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Issues
1 December 2007
ISSN 0022-1767
EISSN 1550-6606
IN THIS ISSUE
PILLARS OF IMMUNOLOGY
Pillars Article: Antigen Presentation by Hapten-Specific B Lymphocytes. 1. Role of Surface Immunoglobulin Receptors. J. Exp. Med. 1984. 160: 1102–1113.
J Immunol (2007) 179 (11): 7194–7205.
Pillars Article: Antigen-Specific Interaction between T and B Cells. Nature 1985. 314: 537–539.
J Immunol (2007) 179 (11): 7206–7208.
BRIEF REVIEWS
Invertebrate Immune Systems–Specific, Quasi-Specific, or Nonspecific?
J Immunol (2007) 179 (11): 7209–7214.
CUTTING EDGE
Cutting Edge: A Transcriptional Repressor and Corepressor Induced by the STAT3-Regulated Anti-Inflammatory Signaling Pathway1
Karim C. El Kasmi; Amber M. Smith; Lynn Williams; Geoffrey Neale; Athanasia Panopolous; Stephanie S. Watowich; Hans Häcker; Brian M. J. Foxwell; Peter J. Murray
J Immunol (2007) 179 (11): 7215–7219.
Cutting Edge: Tissue-Resident Memory CTL Down-Regulate Cytolytic Molecule Expression following Virus Clearance1
J Immunol (2007) 179 (11): 7220–7224.
CELLULAR IMMUNOLOGY AND IMMUNE REGULATION
Intravenous Transfusion of BCR-Activated B Cells Protects NOD Mice from Type 1 Diabetes in an IL-10-Dependent Manner1
J Immunol (2007) 179 (11): 7225–7232.
Cbl-b Regulates Antigen-Induced TCR Down-Regulation and IFN-γ Production by Effector CD8 T Cells without Affecting Functional Avidity1
Mohammed Shamim; Som G. Nanjappa; Anju Singh; Erin Hemmila Plisch; Scott E. LeBlanc; Jane Walent; John Svaren; Christine Seroogy; M. Suresh
J Immunol (2007) 179 (11): 7233–7243.
Specific Immunogenicity of Heat Shock Protein gp96 Derives from Chaperoned Antigenic Peptides and Not from Contaminating Proteins1
J Immunol (2007) 179 (11): 7254–7261.
CUGBP1 Is Required for IFNβ-Mediated Induction of Dominant-Negative CEBPβ and Suppression of SIV Replication in Macrophages1
J Immunol (2007) 179 (11): 7262–7269.
A Novel Approach to Specific Allergy Treatment: The Recombinant Allergen-S-Layer Fusion Protein rSbsC-Bet v 1 Matures Dendritic Cells That Prime Th0/Th1 and IL-10-Producing Regulatory T Cells1
Marianne Gerstmayr; Nicola Ilk; Irma Schabussova; Beatrice Jahn-Schmid; Eva M. Egelseer; Uwe B. Sleytr; Christof Ebner; Barbara Bohle
J Immunol (2007) 179 (11): 7270–7275.
Regulated Expression of BAFF-Binding Receptors during Human B Cell Differentiation1
J Immunol (2007) 179 (11): 7276–7286.
Ikaros Enforces the Costimulatory Requirement for IL2 Gene Expression and Is Required for Anergy Induction in CD4+ T Lymphocytes1
J Immunol (2007) 179 (11): 7305–7315.
A New Role of CTLA-4 on B Cells in Thymus-Dependent Immune Responses In Vivo1
J Immunol (2007) 179 (11): 7316–7324.
Murine Gammaherpesvirus-68 Infection Alters Self-Antigen Presentation and Type 1 Diabetes Onset in NOD Mice1
J Immunol (2007) 179 (11): 7325–7333.
Defective T Cell Development and Function in the Absence of Abelson Kinases1
J Immunol (2007) 179 (11): 7334–7343.
PECAM-1 Ligation Negatively Regulates TLR4 Signaling in Macrophages1
J Immunol (2007) 179 (11): 7344–7351.
CCL2 Inhibits the Apoptosis Program Induced by Growth Factor Deprivation, Rescuing Functional T Cells1
J Immunol (2007) 179 (11): 7352–7357.
CCR7 Expression in Developing Thymocytes Is Linked to the CD4 versus CD8 Lineage Decision1
J Immunol (2007) 179 (11): 7358–7364.
Pivotal Roles of CD4+ Effector T cells in Mediating Agonistic Anti-GITR mAb-Induced-Immune Activation and Tumor Immunity in CT26 Tumors
J Immunol (2007) 179 (11): 7365–7375.
Activation of Immature Hepatic NK Cells As Immunotherapy for Liver Metastatic Disease
Keith S. Bahjat; Rodney A. Prell; Heather E. Allen; Weiqun Liu; Edward E. Lemmens; Meredith L. Leong; Daniel A. Portnoy; Thomas W. Dubensky, Jr.; Dirk G. Brockstedt; Martin A. Giedlin
J Immunol (2007) 179 (11): 7376–7384.
NKp30 Ligation Induces Rapid Activation of the Canonical NF-κB Pathway in NK Cells1
J Immunol (2007) 179 (11): 7385–7396.
Functional Outcome of B Cell Activation by Chromatin Immune Complex Engagement of the B Cell Receptor and TLR91
Liliana Busconi; Jason W. Bauer; Joseph R. Tumang; Amy Laws; Kristin Perkins-Mesires; Abigail S. Tabor; Christina Lau; Ronald B. Corley; Thomas L. Rothstein; Frances E. Lund; Timothy W. Behrens; Ann Marshak-Rothstein
J Immunol (2007) 179 (11): 7397–7405.
Sensitive Gene Expression Profiling of Human T Cell Subsets Reveals Parallel Post-Thymic Differentiation for CD4+ and CD8+ Lineages1
Victor Appay; Andreas Bosio; Stefanie Lokan; Yvonne Wiencek; Christian Biervert; Daniel Küsters; Estelle Devevre; Daniel Speiser; Pedro Romero; Nathalie Rufer; Serge Leyvraz
J Immunol (2007) 179 (11): 7406–7414.
Keratinocyte Growth Factor Induces Expansion of Murine Peripheral CD4+Foxp3+ Regulatory T Cells and Increases Their Thymic Output1
Marieke Bruinsma; Peter L. van Soest; Pieter J. M. Leenen; Bart N. Lambrecht; Tom Cupedo; Bob Löwenberg; Jan J. Cornelissen; Eric Braakman
J Immunol (2007) 179 (11): 7424–7430.
1,3,7-Trimethylxanthine (Caffeine) May Exacerbate Acute Inflammatory Liver Injury by Weakening the Physiological Immunosuppressive Mechanism1
J Immunol (2007) 179 (11): 7431–7438.
Murine Lupus Susceptibility Locus Sle1a Controls Regulatory T Cell Number and Function through Multiple Mechanisms1
J Immunol (2007) 179 (11): 7439–7447.
Loss of IL-7 Receptor α on CD4+ T Cells Defines Terminally Differentiated B Cell-Helping Effector T Cells in a B Cell-Rich Lymphoid Tissue1
J Immunol (2007) 179 (11): 7448–7456.
Functional Role of P-Selectin Glycoprotein Ligand 1/P-Selectin Interaction in the Generation of Tolerogenic Dendritic Cells1
Ana Urzainqui; Gloria Martínez del Hoyo; Amalia Lamana; Hortensia de la Fuente; Olga Barreiro; Isabel M. Olazabal; Pilar Martin; Martin K. Wild; Dietmar Vestweber; Roberto González-Amaro; Francisco Sánchez-Madrid
J Immunol (2007) 179 (11): 7457–7465.
Alloimmunity to Human Endothelial Cells Derived from Cord Blood Progenitors1
J Immunol (2007) 179 (11): 7488–7496.
Continuous RANKL Inhibition in Osteoprotegerin Transgenic Mice and Rats Suppresses Bone Resorption without Impairing Lymphorganogenesis or Functional Immune Responses1
Marina Stolina; Denise Dwyer; Michael S. Ominsky; Timothy Corbin; Gwyneth Van; Brad Bolon; Ildiko Sarosi; James McCabe; Debra J. Zack; Paul Kostenuik
J Immunol (2007) 179 (11): 7497–7505.
A Novel Mutation in the Nfkb2 Gene Generates an NF-κB2 “Super Repressor”1
Elena Tucker; Kristy O’Donnell; Martina Fuchsberger; Adrienne A. Hilton; Donald Metcalf; Kylie Greig; Natalie A. Sims; Julian M. Quinn; Warren S. Alexander; Douglas J. Hilton; Benjamin T. Kile; David M. Tarlinton; Robyn Starr
J Immunol (2007) 179 (11): 7514–7522.
Transgenic Expression of Bcl-xL or Bcl-2 by Murine B Cells Enhances the In Vivo Antipolysaccharide, but Not Antiprotein, Response to Intact Streptococcus pneumoniae12
Gouri Chattopadhyay; Abdul Q. Khan; Goutam Sen; Jesus Colino; Wendy duBois; Anatoly Rubtsov; Raul M. Torres; Michael Potter; Clifford M. Snapper
J Immunol (2007) 179 (11): 7523–7534.
Role of CD30 in B/T Segregation in the Spleen1
Vasileios Bekiaris; David Withers; Stephanie H. Glanville; Fiona M. McConnell; Sonia M. Parnell; Mi-Yeon Kim; Fabrina M. C. Gaspal; Eric Jenkinson; Clive Sweet; Graham Anderson; Peter J. L. Lane
J Immunol (2007) 179 (11): 7535–7543.
Transitional B Cells Lose Their Ability to Receptor Edit but Retain Their Potential for Positive and Negative Selection1
J Immunol (2007) 179 (11): 7544–7552.
X-linked Inhibitor of Apoptosis Regulates T Cell Effector Function1
Simone P. Zehntner; Lyne Bourbonnière; Craig S. Moore; Stephen J. Morris; Danielle Methot; Martine St. Jean; Eric Lacasse; Andrea L. O. Hebb; George S. Robertson; Jon Durkin; John W. Gillard; Trevor Owens
J Immunol (2007) 179 (11): 7553–7560.
Subtle Defects in Pre-TCR Signaling in the Absence of the Tec Kinase Itk1
J Immunol (2007) 179 (11): 7561–7567.
The Rheumatoid Arthritis-Associated Autoantigen hnRNP-A2 (RA33) Is a Major Stimulator of Autoimmunity in Rats with Pristane-Induced Arthritis1
Markus H. Hoffmann; Jonatan Tuncel; Karl Skriner; Makiyeh Tohidast-Akrad; Birgit Türk; Serafin Pinol-Roma; Guy Serre; Georg Schett; Josef S. Smolen; Rikard Holmdahl; Günter Steiner
J Immunol (2007) 179 (11): 7568–7576.
Differential Development of Murine Dendritic Cells by GM-CSF versus Flt3 Ligand Has Implications for Inflammation and Trafficking1
J Immunol (2007) 179 (11): 7577–7584.
Airway Eosinophils: Allergic Inflammation Recruited Professional Antigen-Presenting Cells1
J Immunol (2007) 179 (11): 7585–7592.
Role of STAT3 in CD4+CD25+FOXP3+ Regulatory Lymphocyte Generation: Implications in Graft-versus-Host Disease and Antitumor Immunity1
Jean-René Pallandre; Emilie Brillard; Gilles Créhange; Amandine Radlovic; Jean-Paul Remy-Martin; Philippe Saas; Pierre-Simon Rohrlich; Xavier Pivot; Xiang Ling; Pierre Tiberghien; Christophe Borg
J Immunol (2007) 179 (11): 7593–7604.
MOLECULAR AND STRUCTURAL IMMUNOLOGY
PRDM1/BLIMP-1 Modulates IFN-γ-Dependent Control of the MHC Class I Antigen-Processing and Peptide-Loading Pathway1
J Immunol (2007) 179 (11): 7614–7623.
A Hypoallergenic Vaccine Obtained by Tail-to-Head Restructuring of Timothy Grass Pollen Profilin, Phl p 12, for the Treatment of Cross-Sensitization to Profilin1
Kerstin Westritschnig; Birgit Linhart; Margarete Focke-Tejkl; Tea Pavkov; Walter Keller; Tanja Ball; Adriano Mari; Arnulf Hartl; Angelika Stöcklinger; Sandra Scheiblhofer; Josef Thalhamer; Fatima Ferreira; Stefan Vieths; Lothar Vogel; Alexandra Böhm; Peter Valent; Rudolf Valenta
J Immunol (2007) 179 (11): 7624–7634.
A Novel Population of Human Melanoma-Specific CD8 T Cells Recognizes Melan-AMART-1 Immunodominant Nonapeptide but Not the Corresponding Decapeptide1
Laurent Derré; Mathias Ferber; Cédric Touvrey; Estelle Devevre; Vincent Zoete; Antoine Leimgruber; Pedro Romero; Olivier Michielin; Frédéric Lévy; Daniel E. Speiser
J Immunol (2007) 179 (11): 7635–7645.
Tapasin Increases Efficiency of MHC I Assembly in the Endoplasmic Reticulum but Does Not Affect MHC I Stability at the Cell Surface1
J Immunol (2007) 179 (11): 7646–7652.
Soluble CD14 Discriminates Slight Structural Differences between Lipid As That Lead to Distinct Host Cell Activation1
J Immunol (2007) 179 (11): 7674–7683.
HOST DEFENSE
Characterization of the Deregulated Immune Activation Occurring at Late Stages of Mycobacterial Infection in TNF-Deficient Mice1
J Immunol (2007) 179 (11): 7702–7708.
Novel Structural Determinants on SIRPα that Mediate Binding to CD471
Winston Y. Lee; Dominique A. Weber; Oskar Laur; Eric A. Severson; Ingrid McCall; Rita P. Jen; Alex C. Chin; Tao Wu; Kim M. Gernet; Charles A. Parkos
J Immunol (2007) 179 (11): 7741–7750.
Secretory IgA Mediates Bacterial Translocation to Dendritic Cells in Mouse Peyer’s Patches with Restriction to Mucosal Compartment1
J Immunol (2007) 179 (11): 7751–7757.
In Vivo Depletion of CD11c+ Cells Impairs Scrapie Agent Neuroinvasion from the Intestine1
J Immunol (2007) 179 (11): 7758–7766.
Identification of Signaling Pathways in Macrophage Exposed to Porphyromonas gingivalis or to Its Purified Cell Wall Components1
J Immunol (2007) 179 (11): 7777–7790.
INFLAMMATION
An IL-17F/A Heterodimer Protein Is Produced by Mouse Th17 Cells and Induces Airway Neutrophil Recruitment
Spencer C. Liang; Andrew J. Long; Frann Bennett; Matthew J. Whitters; Riyez Karim; Mary Collins; Samuel J. Goldman; Kyriaki Dunussi-Joannopoulos; Cara M. M. Williams; Jill F. Wright; Lynette A. Fouser
J Immunol (2007) 179 (11): 7791–7799.
Activation of p38 MAPK by Reactive Oxygen Species Is Essential in a Rat Model of Stress-Induced Gastric Mucosal Injury1
Yi-Tao Jia; Wei Wei; Bing Ma; Yu Xu; Wen-Jun Liu; Yu Wang; Kai-Yang Lv; Hong-Tai Tang; Duo Wei; Zhao-Fan Xia
J Immunol (2007) 179 (11): 7808–7819.
Inhibition of CINC-1 Decreases Right Ventricular Damage Caused by Experimental Pulmonary Embolism in Rats1
J Immunol (2007) 179 (11): 7820–7826.
Chemotaxis of Mouse Bone Marrow Neutrophils and Dendritic Cells Is Controlled by ADP-Ribose, the Major Product Generated by the CD38 Enzyme Reaction1
Santiago Partida-Sanchez; Andreas Gasser; Ralf Fliegert; Cornelia C. Siebrands; Werner Dammermann; Guixiu Shi; Betty J. Mousseau; Adriana Sumoza-Toledo; Harivadan Bhagat; Timothy F. Walseth; Andreas H. Guse; Frances E. Lund
J Immunol (2007) 179 (11): 7827–7839.
Heme Oxygenase-1 Inhibits the Expression of Adhesion Molecules Associated with Endothelial Cell Activation via Inhibition of NF-κB RelA Phosphorylation at Serine 2761
Mark P. Seldon; Gabriela Silva; Nadja Pejanovic; Rasmus Larsen; Isabel Pombo Gregoire; Josina Filipe; Josef Anrather; Miguel P. Soares
J Immunol (2007) 179 (11): 7840–7851.
Amelioration of Chronic Murine Colitis by Peptide-Mediated Transduction of the IκB Kinase Inhibitor NEMO Binding Domain Peptide1
Shaival H. Davé; Jeremy S. Tilstra; Katsuyoshi Matsuoka; Fengling Li; Thomas Karrasch; Jennifer K. Uno; Antonia R. Sepulveda; Christian Jobin; Albert S. Baldwin; Paul D. Robbins; Scott E. Plevy
J Immunol (2007) 179 (11): 7852–7859.
NF-κB-Inducing Kinase Regulates Cyclooxygenase 2 Gene Expression in Macrophages by Phosphorylation of PU.11
Anser C. Azim; Xuerong Wang; Gye Young Park; Ruxana T. Sadikot; Hongmei Cao; Biji Mathew; Michael Atchison; Richard B. van Breemen; Myungsoo Joo; John W. Christman
J Immunol (2007) 179 (11): 7868–7875.
Activation of Protein Kinase D1 in Mast Cells in Response to Innate, Adaptive, and Growth Factor Signals1
J Immunol (2007) 179 (11): 7876–7882.
Tissue- and Stimulus-Dependent Role of Phosphatidylinositol 3-Kinase Isoforms for Neutrophil Recruitment Induced by Chemoattractants In Vivo1
Vanessa Pinho; Remo de Castro Russo; Flávio A. Amaral; Lirlândia P. de Sousa; Michele M. Barsante; Danielle G. de Souza; José C. Alves-Filho; Denise C. Cara; Joel S. Hayflick; Christian Rommel; Thomas Ruckle; Adriano G. Rossi; Mauro M. Teixeira
J Immunol (2007) 179 (11): 7891–7898.
Histamine Directly and Synergistically with Lipopolysaccharide Stimulates Cyclooxygenase-2 Expression and Prostaglandin I2 and E2 Production in Human Coronary Artery Endothelial Cells1
Xiaoyu Tan; Suzanne Essengue; Jaya Talreja; Jeff Reese; Daniel J. Stechschulte; Kottarappat N. Dileepan
J Immunol (2007) 179 (11): 7899–7906.
Functional Expression of H4 Histamine Receptor in Human Natural Killer Cells, Monocytes, and Dendritic Cells
J Immunol (2007) 179 (11): 7907–7915.
CLINICAL IMMUNOLOGY
Effective Proliferation of Human Regulatory T Cells Requires a Strong Costimulatory CD28 Signal That Cannot Be Substituted by IL-21
J Immunol (2007) 179 (11): 7924–7931.
Cross-Reactive CD4+ T Cells against One Immunodominant Tumor-Derived Epitope in Melanoma Patients1
Pavol Kudela; Bratislav Janjic; Julien Fourcade; Florence Castelli; Pedro Andrade; John M. Kirkwood; Talal El-Hefnawy; Massimo Amicosante; Bernard Maillere; Hassane M. Zarour
J Immunol (2007) 179 (11): 7932–7940.
TWEAK/Fn14 Interactions Are Instrumental in the Pathogenesis of Nephritis in the Chronic Graft-versus-Host Model of Systemic Lupus erythematosus1
Zeguo Zhao; Linda C. Burkly; Sean Campbell; Noa Schwartz; Alberto Molano; Arpita Choudhury; Robert A. Eisenberg; Jennifer S. Michaelson; Chaim Putterman
J Immunol (2007) 179 (11): 7949–7958.
Agrin Signalling Contributes to Cell Activation and Is Overexpressed in T Lymphocytes from Lupus Patients1
J Immunol (2007) 179 (11): 7975–7983.
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Cover Image
Cover Image
On the cover: The white pulp area of the spleen of CD30–/– mice. B lymphocytes are shown in green and ER-TR7+ stromal cells are shown in red. Normal development of both stromal cells and lymphocytes is necessary for maintenance of the microarchitecture of the white pulp. Bekiaris, V., D. Withers, S. H. Glanville, F. M. McConnell, S. M. Parnell, M.-Y. Kim, F., M. C. Gaspal, E. Jenkinson, C. Sweet, G. Anderson, and P. J. L. Lane. 2007. Role of CD30 in B/T segregation in the spleen. J. Immunol. 179: 7535–7543.
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