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15 October 2006
ISSN 0022-1767
EISSN 1550-6606
IN THIS ISSUE
BRIEF REVIEWS
CUTTING EDGE
Cutting Edge: Treatment of Complement Regulatory Protein Deficiency by Retroviral In Vivo Gene Therapy1
J Immunol (2006) 177 (8): 4953–4956.
Cutting Edge: Abortive Proliferation of CD46-Induced Tr1-Like Cells due to a Defective Akt/Survivin Signaling Pathway1
J Immunol (2006) 177 (8): 4957–4961.
Cutting Edge: Hypoxia-Inducible Factor 1α and Its Activation-Inducible Short Isoform I.1 Negatively Regulate Functions of CD4+ and CD8+ T Lymphocytes
Dmitriy Lukashev; Boris Klebanov; Hidefumi Kojima; Alex Grinberg; Akiko Ohta; Ludmilla Berenfeld; Roland H. Wenger; Akio Ohta; Michail Sitkovsky
J Immunol (2006) 177 (8): 4962–4965.
CELLULAR IMMUNOLOGY AND IMMUNE REGULATION
DAP12 Signaling Directly Augments Proproliferative Cytokine Stimulation of NK Cells during Viral Infections1
Anthony R. French; Hanna Sjölin; Sungjin Kim; Rima Koka; Liping Yang; Deborah A. Young; Cristina Cerboni; Elena Tomasello; Averil Ma; Eric Vivier; Klas Kärre; Wayne M. Yokoyama
J Immunol (2006) 177 (8): 4981–4990.
Role of Galectin-3 in Mast Cell Functions: Galectin-3-Deficient Mast Cells Exhibit Impaired Mediator Release and Defective JNK Expression1
Huan-Yuan Chen; Bhavya B. Sharma; Lan Yu; Riaz Zuberi; I-Chun Weng; Yuko Kawakami; Toshiaki Kawakami; Daniel K. Hsu; Fu-Tong Liu
J Immunol (2006) 177 (8): 4991–4997.
IFN-γ-Mediated Inhibition of Human IgE Synthesis by IL-21 Is Associated with a Polymorphism in the IL-21R Gene1
Jérôme Pène; Laurence Guglielmi; Jean-François Gauchat; Nathalie Harrer; Maximilian Woisetschläger; Vera Boulay; Jean-Michel Fabre; Pascal Demoly; Hans Yssel
J Immunol (2006) 177 (8): 5006–5013.
Peripheral T Cell Lymphopenia and Concomitant Enrichment in Naturally Arising Regulatory T Cells: The Case of the Pre-Tα Gene-Deleted Mouse1
J Immunol (2006) 177 (8): 5014–5023.
A Preferential Role for STAT5, not Constitutively Active STAT3, in Promoting Survival of a Human Lymphoid Tumor1
J Immunol (2006) 177 (8): 5032–5040.
Identification of a Novel Human Granzyme B Inhibitor Secreted by Cultured Sertoli Cells1
Simonetta Sipione; Katia C. Simmen; Sarah J. Lord; Bruce Motyka; Catherine Ewen; Irene Shostak; Gina R. Rayat; Jannette M. Dufour; Greg S. Korbutt; Ray V. Rajotte; R. Chris Bleackley
J Immunol (2006) 177 (8): 5051–5058.
Involvement of the IκB Kinase (IKK)-Related Kinases Tank-Binding Kinase 1/IKKi and Cullin-Based Ubiquitin Ligases in IFN Regulatory Factor-3 Degradation1
Annie Bibeau-Poirier; Simon-Pierre Gravel; Jean-François Clément; Sébastien Rolland; Geneviève Rodier; Philippe Coulombe; John Hiscott; Nathalie Grandvaux; Sylvain Meloche; Marc J. Servant
J Immunol (2006) 177 (8): 5059–5067.
RANTES Modulates TLR4-Induced Cytokine Secretion in Human Peripheral Blood Monocytes1
Shiva Shahrara; Christy C. Park; Vladislav Temkin; Jared W. Jarvis; Michael V. Volin; Richard M. Pope
J Immunol (2006) 177 (8): 5077–5087.
H2-M3-Restricted T Cells Participate in the Priming of Antigen-Specific CD4+ T Cells1
J Immunol (2006) 177 (8): 5098–5104.
A 20-Mb Region of Chromosome 4 Controls TNF-α-Mediated CD8+ T Cell Aggression Toward β Cells in Type 1 Diabetes1
J Immunol (2006) 177 (8): 5105–5114.
Selective Availability of IL-2 Is a Major Determinant Controlling the Production of CD4+CD25+Foxp3+ T Regulatory Cells1
J Immunol (2006) 177 (8): 5115–5121.
IL-10- and IL-12-Independent Down-Regulation of Allergic Sensitization by Stimulation of CD40 Signaling1
Peter W. Hellings; Ahmad Kasran; Dominique Bullens; Lutgart Overbergh; Chantal Mathieu; Hubertine Heremans; Patrick Matthys; Louis Boon; Mark Jorissen; Jan L. Ceuppens
J Immunol (2006) 177 (8): 5138–5144.
A Novel Mechanism for Complement Activation at the Surface of B Cells Following Antigen Binding1
J Immunol (2006) 177 (8): 5155–5162.
Autophagy Is Induced in CD4+ T Cells and Important for the Growth Factor-Withdrawal Cell Death1
Changyou Li; Elizabeth Capan; Yani Zhao; Jianping Zhao; Donna Stolz; Simon C. Watkins; Shengkan Jin; Binfeng Lu
J Immunol (2006) 177 (8): 5163–5168.
The Cyclin-Dependent Kinase Inhibitor p27kip1 Is Required for Transplantation Tolerance Induced by Costimulatory Blockade1
J Immunol (2006) 177 (8): 5169–5176.
Distinct Characteristics of Murine STAT4 Activation in Response to IL-12 and IFN-α1
J Immunol (2006) 177 (8): 5195–5203.
Establishment of Lymphotoxin β Receptor Signaling-Dependent Cell Lines with Follicular Dendritic Cell Phenotypes from Mouse Lymph Nodes1
Yumiko Nishikawa; Masaki Hikida; Masaki Magari; Naoki Kanayama; Masaharu Mori; Hiroshi Kitamura; Tomohiro Kurosaki; Hitoshi Ohmori
J Immunol (2006) 177 (8): 5204–5214.
Expression of CD1d Molecules by Human Schwann Cells and Potential Interactions with Immunoregulatory Invariant NK T Cells1
Jin S. Im; Nikos Tapinos; Gue-Tae Chae; Petr A. Illarionov; Gurdyal S. Besra; George H. DeVries; Robert L. Modlin; Peter A. Sieling; Anura Rambukkana; Steven A. Porcelli
J Immunol (2006) 177 (8): 5226–5235.
Kinetics of Human B Cell Behavior and Amplification of Proliferative Responses following Stimulation with IL-211
J Immunol (2006) 177 (8): 5236–5247.
IL-4-Secreting NKT Cells Prevent Hypersensitivity Pneumonitis by Suppressing IFN-γ-Producing Neutrophils1
J Immunol (2006) 177 (8): 5258–5268.
Innate Response to Focal Necrotic Injury Inside the Blood-Brain Barrier1
J Immunol (2006) 177 (8): 5269–5277.
CXCR5 Identifies a Subset of Vγ9Vδ2 T Cells which Secrete IL-4 and IL-10 and Help B Cells for Antibody Production1
Nadia Caccamo; Luca Battistini; Marc Bonneville; Fabrizio Poccia; Jean Jacques Fournié; Serena Meraviglia; Giovanna Borsellino; Richard A. Kroczek; Carmela La Mendola; Emmanuel Scotet; Francesco Dieli; Alfredo Salerno
J Immunol (2006) 177 (8): 5290–5295.
Suppression of Experimental Autoimmune Myasthenia Gravis by Granulocyte-Macrophage Colony-Stimulating Factor Is Associated with an Expansion of FoxP3+ Regulatory T Cells1
Jian Rong Sheng; Liangcheng Li; Balaji B. Ganesh; Chenthamarakshan Vasu; Bellur S. Prabhakar; Matthew N. Meriggioli
J Immunol (2006) 177 (8): 5296–5306.
Absence of Innate MyD88 Signaling Promotes Inducible Allograft Acceptance1
Wendy E. Walker; Isam W. Nasr; Geoffrey Camirand; Bethany M. Tesar; Carmen J. Booth; Daniel R. Goldstein
J Immunol (2006) 177 (8): 5307–5316.
SAP Is Required for Th Cell Function and for Immunity to Influenza1
J Immunol (2006) 177 (8): 5317–5327.
MOLECULAR AND STRUCTURAL IMMUNOLOGY
Galectin-1 Binds Different CD43 Glycoforms to Cluster CD43 and Regulate T Cell Death1
Joseph D. Hernandez; Julie T. Nguyen; Jiale He; Wei Wang; Blair Ardman; Jonathan M. Green; Minoru Fukuda; Linda G. Baum
J Immunol (2006) 177 (8): 5328–5336.
A Single Polymorphism Disrupts the Killer Ig-Like Receptor 2DL2/2DL3 D1 Domain12
J Immunol (2006) 177 (8): 5347–5357.
Two-Sided Roles of IL-27: Induction of Th1 Differentiation on Naive CD4+ T Cells versus Suppression of Proinflammatory Cytokine Production Including IL-23-Induced IL-17 on Activated CD4+ T Cells Partially Through STAT3-Dependent Mechanism1
Takeru Yoshimura; Atsunobu Takeda; Shinjiro Hamano; Yoshiyuki Miyazaki; Ichiko Kinjyo; Tatsuro Ishibashi; Akihiko Yoshimura; Hiroki Yoshida
J Immunol (2006) 177 (8): 5377–5385.
Somatic Hypermutation and Class Switch Recombination in Msh6−/−Ung−/− Double-Knockout Mice1
J Immunol (2006) 177 (8): 5386–5392.
V(D)J Recombinase-Mediated Processing of Coding Junctions at Cryptic Recombination Signal Sequences in Peripheral T Cells during Human Development1
Janet M. Murray; J. Patrick O’Neill; Terri Messier; Jami Rivers; Vernon E. Walker; Brien McGonagle; Lucy Trombley; Lindsay G. Cowell; Garnett Kelsoe; Fraser McBlane; Barry A. Finette
J Immunol (2006) 177 (8): 5393–5404.
Transitional B Cell Fate Is Associated with Developmental Stage-Specific Regulation of Diacylglycerol and Calcium Signaling upon B Cell Receptor Engagement1
Kristen L. Hoek; Pierre Antony; John Lowe; Nicholas Shinners; Bhaskarjyoti Sarmah; Susan R. Wente; Demin Wang; Rachel M. Gerstein; Wasif N. Khan
J Immunol (2006) 177 (8): 5405–5413.
Induced Expression of Murine γ2a by CD40 Ligation Independently of IFN-γ1
J Immunol (2006) 177 (8): 5414–5419.
The DMα and DMβ Chain Cooperate in the Oxidation and Folding of HLA-DM1
J Immunol (2006) 177 (8): 5430–5439.
Processing of a Class I-Restricted Epitope from Tyrosinase Requires Peptide N-Glycanase and the Cooperative Action of Endoplasmic Reticulum Aminopeptidase 1 and Cytosolic Proteases1
Michelle L. Altrich-VanLith; Marina Ostankovitch; Joy M. Polefrone; Claudio A. Mosse; Jeffrey Shabanowitz; Donald F. Hunt; Victor H. Engelhard
J Immunol (2006) 177 (8): 5440–5450.
IMMUNOGENETICS
Antibody Repertoire Development in Fetal and Neonatal Piglets. XIII. Hybrid VH Genes and the Preimmune Repertoire Revisited1
J Immunol (2006) 177 (8): 5459–5470.
Lectin Pathway of Bony Fish Complement: Identification of Two Homologs of the Mannose-Binding Lectin Associated with MASP2 in the Common Carp (Cyprinus carpio)12
Miki Nakao; Takayuki Kajiya; Yuho Sato; Tomonori Somamoto; Yoko Kato-Unoki; Misao Matsushita; Munehiro Nakata; Teizo Fujita; Tomoki Yano
J Immunol (2006) 177 (8): 5471–5479.
Antibody Repertoire Development in Fetal and Neonatal Piglets. XVII. IgG Subclass Transcription Revisited with Emphasis on New IgG31
J Immunol (2006) 177 (8): 5480–5489.
HOST DEFENSE
Increased Human IgE Induced by Killing Schistosoma mansoni In Vivo Is Associated with Pretreatment Th2 Cytokine Responsiveness to Worm Antigens1
Klaudia Walter; Anthony J. C. Fulford; Rowena McBeath; Sarah Joseph; Frances M. Jones; H. Curtis Kariuki; Joseph K. Mwatha; Gachuhi Kimani; Narcis B. Kabatereine; Birgitte J. Vennervald; John H. Ouma; David W. Dunne
J Immunol (2006) 177 (8): 5490–5498.
Critical Role of Prostaglandin E2 Overproduction in Impaired Pulmonary Host Response following Bone Marrow Transplantation1
Megan N. Ballinger; David M. Aronoff; Tracy R. McMillan; Kenneth R. Cooke; Krystyna Olkiewicz; Galen B. Toews; Marc Peters-Golden; Bethany B. Moore
J Immunol (2006) 177 (8): 5499–5508.
Mannose-Binding Lectin Augments the Uptake of Lipid A, Staphylococcus aureus, and Escherichia coli by Kupffer Cells through Increased Cell Surface Expression of Scavenger Receptor A1
Kei Ono; Chiaki Nishitani; Hiroaki Mitsuzawa; Takeyuki Shimizu; Hitomi Sano; Hiroshi Suzuki; Tatsuhiko Kodama; Nobuhiro Fujii; Koichi Fukase; Koichi Hirata; Yoshio Kuroki
J Immunol (2006) 177 (8): 5517–5523.
Mucosal Vaccine Targeting Improves Onset of Mucosal and Systemic Immunity to Botulinum Neurotoxin A1
Massimo Maddaloni; Herman F. Staats; Dagmara Mierzejewska; Teri Hoyt; Amy Robinson; Gayle Callis; Shunji Kozaki; Hiroshi Kiyono; Jerry R. McGhee; Kohtaro Fujihashi; David W. Pascual
J Immunol (2006) 177 (8): 5524–5532.
Differential Modulation of Human Lactoferrin Activity against Both R5 and X4-HIV-1 Adsorption on Epithelial Cells and Dendritic Cells by Natural Antibodies1
Héla Saidi; Jobin Eslaphazir; Cédric Carbonneil; Laetitia Carthagena; Mary Requena; Nadine Nassreddine; Laurent Belec
J Immunol (2006) 177 (8): 5540–5549.
INFLAMMATION
Involvement of the Urokinase Kringle Domain in Lipopolysaccharide-Induced Acute Lung Injury1
J Immunol (2006) 177 (8): 5550–5557.
Membrane-Bound CC Chemokine Inhibitor 35K Provides Localized Inhibition of CC Chemokine Activity In Vitro and In Vivo1
J Immunol (2006) 177 (8): 5567–5573.
Serum Amyloid A Binding to Formyl Peptide Receptor-Like 1 Induces Synovial Hyperplasia and Angiogenesis1
J Immunol (2006) 177 (8): 5585–5594.
Inhibition of Arginase I Activity by RNA Interference Attenuates IL-13-Induced Airways Hyperresponsiveness1
Ming Yang; Danny Rangasamy; Klaus I. Matthaei; Ailsa J. Frew; Nives Zimmmermann; Suresh Mahalingam; Dianne C. Webb; David J. Tremethick; Philip J. Thompson; Simon P. Hogan; Marc E. Rothenberg; William B. Cowden; Paul S. Foster
J Immunol (2006) 177 (8): 5595–5603.
Differential Pattern of Inflammatory Molecule Regulation in Intestinal Epithelial Cells Stimulated with IL-11
J Immunol (2006) 177 (8): 5604–5611.
Deguelin, an Akt Inhibitor, Suppresses IκBα Kinase Activation Leading to Suppression of NF-κB-Regulated Gene Expression, Potentiation of Apoptosis, and Inhibition of Cellular Invasion1
Asha S. Nair; Shishir Shishodia; Kwang Seok Ahn; Ajaikumar B. Kunnumakkara; Gautam Sethi; Bharat B. Aggarwal
J Immunol (2006) 177 (8): 5612–5622.
CLINICAL IMMUNOLOGY
Induction of IL-10 Suppressors in Lung Transplant Patients by CD4+25+ Regulatory T Cells through CTLA-4 Signaling1
J Immunol (2006) 177 (8): 5631–5638.
Reinstalling Antitumor Immunity by Inhibiting Tumor-Derived Immunosuppressive Molecule IDO through RNA Interference1
Xiufen Zheng; James Koropatnick; Mu Li; Xusheng Zhang; Fengjun Ling; Xiubao Ren; Xishan Hao; Hongtao Sun; Costin Vladau; Jacob A. Franek; Biao Feng; Bradley L. Urquhart; Robert Zhong; David J. Freeman; Bertha Garcia; Wei-Ping Min
J Immunol (2006) 177 (8): 5639–5646.
Bacillus Calmette Guerin Vaccination of Human Newborns Induces a Specific, Functional CD8+ T Cell Response1
Rose Ann Murray; Nazma Mansoor; Ryhor Harbacheuski; Jorge Soler; Virginia Davids; Andreia Soares; Anthony Hawkridge; Gregory D. Hussey; Holden Maecker; Gilla Kaplan; Willem A. Hanekom
J Immunol (2006) 177 (8): 5647–5651.
Triosephosphate Isomerase- and Glyceraldehyde-3-Phosphate Dehydrogenase-Reactive Autoantibodies in the Cerebrospinal Fluid of Patients with Multiple Sclerosis1
Johanna Kolln; Hui-Min Ren; Reng-Rong Da; Yiping Zhang; Edzard Spillner; Michael Olek; Neal Hermanowicz; Lutz G. Hilgenberg; Martin A. Smith; Stanley van den Noort; Yufen Qin
J Immunol (2006) 177 (8): 5652–5658.
Differential Expression of CD11c by Peripheral Blood NK Cells Reflects Temporal Activity of Multiple Sclerosis1
J Immunol (2006) 177 (8): 5659–5667.
Human CD4+ T Cells Lyse Target Cells via Granzyme/Perforin upon Circumvention of MHC Class II Restriction by an Antibody-Like Immunoreceptor1
J Immunol (2006) 177 (8): 5668–5675.
Development of Autoimmunity in IL-14α-Transgenic Mice1
Long Shen; Chongjie Zhang; Tao Wang; Stephen Brooks; Richard J. Ford; Yen Chiu Lin-Lee; Amy Kasianowicz; Vijay Kumar; Lisa Martin; Ping Liang; John Cowell; Julian L. Ambrus, Jr
J Immunol (2006) 177 (8): 5676–5686.
Macrophage Migration Inhibitory Factor Deficiency Attenuates Macrophage Recruitment, Glomerulonephritis, and Lethality in MRL/lpr Mice1
Alberta Y. Hoi; Michael J. Hickey; Pamela Hall; Jiro Yamana; Kim M. O’Sullivan; Leilani L. Santos; Will G. James; A. Richard Kitching; Eric F. Morand
J Immunol (2006) 177 (8): 5687–5696.
Reduced Frequency, Diversity, and Function of Human T Cell Leukemia Virus Type 1-Specific CD8+ T Cell in Adult T Cell Leukemia Patients1
Tomohiro Kozako; Naomichi Arima; Shingo Toji; Izumi Masamoto; Masaki Akimoto; Heiichiro Hamada; Xiao-Fang Che; Hiroshi Fujiwara; Kakushi Matsushita; Masahito Tokunaga; Koichi Haraguchi; Kimiharu Uozumi; Susumu Suzuki; Toshiro Takezaki; Shunro Sonoda
J Immunol (2006) 177 (8): 5718–5726.
Interaction of Vascular Endothelial Growth Factor 165 with Neuropilin-1 Protects Rheumatoid Synoviocytes from Apoptotic Death by Regulating Bcl-2 Expression and Bax Translocation1
Wan-Uk Kim; Soon Suk Kang; Seung-Ah Yoo; Kyung-Hee Hong; Dong-Goo Bae; Mi-Sook Lee; Seung Woo Hong; Chi-Bom Chae; Chul-Soo Cho
J Immunol (2006) 177 (8): 5727–5735.
Innate Immune Responses to Human Malaria: Heterogeneous Cytokine Responses to Blood-Stage Plasmodium falciparum Correlate with Parasitological and Clinical Outcomes1
Michael Walther; John Woodruff; Fanny Edele; David Jeffries; Jon E. Tongren; Elizabeth King; Laura Andrews; Philip Bejon; Sarah C. Gilbert; Joseph B. De Souza; Robert Sinden; Adrian V. S. Hill; Eleanor M. Riley
J Immunol (2006) 177 (8): 5736–5745.
CORRECTIONS
Contribution of CD8+ T cells to control of Mycobacterium tuberculosis infection.
J Immunol (2006) 177 (8): 5747.
Functional regulatory T cells are collected in stem cell autografts by mobilization with high-dose cyclophosphamide and granulocyte colony-stimulating factor.
M. Condomines; P. Quittet; Z.-Y. Lu; L. Nadal; P. Latry; E. Lopez; M. Baudard; G. Requirand; C. Duperray; J.-F. Schved; J.-F. Rossi; K. Tarte; B. Klein
J Immunol (2006) 177 (8): 5748.
DAP12 signaling regulates plasmacytoid dendritic cell homeostasis and down-modulates their function during viral infection.
H. Sjölin; S. H. Robbins; G. Bessou; Å. Hidmark; E. Tomasello; M. Johansson; H. Hall; F. Charifi; G. B. K. Hedestam; C. A. Biron; K. Kärre; P. Höglund; E. Vivier; M. Dalod
J Immunol (2006) 177 (8): 5748.
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Cover Image
Cover Image
On the cover: Cytokine-induced HIF-1α localizes to astrocytic nuclei. Primary human astrocytes treated with 10 ng/ml IL-1β+IFN-γ for 24 h were immunostained for hypoxia-inducible factor-α (HIF-1α, red) and the astrocyte marker GFAP (green). Nuclei were stained with DAPI (blue). Cytokine-induced HIF-1α localized to astrocytic nuclei, suggesting that its up-regulation triggered formation of active HIF-1 complexes. Argaw, A. T., Y. Zhang, B. J. Snyder, M.-L. Zhao, N. Kopp, S. C. Lee, C. S. Raine, C. F. Brosnan, and G. R. John. 2006. IL-1β regulates blood-brain barrier permeability via reactivation of the hypoxia-angiogenesis program. J. Immunol. 177: 5574–5584.
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