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Volume 182, Issue 2
15 January 2009
Issue Cover
ISSN 0022-1767
EISSN 1550-6606

IN THIS ISSUE

IN THIS ISSUE
J Immunol (2009) 182 (2): 739–740.
View articletitled, IN THIS ISSUE
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CUTTING EDGE

Cutting Edge: Ikaros Is a Regulator of Th2 Cell Differentiation1
Mary R. Quirion; Gregory D. Gregory; Sarah E. Umetsu; Susan Winandy; Melissa A. Brown
J Immunol (2009) 182 (2): 741–745.
View articletitled, Cutting Edge: Ikaros Is a Regulator of Th2 Cell Differentiation<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal"><sup>1</sup></a></sup>
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Cutting Edge: Developmental Up-Regulation of IFN-γ-Inducible Lysosomal Thiol Reductase Expression Leads to Reduced T Cell Sensitivity and Less Severe Autoimmunity1
Maja Maric; Igor Barjaktarevic; Branka Bogunovic; Milica Stojakovic; Christine Maric; Stanislav Vukmanovic
J Immunol (2009) 182 (2): 746–750.
View articletitled, Cutting Edge: Developmental Up-Regulation of IFN-γ-Inducible Lysosomal Thiol Reductase Expression Leads to Reduced T Cell Sensitivity and Less Severe Autoimmunity<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal"><sup>1</sup></a></sup>
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CELLULAR IMMUNOLOGY AND IMMUNE REGULATION

Pre-TCR-Induced β-Catenin Facilitates Traversal through β-Selection1
Mai Xu; Archna Sharma; David L. Wiest; Jyoti Misra Sen
J Immunol (2009) 182 (2): 751–758.
View articletitled, Pre-TCR-Induced β-Catenin Facilitates Traversal through β-Selection<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal"><sup>1</sup></a></sup>
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Sustained Expression of Pre-TCR Induced β-Catenin in Post-β-Selection Thymocytes Blocks T Cell Development1
Mai Xu; Archna Sharma; M. Zulfiquer Hossain; David L. Wiest; Jyoti Misra Sen
J Immunol (2009) 182 (2): 759–765.
View articletitled, Sustained Expression of Pre-TCR Induced β-Catenin in Post-β-Selection Thymocytes Blocks T Cell Development<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal"><sup>1</sup></a></sup>
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Cross-Linking of CD80 on CD4+ T Cells Activates a Calcium-Dependent Signaling Pathway1
Joseph R. Podojil; Stephen D. Miller
J Immunol (2009) 182 (2): 766–773.
View articletitled, Cross-Linking of CD80 on CD4<sup>+</sup> T Cells Activates a Calcium-Dependent Signaling Pathway<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal"><sup>1</sup></a></sup>
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Priming of CD8+ and CD4+ T Cells in Experimental Leishmaniasis Is Initiated by Different Dendritic Cell Subtypes1
Nancy Brewig; Adrien Kissenpfennig; Bernard Malissen; Alexandra Veit; Thomas Bickert; Bernhard Fleischer; Sven Mostböck; Uwe Ritter
J Immunol (2009) 182 (2): 774–783.
View articletitled, Priming of CD8<sup>+</sup> and CD4<sup>+</sup> T Cells in Experimental Leishmaniasis Is Initiated by Different Dendritic Cell Subtypes<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal"><sup>1</sup></a></sup>
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Clonal Expansions and Loss of Receptor Diversity in the Naive CD8 T Cell Repertoire of Aged Mice1
Mushtaq Ahmed; Kathleen G. Lanzer; Eric J. Yager; Pamela S. Adams; Lawrence L. Johnson; Marcia A. Blackman
J Immunol (2009) 182 (2): 784–792.
View articletitled, Clonal Expansions and Loss of Receptor Diversity in the Naive CD8 T Cell Repertoire of Aged Mice<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal"><sup>1</sup></a></sup>
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Increased CD4+Foxp3+ T Cells in BAFF-Transgenic Mice Suppress T Cell Effector Responses
Stacey Walters; Kylie E. Webster; Andrew Sutherland; Sandra Gardam; Joanna Groom; David Liuwantara; Eliana Mariño; Jessica Thaxton; Anita Weinberg; Fabienne Mackay; Robert Brink; Jonathon Sprent; Shane T. Grey
J Immunol (2009) 182 (2): 793–801.
View articletitled, Increased CD4<sup>+</sup>Foxp3<sup>+</sup> T Cells in BAFF-Transgenic Mice Suppress T Cell Effector Responses
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IL-20 Receptor 2 Signaling Down-Regulates Antigen-Specific T Cell Responses1
Christian Wahl; Werner Müller; Frank Leithäuser; Guido Adler; Franz Oswald; Jörg Reimann; Reinhold Schirmbeck; Anne Seier; Johannes Martin Weiss; Blair Prochnow; Ursula Maria Wegenka
J Immunol (2009) 182 (2): 802–810.
View articletitled, IL-20 Receptor 2 Signaling Down-Regulates Antigen-Specific T Cell Responses<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal"><sup>1</sup></a></sup>
Supplementary data
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Tuberculosis-Induced Variant IL-4 mRNA Encodes a Cytokine Functioning As Growth Factor for (E)-4-Hydroxy-3-Methyl-But-2-Enyl Pyrophosphate-Specific Vγ2Vδ2 T Cells1
ZhuQing Yuan; Richard Wang; Yuyang Lee; Crystal Y. Chen; XingBing Yu; ZhongDao Wu; Dan Huang; Ling Shen; Zheng W. Chen
J Immunol (2009) 182 (2): 811–819.
View articletitled, Tuberculosis-Induced Variant IL-4 mRNA Encodes a Cytokine Functioning As Growth Factor for (<em>E</em>)-4-Hydroxy-3-Methyl-But-2-Enyl Pyrophosphate-Specific Vγ2Vδ2 T Cells<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal"><sup>1</sup></a></sup>
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TLR4 Ligands Induce IFN-α Production by Mouse Conventional Dendritic Cells and Human Monocytes after IFN-β Priming1
Christophe Richez; Kei Yasuda; Amanda A. Watkins; Shizuo Akira; Robert Lafyatis; Jean M. van Seventer; Ian R. Rifkin
J Immunol (2009) 182 (2): 820–828.
View articletitled, TLR4 Ligands Induce IFN-α Production by Mouse Conventional Dendritic Cells and Human Monocytes after IFN-β Priming<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal"><sup>1</sup></a></sup>
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IL-12-Dependent Inducible Expression of the CD94/NKG2A Inhibitory Receptor Regulates CD94/NKG2C+ NK Cell Function1
Andrea Sáez-Borderías; Neus Romo; Giuliana Magri; Mónica Gumá; Ana Angulo; Miguel López-Botet
J Immunol (2009) 182 (2): 829–836.
View articletitled, IL-12-Dependent Inducible Expression of the CD94/NKG2A Inhibitory Receptor Regulates CD94/NKG2C<sup>+</sup> NK Cell Function<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal"><sup>1</sup></a></sup>
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Epicutaneous Immunization with Protein Antigen in the Presence of TLR4 Ligand Induces TCRαβ+CD4+ T Contrasuppressor Cells That Reverse Skin-Induced Suppression of Th1-Mediated Contact Sensitivity1
Włodzimierz Ptak; Monika Majewska; Krzysztof Bryniarski; Maria Ptak; Francis M. Lobo; Katarzyna Zając; Philip W. Askenase; Marian Szczepanik
J Immunol (2009) 182 (2): 837–850.
View articletitled, Epicutaneous Immunization with Protein Antigen in the Presence of TLR4 Ligand Induces TCRαβ<sup>+</sup>CD4<sup>+</sup> T Contrasuppressor Cells That Reverse Skin-Induced Suppression of Th1-Mediated Contact Sensitivity<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal"><sup>1</sup></a></sup>
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The EBV-Encoded dUTPase Activates NF-κB through the TLR2 and MyD88-Dependent Signaling Pathway1
Maria-Eugenia Ariza; Ronald Glaser; Pravin T. P. Kaumaya; Chris Jones; Marshall V. Williams
J Immunol (2009) 182 (2): 851–859.
View articletitled, The EBV-Encoded dUTPase Activates NF-κB through the TLR2 and MyD88-Dependent Signaling Pathway<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal"><sup>1</sup></a></sup>
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Attenuated Expression of A20 Markedly Increases the Efficacy of Double-Stranded RNA-Activated Dendritic Cells As an Anti-Cancer Vaccine1
Karine Breckpot; Cindy Aerts-Toegaert; Carlo Heirman; Uschi Peeters; Rudi Beyaert; Joeri L. Aerts; Kris Thielemans
J Immunol (2009) 182 (2): 860–870.
View articletitled, Attenuated Expression of A20 Markedly Increases the Efficacy of Double-Stranded RNA-Activated Dendritic Cells As an Anti-Cancer Vaccine<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal"><sup>1</sup></a></sup>
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Plasmacytoid Dendritic Cells Are Dispensable during Primary Influenza Virus Infection1
Amaya I. Wolf; Darya Buehler; Scott E. Hensley; Lois L. Cavanagh; E. John Wherry; Philippe Kastner; Susan Chan; Wolfgang Weninger
J Immunol (2009) 182 (2): 871–879.
View articletitled, Plasmacytoid Dendritic Cells Are Dispensable during Primary Influenza Virus Infection<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal"><sup>1</sup></a></sup>
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Modified Adenine (9-Benzyl-2-Butoxy-8-Hydroxyadenine) Redirects Th2-Mediated Murine Lung Inflammation by Triggering TLR71
Alessandra Vultaggio; Francesca Nencini; Paul M. Fitch; Lucia Filì; Laura Maggi; Paola Fanti; Annick deVries; Enrico Beccastrini; Francesca Palandri; Cinzia Manuelli; Daniele Bani; Maria Grazia Giudizi; Antonio Guarna; Francesco Annunziato; Sergio Romagnani; Enrico Maggi; Sarah E. M. Howie; Paola Parronchi
J Immunol (2009) 182 (2): 880–889.
View articletitled, Modified Adenine (9-Benzyl-2-Butoxy-8-Hydroxyadenine) Redirects Th2-Mediated Murine Lung Inflammation by Triggering TLR7<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal"><sup>1</sup></a></sup>
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Resting Human Memory B Cells Are Intrinsically Programmed for Enhanced Survival and Responsiveness to Diverse Stimuli Compared to Naive B Cells1
Kim L. Good; Danielle T. Avery; Stuart G. Tangye
J Immunol (2009) 182 (2): 890–901.
View articletitled, Resting Human Memory B Cells Are Intrinsically Programmed for Enhanced Survival and Responsiveness to Diverse Stimuli Compared to Naive B Cells<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal"><sup>1</sup></a></sup>
Supplementary data
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Kinetics of Major Histocompatibility Class I Antigen Presentation in Acute Infection1
Matthew D. H. Lay; Lei Zhang; Ruy M. Ribeiro; Scott N. Mueller; Gabrielle T. Belz; Miles P. Davenport
J Immunol (2009) 182 (2): 902–911.
View articletitled, Kinetics of Major Histocompatibility Class I Antigen Presentation in Acute Infection<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal"><sup>1</sup></a></sup>
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Graft-versus-Host Disease Prevents the Maturation of Plasmacytoid Dendritic Cells1
Tatjana Banovic; Kate A. Markey; Rachel D. Kuns; Stuart D. Olver; Neil C. Raffelt; Alistair L. Don; Mariapia A. Degli-Esposti; Christian R. Engwerda; Kelli P. A. MacDonald; Geoffrey R. Hill
J Immunol (2009) 182 (2): 912–920.
View articletitled, Graft-versus-Host Disease Prevents the Maturation of Plasmacytoid Dendritic Cells<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal"><sup>1</sup></a></sup>
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Differential Capability of Human Cutaneous Dendritic Cell Subsets to Initiate Th17 Responses1
Alicia R. Mathers; Brian M. Janelsins; Joseph P. Rubin; Olga A. Tkacheva; William J. Shufesky; Simon C. Watkins; Adrian E. Morelli; Adriana T. Larregina
J Immunol (2009) 182 (2): 921–933.
View articletitled, Differential Capability of Human Cutaneous Dendritic Cell Subsets to Initiate Th17 Responses<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal"><sup>1</sup></a></sup>
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Endogenous 4-1BB Ligand Plays a Critical Role in Protection from Influenza-Induced Disease1
Gloria H. Y. Lin; Bradley J. Sedgmen; Theo J. Moraes; Laura M. Snell; David J. Topham; Tania H. Watts
J Immunol (2009) 182 (2): 934–947.
View articletitled, Endogenous 4-1BB Ligand Plays a Critical Role in Protection from Influenza-Induced Disease<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal"><sup>1</sup></a></sup>
Supplementary data
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A Dual Role for Talin in NK Cell Cytotoxicity: Activation of LFA-1-Mediated Cell Adhesion and Polarization of NK Cells1
Emily M. Mace; Susan J. Monkley; David R. Critchley; Fumio Takei
J Immunol (2009) 182 (2): 948–956.
View articletitled, A Dual Role for Talin in NK Cell Cytotoxicity: Activation of LFA-1-Mediated Cell Adhesion and Polarization of NK Cells<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal"><sup>1</sup></a></sup>
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RhoH Plays Critical Roles in FcεRI-Dependent Signal Transduction in Mast Cells1
Hiroyo Oda; Manabu Fujimoto; Michael S. Patrick; Dai Chida; Yoshinori Sato; Yoshinao Azuma; Hiroki Aoki; Takaya Abe; Harumi Suzuki; Mutsunori Shirai
J Immunol (2009) 182 (2): 957–962.
View articletitled, RhoH Plays Critical Roles in FcεRI-Dependent Signal Transduction in Mast Cells<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal"><sup>1</sup></a></sup>
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Plasmacytoid Dendritic Cells Regulate Breach of Self-Tolerance in Autoimmune Arthritis1
Sarah L. Jongbloed; Robert A. Benson; Mohammed B. Nickdel; Paul Garside; Iain B. McInnes; James M. Brewer
J Immunol (2009) 182 (2): 963–968.
View articletitled, Plasmacytoid Dendritic Cells Regulate Breach of Self-Tolerance in Autoimmune Arthritis<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal"><sup>1</sup></a></sup>
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Lymphopenia-Induced Proliferation Is a Potent Activator for CD4+ T Cell-Mediated Autoimmune Disease in the Retina1
Scott W. McPherson; Neal D. Heuss; Dale S. Gregerson
J Immunol (2009) 182 (2): 969–979.
View articletitled, Lymphopenia-Induced Proliferation Is a Potent Activator for CD4<sup>+</sup> T Cell-Mediated Autoimmune Disease in the Retina<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal"><sup>1</sup></a></sup>
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PD-1 Blockade in Rhesus Macaques: Impact on Chronic Infection and Prophylactic Vaccination
Adam C. Finnefrock; Aimin Tang; Fengsheng Li; Daniel C. Freed; Meizhen Feng; Kara S. Cox; Kara J. Sykes; James P. Guare; Michael D. Miller; David B. Olsen; Daria J. Hazuda; John W. Shiver; Danilo R. Casimiro; Tong-Ming Fu
J Immunol (2009) 182 (2): 980–987.
View articletitled, PD-1 Blockade in Rhesus Macaques: Impact on Chronic Infection and Prophylactic Vaccination
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Generation of a Novel System for Studying Spleen Tyrosine Kinase Function in Macrophages and B Cells1
Allison L. Miller; Chao Zhang; Kevan M. Shokat; Clifford A. Lowell
J Immunol (2009) 182 (2): 988–998.
View articletitled, Generation of a Novel System for Studying Spleen Tyrosine Kinase Function in Macrophages and B Cells<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal"><sup>1</sup></a></sup>
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Critical Role for the Transcription Regulator CCCTC-Binding Factor in the Control of Th2 Cytokine Expression1
Claudia Ribeiro de Almeida; Helen Heath; Sanja Krpic; Gemma M. Dingjan; Jan Piet van Hamburg; Ingrid Bergen; Suzanne van de Nobelen; Frank Sleutels; Frank Grosveld; Niels Galjart; Rudi W. Hendriks
J Immunol (2009) 182 (2): 999–1010.
View articletitled, Critical Role for the Transcription Regulator CCCTC-Binding Factor in the Control of Th2 Cytokine Expression<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal"><sup>1</sup></a></sup>
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MOLECULAR AND STRUCTURAL IMMUNOLOGY

JNK MAPK Pathway Regulates Constitutive Transcription of CCL5 by Human NK Cells through SP11
Dilip Kumar; Judith Hosse; Christine von Toerne; Elfriede Noessner; Peter J. Nelson
J Immunol (2009) 182 (2): 1011–1020.
View articletitled, JNK MAPK Pathway Regulates Constitutive Transcription of CCL5 by Human NK Cells through SP1<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal"><sup>1</sup></a></sup>
Supplementary data
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Ezrin and Moesin Function Together to Promote T Cell Activation1
Meredith H. Shaffer; Renell S. Dupree; Peimin Zhu; Ichiko Saotome; Richard F. Schmidt; Andrea I. McClatchey; Bruce D. Freedman; Janis K. Burkhardt
J Immunol (2009) 182 (2): 1021–1032.
View articletitled, Ezrin and Moesin Function Together to Promote T Cell Activation<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal"><sup>1</sup></a></sup>
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Ig-Like Transcript 4 Inhibits Lipid Antigen Presentation through Direct CD1d Interaction1
Demin Li; Lili Wang; Li Yu; Eric C. Freundt; Boquan Jin; Gavin R. Screaton; Xiao-Ning Xu
J Immunol (2009) 182 (2): 1033–1040.
View articletitled, Ig-Like Transcript 4 Inhibits Lipid Antigen Presentation through Direct CD1d Interaction<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal"><sup>1</sup></a></sup>
Supplementary data
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Regulation of the foxp3 Gene by the Th1 Cytokines: The Role of IL-27-Induced STAT11
Nadia Ouaked; Pierre-Yves Mantel; Claudio Bassin; Simone Burgler; Kerstin Siegmund; Cezmi A. Akdis; Carsten B. Schmidt-Weber
J Immunol (2009) 182 (2): 1041–1049.
View articletitled, Regulation of the <em>foxp3</em> Gene by the Th1 Cytokines: The Role of IL-27-Induced STAT1<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal"><sup>1</sup></a></sup>
Supplementary data
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14-3-3γ Is Stimulated by IL-3 and Promotes Cell Proliferation1
Brijesh S. Ajjappala; Yong-Soo Kim; Myung-Sun Kim; Min-Young Lee; Kwang-Youl Lee; Ho-Yun Ki; Dong-Hyun Cha; Kwang-Hyun Baek
J Immunol (2009) 182 (2): 1050–1060.
View articletitled, 14-3-3γ Is Stimulated by IL-3 and Promotes Cell Proliferation<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal"><sup>1</sup></a></sup>
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HOST DEFENSE

Polyanion-Induced Self-Association of Complement Factor H1
Michael K. Pangburn; Nenoo Rawal; Claudio Cortes; M. Nurul Alam; Viviana P. Ferreira; Mark A. L. Atkinson
J Immunol (2009) 182 (2): 1061–1068.
View articletitled, Polyanion-Induced Self-Association of Complement Factor H<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal"><sup>1</sup></a></sup>
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Cell-Mediated Immunity to Toxoplasma gondii Develops Primarily by Local Th1 Host Immune Responses in the Absence of Parasite Replication1
Jason P. Gigley; Barbara A. Fox; David J. Bzik
J Immunol (2009) 182 (2): 1069–1078.
View articletitled, Cell-Mediated Immunity to <em>Toxoplasma gondii</em> Develops Primarily by Local Th1 Host Immune Responses in the Absence of Parasite Replication<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal"><sup>1</sup></a></sup>
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Fulminant Lymphocytic Choriomeningitis Virus-Induced Inflammation of the CNS Involves a Cytokine-Chemokine-Cytokine-Chemokine Cascade1
Jeanette E. Christensen; Stine Simonsen; Christina Fenger; Maria R. Sørensen; Torben Moos; Jan P. Christensen; Bente Finsen; Allan R. Thomsen
J Immunol (2009) 182 (2): 1079–1087.
View articletitled, Fulminant Lymphocytic Choriomeningitis Virus-Induced Inflammation of the CNS Involves a Cytokine-Chemokine-Cytokine-Chemokine Cascade<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal"><sup>1</sup></a></sup>
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Induction of Proinflammatory Cytokines in Primary Human Macrophages by Influenza A Virus (H5N1) Is Selectively Regulated by IFN Regulatory Factor 3 and p38 MAPK1
Kenrie P. Y. Hui; Suki M. Y. Lee; Chung-yan Cheung; Iris H. Y. Ng; Leo L. M. Poon; Yi Guan; Nancy Y. Y. Ip; Allan S. Y. Lau; J. S. Malik Peiris
J Immunol (2009) 182 (2): 1088–1098.
View articletitled, Induction of Proinflammatory Cytokines in Primary Human Macrophages by Influenza A Virus (H5N1) Is Selectively Regulated by IFN Regulatory Factor 3 and p38 MAPK<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal"><sup>1</sup></a></sup>
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Type I IFN-Mediated Protection of Macrophages and Dendritic Cells Secures Control of Murine Coronavirus Infection1
Luisa Cervantes-Barragán; Ulrich Kalinke; Roland Züst; Martin König; Boris Reizis; Constantino López-Macías; Volker Thiel; Burkhard Ludewig
J Immunol (2009) 182 (2): 1099–1106.
View articletitled, Type I IFN-Mediated Protection of Macrophages and Dendritic Cells Secures Control of Murine Coronavirus Infection<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal"><sup>1</sup></a></sup>
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IL-10 Dampens TNF/Inducible Nitric Oxide Synthase-Producing Dendritic Cell-Mediated Pathogenicity during Parasitic Infection1
Martin Guilliams; Kiavash Movahedi; Tom Bosschaerts; Thierry VandenDriessche; Marinee Khim Chuah; Michel Hérin; Abel Acosta-Sanchez; Ling Ma; Muriel Moser; Jo A. Van Ginderachter; Lea Brys; Patrick De Baetselier; Alain Beschin
J Immunol (2009) 182 (2): 1107–1118.
View articletitled, IL-10 Dampens TNF/Inducible Nitric Oxide Synthase-Producing Dendritic Cell-Mediated Pathogenicity during Parasitic Infection<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal"><sup>1</sup></a></sup>
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INFLAMMATION

Dectin-2 Recognition of House Dust Mite Triggers Cysteinyl Leukotriene Generation by Dendritic Cells1
Nora A. Barrett; Akiko Maekawa; Opu M. Rahman; K. Frank Austen; Yoshihide Kanaoka
J Immunol (2009) 182 (2): 1119–1128.
View articletitled, Dectin-2 Recognition of House Dust Mite Triggers Cysteinyl Leukotriene Generation by Dendritic Cells<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal"><sup>1</sup></a></sup>
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P2Y6 Receptors Require an Intact Cysteinyl Leukotriene Synthetic and Signaling System to Induce Survival and Activation of Mast Cells1
Yongfeng Jiang; Laura Borrelli; Brian J. Bacskai; Yoshihide Kanaoka; Joshua A. Boyce
J Immunol (2009) 182 (2): 1129–1137.
View articletitled, P2Y6 Receptors Require an Intact Cysteinyl Leukotriene Synthetic and Signaling System to Induce Survival and Activation of Mast Cells<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal"><sup>1</sup></a></sup>
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Increased Reactivity of Dendritic Cells from Aged Subjects to Self-Antigen, the Human DNA1
Anshu Agrawal; Jia Tay; Steven Ton; Sudhanshu Agrawal; Sudhir Gupta
J Immunol (2009) 182 (2): 1138–1145.
View articletitled, Increased Reactivity of Dendritic Cells from Aged Subjects to Self-Antigen, the Human DNA<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal"><sup>1</sup></a></sup>
Supplementary data
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Differential Use of CARD9 by Dectin-1 in Macrophages and Dendritic Cells1
Helen S. Goodridge; Takahiro Shimada; Andrea J. Wolf; Yen-Michael S. Hsu; Courtney A. Becker; Xin Lin; David M. Underhill
J Immunol (2009) 182 (2): 1146–1154.
View articletitled, Differential Use of CARD9 by Dectin-1 in Macrophages and Dendritic Cells<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal"><sup>1</sup></a></sup>
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Mobilization and Margination of Bone Marrow Gr-1high Monocytes during Subclinical Endotoxemia Predisposes the Lungs toward Acute Injury1
Kieran P. O'Dea; Michael R. Wilson; Justina O. Dokpesi; Kenji Wakabayashi; Louise Tatton; Nico van Rooijen; Masao Takata
J Immunol (2009) 182 (2): 1155–1166.
View articletitled, Mobilization and Margination of Bone Marrow Gr-1<sup>high</sup> Monocytes during Subclinical Endotoxemia Predisposes the Lungs toward Acute Injury<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal"><sup>1</sup></a></sup>
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Galectin-3 Deficiency Reduces the Severity of Experimental Autoimmune Encephalomyelitis1
Hui-Rong Jiang; Zakeya Al Rasebi; Eric Mensah-Brown; Allen Shahin; Damo Xu; Carl S. Goodyear; Sandra Y. Fukada; Fu-Tong Liu; Foo Y. Liew; Miodrag L. Lukic
J Immunol (2009) 182 (2): 1167–1173.
View articletitled, Galectin-3 Deficiency Reduces the Severity of Experimental Autoimmune Encephalomyelitis<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal"><sup>1</sup></a></sup>
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Pulmonary Vγ4+ γδ T Cells Have Proinflammatory and Antiviral Effects in Viral Lung Disease1
Jonathan Dodd; Sabine Riffault; Jayanie S. Kodituwakku; Adrian C. Hayday; Peter J. M. Openshaw
J Immunol (2009) 182 (2): 1174–1181.
View articletitled, Pulmonary Vγ4<sup>+</sup> γδ T Cells Have Proinflammatory and Antiviral Effects in Viral Lung Disease<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal"><sup>1</sup></a></sup>
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Acquisition of Anergy to Proinflammatory Cytokines in Nonimmune Cells through Endoplasmic Reticulum Stress Response: A Mechanism for Subsidence of Inflammation1
Kunihiro Hayakawa; Nobuhiko Hiramatsu; Maro Okamura; Hiroaki Yamazaki; Shotaro Nakajima; Jian Yao; Adrienne W. Paton; James C. Paton; Masanori Kitamura
J Immunol (2009) 182 (2): 1182–1191.
View articletitled, Acquisition of Anergy to Proinflammatory Cytokines in Nonimmune Cells through Endoplasmic Reticulum Stress Response: A Mechanism for Subsidence of Inflammation<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal"><sup>1</sup></a></sup>
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CLINICAL IMMUNOLOGY

Potent Induction of IFN-α and Chemokines by Autoantibodies in the Cerebrospinal Fluid of Patients with Neuropsychiatric Lupus1
Deanna M. Santer; Taku Yoshio; Seiji Minota; Thomas Möller; Keith B. Elkon
J Immunol (2009) 182 (2): 1192–1201.
View articletitled, Potent Induction of IFN-α and Chemokines by Autoantibodies in the Cerebrospinal Fluid of Patients with Neuropsychiatric Lupus<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal"><sup>1</sup></a></sup>
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Rapid Degranulation of NK Cells following Activation by HIV-Specific Antibodies1
Amy W. Chung; Erik Rollman; Rob J. Center; Stephen J. Kent; Ivan Stratov
J Immunol (2009) 182 (2): 1202–1210.
View articletitled, Rapid Degranulation of NK Cells following Activation by HIV-Specific Antibodies<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal"><sup>1</sup></a></sup>
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Mucosally Delivered Salmonella Typhi Expressing the Yersinia pestis F1 Antigen Elicits Mucosal and Systemic Immunity Early in Life and Primes the Neonatal Immune System for a Vigorous Anamnestic Response to Parenteral F1 Boost1
Karina Ramirez; Alejandra V. E. Capozzo; Scott A. Lloyd; Marcelo B. Sztein; James P. Nataro; Marcela F. Pasetti
J Immunol (2009) 182 (2): 1211–1222.
View articletitled, Mucosally Delivered <em>Salmonella</em> Typhi Expressing the <em>Yersinia pestis</em> F1 Antigen Elicits Mucosal and Systemic Immunity Early in Life and Primes the Neonatal Immune System for a Vigorous Anamnestic Response to Parenteral F1 Boost<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal"><sup>1</sup></a></sup>
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  • Cover Image

    Cover Image

    issue cover

    On the cover: Plasmacytoid dendritic cell (pDC) depletion in vivo enhanced the severity of articular pathology and enhanced spontaneous T and B cell autoimmune responses in a novel arthritis model. pDC may offer a net anti-inflammatory function in the context of articular breach of tolerance. Jongbloed, S. L., R. A. Benson, M. B. Nickdel, P. Garside, I. B. McInnes, and J. M. Brewer. 2009. Plasmacytoid dendritic cells regulate breach of self-tolerance in autoimmune arthritis. J. Immunol. 182: 963–968.

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