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J Immunol (2007) 178 (4): 1973–1974.

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BRIEF REVIEWS

Unique Human Tumor Antigens: Immunobiology and Use in Clinical Trials ¹

Giorgio Parmiani; Annamaria De Filippo; Luisa Novellino; Chiara Castelli

J Immunol (2007) 178 (4): 1975–1979.

View articletitled, Unique Human Tumor Antigens: Immunobiology and Use in Clinical Trials<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal"><sup>1</sup></a></sup>

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CUTTING EDGE

Cutting Edge: The PI3K p110δ Is Required for Down-Regulation of RAG Expression in Immature B Cells ¹

Miriam Llorian; Zania Stamataki; Susan Hill; Martin Turner; Inga-Lill Mårtensson

J Immunol (2007) 178 (4): 1981–1985.

View articletitled, Cutting Edge: The PI3K p110δ Is Required for Down-Regulation of RAG Expression in Immature B Cells<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal"><sup>1</sup></a></sup>

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Cutting Edge: Loss of TLR2, TLR4, and TLR5 on Langerhans Cells Abolishes Bacterial Recognition ¹

Angelic M.G. van der Aar; Regien M. R. Sylva-Steenland; Jan D. Bos; Martien L. Kapsenberg; Esther C. de Jong; Marcel B. M. Teunissen

J Immunol (2007) 178 (4): 1986–1990.

View articletitled, Cutting Edge: Loss of TLR2, TLR4, and TLR5 on Langerhans Cells Abolishes Bacterial Recognition<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal"><sup>1</sup></a></sup>

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CELLULAR IMMUNOLOGY AND IMMUNE REGULATION

Non-T Cell Activation Linker (NTAL) Negatively Regulates TREM-1/DAP12-Induced Inflammatory Cytokine Production in Myeloid Cells ¹

Anja S. Tessarz; Sandra Weiler; Kai Zanzinger; Pavla Angelisová; Václav Horejsí; Adelheid Cerwenka

J Immunol (2007) 178 (4): 1991–1999.

View articletitled, Non-T Cell Activation Linker (NTAL) Negatively Regulates TREM-1/DAP12-Induced Inflammatory Cytokine Production in Myeloid Cells<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal"><sup>1</sup></a></sup>

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Distinct Differentiation Potential of Blood Monocyte Subsets in the Lung ¹

Limor Landsman; Chen Varol; Steffen Jung

J Immunol (2007) 178 (4): 2000–2007.

View articletitled, Distinct Differentiation Potential of Blood Monocyte Subsets in the Lung<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal"><sup>1</sup></a></sup>

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Selective Thymus Settling Regulated by Cytokine and Chemokine Receptors ¹

Benjamin A. Schwarz; Arivazhagan Sambandam; Ivan Maillard; Benjamin C. Harman; Paul E. Love; Avinash Bhandoola

J Immunol (2007) 178 (4): 2008–2017.

View articletitled, Selective Thymus Settling Regulated by Cytokine and Chemokine Receptors<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal"><sup>1</sup></a></sup>

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IL-2 Is Essential for TGF-β to Convert Naive CD4⁺CD25⁻ Cells to CD25⁺Foxp3⁺ Regulatory T Cells and for Expansion of These Cells ¹

Song Guo Zheng; Juhua Wang; Pu Wang; J. Dixon Gray; David A. Horwitz

J Immunol (2007) 178 (4): 2018–2027.

View articletitled, IL-2 Is Essential for TGF-β to Convert Naive CD4<sup>+</sup>CD25<sup>−</sup> Cells to CD25<sup>+</sup>Foxp3<sup>+</sup> Regulatory T Cells and for Expansion of These Cells<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal"><sup>1</sup></a></sup>

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Imatinib Mesylate Inhibits Antigen-Specific Memory CD8 T Cell Responses In Vivo ¹

Parisa Sinai; Rance E. Berg; J. Marshall Haynie; Merrill J. Egorin; Robert L. Ilaria, Jr; James Forman

J Immunol (2007) 178 (4): 2028–2037.

View articletitled, Imatinib Mesylate Inhibits Antigen-Specific Memory CD8 T Cell Responses In Vivo<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal"><sup>1</sup></a></sup>

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Identification of pH-Regulated Antigen 1 Released from Candida albicans as the Major Ligand for Leukocyte Integrin α_Mβ₂ ¹

Dmitry A. Soloviev; William A. Fonzi; Rafael Sentandreu; Elzbieta Pluskota; Christopher B. Forsyth; Satya Yadav; Edward F. Plow

J Immunol (2007) 178 (4): 2038–2046.

View articletitled, Identification of pH-Regulated Antigen 1 Released from <em>Candida albicans</em> as the Major Ligand for Leukocyte Integrin α<sub>M</sub>β<sub>2</sub><sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal"><sup>1</sup></a></sup>

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Differential CD40/CD40L Expression Results in Counteracting Antitumor Immune Responses ¹

Gopal Murugaiyan; Reena Agrawal; Gyan C. Mishra; Debashis Mitra; Bhaskar Saha

J Immunol (2007) 178 (4): 2047–2055.

View articletitled, Differential CD40/CD40L Expression Results in Counteracting Antitumor Immune Responses<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal"><sup>1</sup></a></sup>

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Changes in the Role of the CD45 Protein Tyrosine Phosphatase in Regulating Lck Tyrosine Phosphorylation during Thymic Development ¹

Rustom Falahati; David Leitenberg

J Immunol (2007) 178 (4): 2056–2064.

View articletitled, Changes in the Role of the CD45 Protein Tyrosine Phosphatase in Regulating Lck Tyrosine Phosphorylation during Thymic Development<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal"><sup>1</sup></a></sup>

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Francisella tularensis-Infected Macrophages Release Prostaglandin E₂ that Blocks T Cell Proliferation and Promotes a Th2-Like Response ¹

Matthew D. Woolard; Justin E. Wilson; Lucinda L. Hensley; Leigh A. Jania; Thomas H. Kawula; James R. Drake; Jeffrey A. Frelinger

J Immunol (2007) 178 (4): 2065–2074.

View articletitled, <em>Francisella tularensis</em>-Infected Macrophages Release Prostaglandin E<sub>2</sub> that Blocks T Cell Proliferation and Promotes a Th2-Like Response<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal"><sup>1</sup></a></sup>

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Stromal Derived Growth Factor-1α: Another Mediator in Neural-Emerging Immune System through Tac1 Expression in Bone Marrow Stromal Cells ¹

Kelly E. Corcoran; Nitixa Patel; Pranela Rameshwar

J Immunol (2007) 178 (4): 2075–2082.

View articletitled, Stromal Derived Growth Factor-1α: Another Mediator in Neural-Emerging Immune System through <em>Tac1</em> Expression in Bone Marrow Stromal Cells<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal"><sup>1</sup></a></sup>

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Type I IFN-Producing CD4 Vα14i NKT Cells Facilitate Priming of IL-10-Producing CD8 T Cells by Hepatocytes ¹

Christian Wahl; Petra Bochtler; Reinhold Schirmbeck; Jörg Reimann

J Immunol (2007) 178 (4): 2083–2093.

View articletitled, Type I IFN-Producing CD4 Vα14<em>i</em> NKT Cells Facilitate Priming of IL-10-Producing CD8 T Cells by Hepatocytes<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal"><sup>1</sup></a></sup>

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Cognate CD4⁺ Help Elicited by Resting Dendritic Cells Does Not Impair the Induction of Peripheral Tolerance in CD8⁺ T Cells ¹

Raymond J. Steptoe; Janine M. Ritchie; Nicholas S. Wilson; Jose A. Villadangos; Andrew M. Lew; Leonard C. Harrison

J Immunol (2007) 178 (4): 2094–2103.

View articletitled, Cognate CD4<sup>+</sup> Help Elicited by Resting Dendritic Cells Does Not Impair the Induction of Peripheral Tolerance in CD8<sup>+</sup> T Cells<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal"><sup>1</sup></a></sup>

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CD18 Is Required for Intestinal T Cell Responses at Multiple Immune Checkpoints ¹

Marissa Marski; Alice L. Ye; Clara Abraham

J Immunol (2007) 178 (4): 2104–2112.

View articletitled, CD18 Is Required for Intestinal T Cell Responses at Multiple Immune Checkpoints<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal"><sup>1</sup></a></sup>

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Regulation of CD8⁺ T Lymphocyte Effector Function and Macrophage Inflammatory Cytokine Production by Retinoic Acid Receptor γ ¹

Ivan Dzhagalov; Pierre Chambon; You-Wen He

J Immunol (2007) 178 (4): 2113–2121.

View articletitled, Regulation of CD8<sup>+</sup> T Lymphocyte Effector Function and Macrophage Inflammatory Cytokine Production by Retinoic Acid Receptor γ<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal"><sup>1</sup></a></sup>

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Peroxisome Proliferator-Activated Receptor γ Control of Dendritic Cell Function Contributes to Development of CD4⁺ T Cell Anergy

Luisa Klotz; Indra Dani; Frank Edenhofer; Lars Nolden; Bernd Evert; Bianca Paul; Waldemar Kolanus; Thomas Klockgether; Percy Knolle; Linda Diehl

J Immunol (2007) 178 (4): 2122–2131.

View articletitled, Peroxisome Proliferator-Activated Receptor γ Control of Dendritic Cell Function Contributes to Development of CD4<sup>+</sup> T Cell Anergy

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High IFN-γ Production of Individual CD8 T Lymphocytes Is Controlled by CD152 (CTLA-4)¹

Pushpa Pandiyan; J. Kolja E. Hegel; Manuela Krueger; Dagmar Quandt; Monika C. Brunner-Weinzierl

J Immunol (2007) 178 (4): 2132–2140.

View articletitled, High IFN-γ Production of Individual CD8 T Lymphocytes Is Controlled by CD152 (CTLA-4)<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal"><sup>1</sup></a></sup>

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NK3-Like NK Cells Are Involved in Protective Effect of Polyinosinic-Polycytidylic Acid on Type 1 Diabetes in Nonobese Diabetic Mice ¹

Rongbin Zhou; Haiming Wei; Zhigang Tian

J Immunol (2007) 178 (4): 2141–2147.

View articletitled, NK3-Like NK Cells Are Involved in Protective Effect of Polyinosinic-Polycytidylic Acid on Type 1 Diabetes in Nonobese Diabetic Mice<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal"><sup>1</sup></a></sup>

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Selective Use of TRAM in Lipopolysaccharide (LPS) and Lipoteichoic Acid (LTA) Induced NF-κB Activation and Cytokine Production in Primary Human Cells: TRAM Is an Adaptor for LPS and LTA Signaling ¹

Sandra M. Sacre; Anna M. C. Lundberg; Evangelos Andreakos; Corinne Taylor; Marc Feldmann; Brian M. Foxwell

J Immunol (2007) 178 (4): 2148–2154.

View articletitled, Selective Use of TRAM in Lipopolysaccharide (LPS) and Lipoteichoic Acid (LTA) Induced NF-κB Activation and Cytokine Production in Primary Human Cells: TRAM Is an Adaptor for LPS and LTA Signaling<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal"><sup>1</sup></a></sup>

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Natural Regulatory T Cells and De Novo-Induced Regulatory T Cells Contribute Independently to Tumor-Specific Tolerance ¹

Gang Zhou; Hyam I. Levitsky

J Immunol (2007) 178 (4): 2155–2162.

View articletitled, Natural Regulatory T Cells and De Novo-Induced Regulatory T Cells Contribute Independently to Tumor-Specific Tolerance<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal"><sup>1</sup></a></sup>

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A Role for Mammalian Target of Rapamycin in Regulating T Cell Activation versus Anergy ¹

Yan Zheng; Samuel L. Collins; Michael A. Lutz; Amy N. Allen; Thomas P. Kole; Paul E. Zarek; Jonathan D. Powell

J Immunol (2007) 178 (4): 2163–2170.

View articletitled, A Role for Mammalian Target of Rapamycin in Regulating T Cell Activation versus Anergy<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal"><sup>1</sup></a></sup>

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Bacterial c-di-GMP Is an Immunostimulatory Molecule ¹

David K. R. Karaolis; Terry K. Means; De Yang; Munehisa Takahashi; Teizo Yoshimura; Eric Muraille; Dana Philpott; John T. Schroeder; Mamoru Hyodo; Yoshihiro Hayakawa; Brian G. Talbot; Eric Brouillette; François Malouin

J Immunol (2007) 178 (4): 2171–2181.

View articletitled, Bacterial c-di-GMP Is an Immunostimulatory Molecule<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal"><sup>1</sup></a></sup>

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TLR Signaling Fine-Tunes Anti-Influenza B Cell Responses without Regulating Effector T Cell Responses ¹

Alex K. Heer; Abdijapar Shamshiev; Alena Donda; Satoshi Uematsu; Shizuo Akira; Manfred Kopf; Benjamin J. Marsland

J Immunol (2007) 178 (4): 2182–2191.

View articletitled, TLR Signaling Fine-Tunes Anti-Influenza B Cell Responses without Regulating Effector T Cell Responses<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal"><sup>1</sup></a></sup>

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AID^−/−μs^−/− Mice Are Agammaglobulinemic and Fail to Maintain B220⁻CD138⁺ Plasma Cells ¹

Kaori Kumazaki; Boaz Tirosh; René Maehr; Marianne Boes; Tasuku Honjo; Hidde L. Ploegh

J Immunol (2007) 178 (4): 2192–2203.

View articletitled, AID<sup>−/−</sup>μs<sup>−/−</sup> Mice Are Agammaglobulinemic and Fail to Maintain B220<sup>−</sup>CD138<sup>+</sup> Plasma Cells<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal"><sup>1</sup></a></sup>

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Suppression of the Effector Phase of Inflammatory Arthritis by Double-Stranded RNA Is Mediated by Type I IFNs ¹

Anna Yarilina; Edward DiCarlo; Lionel B. Ivashkiv

J Immunol (2007) 178 (4): 2204–2211.

View articletitled, Suppression of the Effector Phase of Inflammatory Arthritis by Double-Stranded RNA Is Mediated by Type I IFNs<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal"><sup>1</sup></a></sup>

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Peripheral Tolerance Induction Using Ethylenecarbodiimide-Fixed APCs Uses both Direct and Indirect Mechanisms of Antigen Presentation for Prevention of Experimental Autoimmune Encephalomyelitis ¹

Danielle M. Turley; Stephen D. Miller

J Immunol (2007) 178 (4): 2212–2220.

View articletitled, Peripheral Tolerance Induction Using Ethylenecarbodiimide-Fixed APCs Uses both Direct and Indirect Mechanisms of Antigen Presentation for Prevention of Experimental Autoimmune Encephalomyelitis<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal"><sup>1</sup></a></sup>

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Abrogation of Antibody-Mediated Allograft Rejection by Regulatory CD4 T Cells with Indirect Allospecificity ¹

Chris J. Callaghan; Foad J. Rouhani; Margaret C. Negus; Allison J. Curry; Eleanor M. Bolton; J. Andrew Bradley; Gavin J. Pettigrew

J Immunol (2007) 178 (4): 2221–2228.

View articletitled, Abrogation of Antibody-Mediated Allograft Rejection by Regulatory CD4 T Cells with Indirect Allospecificity<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal"><sup>1</sup></a></sup>

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The Effects of IL-20 Subfamily Cytokines on Reconstituted Human Epidermis Suggest Potential Roles in Cutaneous Innate Defense and Pathogenic Adaptive Immunity in Psoriasis

Susan M. Sa; Patricia A. Valdez; Jianfeng Wu; Kenneth Jung; Fiona Zhong; Linda Hall; Ian Kasman; Jane Winer; Zora Modrusan; Dimitry M. Danilenko; Wenjun Ouyang

J Immunol (2007) 178 (4): 2229–2240.

View articletitled, The Effects of IL-20 Subfamily Cytokines on Reconstituted Human Epidermis Suggest Potential Roles in Cutaneous Innate Defense and Pathogenic Adaptive Immunity in Psoriasis

Supplementary data

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The Role of Endoplasmic Reticulum-Associated Aminopeptidase 1 in Immunity to Infection and in Cross-Presentation ¹

Elke Firat; Loredana Saveanu; Peter Aichele; Peter Staeheli; Jisen Huai; Simone Gaedicke; Ahmed Nil; Gilles Besin; Benoît Kanzler; Peter van Endert; Gabriele Niedermann

J Immunol (2007) 178 (4): 2241–2248.

View articletitled, The Role of Endoplasmic Reticulum-Associated Aminopeptidase 1 in Immunity to Infection and in Cross-Presentation<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal"><sup>1</sup></a></sup>

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Epitope-Dependent Effect of Anti-Murine TIM-1 Monoclonal Antibodies on T Cell Activity and Lung Immune Responses

Irene D. Sizing; Véronique Bailly; Patricia McCoon; Wenjie Chang; Sambasiva Rao; Lourdes Pablo; Rachel Rennard; Meghan Walsh; Zhifang Li; Mohammad Zafari; Max Dobles; Leticia Tarilonte; Steven Miklasz; Gerard Majeau; Kevin Godbout; Martin L. Scott; Paul D. Rennert

J Immunol (2007) 178 (4): 2249–2261.

View articletitled, Epitope-Dependent Effect of Anti-Murine TIM-1 Monoclonal Antibodies on T Cell Activity and Lung Immune Responses

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Dendritic Cells Sensitize TCRs through Self-MHC-Mediated Src Family Kinase Activation ¹

Paul Meraner; Václav Horejsí; Alois Wolpl; Gottfried F. Fischer; Georg Stingl; Dieter Maurer

J Immunol (2007) 178 (4): 2262–2271.

View articletitled, Dendritic Cells Sensitize TCRs through Self-MHC-Mediated Src Family Kinase Activation<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal"><sup>1</sup></a></sup>

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TNF Receptor-Associated Factor 2-Dependent Canonical Pathway Is Crucial for the Development of Peyer’s Patches ¹

Jiang-Hu Piao; Hisahiro Yoshida; Wen-Chen Yeh; Takahiro Doi; Xin Xue; Hideo Yagita; Ko Okumura; Hiroyasu Nakano

J Immunol (2007) 178 (4): 2272–2277.

View articletitled, TNF Receptor-Associated Factor 2-Dependent Canonical Pathway Is Crucial for the Development of Peyer’s Patches<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal"><sup>1</sup></a></sup>

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CXC Chemokine Ligand 9/Monokine Induced by IFN-γ Production by Tumor Cells Is Critical for T Cell-Mediated Suppression of Cutaneous Tumors ¹

Anton V. Gorbachev; Hirohito Kobayashi; Daisuke Kudo; Charles S. Tannenbaum; James H. Finke; Suyu Shu; Joshua M. Farber; Robert L. Fairchild

J Immunol (2007) 178 (4): 2278–2286.

View articletitled, CXC Chemokine Ligand 9/Monokine Induced by IFN-γ Production by Tumor Cells Is Critical for T Cell-Mediated Suppression of Cutaneous Tumors<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal"><sup>1</sup></a></sup>

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Fas Receptor Clustering and Involvement of the Death Receptor Pathway in Rituximab-Mediated Apoptosis with Concomitant Sensitization of Lymphoma B Cells to Fas-Induced Apoptosis ¹

Alja J. Stel; Bram ten Cate; Susan Jacobs; Jan Willem Kok; Diana C. J. Spierings; Monica Dondorff; Wijnand Helfrich; Hanneke C. Kluin-Nelemans; Lou F. M. H. de Leij; Sebo Withoff; Bart Jan Kroesen

J Immunol (2007) 178 (4): 2287–2295.

View articletitled, Fas Receptor Clustering and Involvement of the Death Receptor Pathway in Rituximab-Mediated Apoptosis with Concomitant Sensitization of Lymphoma B Cells to Fas-Induced Apoptosis<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal"><sup>1</sup></a></sup>

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p21^CIP1/WAF1 Controls Proliferation of Activated/Memory T Cells and Affects Homeostasis and Memory T Cell Responses ¹

Cristina F. Arias; André Ballesteros-Tato; María Isabel García; Juan Martín-Caballero; Juana M. Flores; Carlos Martínez-A; Dimitrios Balomenos

J Immunol (2007) 178 (4): 2296–2306.

View articletitled, p21<sup>CIP1/WAF1</sup> Controls Proliferation of Activated/Memory T Cells and Affects Homeostasis and Memory T Cell Responses<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal"><sup>1</sup></a></sup>

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A Novel Postpriming Regulatory Check Point of Effector/Memory T Cells Dictated through Antigen Density Threshold-Dependent Anergy

Kfir Oved; Omer Ziv; Jasmine Jacob-Hirsch; Roy Noy; Hila Novak; Oryan Makler; Denkberg Galit; Sinik Keren; Dina Segal; Chen Gefen-Dor; Ninette Amariglio; Gideon Rechavi; Yoram Reiter

J Immunol (2007) 178 (4): 2307–2317.

View articletitled, A Novel Postpriming Regulatory Check Point of Effector/Memory T Cells Dictated through Antigen Density Threshold-Dependent Anergy

Supplementary data

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Phenotypic and Functional Analysis of Immune CD8⁺ T Cell Responses Induced by a Single Injection of a HIV DNA Vaccine in Mice ¹

Geraldine Arrode; Ramakrishna Hegde; Arunmani Mani; Yuhuai Jin; Yahia Chebloune; Opendra Narayan

J Immunol (2007) 178 (4): 2318–2327.

View articletitled, Phenotypic and Functional Analysis of Immune CD8<sup>+</sup> T Cell Responses Induced by a Single Injection of a HIV DNA Vaccine in Mice<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal"><sup>1</sup></a></sup>

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MOLECULAR AND STRUCTURAL IMMUNOLOGY

Requirement for Phosphoinositide 3-Kinase p110δ Signaling in B Cell Antigen Receptor-Mediated Antigen Presentation ¹

Monther M. Al-Alwan; Klaus Okkenhaug; Bart Vanhaesebroeck; Joel S. Hayflick; Aaron J. Marshall

J Immunol (2007) 178 (4): 2328–2335.

View articletitled, Requirement for Phosphoinositide 3-Kinase p110δ Signaling in B Cell Antigen Receptor-Mediated Antigen Presentation<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal"><sup>1</sup></a></sup>

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The N Terminus of the Non-T Cell Activation Linker (NTAL) Confers Inhibitory Effects on Pre-B Cell Differentiation ¹

Sebastian Herzog; Hassan Jumaa

J Immunol (2007) 178 (4): 2336–2343.

View articletitled, The N Terminus of the Non-T Cell Activation Linker (NTAL) Confers Inhibitory Effects on Pre-B Cell Differentiation<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal"><sup>1</sup></a></sup>

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IMMUNOGENETICS

The Arthritis Severity Quantitative Trait Loci Cia4 and Cia6 Regulate Neutrophil Migration into Inflammatory Sites and Levels of TNF-α and Nitric Oxide ¹

Teresina Laragione; Nuriza C. Yarlett; Max Brenner; Adriana Mello; Barbara Sherry; Edmund J. Miller; Christine N. Metz; Pércio S. Gulko

J Immunol (2007) 178 (4): 2344–2351.

View articletitled, The Arthritis Severity Quantitative Trait Loci <em>Cia4</em> and <em>Cia6</em> Regulate Neutrophil Migration into Inflammatory Sites and Levels of TNF-α and Nitric Oxide<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal"><sup>1</sup></a></sup>

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Genetic Dissection of Spontaneous Autoimmunity Driven by 129-Derived Chromosome 1 Loci When Expressed on C57BL/6 Mice ¹

Francesco Carlucci; Josefina Cortes-Hernandez; Liliane Fossati-Jimack; Anne E. Bygrave; Mark J. Walport; Timothy J. Vyse; H. Terence Cook; Marina Botto

J Immunol (2007) 178 (4): 2352–2360.

View articletitled, Genetic Dissection of Spontaneous Autoimmunity Driven by 129-Derived Chromosome 1 Loci When Expressed on C57BL/6 Mice<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal"><sup>1</sup></a></sup>

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HOST DEFENSE

Insect Baculoviruses Strongly Potentiate Adaptive Immune Responses by Inducing Type I IFN ¹

Sandra Hervas-Stubbs; Paloma Rueda; Lissette Lopez; Claude Leclerc

J Immunol (2007) 178 (4): 2361–2369.

View articletitled, Insect Baculoviruses Strongly Potentiate Adaptive Immune Responses by Inducing Type I IFN<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal"><sup>1</sup></a></sup>

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Mucosal HIV-1 Pox Virus Prime-Boost Immunization Induces High-Avidity CD8⁺ T Cells with Regime-Dependent Cytokine/Granzyme B Profiles ¹

Charani Ranasinghe; Stephen J. Turner; Craig McArthur; Duncan B. Sutherland; Jee-Hye Kim; Peter C. Doherty; Ian A. Ramshaw

J Immunol (2007) 178 (4): 2370–2379.

View articletitled, Mucosal HIV-1 Pox Virus Prime-Boost Immunization Induces High-Avidity CD8<sup>+</sup> T Cells with Regime-Dependent Cytokine/Granzyme B Profiles<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal"><sup>1</sup></a></sup>

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RICK/RIP2 Mediates Innate Immune Responses Induced through Nod1 and Nod2 but Not TLRs ¹

Jong-Hwan Park; Yun-Gi Kim; Christine McDonald; Thirumala-Devi Kanneganti; Mizuho Hasegawa; Mathilde Body-Malapel; Naohiro Inohara; Gabriel Núñez

J Immunol (2007) 178 (4): 2380–2386.

View articletitled, RICK/RIP2 Mediates Innate Immune Responses Induced through Nod1 and Nod2 but Not TLRs<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal"><sup>1</sup></a></sup>

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Mucosal Luminal Manipulation of T Cell Geography Switches on Protective Efficacy by Otherwise Ineffective Parenteral Genetic Immunization ¹

Michael Santosuosso; Sarah McCormick; Elizabeth Roediger; Xizhong Zhang; Anna Zganiacz; Brian D. Lichty; Zhou Xing

J Immunol (2007) 178 (4): 2387–2395.

View articletitled, Mucosal Luminal Manipulation of T Cell Geography Switches on Protective Efficacy by Otherwise Ineffective Parenteral Genetic Immunization<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal"><sup>1</sup></a></sup>

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Rapid Clonal Expansion and Prolonged Maintenance of Memory CD8⁺ T Cells of the Effector (CD44^highCD62L^low) and Central (CD44^highCD62L^high) Phenotype by an Archaeosome Adjuvant Independent of TLR2 ¹

Lakshmi Krishnan; Komal Gurnani; Chantal J. Dicaire; Henk van Faassen; Ahmed Zafer; Carsten J. Kirschning; Subash Sad; G. Dennis Sprott

J Immunol (2007) 178 (4): 2396–2406.

View articletitled, Rapid Clonal Expansion and Prolonged Maintenance of Memory CD8<sup>+</sup> T Cells of the Effector (CD44<sup>high</sup>CD62L<sup>low</sup>) and Central (CD44<sup>high</sup>CD62L<sup>high</sup>) Phenotype by an Archaeosome Adjuvant Independent of TLR2<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal"><sup>1</sup></a></sup>

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Expression of the p60 Autolysin Enhances NK Cell Activation and Is Required for Listeria monocytogenes Expansion in IFN-γ-Responsive Mice ¹

Jessica Humann; Ryan Bjordahl; Karl Andreasen; Laurel L. Lenz

J Immunol (2007) 178 (4): 2407–2414.

View articletitled, Expression of the p60 Autolysin Enhances NK Cell Activation and Is Required for <em>Listeria monocytogenes</em> Expansion in IFN-γ-Responsive Mice<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal"><sup>1</sup></a></sup>

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TLR9 Signaling in B Cells Determines Class Switch Recombination to IgG2a

Andrea Jegerlehner; Patrik Maurer; Juliana Bessa; Heather J. Hinton; Manfred Kopf; Martin F. Bachmann

J Immunol (2007) 178 (4): 2415–2420.

View articletitled, TLR9 Signaling in B Cells Determines Class Switch Recombination to IgG2a

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Heat Shock Protein 27 Regulates Neutrophil Chemotaxis and Exocytosis through Two Independent Mechanisms ¹

Neelakshi R. Jog; Venkatakrishna R. Jala; Richard A. Ward; Madhavi J. Rane; Bodduluri Haribabu; Kenneth R. McLeish

J Immunol (2007) 178 (4): 2421–2428.

View articletitled, Heat Shock Protein 27 Regulates Neutrophil Chemotaxis and Exocytosis through Two Independent Mechanisms<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal"><sup>1</sup></a></sup>

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Fas-Associated Death Domain-Containing Protein-Mediated Antiviral Innate Immune Signaling Involves the Regulation of Irf7¹

Siddharth Balachandran; Thiagarajan Venkataraman; Paul B. Fisher; Glen N. Barber

J Immunol (2007) 178 (4): 2429–2439.

View articletitled, Fas-Associated Death Domain-Containing Protein-Mediated Antiviral Innate Immune Signaling Involves the Regulation of <em>Irf7</em><sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal"><sup>1</sup></a></sup>

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PU.1 Redirects Adenovirus to Lysosomes in Alveolar Macrophages, Uncoupling Internalization from Infection ¹

Brenna Carey; Margaret K. Staudt; Dana Bonaminio; Johannes C. M. van der Loo; Bruce C. Trapnell

J Immunol (2007) 178 (4): 2440–2447.

View articletitled, PU.1 Redirects Adenovirus to Lysosomes in Alveolar Macrophages, Uncoupling Internalization from Infection<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal"><sup>1</sup></a></sup>

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Evidence for Phagocytosis of Influenza Virus-Infected, Apoptotic Cells by Neutrophils and Macrophages in Mice ¹

Yumi Hashimoto; Takeshi Moki; Takenori Takizawa; Akiko Shiratsuchi; Yoshinobu Nakanishi

J Immunol (2007) 178 (4): 2448–2457.

View articletitled, Evidence for Phagocytosis of Influenza Virus-Infected, Apoptotic Cells by Neutrophils and Macrophages in Mice<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal"><sup>1</sup></a></sup>

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INFLAMMATION

FTY720 Ameliorates Th1-Mediated Colitis in Mice by Directly Affecting the Functional Activity of CD4⁺CD25⁺ Regulatory T Cells ¹

Carolin Daniel; Nico Sartory; Nadine Zahn; Gerd Geisslinger; Heinfried H. Radeke; Juergen M. Stein

J Immunol (2007) 178 (4): 2458–2468.

View articletitled, FTY720 Ameliorates Th1-Mediated Colitis in Mice by Directly Affecting the Functional Activity of CD4<sup>+</sup>CD25<sup>+</sup> Regulatory T Cells<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal"><sup>1</sup></a></sup>

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CD44 Is a Negative Regulator of Acute Pulmonary Inflammation and Lipopolysaccharide-TLR Signaling in Mouse Macrophages ¹

Jiurong Liang; Dianhua Jiang; Jason Griffith; Shuang Yu; Juan Fan; Xiaojian Zhao; Richard Bucala; Paul W. Noble

J Immunol (2007) 178 (4): 2469–2475.

View articletitled, CD44 Is a Negative Regulator of Acute Pulmonary Inflammation and Lipopolysaccharide-TLR Signaling in Mouse Macrophages<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal"><sup>1</sup></a></sup>

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New Animal Model of Shigellosis in the Guinea Pig: Its Usefulness for Protective Efficacy Studies ¹

Doo-Hee Shim; Toshihiko Suzuki; Sun-Young Chang; Sung-Moo Park; Philippe J. Sansonetti; Chihiro Sasakawa; Mi-Na Kweon

J Immunol (2007) 178 (4): 2476–2482.

View articletitled, New Animal Model of Shigellosis in the Guinea Pig: Its Usefulness for Protective Efficacy Studies<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal"><sup>1</sup></a></sup>

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Receptor for Advanced Glycation Endproducts Mediates Neutrophil Migration across Intestinal Epithelium ¹

Ke Zen; Celia X.-J. Chen; Yi-Tien Chen; Rosemarie Wilton; Yuan Liu

J Immunol (2007) 178 (4): 2483–2490.

View articletitled, Receptor for Advanced Glycation Endproducts Mediates Neutrophil Migration across Intestinal Epithelium<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal"><sup>1</sup></a></sup>

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Regulation of Th2 Cytokine Genes by p38 MAPK-Mediated Phosphorylation of GATA-3 ¹

Kittipong Maneechotesuwan; Yao Xin; Kazuhiro Ito; Elen Jazrawi; Kang-Yun Lee; Omar S. Usmani; Peter J. Barnes; Ian M. Adcock

J Immunol (2007) 178 (4): 2491–2498.

View articletitled, Regulation of Th2 Cytokine Genes by p38 MAPK-Mediated Phosphorylation of GATA-3<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal"><sup>1</sup></a></sup>

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CD43 Collaborates with P-Selectin Glycoprotein Ligand-1 to Mediate E-Selectin-Dependent T Cell Migration into Inflamed Skin ¹

Masanori Matsumoto; Akiko Shigeta; Yuko Furukawa; Toshiyuki Tanaka; Masayuki Miyasaka; Takako Hirata

J Immunol (2007) 178 (4): 2499–2506.

View articletitled, CD43 Collaborates with P-Selectin Glycoprotein Ligand-1 to Mediate E-Selectin-Dependent T Cell Migration into Inflamed Skin<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal"><sup>1</sup></a></sup>

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Simvastatin Potentiates TNF-α-Induced Apoptosis through the Down-Regulation of NF-κB-Dependent Antiapoptotic Gene Products: Role of IκBα Kinase and TGF-β-Activated Kinase-1 ¹

Kwang Seok Ahn; Gautam Sethi; Bharat B. Aggarwal

J Immunol (2007) 178 (4): 2507–2516.

View articletitled, Simvastatin Potentiates TNF-α-Induced Apoptosis through the Down-Regulation of NF-κB-Dependent Antiapoptotic Gene Products: Role of IκBα Kinase and TGF-β-Activated Kinase-1<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal"><sup>1</sup></a></sup>

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Glucocorticoid Conditioning of Myeloid Progenitors Enhances TLR4 Signaling via Negative Regulation of the Phosphatidylinositol 3-Kinase-Akt Pathway ¹

Tian Y. Zhang; Raymond A. Daynes

J Immunol (2007) 178 (4): 2517–2526.

View articletitled, Glucocorticoid Conditioning of Myeloid Progenitors Enhances TLR4 Signaling via Negative Regulation of the Phosphatidylinositol 3-Kinase-Akt Pathway<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal"><sup>1</sup></a></sup>

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K-ras Is Critical for Modulating Multiple c-kit-Mediated Cellular Functions in Wild-Type and Nf1^+/− Mast Cells ¹

Waleed F. Khalaf; Feng-Chun Yang; Shi Chen; Hilary White; Waylan Bessler; David A. Ingram; D. Wade Clapp

J Immunol (2007) 178 (4): 2527–2534.

View articletitled, <em>K-ras</em> Is Critical for Modulating Multiple c-kit-Mediated Cellular Functions in Wild-Type and <em>Nf1</em><sup>+/−</sup> Mast Cells<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal"><sup>1</sup></a></sup>

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IgE Modulates Neutrophil Survival in Asthma: Role of Mitochondrial Pathway ¹

Arash Shoja Saffar; Martin P. Alphonse; Lianyu Shan; Kent T. HayGlass; F. Estelle R. Simons; Abdelilah Soussi Gounni

J Immunol (2007) 178 (4): 2535–2541.

View articletitled, IgE Modulates Neutrophil Survival in Asthma: Role of Mitochondrial Pathway<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal"><sup>1</sup></a></sup>

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Signaling in Lipopolysaccharide-Induced Stabilization of Formyl Peptide Receptor 1 mRNA in Mouse Peritoneal Macrophages ¹

Palash Mandal; Thomas Hamilton

J Immunol (2007) 178 (4): 2542–2548.

View articletitled, Signaling in Lipopolysaccharide-Induced Stabilization of Formyl Peptide Receptor 1 mRNA in Mouse Peritoneal Macrophages<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal"><sup>1</sup></a></sup>

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Selective Activation of Fyn/PI3K and p38 MAPK Regulates IL-4 Production in BMMC under Nontoxic Stress Condition ¹

Barbara Frossi; Juan Rivera; Emilio Hirsch; Carlo Pucillo

J Immunol (2007) 178 (4): 2549–2555.

View articletitled, Selective Activation of Fyn/PI3K and p38 MAPK Regulates IL-4 Production in BMMC under Nontoxic Stress Condition<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal"><sup>1</sup></a></sup>

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CLINICAL IMMUNOLOGY

Differential Biological Role of CD3 Chains Revealed by Human Immunodeficiencies ¹

María J. Recio; Miguel Angel Moreno-Pelayo; Sara S. Kiliç; Alberto C. Guardo; Ozden Sanal; Luis M. Allende; Verónica Pérez-Flores; Angeles Mencía; Silvia Modamio-Høybjør; Elena Seoane; José R. Regueiro

J Immunol (2007) 178 (4): 2556–2564.

View articletitled, Differential Biological Role of CD3 Chains Revealed by Human Immunodeficiencies<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal"><sup>1</sup></a></sup>

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A SmD Peptide Induces Better Antibody Responses to Other Proteins within the Small Nuclear Ribonucleoprotein Complex than to SmD Protein via Intermolecular Epitope Spreading ¹

Umesh S. Deshmukh; Harini Bagavant; Davis Sim; Vyankatesh Pidiyar; Shu Man Fu

J Immunol (2007) 178 (4): 2565–2571.

View articletitled, A SmD Peptide Induces Better Antibody Responses to Other Proteins within the Small Nuclear Ribonucleoprotein Complex than to SmD Protein via Intermolecular Epitope Spreading<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal"><sup>1</sup></a></sup>

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Expansion of CD4⁺CD25⁺and FOXP3⁺ Regulatory T Cells during the Follicular Phase of the Menstrual Cycle: Implications for Human Reproduction ¹

Lourdes Arruvito; Marianela Sanz; Alison H. Banham; Leonardo Fainboim

J Immunol (2007) 178 (4): 2572–2578.

View articletitled, Expansion of CD4<sup>+</sup>CD25<sup>+</sup>and FOXP3<sup>+</sup> Regulatory T Cells during the Follicular Phase of the Menstrual Cycle: Implications for Human Reproduction<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal"><sup>1</sup></a></sup>

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Deficient CD4⁺CD25^high T Regulatory Cell Function in Patients with Active Systemic Lupus Erythematosus ¹

Xavier Valencia; Cheryl Yarboro; Gabor Illei; Peter E. Lipsky

J Immunol (2007) 178 (4): 2579–2588.

View articletitled, Deficient CD4<sup>+</sup>CD25<sup>high</sup> T Regulatory Cell Function in Patients with Active Systemic Lupus Erythematosus<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal"><sup>1</sup></a></sup>

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IL-23 Is Critical in the Induction but Not in the Effector Phase of Experimental Autoimmune Encephalomyelitis

Paresh Thakker; Michael W. Leach; Wen Kuang; Stephen E. Benoit; John P. Leonard; Suzana Marusic

J Immunol (2007) 178 (4): 2589–2598.

View articletitled, IL-23 Is Critical in the Induction but Not in the Effector Phase of Experimental Autoimmune Encephalomyelitis

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Cover Image

Cover Image

On the cover: Whole mount immunostainings of the intestines of wild-type and tnfr1^-/- mice with anti-VCAM-1 (upper panels) or anti-CXCL13 (lower panels) antibody. Accumulation of VCAM-1 positive stromal cells and expression of CXCL13 (brown spots) in Peyer's patch anlagen were severely impaired in tnfr1^-/- mice (right panels) compared to wild-type mice (left panels). Piao, J.-H., H. Yoshida, W.-C. Yeh, T. Doi, X. Xue, H. Yagita, K. Okumura, and H. Nakano. 2007. TNF receptor-associated factor 2-dependent canonical pathway is crucial for the development of Peyer's patches. J. Immunol. 178: 2272–2277.
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