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1 September 2006
ISSN 0022-1767
EISSN 1550-6606
IN THIS ISSUE
PILLARS OF IMMUNOLOGY
Pillars Article: Allele-Specific Motifs Revealed by Sequencing of Self-Peptides Eluted from MHC Molecules. Nature 1991. 351: 290–296.
J Immunol (2006) 177 (5): 2741–2747.
BRIEF REVIEWS
CUTTING EDGE
Cutting Edge: Interleukin 4-Dependent Mast Cell Proliferation Requires Autocrine/Intracrine Cysteinyl Leukotriene-Induced Signaling1
J Immunol (2006) 177 (5): 2755–2759.
Cutting Edge: IL-23 Cross-Regulates IL-12 Production in T Cell-Dependent Experimental Colitis1
Christoph Becker; Heike Dornhoff; Clemens Neufert; Massimo C. Fantini; Stefan Wirtz; Sabine Huebner; Alexei Nikolaev; Hans-Anton Lehr; Andrew J. Murphy; David M. Valenzuela; George D. Yancopoulos; Peter R. Galle; Margaret Karow; Markus F. Neurath
J Immunol (2006) 177 (5): 2760–2764.
Cutting Edge: Decreased Accumulation and Regulatory Function of CD4+CD25high T Cells in Human STAT5b Deficiency1
Aileen C. Cohen; Kari C. Nadeau; Wenwei Tu; Vivian Hwa; Kira Dionis; Liliana Bezrodnik; Alejandro Teper; Maria Gaillard; Juan Heinrich; Alan M. Krensky; Ron G. Rosenfeld; David B. Lewis
J Immunol (2006) 177 (5): 2770–2774.
CELLULAR IMMUNOLOGY AND IMMUNE REGULATION
CD103 Is a Marker for Alloantigen-Induced Regulatory CD8+ T Cells
Elena Uss; Ajda T. Rowshani; Berend Hooibrink; Neubury M. Lardy; René A. W. van Lier; Ineke J. M. ten Berge
J Immunol (2006) 177 (5): 2775–2783.
Age-Related CD8+ T Cell Clonal Expansions Express Elevated Levels of CD122 and CD127 and Display Defects in Perceiving Homeostatic Signals1
J Immunol (2006) 177 (5): 2784–2792.
EBV Latent Membrane Protein 2A Induces Autoreactive B Cell Activation and TLR Hypersensitivity1
Hongsheng Wang; Matilda W. Nicholas; Kara L. Conway; Pradip Sen; Ramiro Diz; Roland M. Tisch; Stephen H. Clarke
J Immunol (2006) 177 (5): 2793–2802.
Double-Negative T Regulatory Cells Can Develop Outside the Thymus and Do Not Mature from CD8+ T Cell Precursors1
J Immunol (2006) 177 (5): 2803–2809.
Humoral Immune Response to Flagellin Requires T Cells and Activation of Innate Immunity1
J Immunol (2006) 177 (5): 2810–2818.
P2X7 Receptor-Dependent Cell Death Is Modulated during Murine T Cell Maturation and Mediated by Dual Signaling Pathways1
J Immunol (2006) 177 (5): 2842–2850.
All-trans Retinoic Acid Stimulates IL-2-Mediated Proliferation of Human T Lymphocytes: Early Induction of Cyclin D31
J Immunol (2006) 177 (5): 2851–2861.
T Helper Lymphocytes Rescue CTL from Activation-Induced Cell Death1
J Immunol (2006) 177 (5): 2862–2872.
Primitive Lymphoid Progenitors in Bone Marrow with T Lineage Reconstituting Potential1
J Immunol (2006) 177 (5): 2880–2887.
CD4 T Cell-Mediated Protection from Lethal Influenza: Perforin and Antibody-Mediated Mechanisms Give a One-Two Punch1
J Immunol (2006) 177 (5): 2888–2898.
Indirect Effects of Leptin Receptor Deficiency on Lymphocyte Populations and Immune Response in db/db Mice1
Gaby Palmer; Michel Aurrand-Lions; Emmanuel Contassot; Dominique Talabot-Ayer; Dominique Ducrest-Gay; Christian Vesin; Véronique Chobaz-Péclat; Nathalie Busso; Cem Gabay
J Immunol (2006) 177 (5): 2899–2907.
DAP12 Signaling Regulates Plasmacytoid Dendritic Cell Homeostasis and Down-Modulates Their Function during Viral Infection1
Hanna Sjölin; Scott H. Robbins; Gilles Bessou; Åsa Hidmark; Elena Tomasello; Maria Johansson; Håkan Hall; Férose Charifi; Gunilla B. Karlsson Hedestam; Christine A. Biron; Klas Kärre; Petter Höglund; Eric Vivier; Marc Dalod
J Immunol (2006) 177 (5): 2908–2916.
Addition of a Prominent Epitope Affects Influenza A Virus-Specific CD8+ T Cell Immunodominance Hierarchies When Antigen Is Limiting1
J Immunol (2006) 177 (5): 2917–2925.
CD38 Is Required for the Peripheral Survival of Immunotolerogenic CD4+ Invariant NK T Cells in Nonobese Diabetic Mice1
Yi-Guang Chen; Jing Chen; Melissa A. Osborne; Harold D. Chapman; Gurdyal S. Besra; Steven A. Porcelli; Edward H. Leiter; S. Brian Wilson; David V. Serreze
J Immunol (2006) 177 (5): 2939–2947.
CD4+ T Cell Expressed CD80 Regulates Central Nervous System Effector Function and Survival during Experimental Autoimmune Encephalomyelitis1
J Immunol (2006) 177 (5): 2948–2958.
Phosphatidylinositol Mannoside from Mycobacterium tuberculosis Binds α5β1 Integrin (VLA-5) on CD4+ T Cells and Induces Adhesion to Fibronectin1
Roxana E. Rojas; Jeremy J. Thomas; Adam J. Gehring; Preston J. Hill; John T. Belisle; Clifford V. Harding; W. Henry Boom
J Immunol (2006) 177 (5): 2959–2968.
Requirement for CD70 in CD4+ Th Cell-Dependent and Innate Receptor-Mediated CD8+ T Cell Priming1
J Immunol (2006) 177 (5): 2969–2975.
IFN-γ Regulates Donor CD8 T Cell Expansion, Migration, and Leads to Apoptosis of Cells of a Solid Tumor1
J Immunol (2006) 177 (5): 3004–3011.
T Cell Conditioning Explains Early Disappearance of the Memory CD8 T Cell Response to Infection1
J Immunol (2006) 177 (5): 3012–3018.
Human Macrophages Constitute Targets for Immunotoxic Inorganic Arsenic1
J Immunol (2006) 177 (5): 3019–3027.
A Second Generation of Double Mutant Cholera Toxin Adjuvants: Enhanced Immunity without Intracellular Trafficking1
Yukari Hagiwara; Yuki I. Kawamura; Kosuke Kataoka; Bibi Rahima; Raymond J. Jackson; Katsuhiro Komase; Taeko Dohi; Prosper N. Boyaka; Yoshifumi Takeda; Hiroshi Kiyono; Jerry R. McGhee; Kohtaro Fujihashi
J Immunol (2006) 177 (5): 3045–3054.
CD4 T Cell-Dependent Autoimmunity against a Melanocyte Neoantigen Induces Spontaneous Vitiligo and Depends upon Fas-Fas Ligand Interactions1
Teresa Lambe; Janson C. H. Leung; Tiphaine Bouriez-Jones; Karlee Silver; Kimmo Makinen; Tanya L. Crockford; Helen Ferry; John V. Forrester; Richard J. Cornall
J Immunol (2006) 177 (5): 3055–3062.
CD22 Ligand Binding Regulates Normal and Malignant B Lymphocyte Survival In Vivo1
J Immunol (2006) 177 (5): 3063–3073.
Neonatal and Adult CD4+CD3− Cells Share Similar Gene Expression Profile, and Neonatal Cells Up-Regulate OX40 Ligand in Response to TL1A (TNFSF15)1
Mi-Yeon Kim; Kai-Michael Toellner; Andrea White; Fiona M. McConnell; Fabrina M. C. Gaspal; Sonia M. Parnell; Eric Jenkinson; Graham Anderson; Peter J. L. Lane
J Immunol (2006) 177 (5): 3074–3081.
Membrane-Associated TGF-β1 Inhibits Human Memory T Cell Signaling in Malignant and Nonmalignant Inflammatory Microenvironments1
J Immunol (2006) 177 (5): 3082–3088.
Expression and Release of HLA-E by Melanoma Cells and Melanocytes: Potential Impact on the Response of Cytotoxic Effector Cells1
Laurent Derré; Murielle Corvaisier; Béatrice Charreau; Anne Moreau; Emmanuelle Godefroy; Agnès Moreau-Aubry; Francine Jotereau; Nadine Gervois
J Immunol (2006) 177 (5): 3100–3107.
MOLECULAR AND STRUCTURAL IMMUNOLOGY
MHC Class I-Like MILL Molecules Are β2-Microglobulin-Associated, GPI-Anchored Glycoproteins That Do Not Require TAP for Cell Surface Expression1
Mizuho Kajikawa; Tomohisa Baba; Utano Tomaru; Yutaka Watanabe; Satoru Koganei; Sachiyo Tsuji-Kawahara; Naoki Matsumoto; Kazuo Yamamoto; Masaaki Miyazawa; Katsumi Maenaka; Akihiro Ishizu; Masanori Kasahara
J Immunol (2006) 177 (5): 3108–3115.
Human Cytomegalovirus-Encoded UL16 Discriminates MIC Molecules by Their α2 Domains1
J Immunol (2006) 177 (5): 3143–3149.
HLA-B44 Polymorphisms at Position 116 of the Heavy Chain Influence TAP Complex Binding via an Effect on Peptide Occupancy1
J Immunol (2006) 177 (5): 3150–3161.
Molecular Analysis of NTB-A Signaling: A Role for EAT-2 in NTB-A-Mediated Activation of Human NK Cells1
J Immunol (2006) 177 (5): 3170–3177.
IMMUNOGENETICS
Murine Vβ3+ and Vβ7+ T Cell Subsets Are Specific Targets for the HERV-K18 Env Superantigen1
Albert K. Tai; Miao Lin; Francesca Chang; Gang Chen; Francis Hsiao; Natalie Sutkowski; Brigitte T. Huber
J Immunol (2006) 177 (5): 3178–3184.
HOST DEFENSE
Dengue Virus Induces Expression of CXC Chemokine Ligand 10/IFN-γ-Inducible Protein 10, Which Competitively Inhibits Viral Binding to Cell Surface Heparan Sulfate1
Jia-Perng Chen; Hsin-Lin Lu; Szu-Liang Lai; Gabriele S. Campanella; Jui-Ming Sung; Mei-Yi Lu; Betty A. Wu-Hsieh; Yi-Ling Lin; Thomas E. Lane; Andrew D. Luster; Fang Liao
J Immunol (2006) 177 (5): 3185–3192.
Leukotrienes Are Essential for the Control of Leishmania amazonensis Infection and Contribute to Strain Variation in Susceptibility1
J Immunol (2006) 177 (5): 3201–3208.
CD40/CD154 Interactions Are Required for the Optimal Maturation of Skin-Derived APCs and the Induction of Helminth-Specific IFN-γ but Not IL-41
J Immunol (2006) 177 (5): 3209–3217.
Coordinated Function of Murine Cytomegalovirus Genes Completely Inhibits CTL Lysis1
J Immunol (2006) 177 (5): 3225–3234.
Exhaustion of Type I Interferon Response following an Acute Viral Infection
Mohammed Alsharifi; Matthias Regner; Robert Blanden; Mario Lobigs; Eva Lee; Aulikki Koskinen; Arno Müllbacher
J Immunol (2006) 177 (5): 3235–3241.
Activation and Regulation of Platelet-Activating Factor Receptor: Role of Gi and Gq in Receptor-Mediated Chemotactic, Cytotoxic, and Cross-Regulatory Signals1
Stephan L. Brown; Venkatakrishna R. Jala; Sandeep K. Raghuwanshi; Mohd W. Nasser; Bodduluri Haribabu; Ricardo M. Richardson
J Immunol (2006) 177 (5): 3242–3249.
Processing and Presentation of a Mycobacterial Antigen 85B Epitope by Murine Macrophages Is Dependent on the Phagosomal Acquisition of Vacuolar Proton ATPase and In Situ Activation of Cathepsin D1
Christopher R. Singh; Rachel A. Moulton; Lisa Y. Armitige; Akhil Bidani; Mark Snuggs; Subramanian Dhandayuthapani; Robert L. Hunter; Chinnaswamy Jagannath
J Immunol (2006) 177 (5): 3250–3259.
Bone Marrow Stromal Cell Antigen 2 Is a Specific Marker of Type I IFN-Producing Cells in the Naive Mouse, but a Promiscuous Cell Surface Antigen following IFN Stimulation1
Amanda L. Blasius; Emanuele Giurisato; Marina Cella; Robert D. Schreiber; Andrey S. Shaw; Marco Colonna
J Immunol (2006) 177 (5): 3260–3265.
Type 1 IFN Deficiency in the Absence of Normal Splenic Architecture during Lymphocytic Choriomeningitis Virus Infection1
J Immunol (2006) 177 (5): 3266–3272.
The Roles of Bacteria and TLR4 in Rat and Murine Models of Necrotizing Enterocolitis1
Tamas Jilling; Dyan Simon; Jing Lu; Fan Jing Meng; Dan Li; Robert Schy; Richard B. Thomson; Antoine Soliman; Moshe Arditi; Michael S. Caplan
J Immunol (2006) 177 (5): 3273–3282.
EBV Can Protect Latently Infected B Cell Lymphomas from Death Receptor-Induced Apoptosis1
Andrew L. Snow; Stacie L. Lambert; Yasodha Natkunam; Carlos O. Esquivel; Sheri M. Krams; Olivia M. Martinez
J Immunol (2006) 177 (5): 3283–3293.
Protective Roles of Mast Cells and Mast Cell-Derived TNF in Murine Malaria
J Immunol (2006) 177 (5): 3294–3302.
Characterization of the Histoplasma capsulatum-Induced Granuloma1
Erika Heninger; Laura H. Hogan; Jozsef Karman; Sinarack Macvilay; Bjork Hill; Jon P. Woods; Matyas Sandor
J Immunol (2006) 177 (5): 3303–3313.
INFLAMMATION
Immune Interactions with CD4+ T Cells Promote the Development of Functional Osteoclasts from Murine CD11c+ Dendritic Cells1
J Immunol (2006) 177 (5): 3314–3326.
Specific Contribution of p19ARF to Nitric Oxide-Dependent Apoptosis1
Miriam Zeini; Paqui G. Través; Raquel López-Fontal; Cristina Pantoja; Ander Matheu; Manuel Serrano; Lisardo Boscá; Sonsoles Hortelano
J Immunol (2006) 177 (5): 3327–3336.
Functional Analysis of the Chemokine Receptor CCR3 on Airway Epithelial Cells
Lisa A. Beck; Brian Tancowny; Mary E. Brummet; S. Yukiko Asaki; Stephanie L. Curry; Margaret B. Penno; Martyn Foster; Ash Bahl; Cristiana Stellato
J Immunol (2006) 177 (5): 3344–3354.
Active Participation of Antigen-Nonspecific Lymphoid Cells in Immune-Mediated Inflammation1
J Immunol (2006) 177 (5): 3362–3368.
Synchrony of High Endothelial Venules and Lymphatic Vessels Revealed by Immunization1
J Immunol (2006) 177 (5): 3369–3379.
Targeted Deletion of CCR2 Impairs Deep Vein Thombosis Resolution in a Mouse Model12
Peter K. Henke; Charles G. Pearce; Daria M. Moaveni; Andrea J. Moore; Erin M. Lynch; Christopher Longo; Manu Varma; Nicholas A. Dewyer; K. Barry Deatrick; Gilbert R. Upchurch, Jr; Thomas W. Wakefield; Cory Hogaboam; Steven L. Kunkel
J Immunol (2006) 177 (5): 3388–3397.
CD100 Enhances Dendritic Cell and CD4+ Cell Activation Leading to Pathogenetic Humoral Responses and Immune Complex Glomerulonephritis1
Ming Li; Kim M. O’Sullivan; Lynelle K. Jones; Timothy Semple; Atsushi Kumanogoh; Hitoshi Kikutani; Stephen R. Holdsworth; A. Richard Kitching
J Immunol (2006) 177 (5): 3406–3412.
Role of MAPK in the Regulation of Double-Stranded RNA- and Encephalomyocarditis Virus-Induced Cyclooxygenase-2 Expression by Macrophages1
J Immunol (2006) 177 (5): 3413–3420.
Stat5 Expression Is Required for IgE-Mediated Mast Cell Function1
Brian O. Barnstein; Geqiang Li; Zhengqi Wang; Sarah Kennedy; Charles Chalfant; Hiroshi Nakajima; Kevin D. Bunting; John J. Ryan
J Immunol (2006) 177 (5): 3421–3426.
c-Src Mediates Thrombin-Induced NF-κB Activation and IL-8/CXCL8 Expression in Lung Epithelial Cells1
J Immunol (2006) 177 (5): 3427–3438.
Leukotriene B4 Receptors BLT1 and BLT2: Expression and Function in Human and Murine Mast Cells
J Immunol (2006) 177 (5): 3439–3447.
CLINICAL IMMUNOLOGY
Cooperative Induction of a Tolerogenic Dendritic Cell Phenotype by Cytokines Secreted by Pancreatic Carcinoma Cells1
Graziella Bellone; Anna Carbone; Carlo Smirne; Tiziana Scirelli; Alessandra Buffolino; Anna Novarino; Alessandra Stacchini; Oscar Bertetto; Giorgio Palestro; Claudio Sorio; Aldo Scarpa; Giorgio Emanuelli; Ulrich Rodeck
J Immunol (2006) 177 (5): 3448–3460.
Factor I-Mediated Processing of Complement Fragments on HIV Immune Complexes Targets HIV to CR2-Expressing B Cells and Facilitates B Cell-Mediated Transmission of Opsonized HIV to T Cells1
Zoltán Bánki; Doris Wilflingseder; Christoph G. Ammann; Monika Pruenster; Brigitte Müllauer; Karoline Holländer; Martina Meyer; Georg M. Sprinzl; Jan van Lunzen; Hans-Jürgen Stellbrink; Manfred P. Dierich; Heribert Stoiber
J Immunol (2006) 177 (5): 3469–3476.
Phase II Enzymes Induction Blocks the Enhanced IgE Production in B Cells by Diesel Exhaust Particles1
J Immunol (2006) 177 (5): 3477–3483.
Evaluation of the Function of Human Invariant NKT Cells from Cancer Patients Using α-Galactosylceramide-Loaded Murine Dendritic Cells1
Kanako Shimizu; Michihiro Hidaka; Norimitsu Kadowaki; Noriko Makita; Naoko Konishi; Koji Fujimoto; Takashi Uchiyama; Fumio Kawano; Masaru Taniguchi; Shin-ichiro Fujii
J Immunol (2006) 177 (5): 3484–3492.
CORRECTIONS
Chlamydia heat shock protein 60 induces trophoblast apoptosis through TLR4
O. Equils; D. Lu; M. Gatter; S. S. Witkin; C. Bertolotto; M. Arditi; J. A. McGregor; C. F. Simmons; C. J. Hobel
J Immunol (2006) 177 (5): 3493.
Inhibition of MHC class II expression and immune responses by c-MIR
M. Ohmura-Hoshino; Y. Matsuki; M. Aoki; E. Goto; M. Mito; M. Uematsu; T. Kakiuchi; H. Hotta; S. Ishido
J Immunol (2006) 177 (5): 3493.
Heat shock protein-70 mediates the cytoprotective effect of carbon monoxide: involvement of p38β MAPK and heat shock factor-1
J Immunol (2006) 177 (5): 3494.
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Cover Image
Cover Image
On the cover: Image shown is a pseudocolor overlay of toll-like receptor 4 (TLR4) immunofluorescence (green) and nuclear labeling with Hoechst 33258 (blue) in a frozen section of the ileum from formula-fed and hypoxia-stressed neonatal mice at postnatal 48 h. The intense apical TLR4 labeling in enterocytes is characteristic of samples from animals exposed to formula feeding and hypoxia and it is diminished in mother-fed pups. Jilling, T., D. Simon, J. Lu, F. J. Meng, D. Li, R. Schy, R. B. Thomson, A. Soliman, M. Arditi, and M. S. Caplan. 2006. The roles of bacteria and TLR4 in rat and murine models of necrotizing enterocolitis. J. Immunol. 177: 3273–3282.
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