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EDITORIALS

From Whence We Come (Happy Birthday to Us)

Robert R. Rich

J Immunol (2006) 176 (4): 2031–2032.

View articletitled, From Whence We Come (Happy Birthday to Us)

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90th Anniversary Article: Studies in Anaphylaxis. XIV. On the Relation between Precipitin and Sensitizin. J. Immunol. 1916. 1: 1–18.

Richard Weil

J Immunol (2006) 176 (4): 2033–2050.

View articletitled, 90th Anniversary Article: Studies in Anaphylaxis. XIV. On the Relation between Precipitin and Sensitizin. J. Immunol. 1916. 1: 1–18.

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IN THIS ISSUE

J Immunol (2006) 176 (4): 2051–2052.

View articletitled, IN THIS ISSUE

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BRIEF REVIEWS

Experimental Models to Study Development and Function of the Human Immune System In Vivo

Nicolas Legrand; Kees Weijer; Hergen Spits

J Immunol (2006) 176 (4): 2053–2058.

Abstract

View articletitled, Experimental Models to Study Development and Function of the Human Immune System In Vivo

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CUTTING EDGE

Cutting Edge: An Alternative Pathway of CD4⁺ T Cell Differentiation Is Induced Following Activation in the Absence of γ-Chain-Dependent Cytokine Signals ¹

Shane R. Mayack; Leslie J. Berg

J Immunol (2006) 176 (4): 2059–2063.

Abstract

View articletitled, Cutting Edge: An Alternative Pathway of CD4+ T Cell Differentiation Is Induced Following Activation in the Absence of γ-Chain-Dependent Cytokine Signals<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Cutting Edge: Influence of the TCR Vβ Domain on the Selection of Semi-Invariant NKT Cells by Endogenous Ligands ¹

Jens Schümann; Marcin P. Mycko; Paolo Dellabona; Giulia Casorati; H. Robson MacDonald

J Immunol (2006) 176 (4): 2064–2068.

Abstract

View articletitled, Cutting Edge: Influence of the TCR Vβ Domain on the Selection of Semi-Invariant NKT Cells by Endogenous Ligands<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Cutting Edge: Novel Human Dendritic Cell- and Monocyte-Attracting Chemokine-Like Protein Identified by Fold Recognition Methods

M. Teresa Pisabarro; Beatrice Leung; Mandy Kwong; Racquel Corpuz; Gretchen D. Frantz; Nancy Chiang; Richard Vandlen; Lauri J. Diehl; Nicholas Skelton; Hok Seon Kim; Dan Eaton; Kerstin N. Schmidt

J Immunol (2006) 176 (4): 2069–2073.

Abstract

View articletitled, Cutting Edge: Novel Human Dendritic Cell- and Monocyte-Attracting Chemokine-Like Protein Identified by Fold Recognition Methods

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Cutting Edge: Enhancement of Antibody Responses Through Direct Stimulation of B and T Cells by Type I IFN ¹

Agnes Le Bon; Clare Thompson; Elisabeth Kamphuis; Vanessa Durand; Cornelia Rossmann; Ulrich Kalinke; David F. Tough

J Immunol (2006) 176 (4): 2074–2078.

Abstract

View articletitled, Cutting Edge: Enhancement of Antibody Responses Through Direct Stimulation of B and T Cells by Type I IFN<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Cutting Edge: Gut Microenvironment Promotes Differentiation of a Unique Memory CD8 T Cell Population

David Masopust; Vaiva Vezys; E. John Wherry; Daniel L. Barber; Rafi Ahmed

J Immunol (2006) 176 (4): 2079–2083.

Abstract

View articletitled, Cutting Edge: Gut Microenvironment Promotes Differentiation of a Unique Memory CD8 T Cell Population

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CELLULAR IMMUNOLOGY AND IMMUNE REGULATION

CD11b⁺/Gr-1⁺ Myeloid Suppressor Cells Cause T Cell Dysfunction after Traumatic Stress ¹

Valeriya P. Makarenkova; Vishal Bansal; Benjamin M. Matta; Lori Ann Perez; Juan B. Ochoa

J Immunol (2006) 176 (4): 2085–2094.

Abstract

View articletitled, CD11b+/Gr-1+ Myeloid Suppressor Cells Cause T Cell Dysfunction after Traumatic Stress<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Accelerated Macrophage Apoptosis Induces Autoantibody Formation and Organ Damage in Systemic Lupus Erythematosus ¹

Michael F. Denny; Parthapratim Chandaroy; Paul D. Killen; Roberto Caricchio; Emily E. Lewis; Bruce C. Richardson; Kyung-Dall Lee; Jerrie Gavalchin; Mariana J. Kaplan

J Immunol (2006) 176 (4): 2095–2104.

Abstract

View articletitled, Accelerated Macrophage Apoptosis Induces Autoantibody Formation and Organ Damage in Systemic Lupus Erythematosus<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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LFA-1-Dependent HuR Nuclear Export and Cytokine mRNA Stabilization in T Cell Activation ¹

Jin Gene Wang; Mark Collinge; Vinod Ramgolam; Oran Ayalon; Xinhao Cynthia Fan; Ruggero Pardi; Jeffrey R. Bender

J Immunol (2006) 176 (4): 2105–2113.

Abstract

View articletitled, LFA-1-Dependent HuR Nuclear Export and Cytokine mRNA Stabilization in T Cell Activation<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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IL-3-Mediated TNF Production Is Necessary for Mast Cell Development ¹

Harry V. Wright; Daniel Bailey; Mohit Kashyap; Christopher L. Kepley; Marina S. Drutskaya; Sergei A. Nedospasov; John J. Ryan

J Immunol (2006) 176 (4): 2114–2121.

Abstract

View articletitled, IL-3-Mediated TNF Production Is Necessary for Mast Cell Development<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Role of MHC Class II on Memory B Cells in Post-Germinal Center B Cell Homeostasis and Memory Response ¹

Michiko Shimoda; Tao Li; Jeanene P. S. Pihkala; Pandelakis A. Koni

J Immunol (2006) 176 (4): 2122–2133.

Abstract

View articletitled, Role of MHC Class II on Memory B Cells in Post-Germinal Center B Cell Homeostasis and Memory Response<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Hyperthermia Enhances CTL Cross-Priming ¹

Hongzhen Shi; Tinghua Cao; John E. Connolly; Laurence Monnet; Lynda Bennett; Sylvie Chapel; Claude Bagnis; Patrice Mannoni; Jean Davoust; A. Karolina Palucka; Jacques Banchereau

J Immunol (2006) 176 (4): 2134–2141.

Abstract

View articletitled, Hyperthermia Enhances CTL Cross-Priming<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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B Cell Tolerance Checkpoints That Restrict Pathways of Antigen-Driven Differentiation ¹

Jacqueline William; Chad Euler; Nicole Primarolo; Mark J. Shlomchik

J Immunol (2006) 176 (4): 2142–2151.

Abstract

View articletitled, B Cell Tolerance Checkpoints That Restrict Pathways of Antigen-Driven Differentiation<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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P2X₇ Receptors Regulate NKT Cells in Autoimmune Hepatitis ¹

Hiroki Kawamura; Fred Aswad; Masahiro Minagawa; Sugantha Govindarajan; Gunther Dennert

J Immunol (2006) 176 (4): 2152–2160.

Abstract

View articletitled, P2X7 Receptors Regulate NKT Cells in Autoimmune Hepatitis<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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A Major Lung CD103 (α_E)-β₇ Integrin-Positive Epithelial Dendritic Cell Population Expressing Langerin and Tight Junction Proteins ¹

Sun-Sang J. Sung; Shu Man Fu; C. Edward Rose, Jr.; Felicia Gaskin; Shyr-Te Ju; Steven R. Beaty

J Immunol (2006) 176 (4): 2161–2172.

Abstract

View articletitled, A Major Lung CD103 (αE)-β7 Integrin-Positive Epithelial Dendritic Cell Population Expressing Langerin and Tight Junction Proteins<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Distinct Mechanisms Control Human Naive and Antigen-Experienced CD8⁺ T Lymphocyte Proliferation ¹

Marco Migliaccio; Pedro Miguel Sousa Alves; Pedro Romero; Nathalie Rufer

J Immunol (2006) 176 (4): 2173–2182.

Abstract

View articletitled, Distinct Mechanisms Control Human Naive and Antigen-Experienced CD8+ T Lymphocyte Proliferation<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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NF-κB-Dependent Regulation of the Timing of Activation-Induced Cell Death of T Lymphocytes ¹

Akanksha Mittal; Salvatore Papa; Guido Franzoso; Ranjan Sen

J Immunol (2006) 176 (4): 2183–2189.

Abstract

View articletitled, NF-κB-Dependent Regulation of the Timing of Activation-Induced Cell Death of T Lymphocytes<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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CD8 T Cells Specific for a Donor-Derived, Self-Restricted Transplant Antigen Are Nonpathogenic Bystanders after Vascularized Heart Transplantation in Mice ¹

Anna Valujskikh; Qiwei Zhang; Peter S. Heeger

J Immunol (2006) 176 (4): 2190–2196.

Abstract

View articletitled, CD8 T Cells Specific for a Donor-Derived, Self-Restricted Transplant Antigen Are Nonpathogenic Bystanders after Vascularized Heart Transplantation in Mice<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Expression and Regulation of the Orphan Receptor RDC1 and Its Putative Ligand in Human Dendritic and B Cells ¹

Simona Infantino; Barbara Moepps; Marcus Thelen

J Immunol (2006) 176 (4): 2197–2207.

Abstract

View articletitled, Expression and Regulation of the Orphan Receptor RDC1 and Its Putative Ligand in Human Dendritic and B Cells<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Differential Role for Cyclic AMP Response Element Binding Protein-1 in Multiple Stages of B Cell Development, Differentiation, and Survival ¹

Hui-Chen Chen; John C. Byrd; Natarajan Muthusamy

J Immunol (2006) 176 (4): 2208–2218.

Abstract

View articletitled, Differential Role for Cyclic AMP Response Element Binding Protein-1 in Multiple Stages of B Cell Development, Differentiation, and Survival<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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The JNK Are Important for Development and Survival of Macrophages

S. Roy Himes; David P. Sester; Timothy Ravasi; Stephen L. Cronau; Tedjo Sasmono; David A. Hume

J Immunol (2006) 176 (4): 2219–2228.

Abstract

View articletitled, The JNK Are Important for Development and Survival of Macrophages

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Developmental Alterations in Thymocyte Sensitivity Are Actively Regulated by MHC Class II Expression in the Thymic Medulla ¹

Steven C. Eck; Peimin Zhu; Marion Pepper; Steven J. Bensinger; Bruce D. Freedman; Terri M. Laufer

J Immunol (2006) 176 (4): 2229–2237.

Abstract

View articletitled, Developmental Alterations in Thymocyte Sensitivity Are Actively Regulated by MHC Class II Expression in the Thymic Medulla<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Mast Cells Enhance T Cell Activation: Importance of Mast Cell Costimulatory Molecules and Secreted TNF ¹

Susumu Nakae; Hajime Suto; Motoyasu Iikura; Maki Kakurai; Jonathon D. Sedgwick; Mindy Tsai; Stephen J. Galli

J Immunol (2006) 176 (4): 2238–2248.

Abstract

View articletitled, Mast Cells Enhance T Cell Activation: Importance of Mast Cell Costimulatory Molecules and Secreted TNF<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Re-evaluating the Generation of a “Proteasome-Independent” MHC Class I-Restricted CD8 T Cell Epitope ¹

E. John Wherry; Tatiana N. Golovina; Susan E. Morrison; Gomathinayagam Sinnathamby; Michael J. McElhaugh; David C. Shockey; Laurence C. Eisenlohr

J Immunol (2006) 176 (4): 2249–2261.

Abstract

View articletitled, Re-evaluating the Generation of a “Proteasome-Independent” MHC Class I-Restricted CD8 T Cell Epitope<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Temporal and Dose-Dependent Relationships between In Vivo B Cell Receptor-Targeted Proliferation and Deletion-Induced by a Microbial B Cell Toxin ¹

Carl S. Goodyear; Fujimi Sugiyama; Gregg J. Silverman

J Immunol (2006) 176 (4): 2262–2271.

Abstract

View articletitled, Temporal and Dose-Dependent Relationships between In Vivo B Cell Receptor-Targeted Proliferation and Deletion-Induced by a Microbial B Cell Toxin<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Human Mast Cells Undergo TRAIL-Induced Apoptosis ¹

Beata Berent-Maoz; Adrian M. Piliponsky; Isabelle Daigle; Hans-Uwe Simon; Francesca Levi-Schaffer

J Immunol (2006) 176 (4): 2272–2278.

Abstract

View articletitled, Human Mast Cells Undergo TRAIL-Induced Apoptosis<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Adaptive Tolerance and Clonal Anergy Are Distinct Biochemical States ¹

Lynda Chiodetti; Seeyoung Choi; Daniel L. Barber; Ronald H. Schwartz

J Immunol (2006) 176 (4): 2279–2291.

Abstract

View articletitled, Adaptive Tolerance and Clonal Anergy Are Distinct Biochemical States<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Antigen Exposure during Enhanced CTLA-4 Expression Promotes Allograft Tolerance In Vivo ¹

Paolo R. O. Salvalaggio; Geoffrey Camirand; Charlotte E. Ariyan; Songyan Deng; Linda Rogozinski; Giacomo P. Basadonna; David M. Rothstein

J Immunol (2006) 176 (4): 2292–2298.

Abstract

View articletitled, Antigen Exposure during Enhanced CTLA-4 Expression Promotes Allograft Tolerance In Vivo<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Thymocyte Negative Selection Is Mediated by Protein Kinase C- and Ca²⁺-Dependent Transcriptional Induction of Bim ¹

Kirsten Canté-Barrett; Elena M. Gallo; Monte M. Winslow; Gerald R. Crabtree

J Immunol (2006) 176 (4): 2299–2306.

Abstract

View articletitled, Thymocyte Negative Selection Is Mediated by Protein Kinase C- and Ca2+-Dependent Transcriptional Induction of Bim<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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CD4-Dependent Potentiation of a High Molecular Weight-Melanoma-Associated Antigen-Specific CTL Response Elicited in HLA-A2/K^b Transgenic Mice ¹

Liaomin Peng; Eric Ko; Wei Luo; Xinhui Wang; Protul A. Shrikant; Soldano Ferrone

J Immunol (2006) 176 (4): 2307–2315.

Abstract

View articletitled, CD4-Dependent Potentiation of a High Molecular Weight-Melanoma-Associated Antigen-Specific CTL Response Elicited in HLA-A2/Kb Transgenic Mice<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Effector and Memory CD8⁺ T Cells Can Be Generated in Response to Alloantigen Independently of CD4⁺ T Cell Help ¹

Nick D. Jones; Manuela Carvalho-Gaspar; Shiqiao Luo; Matthew O. Brook; Laurent Martin; Kathryn J. Wood

J Immunol (2006) 176 (4): 2316–2323.

Abstract

View articletitled, Effector and Memory CD8+ T Cells Can Be Generated in Response to Alloantigen Independently of CD4+ T Cell Help<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Frequency of Natural Regulatory CD4⁺CD25⁺ T Lymphocytes Determines the Outcome of Tolerance across Fully Mismatched MHC Barrier through Linked Recognition of Self and Allogeneic Stimuli ¹

Rita Fucs; Joszilene T. Jesus; Paulo H. N. Souza Junior; Larissa Franco; Mauricio Verícimo; Maria Bellio; Alberto Nobrega

J Immunol (2006) 176 (4): 2324–2329.

Abstract

View articletitled, Frequency of Natural Regulatory CD4+CD25+ T Lymphocytes Determines the Outcome of Tolerance across Fully Mismatched MHC Barrier through Linked Recognition of Self and Allogeneic Stimuli<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Ex Vivo Characterization of Allo-MHC-Restricted T Cells Specific for a Single MHC-Peptide Complex ¹

Mikaël J. Pittet; Asma Gati; Frederic-Anne Le Gal; Gilles Bioley; Philippe Guillaume; Magda de Smedt; Jean Plum; Daniel E. Speiser; Jean-Charles Cerottini; Pierre-Yves Dietrich; Pedro Romero; Alfred Zippelius

J Immunol (2006) 176 (4): 2330–2336.

Abstract

View articletitled, Ex Vivo Characterization of Allo-MHC-Restricted T Cells Specific for a Single MHC-Peptide Complex<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Chemokine Receptor CXCR3 Desensitization by IL-16/CD4 Signaling Is Dependent on CCR5 and Intact Membrane Cholesterol ¹

Shilpa Rahangdale; Roger Morgan; Claudia Heijens; Thomas C. Ryan; Hisato Yamasaki; Elizabeth Bentley; Elizabeth Sullivan; David M. Center; William W. Cruikshank

J Immunol (2006) 176 (4): 2337–2345.

Abstract

View articletitled, Chemokine Receptor CXCR3 Desensitization by IL-16/CD4 Signaling Is Dependent on CCR5 and Intact Membrane Cholesterol<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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CCL5 Modulates Pneumococcal Immunity and Carriage ¹

Ravichandran Palaniappan; Shailesh Singh; Udai P. Singh; Rajesh Singh; Edwin W. Ades; David E. Briles; Susan K. Hollingshead; Walter Royal, III; Jacquelyn S. Sampson; Jonathan K. Stiles; Dennis D. Taub; James W. Lillard, Jr.

J Immunol (2006) 176 (4): 2346–2356.

Abstract

View articletitled, CCL5 Modulates Pneumococcal Immunity and Carriage<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Langerhans-Type Dendritic Cells Genetically Modified to Express Full-Length Antigen Optimally Stimulate CTLs in a CD4-Dependent Manner ¹

Jianda Yuan; Jean-Baptiste Latouche; Joanna Hodges; Alan N. Houghton; Glenn Heller; Michel Sadelain; Isabelle Riviere; James W. Young

J Immunol (2006) 176 (4): 2357–2365.

Abstract

View articletitled, Langerhans-Type Dendritic Cells Genetically Modified to Express Full-Length Antigen Optimally Stimulate CTLs in a CD4-Dependent Manner<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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A Polymeric Bacterial Protein Activates Dendritic Cells via TLR4 ¹

Paula M. Berguer; Juliana Mundiñano; Isabel Piazzon; Fernando A. Goldbaum

J Immunol (2006) 176 (4): 2366–2372.

Abstract

View articletitled, A Polymeric Bacterial Protein Activates Dendritic Cells via TLR4<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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MOLECULAR AND STRUCTURAL IMMUNOLOGY

Meningococcal Porin PorB Binds to TLR2 and Requires TLR1 for Signaling ¹

Paola Massari; Alberto Visintin; Jay Gunawardana; Kristen A. Halmen; Carol A. King; Douglas T. Golenbock; Lee M. Wetzler

J Immunol (2006) 176 (4): 2373–2380.

Abstract

View articletitled, Meningococcal Porin PorB Binds to TLR2 and Requires TLR1 for Signaling<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Position-Dependent Repression and Promotion of DQB1 Intron 3 Splicing by GGGG Motifs ¹

Jana Královic̆ová; Igor Vor̆echovský

J Immunol (2006) 176 (4): 2381–2388.

Abstract

View articletitled, Position-Dependent Repression and Promotion of DQB1 Intron 3 Splicing by GGGG Motifs<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

Supplementary data

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B Cell-Specific Deficiency for Smad2 In Vivo Leads to Defects in TGF-β-Directed IgA Switching and Changes in B Cell Fate ¹

Jörg Klein; Wenjun Ju; Jörg Heyer; Britta Wittek; Torsten Haneke; Petra Knaus; Raju Kucherlapati; Erwin P. Böttinger; Lars Nitschke; Burkhard Kneitz

J Immunol (2006) 176 (4): 2389–2396.

Abstract

View articletitled, B Cell-Specific Deficiency for Smad2 In Vivo Leads to Defects in TGF-β-Directed IgA Switching and Changes in B Cell Fate<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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CD161 (Human NKR-P1A) Signaling in NK Cells Involves the Activation of Acid Sphingomyelinase ¹

David Pozo; Mar Valés-Gómez; Nasim Mavaddat; Sharon C. Williamson; Susan E. Chisholm; Hugh Reyburn

J Immunol (2006) 176 (4): 2397–2406.

Abstract

View articletitled, CD161 (Human NKR-P1A) Signaling in NK Cells Involves the Activation of Acid Sphingomyelinase<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Involvement of Protein Kinase Cε in the Negative Regulation of Akt Activation Stimulated by Granulocyte Colony-Stimulating Factor ¹

Hong Liu; Yaling Qiu; Lei Xiao; Fan Dong

J Immunol (2006) 176 (4): 2407–2413.

Abstract

View articletitled, Involvement of Protein Kinase Cε in the Negative Regulation of Akt Activation Stimulated by Granulocyte Colony-Stimulating Factor<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Endotoxin-Induced Down-Regulation of Elk-3 Facilitates Heme Oxygenase-1 Induction in Macrophages ¹

Su Wol Chung; Yen-Hsu Chen; Shaw-Fang Yet; Matthew D. Layne; Mark A. Perrella

J Immunol (2006) 176 (4): 2414–2420.

Abstract

View articletitled, Endotoxin-Induced Down-Regulation of Elk-3 Facilitates Heme Oxygenase-1 Induction in Macrophages<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Scaffolding Adapter Grb2-Associated Binder 2 Requires Syk to Transmit Signals from FcεRI ¹

Min Yu; Cliff A. Lowell; Benjamin G. Neel; Haihua Gu

J Immunol (2006) 176 (4): 2421–2429.

Abstract

View articletitled, Scaffolding Adapter Grb2-Associated Binder 2 Requires Syk to Transmit Signals from FcεRI<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Functional Hierarchy of the N-Terminal Tyrosines of SLP-76 ¹

Martha S. Jordan; Jeffrey Sadler; Jessica E. Austin; Lisa D. Finkelstein; Andrew L. Singer; Pamela L. Schwartzberg; Gary A. Koretzky

J Immunol (2006) 176 (4): 2430–2438.

Abstract

View articletitled, Functional Hierarchy of the N-Terminal Tyrosines of SLP-76<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Regulation of IgH Gene Assembly: Role of the Intronic Enhancer and 5′D_Q52 Region in Targeting D_HJ_H Recombination ¹

Roshi Afshar; Steven Pierce; Daniel J. Bolland; Anne Corcoran; Eugene M. Oltz

J Immunol (2006) 176 (4): 2439–2447.

Abstract

View articletitled, Regulation of IgH Gene Assembly: Role of the Intronic Enhancer and 5′DQ52 Region in Targeting DHJH Recombination<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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IMMUNOGENETICS

The Molecular Basis for Galα(1,3)Gal Expression in Animals with a Deletion of the α1,3Galactosyltransferase Gene ¹^²

Julie Milland; Dale Christiansen; Brooke D. Lazarus; Simon G. Taylor; Pei Xiang Xing; Mauro S. Sandrin

J Immunol (2006) 176 (4): 2448–2454.

Abstract

View articletitled, The Molecular Basis for Galα(1,3)Gal Expression in Animals with a Deletion of the α1,3Galactosyltransferase Gene<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a><a href="javascript:;" reveal-id="FN2" data-open="FN2" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">2</a>

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HOST DEFENSE

Modulation of the TLR-Mediated Inflammatory Response by the Endogenous Human Host Defense Peptide LL-37 ¹

Neeloffer Mookherjee; Kelly L. Brown; Dawn M. E. Bowdish; Silvana Doria; Reza Falsafi; Karsten Hokamp; Fiona M. Roche; Ruixia Mu; Gregory H. Doho; Jelena Pistolic; Jon-Paul Powers; Jenny Bryan; Fiona S. L. Brinkman; Robert E. W. Hancock

J Immunol (2006) 176 (4): 2455–2464.

Abstract

View articletitled, Modulation of the TLR-Mediated Inflammatory Response by the Endogenous Human Host Defense Peptide LL-37<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Transepithelial Pathogen Uptake into the Small Intestinal Lamina Propria ¹

Alexandra Vallon-Eberhard; Limor Landsman; Nir Yogev; Bernard Verrier; Steffen Jung

J Immunol (2006) 176 (4): 2465–2469.

Abstract

View articletitled, Transepithelial Pathogen Uptake into the Small Intestinal Lamina Propria<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Cytolytic CD8⁺ T Cells Directed against a Cryptic Epitope Derived from a Retroviral Alternative Reading Frame Confer Disease Protection ¹

On Ho; William R. Green

J Immunol (2006) 176 (4): 2470–2475.

Abstract

View articletitled, Cytolytic CD8+ T Cells Directed against a Cryptic Epitope Derived from a Retroviral Alternative Reading Frame Confer Disease Protection<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Activation of Invariant NKT Cells by the Helminth Parasite Schistosoma mansoni¹

Thierry Mallevaey; Jean Pierre Zanetta; Christelle Faveeuw; Josette Fontaine; Emmanuel Maes; Frances Platt; Monique Capron; Maria Leite- de-Moraes; François Trottein

J Immunol (2006) 176 (4): 2476–2485.

Abstract

View articletitled, Activation of Invariant NKT Cells by the Helminth Parasite Schistosoma mansoni<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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OX40 Ligation of CD4⁺ T Cells Enhances Virus-Specific CD8⁺ T Cell Memory Responses Independently of IL-2 and CD4⁺ T Regulatory Cell Inhibition ¹

Qigui Yu; Feng Yun Yue; Xiao X. Gu; Herbert Schwartz; Colin M. Kovacs; Mario A. Ostrowski

J Immunol (2006) 176 (4): 2486–2495.

Abstract

View articletitled, OX40 Ligation of CD4+ T Cells Enhances Virus-Specific CD8+ T Cell Memory Responses Independently of IL-2 and CD4+ T Regulatory Cell Inhibition<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Impaired Protection against Mycobacterium bovis Bacillus Calmette-Guérin Infection in IL-15-Deficient Mice ¹

Kimika Saito; Toshiki Yajima; Shino Kumabe; Takehiko Doi; Hisakata Yamada; Subash Sad; Hao Shen; Yasunobu Yoshikai

J Immunol (2006) 176 (4): 2496–2504.

Abstract

View articletitled, Impaired Protection against Mycobacterium bovis Bacillus Calmette-Guérin Infection in IL-15-Deficient Mice<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Induction of Enhanced Immunity to Intestinal Nematodes Using IL-9-Producing Dendritic Cells ¹

Melanie D. Leech; Richard K. Grencis

J Immunol (2006) 176 (4): 2505–2511.

Abstract

View articletitled, Induction of Enhanced Immunity to Intestinal Nematodes Using IL-9-Producing Dendritic Cells<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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INFLAMMATION

Gliadin Stimulation of Murine Macrophage Inflammatory Gene Expression and Intestinal Permeability Are MyD88-Dependent: Role of the Innate Immune Response in Celiac Disease ¹

Karen E. Thomas; Anna Sapone; Alessio Fasano; Stefanie N. Vogel

J Immunol (2006) 176 (4): 2512–2521.

Abstract

View articletitled, Gliadin Stimulation of Murine Macrophage Inflammatory Gene Expression and Intestinal Permeability Are MyD88-Dependent: Role of the Innate Immune Response in Celiac Disease<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Proinflammatory Cytokine Production in Liver Regeneration Is Myd88-Dependent, but Independent of Cd14, Tlr2, and Tlr4¹

Jean S. Campbell; Kimberly J. Riehle; John T. Brooling; Renay L. Bauer; Claudia Mitchell; Nelson Fausto

J Immunol (2006) 176 (4): 2522–2528.

Abstract

View articletitled, Proinflammatory Cytokine Production in Liver Regeneration Is Myd88-Dependent, but Independent of Cd14, Tlr2, and Tlr4<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Priming of Glomerular Mesangial Cells by Activated Macrophages Causes Blunted Responses to Proinflammatory Stimuli ¹

Kunihiro Hayakawa; Yiman Meng; Nobuhiko Hiramatsu; Ayumi Kasai; Kozue Yamauchi; Jian Yao; Masanori Kitamura

J Immunol (2006) 176 (4): 2529–2537.

Abstract

View articletitled, Priming of Glomerular Mesangial Cells by Activated Macrophages Causes Blunted Responses to Proinflammatory Stimuli<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Neutrophils Regulate Airway Responses in a Model of Fungal Allergic Airways Disease ¹

Stacy J. Park; Maria T. Wiekowski; Sergio A. Lira; Borna Mehrad

J Immunol (2006) 176 (4): 2538–2545.

Abstract

View articletitled, Neutrophils Regulate Airway Responses in a Model of Fungal Allergic Airways Disease<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Impaired GATA3-Dependent Chromatin Remodeling and Th2 Cell Differentiation Leading to Attenuated Allergic Airway Inflammation in Aging Mice ¹

Akihiro Hasegawa; Takako Miki; Hiroyuki Hosokawa; Mohammad B. Hossain; Chiori Shimizu; Kahoko Hashimoto; Motoko Y. Kimura; Masakatsu Yamashita; Toshinori Nakayama

J Immunol (2006) 176 (4): 2546–2554.

Abstract

View articletitled, Impaired GATA3-Dependent Chromatin Remodeling and Th2 Cell Differentiation Leading to Attenuated Allergic Airway Inflammation in Aging Mice<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Involvement of Group VIA Calcium-Independent Phospholipase A₂ in Macrophage Engulfment of Hydrogen Peroxide-Treated U937 Cells ¹

Rebeca Pérez; María A. Balboa; Jesús Balsinde

J Immunol (2006) 176 (4): 2555–2561.

Abstract

View articletitled, Involvement of Group VIA Calcium-Independent Phospholipase A2 in Macrophage Engulfment of Hydrogen Peroxide-Treated U937 Cells<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Deletion of CCR1 Attenuates Pathophysiologic Responses during Respiratory Syncytial Virus Infection

Allison L. Miller; Craig Gerard; Matthew Schaller; Achim D. Gruber; Allison A. Humbles; Nicholas W. Lukacs

J Immunol (2006) 176 (4): 2562–2567.

Abstract

View articletitled, Deletion of CCR1 Attenuates Pathophysiologic Responses during Respiratory Syncytial Virus Infection

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Inhalation Tolerance Is Induced Selectively in Thoracic Lymph Nodes but Executed Pervasively at Distant Mucosal and Nonmucosal Tissues ¹

David Alvarez; Filip K. Swirski; Teng-Chih Yang; Ramzi Fattouh; Ken Croitoru; Jonathan L. Bramson; Martin R. Stämpfli; Manel Jordana

J Immunol (2006) 176 (4): 2568–2580.

Abstract

View articletitled, Inhalation Tolerance Is Induced Selectively in Thoracic Lymph Nodes but Executed Pervasively at Distant Mucosal and Nonmucosal Tissues<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Epithelial CXCR3-B Regulates Chemokines Bioavailability in Normal, but Not in Sjögren’s Syndrome, Salivary Glands ¹

Paolo Sfriso; Francesca Oliviero; Fiorella Calabrese; Marta Miorin; Monica Facco; Antonella Contri; Anna Cabrelle; Ilenia Baesso; Franco Cozzi; Marilisa Andretta; Marco Antonio Cassatella; Ugo Fiocco; Silvano Todesco; Yrjö T. Konttinen; Leonardo Punzi; Carlo Agostini

J Immunol (2006) 176 (4): 2581–2589.

Abstract

View articletitled, Epithelial CXCR3-B Regulates Chemokines Bioavailability in Normal, but Not in Sjögren’s Syndrome, Salivary Glands<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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CLINICAL IMMUNOLOGY

Ceramide-Dependent Regulation of Human Epidermal Keratinocyte CD1d Expression during Terminal Differentiation ¹

Rita Fishelevich; Alla Malanina; Irina Luzina; Sergei Atamas; Miriam J. Smyth; Steven A. Porcelli; Anthony A. Gaspari

J Immunol (2006) 176 (4): 2590–2599.

Abstract

View articletitled, Ceramide-Dependent Regulation of Human Epidermal Keratinocyte CD1d Expression during Terminal Differentiation<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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The Shaving Reaction: Rituximab/CD20 Complexes Are Removed from Mantle Cell Lymphoma and Chronic Lymphocytic Leukemia Cells by THP-1 Monocytes ¹

Paul V. Beum; Adam D. Kennedy; Michael E. Williams; Margaret A. Lindorfer; Ronald P. Taylor

J Immunol (2006) 176 (4): 2600–2609.

Abstract

View articletitled, The Shaving Reaction: Rituximab/CD20 Complexes Are Removed from Mantle Cell Lymphoma and Chronic Lymphocytic Leukemia Cells by THP-1 Monocytes<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Human NK Cells Positively Regulate γδ T Cells in Response to Mycobacterium tuberculosis¹

Ruijun Zhang; Xiaodong Zheng; Baiqing Li; Haiming Wei; Zhigang Tian

J Immunol (2006) 176 (4): 2610–2616.

Abstract

View articletitled, Human NK Cells Positively Regulate γδ T Cells in Response to Mycobacterium tuberculosis<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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TNF-α Blockade Down-Regulates the CD40/CD40L Pathway in the Mucosal Microcirculation: A Novel Anti-Inflammatory Mechanism of Infliximab in Crohn’s Disease ¹

Silvio Danese; Miquel Sans; Franco Scaldaferri; Alessandro Sgambato; Sergio Rutella; Achille Cittadini; Josep M. Piqué; Julian Panes; Jeffry A. Katz; Antonio Gasbarrini; Claudio Fiocchi

J Immunol (2006) 176 (4): 2617–2624.

Abstract

View articletitled, TNF-α Blockade Down-Regulates the CD40/CD40L Pathway in the Mucosal Microcirculation: A Novel Anti-Inflammatory Mechanism of Infliximab in Crohn’s Disease<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Persistent Cytomegalovirus-Specific Memory Responses in the Lung Allograft and Blood following Primary Infection in Lung Transplant Recipients ¹

Oksana A. Shlobin; Erin E. West; Noah Lechtzin; Susan M. Miller; Marvin Borja; Jonathan B. Orens; Lesia K. Dropulic; John F. McDyer

J Immunol (2006) 176 (4): 2625–2634.

Abstract

View articletitled, Persistent Cytomegalovirus-Specific Memory Responses in the Lung Allograft and Blood following Primary Infection in Lung Transplant Recipients<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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Tolerance Induction by Transcutaneous Immunization through Ultraviolet-Irradiated Skin Is Transferable through CD4⁺CD25⁺ T Regulatory Cells and Is Dependent on Host-Derived IL-10

Mehran Ghoreishi; Jan P. Dutz

J Immunol (2006) 176 (4): 2635–2644.

Abstract

View articletitled, Tolerance Induction by Transcutaneous Immunization through Ultraviolet-Irradiated Skin Is Transferable through CD4+CD25+ T Regulatory Cells and Is Dependent on Host-Derived IL-10

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Longitudinal Studies of Clonally Expanded CD8 T Cells Reveal a Repertoire Shrinkage Predicting Mortality and an Increased Number of Dysfunctional Cytomegalovirus-Specific T Cells in the Very Elderly ¹

Sine Reker Hadrup; Jan Strindhall; Tania Køllgaard; Tina Seremet; Boo Johansson; Graham Pawelec; Per thor Straten; Anders Wikby

J Immunol (2006) 176 (4): 2645–2653.

Abstract

View articletitled, Longitudinal Studies of Clonally Expanded CD8 T Cells Reveal a Repertoire Shrinkage Predicting Mortality and an Increased Number of Dysfunctional Cytomegalovirus-Specific T Cells in the Very Elderly<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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B Cells Are Crucial for Determinant Spreading of T Cell Autoimmunity among β Cell Antigens in Diabetes-Prone Nonobese Diabetic Mice ¹

Jide Tian; Dan Zekzer; Yuxin Lu; Hoa Dang; Daniel L. Kaufman

J Immunol (2006) 176 (4): 2654–2661.

Abstract

View articletitled, B Cells Are Crucial for Determinant Spreading of T Cell Autoimmunity among β Cell Antigens in Diabetes-Prone Nonobese Diabetic Mice<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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HIV-Specific Cytotoxic Cell Frequencies Measured Directly Ex Vivo by the Lysispot Assay Can Be Higher or Lower Than the Frequencies of IFN-γ-Secreting Cells: Anti-HIV Cytotoxicity Is Not Generally Impaired Relative to Other Chronic Virus Responses ¹

Jennifer E. Snyder-Cappione; Anagha A. Divekar; Genny M. Maupin; Xia Jin; Lisa M. Demeter; Tim R. Mosmann

J Immunol (2006) 176 (4): 2662–2668.

Abstract

View articletitled, HIV-Specific Cytotoxic Cell Frequencies Measured Directly Ex Vivo by the Lysispot Assay Can Be Higher or Lower Than the Frequencies of IFN-γ-Secreting Cells: Anti-HIV Cytotoxicity Is Not Generally Impaired Relative to Other Chronic Virus Responses<a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a>

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CORRECTIONS

Constitutively active protein kinase B enhances Lck and Erk activities and influences thymocyte selection and activation.

S.-Y. Na; A. Patra; Y. Scheuring; A. Marx; M. Tolaini; D. Kioussis; B. Hemmings; T. Hünig; U. Bommhardt

J Immunol (2006) 176 (4): 2669.

View articletitled, Constitutively active protein kinase B enhances Lck and Erk activities and influences thymocyte selection and activation.

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Identification of high and low responders to lipopolysaccharide in normal subjects: an unbiased approach to identify modulators of innate immunity

M. M. Wurfel; W. Y. Park; F. Radella; J. Ruzinski; A. Sandstrom; J. Strout; R. E. Bumgarner; T. R. Martin

J Immunol (2006) 176 (4): 2669.

View articletitled, Identification of high and low responders to lipopolysaccharide in normal subjects: an unbiased approach to identify modulators of innate immunity

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HIV Nef-mediated CD4 down-regulation is adaptor protein complex 2 dependent

Y.-J. Jin; C. Y. Cai; X. Zhang; H.-T. Zhang; J. A. Hirst; S. J. Burakoff

J Immunol (2006) 176 (4): 2669.

View articletitled, HIV Nef-mediated CD4 down-regulation is adaptor protein complex 2 dependent

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