Jayanthi Ramprakash; Martha Sedegah; Yupin Charoenvit; Roxanne Baumgartner; Sanjai Kumar; Stephen L. Hoffman; Walter R. Weiss

J Immunol (2000) 165 (7): 3772–3781.

Abstract

View articletitled, Plasmid Vaccine Expressing Granulocyte-Macrophage Colony-Stimulating Factor Attracts Infiltrates Including Immature Dendritic Cells into Injected Muscles<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Type 1 IFN Maintains the Survival of Anergic CD4⁺ T Cells ¹

Giovanna Lombardi; Pádraic J. Dunne; Dagmar Scheel-Toellner; Tina Sanyal; Darrell Pilling; Leonie S. Taams; Paul Life; Janet M. Lord; Mike Salmon; Arne N. Akbar

J Immunol (2000) 165 (7): 3782–3789.

Abstract

View articletitled, Type 1 IFN Maintains the Survival of Anergic CD4+ T Cells<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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The Role of the DAP12 Signal in Mouse Myeloid Differentiation ¹

Naoko Aoki; Shoji Kimura; Yumi Takiyama; Yoshiaki Atsuta; Asami Abe; Keisuke Sato; Makoto Katagiri

J Immunol (2000) 165 (7): 3790–3796.

Abstract

View articletitled, The Role of the DAP12 Signal in Mouse Myeloid Differentiation<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Dendritic Cells Capture Killed Tumor Cells and Present Their Antigens to Elicit Tumor-Specific Immune Responses ¹

Mahyar Nouri-Shirazi; Jacques Banchereau; Diana Bell; Susan Burkeholder; Elizabeth T. Kraus; Jean Davoust; Karolina A. Palucka

J Immunol (2000) 165 (7): 3797–3803.

Abstract

View articletitled, Dendritic Cells Capture Killed Tumor Cells and Present Their Antigens to Elicit Tumor-Specific Immune Responses<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Activation of Toll-Like Receptor 2 on Human Dendritic Cells Triggers Induction of IL-12, But Not IL-10 ¹

Sybille Thoma-Uszynski; Sylvia M. Kiertscher; Maria Teresa Ochoa; Deborah A. Bouis; Michael V. Norgard; Kensuke Miyake; Paul J. Godowski; Michael D. Roth; Robert L. Modlin

J Immunol (2000) 165 (7): 3804–3810.

Abstract

View articletitled, Activation of Toll-Like Receptor 2 on Human Dendritic Cells Triggers Induction of IL-12, But Not IL-10<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Direct Tumor Lysis by NK Cells Uses a Ras-Independent Mitogen-Activated Protein Kinase Signal Pathway ¹

Sheng Wei; Danielle L. Gilvary; Brian C. Corliss; Said Sebti; Jiazhi Sun; David B. Straus; Paul J. Leibson; Joseph A. Trapani; Andrew D. Hamilton; Michael J. Weber; Julie Y. Djeu

J Immunol (2000) 165 (7): 3811–3819.

Abstract

View articletitled, Direct Tumor Lysis by NK Cells Uses a Ras-Independent Mitogen-Activated Protein Kinase Signal Pathway <a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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CD28 Utilizes Vav-1 to Enhance TCR-Proximal Signaling and NF-AT Activation ¹

Frédérique Michel; Giorgio Mangino; Géraldine Attal-Bonnefoy; Loretta Tuosto; Andrés Alcover; Anne Roumier; Daniel Olive; Oreste Acuto

J Immunol (2000) 165 (7): 3820–3829.

Abstract

View articletitled, CD28 Utilizes Vav-1 to Enhance TCR-Proximal Signaling and NF-AT Activation<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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MOLECULAR AND STRUCTURAL IMMUNOLOGY

Conformational Epitopes on the Diabetes Autoantigen GAD65 Identified by Peptide Phage Display and Molecular Modeling

Mark A. Myers; Janet M. Davies; Jonathan C. Tong; James Whisstock; Marita Scealy; Ian R. Mackay; Merrill J. Rowley

J Immunol (2000) 165 (7): 3830–3838.

Abstract

View articletitled, Conformational Epitopes on the Diabetes Autoantigen GAD65 Identified by Peptide Phage Display and Molecular Modeling

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Structure-Guided Identification of C3d Residues Essential for Its Binding to Complement Receptor 2 (CD21)¹

Liliana Clemenza; David E. Isenman

J Immunol (2000) 165 (7): 3839–3848.

Abstract

View articletitled, Structure-Guided Identification of C3d Residues Essential for Its Binding to Complement Receptor 2 (CD21)<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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A Human Monoclonal IgE Antibody Defines a Highly Allergenic Fragment of the Major Timothy Grass Pollen Allergen, Phl p 5: Molecular, Immunological, and Structural Characterization of the Epitope-Containing Domain ¹

Sabine Flicker; Susanne Vrtala; Peter Steinberger; Luca Vangelista; Albrecht Bufe; Arnd Petersen; Minoo Ghannadan; Wolfgang R. Sperr; Peter Valent; Lars Norderhaug; Barbara Bohle; Hannes Stockinger; Cenk Suphioglu; Eng Kok Ong; Dietrich Kraft; Rudolf Valenta

J Immunol (2000) 165 (7): 3849–3859.

Abstract

View articletitled, A Human Monoclonal IgE Antibody Defines a Highly Allergenic Fragment of the Major Timothy Grass Pollen Allergen, Phl p 5: Molecular, Immunological, and Structural Characterization of the Epitope-Containing Domain<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Phosphatidylinositol 3-Kinase and NF-κB/Rel Are at the Divergence of CD40-Mediated Proliferation and Survival Pathways

Sofija Andjelic; Constance Hsia; Harumi Suzuki; Takashi Kadowaki; Shigeo Koyasu; Hsiou-Chi Liou

J Immunol (2000) 165 (7): 3860–3867.

Abstract

View articletitled, Phosphatidylinositol 3-Kinase and NF-κB/Rel Are at the Divergence of CD40-Mediated Proliferation and Survival Pathways

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Functional Analysis of Ligand-Binding and Signal Transduction Domains of CD69 and CD23 C-Type Lectin Leukocyte Receptors ¹

David Sancho; Ana G. Santis; José L. Alonso-Lebrero; Fernando Viedma; Reyes Tejedor; Francisco Sánchez-Madrid

J Immunol (2000) 165 (7): 3868–3875.

Abstract

View articletitled, Functional Analysis of Ligand-Binding and Signal Transduction Domains of CD69 and CD23 C-Type Lectin Leukocyte Receptors<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Alanine Scanning Mutants of Rat Proinsulin I Show Functional Diversity of Anti-Insulin Monoclonal Antibodies ¹

O. Yu Tikhomirov; James W. Thomas

J Immunol (2000) 165 (7): 3876–3882.

Abstract

View articletitled, Alanine Scanning Mutants of Rat Proinsulin I Show Functional Diversity of Anti-Insulin Monoclonal Antibodies<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Signal Joint Formation Is Also Impaired in DNA-Dependent Protein Kinase Catalytic Subunit Knockout Cells ¹

Ryutaro Fukumura; Ryoko Araki; Akira Fujimori; Yoko Tsutsumi; Akihiro Kurimasa; Gloria C. Li; David J. Chen; Kouichi Tatsumi; Masumi Abe

J Immunol (2000) 165 (7): 3883–3889.

Abstract

View articletitled, Signal Joint Formation Is Also Impaired in DNA-Dependent Protein Kinase Catalytic Subunit Knockout Cells<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Restriction in Vκ Gene Use and Antigen Selection in Anti-Myeloperoxidase Response in Mice

Hitendra S. Jethwa; Stephen H. Clarke; Yoshie Itoh-Lindstrom; Ronald J. Falk; J. Charles Jennette; Patrick H. Nachman

J Immunol (2000) 165 (7): 3890–3897.

Abstract

View articletitled, Restriction in Vκ Gene Use and Antigen Selection in Anti-Myeloperoxidase Response in Mice

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Mechanism of IL-4-Mediated Up-Regulation of the Polymeric Ig Receptor: Role of STAT6 in Cell Type-Specific Delayed Transcriptional Response ¹

Hilde Schjerven; Per Brandtzaeg; Finn-Eirik Johansen

J Immunol (2000) 165 (7): 3898–3906.

Abstract

View articletitled, Mechanism of IL-4-Mediated Up-Regulation of the Polymeric Ig Receptor: Role of STAT6 in Cell Type-Specific Delayed Transcriptional Response<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Identification of a Novel Cytokine Response Element in the Human IFN Regulatory Factor-1 Gene Promoter ¹

Daisuke Imanishi; Kazuo Yamamoto; Hideki Tsushima; Yasushi Miyazaki; Kazutaka Kuriyama; Masao Tomonaga; Toshifumi Matsuyama

J Immunol (2000) 165 (7): 3907–3916.

Abstract

View articletitled, Identification of a Novel Cytokine Response Element in the Human IFN Regulatory Factor-1 Gene Promoter<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Allergy-Associated Polymorphisms of the FcεRIβ Subunit Do Not Impact Its Two Amplification Functions

Emmanuel Donnadieu; William O. Cookson; Marie-Hélène Jouvin; Jean-Pierre Kinet

J Immunol (2000) 165 (7): 3917–3922.

Abstract

View articletitled, Allergy-Associated Polymorphisms of the FcεRIβ Subunit Do Not Impact Its Two Amplification Functions

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HOST DEFENSE

Group B Streptococcus Induces Apoptosis in Macrophages ¹

Katia Fettucciari; Emanuela Rosati; Lucia Scaringi; Paola Cornacchione; Graziella Migliorati; Rita Sabatini; Ilaria Fetriconi; Ruggero Rossi; Pierfrancesco Marconi

J Immunol (2000) 165 (7): 3923–3933.

Abstract

View articletitled, Group B Streptococcus Induces Apoptosis in Macrophages<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Distinct Effects of Surfactant Protein A or D Deficiency During Bacterial Infection on the Lung ¹

Ann Marie LeVine; Jeffrey A. Whitsett; Jodie A. Gwozdz; Theresa R. Richardson; James H. Fisher; Michael S. Burhans; Thomas R. Korfhagen

J Immunol (2000) 165 (7): 3934–3940.

Abstract

View articletitled, Distinct Effects of Surfactant Protein A or D Deficiency During Bacterial Infection on the Lung<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Role of Cystic Fibrosis Transmembrane Conductance Regulator in Pulmonary Clearance of Pseudomonas aeruginosa In Vivo ¹

Zissis C. Chroneos; Susan E. Wert; Jennifer L. Livingston; Daniel J. Hassett; Jeffrey A. Whitsett

J Immunol (2000) 165 (7): 3941–3950.

Abstract

View articletitled, Role of Cystic Fibrosis Transmembrane Conductance Regulator in Pulmonary Clearance of Pseudomonas aeruginosa In Vivo<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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INFLAMMATION

Exaggerated Human Monocyte IL-10 Concomitant to Minimal TNF-α Induction by Heat-Shock Protein 27 (Hsp27) Suggests Hsp27 Is Primarily an Antiinflammatory Stimulus ¹

Asit K. De; Karen M. Kodys; Berhan S. Yeh; Carol Miller-Graziano

J Immunol (2000) 165 (7): 3951–3958.

Abstract

View articletitled, Exaggerated Human Monocyte IL-10 Concomitant to Minimal TNF-α Induction by Heat-Shock Protein 27 (Hsp27) Suggests Hsp27 Is Primarily an Antiinflammatory Stimulus<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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IL-1β Attenuates IFN-αβ-Induced Antiviral Activity and STAT1 Activation in the Liver: Involvement of Proteasome-Dependent Pathway ¹

Zhigang Tian; Xuening Shen; Hong Feng; Bin Gao

J Immunol (2000) 165 (7): 3959–3965.

Abstract

View articletitled, IL-1β Attenuates IFN-αβ-Induced Antiviral Activity and STAT1 Activation in the Liver: Involvement of Proteasome-Dependent Pathway<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Granzyme Activity in the Inflamed Lung Is Not Controlled by Endogenous Serine Proteinase Inhibitors ¹

Guy M. Tremblay; Angela M. Wolbink; Yvon Cormier; C. Erik Hack

J Immunol (2000) 165 (7): 3966–3969.

Abstract

View articletitled, Granzyme Activity in the Inflamed Lung Is Not Controlled by Endogenous Serine Proteinase Inhibitors<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Impaired IFN-γ Production in IFN Regulatory Factor-1 Knockout Mice During Endotoxemia Is Secondary to a Loss of Both IL-12 and IL-12 Receptor Expression ¹

Cindy A. Salkowski; Karen E. Thomas; M. Joshua Cody; Stefanie N. Vogel

J Immunol (2000) 165 (7): 3970–3977.

Abstract

View articletitled, Impaired IFN-γ Production in IFN Regulatory Factor-1 Knockout Mice During Endotoxemia Is Secondary to a Loss of Both IL-12 and IL-12 Receptor Expression<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Nitric Oxide-Dependent Ribosomal RNA Cleavage Is Associated with Inhibition of Ribosomal Peptidyl Transferase Activity in ANA-1 Murine Macrophages ¹

Charles Q. Cai; Hongtao Guo; Rebecca A. Schroeder; Cecile Punzalan; Paul C. Kuo

J Immunol (2000) 165 (7): 3978–3984.

Abstract

View articletitled, Nitric Oxide-Dependent Ribosomal RNA Cleavage Is Associated with Inhibition of Ribosomal Peptidyl Transferase Activity in ANA-1 Murine Macrophages<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Cyclooxygenase-2 Expression in Macrophages: Modulation by Protein Kinase C-α ¹

Mélanie Giroux; Albert Descoteaux

J Immunol (2000) 165 (7): 3985–3991.

Abstract

View articletitled, Cyclooxygenase-2 Expression in Macrophages: Modulation by Protein Kinase C-α<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Capsaicin Inhibits Platelet-Activating Factor-Induced Cytosolic Ca²⁺ Rise and Superoxide Production ¹

Se-Young Choi; Hyunjung Ha; Kyong-Tai Kim

J Immunol (2000) 165 (7): 3992–3998.

Abstract

View articletitled, Capsaicin Inhibits Platelet-Activating Factor-Induced Cytosolic Ca2+ Rise and Superoxide Production<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Cooperation Between Decay-Accelerating Factor and Membrane Cofactor Protein in Protecting Cells from Autologous Complement Attack ¹

William G. Brodbeck; Carolyn Mold; John P. Atkinson; M. Edward Medof

J Immunol (2000) 165 (7): 3999–4006.

Abstract

View articletitled, Cooperation Between Decay-Accelerating Factor and Membrane Cofactor Protein in Protecting Cells from Autologous Complement Attack<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Redundant and Segregated Functions of Granule-Associated Heparin-Binding Group II Subfamily of Secretory Phospholipases A₂ in the Regulation of Degranulation and Prostaglandin D₂ Synthesis in Mast Cells ¹

Ayako Enomoto; Makoto Murakami; Emmanuel Valentin; Gerard Lambeau; Michael H. Gelb; Ichiro Kudo

J Immunol (2000) 165 (7): 4007–4014.

Abstract

View articletitled, Redundant and Segregated Functions of Granule-Associated Heparin-Binding Group II Subfamily of Secretory Phospholipases A2 in the Regulation of Degranulation and Prostaglandin D2 Synthesis in Mast Cells<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Macrophage Inflammatory Protein-2 and KC Induce Chemokine Production by Mouse Astrocytes ¹

Yi Luo; Falko R. Fischer; Wayne W. Hancock; Martin E. Dorf

J Immunol (2000) 165 (7): 4015–4023.

Abstract

View articletitled, Macrophage Inflammatory Protein-2 and KC Induce Chemokine Production by Mouse Astrocytes<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Studies on a Mechanism by Which Cytosolic Phospholipase A₂ Regulates the Expression and Function of Type IIA Secretory Phospholipase A₂ ¹

Hiroshi Kuwata; Shinji Yamamoto; Yoshitaka Miyazaki; Satoko Shimbara; Yoshihito Nakatani; Hiroshi Suzuki; Natsuo Ueda; Shozo Yamamoto; Makoto Murakami; Ichiro Kudo

J Immunol (2000) 165 (7): 4024–4031.

Abstract

View articletitled, Studies on a Mechanism by Which Cytosolic Phospholipase A2 Regulates the Expression and Function of Type IIA Secretory Phospholipase A2<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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GM-CSF Regulates Bleomycin-Induced Pulmonary Fibrosis Via a Prostaglandin-Dependent Mechanism

Bethany B. Moore; Michael J. Coffey; Paul Christensen; Stephanie Sitterding; Rose Ngan; Carol A. Wilke; Rod McDonald; Susan M. Phare; Marc Peters-Golden; Robert Paine, III; Galen B. Toews

J Immunol (2000) 165 (7): 4032–4039.

Abstract

View articletitled, GM-CSF Regulates Bleomycin-Induced Pulmonary Fibrosis Via a Prostaglandin-Dependent Mechanism

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Eosinophilopoiesis in A Murine Model of Allergic Airway Eosinophilia: Involvement of Bone Marrow IL-5 and IL-5 Receptor α ¹

Masafumi Tomaki; Lin-Ling Zhao; Joachim Lundahl; Margareta Sjöstrand; Manel Jordana; Anders Lindén; Paul O’Byrne; Jan Lötvall

J Immunol (2000) 165 (7): 4040–4050.

Abstract

View articletitled, Eosinophilopoiesis in A Murine Model of Allergic Airway Eosinophilia: Involvement of Bone Marrow IL-5 and IL-5 Receptor α<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Endogenous and Exogenous IL-6 Inhibit Aeroallergen-Induced Th2 Inflammation ¹

Jingming Wang; Robert J. Homer; Qingsheng Chen; Jack A. Elias

J Immunol (2000) 165 (7): 4051–4061.

Abstract

View articletitled, Endogenous and Exogenous IL-6 Inhibit Aeroallergen-Induced Th2 Inflammation<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Experimentally Induced Recruitment of Plasmacytoid (CD123^high) Dendritic Cells in Human Nasal Allergy ¹

Frode L. Jahnsen; Fridtjof Lund-Johansen; John F. Dunne; Lorant Farkas; Rolf Haye; Per Brandtzaeg

J Immunol (2000) 165 (7): 4062–4068.

Abstract

View articletitled, Experimentally Induced Recruitment of Plasmacytoid (CD123high) Dendritic Cells in Human Nasal Allergy<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Eosinophils Maintain Their Capacity to Signal and Release Eosinophil Cationic Protein Upon Repetitive Stimulation with the Same Agonist ¹

Hans-Uwe Simon; Martina Weber; Eva Becker; Yael Zilberman; Kurt Blaser; Francesca Levi-Schaffer

J Immunol (2000) 165 (7): 4069–4075.

Abstract

View articletitled, Eosinophils Maintain Their Capacity to Signal and Release Eosinophil Cationic Protein Upon Repetitive Stimulation with the Same Agonist<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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CLINICAL IMMUNOLOGY

Overexpression of CD1d by Keratinocytes in Psoriasis and CD1d-Dependent IFN-γ Production by NK-T Cells ¹

Brian Bonish; Denis Jullien; Yves Dutronc; Barbara Bei Huang; Robert Modlin; Franca M. Spada; Steven A. Porcelli; Brian J. Nickoloff

J Immunol (2000) 165 (7): 4076–4085.

Abstract

View articletitled, Overexpression of CD1d by Keratinocytes in Psoriasis and CD1d-Dependent IFN-γ Production by NK-T Cells<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Peptide Dose, MHC Affinity, and Target Self-Antigen Expression Are Critical for Effective Immunotherapy of Nonobese Diabetic Mouse Prediabetes ¹

Shawn Winer; Lakshman Gunaratnam; Igor Astsatourov; Roy K. Cheung; Violetta Kubiak; Wolfram Karges; Denise Hammond-McKibben; Roger Gaedigk; Daniel Graziano; Massimo Trucco; Dorothy J. Becker; H.-Michael Dosch

J Immunol (2000) 165 (7): 4086–4094.

Abstract

View articletitled, Peptide Dose, MHC Affinity, and Target Self-Antigen Expression Are Critical for Effective Immunotherapy of Nonobese Diabetic Mouse Prediabetes<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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CD4⁺ T Lymphocytes with Constitutive CD40 Ligand in Preautoimmune (NZB × NZW)F₁ Lupus-Prone Mice: Phenotype and Possible Role in Autoreactivity ¹

Helene Lettesjö; Gary P. Burd; Rizgar A. Mageed

J Immunol (2000) 165 (7): 4095–4104.

Abstract

View articletitled, CD4+ T Lymphocytes with Constitutive CD40 Ligand in Preautoimmune (NZB × NZW)F1 Lupus-Prone Mice: Phenotype and Possible Role in Autoreactivity<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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B Lymphoblastoid Cell Lines as Efficient APC to Elicit CD8⁺ T Cell Responses Against a Cytomegalovirus Antigen ¹

Qi Sun; Robert L. Burton; Li-Jun Dai; William J. Britt; Kenneth G. Lucas

J Immunol (2000) 165 (7): 4105–4111.

Abstract

View articletitled, B Lymphoblastoid Cell Lines as Efficient APC to Elicit CD8+ T Cell Responses Against a Cytomegalovirus Antigen<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Expression of a Human Coxsackie/Adenovirus Receptor Transgene Permits Adenovirus Infection of Primary Lymphocytes ¹

Madelyn R. Schmidt; Brian Piekos; Mark S. Cabatingan; Robert T. Woodland

J Immunol (2000) 165 (7): 4112–4119.

Abstract

View articletitled, Expression of a Human Coxsackie/Adenovirus Receptor Transgene Permits Adenovirus Infection of Primary Lymphocytes<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Impairment of STAT Activation by IL-12 in a Patient with Atypical Mycobacterial and Staphylococcal Infections ¹

Jared A. Gollob; Korina G. Veenstra; Harumi Jyonouchi; Anne M. Kelly; Patricia Ferrieri; David J. Panka; Frédéric Altare; Claire Fieschi; Jean-Laurent Casanova; David A. Frank; James W. Mier

J Immunol (2000) 165 (7): 4120–4126.

Abstract

View articletitled, Impairment of STAT Activation by IL-12 in a Patient with Atypical Mycobacterial and Staphylococcal Infections<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Spontaneous Production of C-C Chemokines by Individuals Infected with Human T Lymphotropic Virus Type II (HTLV-II) Alone and HTLV-II/HIV-1 Coinfected Individuals ¹

Martha J. Lewis; Virginie W. Gautier; Xue-Ping Wang; Mark H. Kaplan; William W. Hall

J Immunol (2000) 165 (7): 4127–4132.

Abstract

View articletitled, Spontaneous Production of C-C Chemokines by Individuals Infected with Human T Lymphotropic Virus Type II (HTLV-II) Alone and HTLV-II/HIV-1 Coinfected Individuals<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Generation of Tumor-Reactive CTL Against the Tumor-Associated Antigen HER2 Using Retrovirally Transduced Dendritic Cells Derived from CD34⁺ Hemopoietic Progenitor Cells ¹

Christian Meyer zum Büschenfelde; Nicole Nicklisch; Stefan Rose-John; Christian Peschel; Helga Bernhard

J Immunol (2000) 165 (7): 4133–4140.

Abstract

View articletitled, Generation of Tumor-Reactive CTL Against the Tumor-Associated Antigen HER2 Using Retrovirally Transduced Dendritic Cells Derived from CD34+ Hemopoietic Progenitor Cells<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Issues

CUTTING EDGE

CELLULAR IMMUNOLOGY AND IMMUNE REGULATION

MOLECULAR AND STRUCTURAL IMMUNOLOGY

HOST DEFENSE

INFLAMMATION

CLINICAL IMMUNOLOGY

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