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Issues
1 October 2006
ISSN 0022-1767
EISSN 1550-6606
IN THIS ISSUE
PILLARS OF IMMUNOLOGY
Pillars Article: Origin of Antibody Variation. Nature 1966. 211: 242–243.
J Immunol (2006) 177 (7): 4237–4238.
BRIEF REVIEWS
The Inflammatory Caspases: Key Players in the Host Response to Pathogenic Invasion and Sepsis
J Immunol (2006) 177 (7): 4239–4245.
CUTTING EDGE
Cutting Edge: IL-7-Independent Regulation of IL-7 Receptor α Expression and Memory CD8 T Cell Development1
J Immunol (2006) 177 (7): 4247–4251.
Cutting Edge: ASC Mediates the Induction of Multiple Cytokines by Porphyromonas gingivalis via Caspase-1-Dependent and -Independent Pathways1
Debra J. Taxman; Jinghua Zhang; Catherine Champagne; Daniel T. Bergstralh; Heather A. Iocca; John D. Lich; Jenny Pan-Yun Ting
J Immunol (2006) 177 (7): 4252–4256.
Cutting Edge: Paracrine, but Not Autocrine, IL-2 Signaling Is Sustained during Early Antiviral CD4 T Cell Response1
J Immunol (2006) 177 (7): 4257–4261.
Cutting Edge: T Cell Requirement for CD28 Costimulation Is Due to Negative Regulation of TCR Signals by PTEN1
J Immunol (2006) 177 (7): 4262–4266.
Cutting Edge: Rho Activation and Actin Polarization Are Dependent on Plexin-A1 in Dendritic Cells1
So-Young Eun; Brian P. O’Connor; Athena W. Wong; Hendrick W. van Deventer; Debra J. Taxman; William Reed; Ping Li; Janice S. Blum; Karen P. McKinnon; Jenny P.-Y. Ting
J Immunol (2006) 177 (7): 4271–4275.
Cutting Edge: Uniqueness of Lymphoid Chemokine Requirement for the Initiation and Maturation of Nasopharynx-Associated Lymphoid Tissue Organogenesis1
Satoshi Fukuyama; Takahiro Nagatake; Dong-Young Kim; Kaoru Takamura; Eun Jeong Park; Tsuneyasu Kaisho; Norimitsu Tanaka; Yuichi Kurono; Hiroshi Kiyono
J Immunol (2006) 177 (7): 4276–4280.
CELLULAR IMMUNOLOGY AND IMMUNE REGULATION
Combination of Vaccination and Chimeric Receptor Expressing T Cells Provides Improved Active Therapy of Tumors1
J Immunol (2006) 177 (7): 4288–4298.
T Cell, Ig Domain, Mucin Domain-2 Gene-Deficient Mice Reveal a Novel Mechanism for the Regulation of Th2 Immune Responses and Airway Inflammation1
Paul D. Rennert; Takaharu Ichimura; Irene D. Sizing; Veronique Bailly; Zhifang Li; Rachel Rennard; Patricia McCoon; Lourdes Pablo; Steven Miklasz; Leticia Tarilonte; Joseph V. Bonventre
J Immunol (2006) 177 (7): 4311–4321.
Three Memory Subsets of Human CD8+ T Cells Differently Expressing Three Cytolytic Effector Molecules1
J Immunol (2006) 177 (7): 4330–4340.
Identification and Characterization of the Precursors Committed to Osteoclasts Induced by TNF-Related Activation-Induced Cytokine/Receptor Activator of NF-κB Ligand1
Ayako Mochizuki; Masamichi Takami; Tadaharu Kawawa; Reina Suzumoto; Takahisa Sasaki; Akihiko Shiba; Hiroaki Tsukasaki; Baohong Zhao; Rika Yasuhara; Tetsuo Suzawa; Yoichi Miyamoto; Yongwon Choi; Ryutaro Kamijo
J Immunol (2006) 177 (7): 4360–4368.
Inhibitory Role of IFN-γ-Inducible Lysosomal Thiol Reductase in T Cell Activation1
Igor Barjaktarević; Ayman Rahman; Sasa Radoja; Branka Bogunović; Alison Vollmer; Stanislav Vukmanović; Maja Marić
J Immunol (2006) 177 (7): 4369–4375.
Blockade of CTLA-4 on CD4+CD25+ Regulatory T Cells Abrogates Their Function In Vivo1
Simon Read; Rebecca Greenwald; Ana Izcue; Nicholas Robinson; Didier Mandelbrot; Loise Francisco; Arlene H. Sharpe; Fiona Powrie
J Immunol (2006) 177 (7): 4376–4383.
Induction of Autoimmunity by Expansion of Autoreactive CD4+CD62Llow Cells In Vivo1
Bastian Amend; Hong Doster; Christian Lange; Evelyn Dubois; Hubert Kalbacher; Arthur Melms; Felix Bischof
J Immunol (2006) 177 (7): 4384–4390.
The Effects of Age, Thymectomy, and HIV Infection on α and β TCR Excision Circles in Naive T Cells1
J Immunol (2006) 177 (7): 4391–4401.
A Large T Cell Invagination with CD2 Enrichment Resets Receptor Engagement in the Immunological Synapse1
Kentner Singleton; Nadia Parvaze; Kavyya R. Dama; Kenneth S. Chen; Paula Jennings; Bozidar Purtic; Michael D. Sjaastad; Christopher Gilpin; Mark M. Davis; Christoph Wülfing
J Immunol (2006) 177 (7): 4402–4413.
Host-Derived Langerhans Cells Persist after MHC-Matched Allografting Independent of Donor T Cells and Critically Influence the Alloresponses Mediated by Donor Lymphocyte Infusions1
Nadira Durakovic; Karl B. Bezak; Mario Skarica; Vedran Radojcic; Ephraim J. Fuchs; George F. Murphy; Leo Luznik
J Immunol (2006) 177 (7): 4414–4425.
Early Exposure to IL-4 Stabilizes IL-4 mRNA in CD4+ T Cells via RNA-Binding Protein HuR1
J Immunol (2006) 177 (7): 4426–4435.
Regulatory Role of γδ T Cells in the Recruitment of CD4+ and CD8+ T Cells to Lung and Subsequent Pulmonary Fibrosis1
Philip L. Simonian; Christina L. Roark; Fernando Diaz del Valle; Brent E. Palmer; Ivor S. Douglas; Koichi Ikuta; Willi K. Born; Rebecca L. O’Brien; Andrew P. Fontenot
J Immunol (2006) 177 (7): 4436–4443.
Cell-Autonomous CCL5 Transcription by Memory CD8 T Cells Is Regulated by IL-41
Antoine Marçais; Charles-Antoine Coupet; Thierry Walzer; Martine Tomkowiak; Raffaella Ghittoni; Jacqueline Marvel
J Immunol (2006) 177 (7): 4451–4457.
Augmented IL-7 Signaling during Viral Infection Drives Greater Expansion of Effector T Cells but Does Not Enhance Memory1
J Immunol (2006) 177 (7): 4458–4463.
Functional Dichotomy between OX40 and 4-1BB in Modulating Effector CD8 T Cell Responses1
J Immunol (2006) 177 (7): 4464–4472.
B Cells Drive Early T Cell Autoimmunity In Vivo prior to Dendritic Cell-Mediated Autoantigen Presentation1
J Immunol (2006) 177 (7): 4481–4487.
Ligation of CD80 Is Critical for High-Level CD25 Expression on CD8+ T Lymphocytes1
J Immunol (2006) 177 (7): 4495–4502.
A Novel Role for Viral-Defective Interfering Particles in Enhancing Dendritic Cell Maturation1
J Immunol (2006) 177 (7): 4503–4513.
Trauma-Hemorrhage Induces Depressed Splenic Dendritic Cell Functions in Mice1
Takashi Kawasaki; William J. Hubbard; Mashkoor A. Choudhry; Martin G. Schwacha; Kirby I. Bland; Irshad H. Chaudry
J Immunol (2006) 177 (7): 4514–4520.
Homeostatic Proliferation as an Isolated Variable Reverses CD8+ T Cell Anergy and Promotes Tumor Rejection1
J Immunol (2006) 177 (7): 4521–4529.
STAT1-Independent Cell Type-Specific Regulation of Antiviral APOBEC3G by IFN-α1
J Immunol (2006) 177 (7): 4530–4540.
Rac1 Negatively Regulates Lipopolysaccharide-Induced IL-23 p19 Expression in Human Macrophages and Dendritic Cells and NF-κB p65 trans Activation Plays a Novel Role1
Mitsuyoshi Utsugi; Kunio Dobashi; Tamotsu Ishizuka; Tadayoshi Kawata; Takeshi Hisada; Yasuo Shimizu; Akihiro Ono; Masatomo Mori
J Immunol (2006) 177 (7): 4550–4557.
CD25+CD4+ Regulatory T Cells and Memory T Cells Prevent Lymphopenia-Induced Proliferation of Naive T Cells in Transient States of Lymphopenia1
J Immunol (2006) 177 (7): 4558–4566.
MOLECULAR AND STRUCTURAL IMMUNOLOGY
Structural Characterization of Mycobacterial Phosphatidylinositol Mannoside Binding to Mouse CD1d12
J Immunol (2006) 177 (7): 4577–4583.
Repression of IFN-γ Induction of Class II Transactivator: A Role for PRDM1/Blimp-1 in Regulation of Cytokine Signaling1
J Immunol (2006) 177 (7): 4584–4593.
Molecular Mechanisms for Transcriptional Regulation of Human High-Affinity IgE Receptor β-Chain Gene Induced by GM-CSF1
J Immunol (2006) 177 (7): 4605–4611.
IMMUNOGENETICS
Identification of Susceptibility Loci for Skin Disease in a Murine Psoriasis Model1
Daniel Kess; Anna-Karin B. Lindqvist; Thorsten Peters; Honglin Wang; Jan Zamek; Roswitha Nischt; Karl W. Broman; Robert Blakytny; Thomas Krieg; Rikard Holmdahl; Karin Scharffetter-Kochanek
J Immunol (2006) 177 (7): 4612–4619.
MHC Class II Molecules Control Murine B Cell Responsiveness to Lipopolysaccharide Stimulation1
J Immunol (2006) 177 (7): 4620–4626.
HOST DEFENSE
Restoration of Natural IgM Production from Liver B Cells by Exogenous IL-18 Improves the Survival of Burn-Injured Mice Infected with Pseudomonas aeruginosa1
Manabu Kinoshita; Nariyoshi Shinomiya; Satoshi Ono; Hironori Tsujimoto; Toshinobu Kawabata; Atsushi Matsumoto; Hoshio Hiraide; Shuhji Seki
J Immunol (2006) 177 (7): 4627–4635.
Fatal Recall Responses Mediated by CD8 T cells during Intracellular Bacterial Challenge Infection1
J Immunol (2006) 177 (7): 4644–4651.
IL-17 Production Is Dominated by γδ T Cells rather than CD4 T Cells during Mycobacterium tuberculosis Infection1
J Immunol (2006) 177 (7): 4662–4669.
Murine γ-Herpesvirus 68 Limits Naturally Occurring CD4+CD25+ T Regulatory Cell Activity following Infection1
J Immunol (2006) 177 (7): 4670–4678.
Specific Recognition of Candida albicans by Macrophages Requires Galectin-3 to Discriminate Saccharomyces cerevisiae and Needs Association with TLR2 for Signaling1
Thierry Jouault; Miryam El Abed-El Behi; María Martínez-Esparza; Laetitia Breuilh; Pierre-André Trinel; Mathias Chamaillard; Francois Trottein; Daniel Poulain
J Immunol (2006) 177 (7): 4679–4687.
The Reduced Bactericidal Function of Complement C5-Deficient Murine Macrophages Is Associated with Defects in the Synthesis and Delivery of Reactive Oxygen Radicals to Mycobacterial Phagosomes1
D. Sundarsingh Daniel; Guixiang Dai; Christopher R. Singh; Devin R. Lindsey; Amanda K. Smith; Subramanian Dhandayuthapani; Robert L. Hunter, Jr; Chinnaswamy Jagannath
J Immunol (2006) 177 (7): 4688–4698.
Differential Selection Pressure Exerted on HIV by CTL Targeting Identical Epitopes but Restricted by Distinct HLA Alleles from the Same HLA Supertype1
Alasdair Leslie; David A. Price; Pamela Mkhize; Karen Bishop; Almas Rathod; Cheryl Day; Hayley Crawford; Isobella Honeyborne; Tedi E. Asher; Graz Luzzi; Anne Edwards; Christine M. Rosseau; James I. Mullins; Gareth Tudor-Williams; Vas Novelli; Christian Brander; Daniel C. Douek; Photini Kiepiela; Bruce D. Walker; Philip J. R. Goulder
J Immunol (2006) 177 (7): 4699–4708.
Galectin-3 Induces Death of Candida Species Expressing Specific β-1,2-Linked Mannans1
J Immunol (2006) 177 (7): 4718–4726.
INFLAMMATION
Activation of the Lectin Pathway by Natural IgM in a Model of Ischemia/Reperfusion Injury1
Ming Zhang; Kazue Takahashi; Elisabeth M. Alicot; Thomas Vorup-Jensen; Benedikt Kessler; Steffen Thiel; Jens Christian Jensenius; R. Alan B. Ezekowitz; Francis D. Moore; Michael C. Carroll
J Immunol (2006) 177 (7): 4727–4734.
The Monoclonal Antibody CHO-131 Identifies a Subset of Cutaneous Lymphocyte-Associated Antigen T Cells Enriched in P-Selectin-Binding Cells1
J Immunol (2006) 177 (7): 4742–4748.
Follistatin-Like Protein-1 Is a Novel Proinflammatory Molecule1
Takako Miyamae; Anthony D. Marinov; Dawn Sowders; David C. Wilson; Jason Devlin; Robert Boudreau; Paul Robbins; Raphael Hirsch
J Immunol (2006) 177 (7): 4758–4762.
TCR ζ Down-Regulation under Chronic Inflammation Is Mediated by Myeloid Suppressor Cells Differentially Distributed between Various Lymphatic Organs1
Analía V. Ezernitchi; Ilan Vaknin; Leonor Cohen-Daniel; Ofer Levy; Efrat Manaster; Amal Halabi; Eli Pikarsky; Lior Shapira; Michal Baniyash
J Immunol (2006) 177 (7): 4763–4772.
Renal Collecting Duct Epithelial Cells React to Pyelonephritis-Associated Escherichia coli by Activating Distinct TLR4-Dependent and -Independent Inflammatory Pathways1
Cécilia Chassin; Jean-Michel Goujon; Sylvie Darche; Laurence du Merle; Marcelle Bens; Françoise Cluzeaud; Catherine Werts; Eric Ogier-Denis; Chantal Le Bouguénec; Dominique Buzoni-Gatel; Alain Vandewalle
J Immunol (2006) 177 (7): 4773–4784.
Cyclooxygenase-1 Overexpression Decreases Basal Airway Responsiveness but Not Allergic Inflammation1
Jeffrey W. Card; Michelle A. Carey; J. Alyce Bradbury; Joan P. Graves; Fred B. Lih; Michael P. Moorman; Daniel L. Morgan; Laura M. DeGraff; Yun Zhao; Julie F. Foley; Darryl C. Zeldin
J Immunol (2006) 177 (7): 4785–4793.
A Novel C5a Receptor-Tissue Factor Cross-Talk in Neutrophils Links Innate Immunity to Coagulation Pathways1
Konstantinos Ritis; Michael Doumas; Dimitrios Mastellos; Anastasia Micheli; Stavros Giaglis; Paola Magotti; Stavros Rafail; Georgios Kartalis; Paschalis Sideras; John D. Lambris
J Immunol (2006) 177 (7): 4794–4802.
Complement-Dependent Control of Teratoma Formation by Embryonic Stem Cells1
J Immunol (2006) 177 (7): 4803–4809.
A Role for Inflammatory Mediators in the Induction of Immunoregulatory B Cells1
J Immunol (2006) 177 (7): 4810–4817.
A Microbial TLR2 Agonist Imparts Macrophage-Activating Ability to Apolipoprotein A-11
J Immunol (2006) 177 (7): 4826–4832.
Collaborative Action of NF-κB and p38 MAPK Is Involved in CpG DNA-Induced IFN-α and Chemokine Production in Human Plasmacytoid Dendritic Cells1
Youko Osawa; Sumiko Iho; Rumiko Takauji; Hisakazu Takatsuka; Saburo Yamamoto; Takayuki Takahashi; Satomi Horiguchi; Yoshimasa Urasaki; Takasumi Matsuki; Shigeharu Fujieda
J Immunol (2006) 177 (7): 4841–4852.
Eosinophil-Derived Cationic Proteins Activate the Synthesis of Remodeling Factors by Airway Epithelial Cells1
J Immunol (2006) 177 (7): 4861–4869.
Novel Approach to Inhibit Asthma-Mediated Lung Inflammation Using Anti-CD147 Intervention1
William M. Gwinn; Jesse M. Damsker; Rustom Falahati; Ifeanyi Okwumabua; Ann Kelly-Welch; Achsah D. Keegan; Christophe Vanpouille; James J. Lee; Lindsay A. Dent; David Leitenberg; Michael I. Bukrinsky; Stephanie L. Constant
J Immunol (2006) 177 (7): 4870–4879.
CLINICAL IMMUNOLOGY
Essential Role for IL-10 in Resistance to Lipopolysaccharide-Induced Preterm Labor in Mice1
J Immunol (2006) 177 (7): 4888–4896.
Functional Reversion of Antigen-Specific CD8+ T Cells from Patients with Hodgkin Lymphoma following In Vitro Stimulation with Recombinant Polyepitope1
Corey Smith; Leanne Cooper; Melinda Burgess; Michael Rist; Natasha Webb; Eleanore Lambley; Judy Tellam; Paula Marlton; John F. Seymour; Maher Gandhi; Rajiv Khanna
J Immunol (2006) 177 (7): 4897–4906.
An Unconventional Antigen Translated by a Novel Internal Ribosome Entry Site Elicits Antitumor Humoral Immune Reactions1
Zeyu Xiong; Enli Liu; Yan Yan; Richard T. Silver; Fan Yang; Irene H. Chen; Yangyang Chen; Srdan Verstovsek; Hong Wang; Josef Prchal; Xiao-Feng Yang
J Immunol (2006) 177 (7): 4907–4916.
An Anti-IL-12p40 Antibody Down-Regulates Type 1 Cytokines, Chemokines, and IL-12/IL-23 in Psoriasis1
Eiko Toichi; Gisela Torres; Thomas S. McCormick; Timothy Chang; Mary Ann Mascelli; Catharine L. Kauffman; Nancy Aria; Alice B. Gottlieb; Daniel E. Everitt; Bart Frederick; Charles E. Pendley; Kevin D. Cooper
J Immunol (2006) 177 (7): 4917–4926.
ICOS Deficiency Is Associated with a Severe Reduction of CXCR5+CD4 Germinal Center Th Cells1
Lukas Bossaller; Jan Burger; Ruth Draeger; Bodo Grimbacher; Rolf Knoth; Alessandro Plebani; Anne Durandy; Ulrich Baumann; Michael Schlesier; Andrew A. Welcher; Hans Hartmut Peter; Klaus Warnatz
J Immunol (2006) 177 (7): 4927–4932.
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Cover Image
Cover Image
On the cover: Upon tight T cell/APC couple formation, a deep T cell invagination forms at the center of the cellular interface with APC cell membrane still attached. It is enriched in receptor/ligand couples, most prominently CD2/CD48. CD48GFP fluorescence from the APC reaching into the T cell invagination is shown (1 min steps). Singleton, K., N. Parvaze, K. R. Dama, K. S. Chen, P. Jennings, B. Purtic, M. D. Sjaastad, C. Gilpin, M. M. Davis, and C. Wülfing. 2006. A large T cell invagination with CD2 enrichment resets receptor engagement in the immunological synapse. J. Immunol. 177: 4402–4413.
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