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15 July 2009
ISSN 0022-1767
EISSN 1550-6606
IN THIS ISSUE
CUTTING EDGE
Cutting Edge: NF-κB Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression1
Franz G. Bauernfeind; Gabor Horvath; Andrea Stutz; Emad S. Alnemri; Kelly MacDonald; David Speert; Teresa Fernandes-Alnemri; Jianghong Wu; Brian G. Monks; Katherine A. Fitzgerald; Veit Hornung; Eicke Latz
J Immunol (2009) 183 (2): 787–791.
Cutting Edge: TNF-α Mediates Sensitization to ATP and Silica via the NLRP3 Inflammasome in the Absence of Microbial Stimulation1
J Immunol (2009) 183 (2): 792–796.
Cutting Edge: IL-27 Induces the Transcription Factor c-Maf, Cytokine IL-21, and the Costimulatory Receptor ICOS that Coordinately Act Together to Promote Differentiation of IL-10-Producing Tr1 Cells1
Caroline Pot; Hulin Jin; Amit Awasthi; Sue Min Liu; Chen-Yen Lai; Rajat Madan; Arlene H. Sharpe; Christopher L. Karp; Shi-Chuen Miaw; I-Cheng Ho; Vijay K. Kuchroo
J Immunol (2009) 183 (2): 797–801.
CELLULAR IMMUNOLOGY AND IMMUNE REGULATION
Ablation and Regeneration of Tolerance-Inducing Medullary Thymic Epithelial Cells after Cyclosporine, Cyclophosphamide, and Dexamethasone Treatment1
Anne L. Fletcher; Tamara E. Lowen; Samy Sakkal; Jessica J. Reiseger; Maree V. Hammett; Natalie Seach; Hamish S. Scott; Richard L. Boyd; Ann P. Chidgey
J Immunol (2009) 183 (2): 823–831.
Prednisolone Treatment Induces Tolerogenic Dendritic Cells and a Regulatory Milieu in Myasthenia Gravis Patients1
Claudia Luther; Eleni Adamopoulou; Christina Stoeckle; Verena Brucklacher-Waldert; Daniela Rosenkranz; Lars Stoltze; Sigrid Lauer; Simone Poeschel; Arthur Melms; Eva Tolosa
J Immunol (2009) 183 (2): 841–848.
Glycogen Synthase Kinase-3β Facilitates IFN-γ-Induced STAT1 Activation by Regulating Src Homology-2 Domain-Containing Phosphatase 21
Cheng-Chieh Tsai; Jui-In Kai; Wei-Ching Huang; Chi-Yun Wang; Yi Wang; Chia-Ling Chen; Yi-Ting Fang; Yee-Shin Lin; Robert Anderson; Shun-Hua Chen; Chiung-Wen Tsao; Chiou-Feng Lin
J Immunol (2009) 183 (2): 856–864.
IL-17A Controls IL-17F Production and Maintains Blood Neutrophil Counts in Mice1
J Immunol (2009) 183 (2): 865–873.
Mechanisms of Opioid-Mediated Inhibition of Human T Cell Receptor Signaling1
Christine Börner; Beate Warnick; Michal Smida; Roland Hartig; Jonathan A. Lindquist; Burkhart Schraven; Volker Höllt; Jürgen Kraus
J Immunol (2009) 183 (2): 882–889.
Heat Shock Protein 60, via MyD88 Innate Signaling, Protects B Cells from Apoptosis, Spontaneous and Induced1
J Immunol (2009) 183 (2): 890–896.
Propionic Acid Secreted from Propionibacteria Induces NKG2D Ligand Expression on Human-Activated T Lymphocytes and Cancer Cells1
Lars Andresen; Karen Aagaard Hansen; Helle Jensen; Stine Falsig Pedersen; Peter Stougaard; Helle Rüsz Hansen; Jesper Jurlander; Søren Skov
J Immunol (2009) 183 (2): 897–906.
FOXP3 Inhibits Activation-Induced NFAT2 Expression in T Cells Thereby Limiting Effector Cytokine Expression1
Troy R. Torgerson; Anna Genin; Chunxia Chen; Mingce Zhang; Bin Zhou; Stephanie Añover-Sombke; M. Barton Frank; Igor Dozmorov; Elizabeth Ocheltree; Petri Kulmala; Michael Centola; Hans D. Ochs; Andrew D. Wells; Randy Q. Cron
J Immunol (2009) 183 (2): 907–915.
Patent Filarial Infection Modulates Malaria-Specific Type 1 Cytokine Responses in an IL-10-Dependent Manner in a Filaria/Malaria-Coinfected Population12
Simon Metenou; Benoit Dembélé; Siaka Konate; Housseini Dolo; Siaka Y. Coulibaly; Yaya I. Coulibaly; Abdallah A. Diallo; Lamine Soumaoro; Michel E. Coulibaly; Dramane Sanogo; Salif S. Doumbia; Marissa Wagner; Sekou F. Traoré; Amy Klion; Siddhartha Mahanty; Thomas B. Nutman
J Immunol (2009) 183 (2): 916–924.
An Activating and Inhibitory Signal from an Inhibitory Receptor LMIR3/CLM-1: LMIR3 Augments Lipopolysaccharide Response through Association with FcRγ in Mast Cells1
Kumi Izawa; Jiro Kitaura; Yoshinori Yamanishi; Takayuki Matsuoka; Ayako Kaitani; Masahiro Sugiuchi; Mariko Takahashi; Akie Maehara; Yutaka Enomoto; Toshihiko Oki; Toshiyuki Takai; Toshio Kitamura
J Immunol (2009) 183 (2): 925–936.
Myeloid-Derived Suppressor Cells Down-Regulate L-Selectin Expression on CD4+ and CD8+ T Cells1
J Immunol (2009) 183 (2): 937–944.
Cathepsin S Regulates Class II MHC Processing in Human CD4+ HLA-DR+ T Cells1
J Immunol (2009) 183 (2): 945–952.
Lethal Effect of CD3-Specific Antibody in Mice Deficient in TGF-β1 by Uncontrolled Flu-Like Syndrome1
J Immunol (2009) 183 (2): 953–961.
Identification of a Novel IL-1 Cytokine Family Member in Teleost Fish1
Tiehui Wang; Steve Bird; Antonis Koussounadis; Jason W. Holland; Allison Carrington; Jun Zou; Christopher J. Secombes
J Immunol (2009) 183 (2): 962–974.
SHIP Regulates the Reciprocal Development of T Regulatory and Th17 Cells1
Natasha R. Locke; Scott J. Patterson; Melisa J. Hamilton; Laura M. Sly; Gerald Krystal; Megan K. Levings
J Immunol (2009) 183 (2): 975–983.
Immunomodulatory Function of Bone Marrow-Derived Mesenchymal Stem Cells in Experimental Autoimmune Type 1 Diabetes1
Paolo Fiorina; Mollie Jurewicz; Andrea Augello; Andrea Vergani; Shirine Dada; Stefano La Rosa; Martin Selig; Jonathan Godwin; Kenneth Law; Claudia Placidi; R. Neal Smith; Carlo Capella; Scott Rodig; Chaker N. Adra; Mark Atkinson; Mohamed H. Sayegh; Reza Abdi
J Immunol (2009) 183 (2): 993–1004.
B Cell Intrinsic MyD88 Signals Drive IFN-γ Production from T Cells and Control Switching to IgG2c1
J Immunol (2009) 183 (2): 1005–1012.
A Matter of Timing: Unsynchronized Antigen Expression and Antigen Presentation Diminish Secondary T Cell Responses1
J Immunol (2009) 183 (2): 1013–1021.
Reduced Cytotoxic Function of Effector CD8+ T Cells Is Responsible for Indoleamine 2,3-Dioxygenase-Dependent Immune Suppression1
J Immunol (2009) 183 (2): 1022–1031.
Focal Adhesion Kinase Regulates Pathogen-Killing Capability and Life Span of Neutrophils via Mediating Both Adhesion-Dependent and -Independent Cellular Signals1
Anongnard Kasorn; Pilar Alcaide; Yonghui Jia; Kulandayan K. Subramanian; Bara Sarraj; Yitang Li; Fabien Loison; Hidenori Hattori; Leslie E. Silberstein; William F. Luscinskas; Hongbo R. Luo
J Immunol (2009) 183 (2): 1032–1043.
Trans-Presentation of IL-15 by Intestinal Epithelial Cells Drives Development of CD8αα IELs1
J Immunol (2009) 183 (2): 1044–1054.
The Cytoplasmic Tail of the T Cell Receptor CD3 ε Subunit Contains a Phospholipid-Binding Motif that Regulates T Cell Functions1
Laura M. DeFord-Watts; Tara C. Tassin; Amy M. Becker; Jennifer J. Medeiros; Joseph P. Albanesi; Paul E. Love; Christoph Wülfing; Nicolai S. C. van Oers
J Immunol (2009) 183 (2): 1055–1064.
IL-2 Regulates CD103 Expression on CD4+ T Cells in Scurfy Mice that Display Both CD103-Dependent and Independent Inflammation1
J Immunol (2009) 183 (2): 1065–1073.
An Anti-Inflammatory Role for Plasmacytoid Dendritic Cells in Allergic Airway Inflammation1
Mirjam Kool; Menno van Nimwegen; Monique A. M. Willart; Femke Muskens; Louis Boon; Joost J. Smit; Anthony Coyle; Björn E. Clausen; Henk C. Hoogsteden; Bart N. Lambrecht; Hamida Hammad
J Immunol (2009) 183 (2): 1074–1082.
Direct Antigen Presentation and Gap Junction Mediated Cross-Presentation during Apoptosis1
Baoxu Pang; Joost Neijssen; Xiaohang Qiao; Lennert Janssen; Hans Janssen; Christoph Lippuner; Jacques Neefjes
J Immunol (2009) 183 (2): 1083–1090.
Absence of IFN-β Impairs Antigen Presentation Capacity of Splenic Dendritic Cells via Down-Regulation of Heat Shock Protein 701
Natalia Ziętara; Marcin Łyszkiewicz; Nelson Gekara; Jacek Puchałka; Vitor A. P. Martins Dos Santos; Clayton R. Hunt; Tej K. Pandita; Stefan Lienenklaus; Siegfried Weiss
J Immunol (2009) 183 (2): 1099–1109.
SUMO Conjugation Contributes to Immune Deviation in Nonobese Diabetic Mice by Suppressing c-Maf Transactivation of IL-41
J Immunol (2009) 183 (2): 1110–1119.
Differential Association of Programmed Death-1 and CD57 with Ex Vivo Survival of CD8+ T Cells in HIV Infection1
Constantinos Petrovas; Benjamin Chaon; David R. Ambrozak; David A. Price; J. Joseph Melenhorst; Brenna J. Hill; Christof Geldmacher; Joseph P. Casazza; Pratip K. Chattopadhyay; Mario Roederer; Daniel C. Douek; Yvonne M. Mueller; Jeffrey M. Jacobson; Viraj Kulkarni; Barbara K. Felber; George N. Pavlakis; Peter D. Katsikis; Richard A. Koup
J Immunol (2009) 183 (2): 1120–1132.
Skin Inflammation Is Not Sufficient to Break Tolerance Induced against a Novel Antigen1
Martin Holcmann; Patrizia Stoitzner; Barbara Drobits; Petra Luehrs; Georg Stingl; Nikolaus Romani; Dieter Maurer; Maria Sibilia
J Immunol (2009) 183 (2): 1133–1143.
TLR9 Activation Coupled to IL-10 Deficiency Induces Adverse Pregnancy Outcomes1
J Immunol (2009) 183 (2): 1144–1154.
Lymphocytes in the Peritoneum Home to the Omentum and Are Activated by Resident Dendritic Cells1
J Immunol (2009) 183 (2): 1155–1165.
MOLECULAR AND STRUCTURAL IMMUNOLOGY
The Impact of TCR-Binding Properties and Antigen Presentation Format on T Cell Responsiveness1
Adam S. Chervin; Jennifer D. Stone; Phillip D. Holler; Ailin Bai; Jianzhu Chen; Herman N. Eisen; David M. Kranz
J Immunol (2009) 183 (2): 1166–1178.
Initiation of Antigen Receptor-Dependent Differentiation into Plasma Cells by Calmodulin Inhibition of E2A1
J Immunol (2009) 183 (2): 1179–1187.
Expression of a Modified Form of CD4 Results in the Release of an Anti-HIV Factor Derived from the Env Sequence1
J Immunol (2009) 183 (2): 1188–1196.
Tristetraprolin Is Required for Full Anti-Inflammatory Response of Murine Macrophages to IL-101
Barbara Schaljo; Franz Kratochvill; Nina Gratz; Iwona Sadzak; Ines Sauer; Michael Hammer; Claus Vogl; Birgit Strobl; Mathias Müller; Perry J. Blackshear; Valeria Poli; Roland Lang; Peter J. Murray; Pavel Kovarik
J Immunol (2009) 183 (2): 1197–1206.
MASP-1, a Promiscuous Complement Protease: Structure of Its Catalytic Region Reveals the Basis of Its Broad Specificity1
J Immunol (2009) 183 (2): 1207–1214.
The Polarity Protein Par1b/EMK/MARK2 Regulates T Cell Receptor-Induced Microtubule-Organizing Center Polarization1
J Immunol (2009) 183 (2): 1215–1221.
Significance of N-Terminal Proteolysis of CCL14a to Activity on the Chemokine Receptors CCR1 and CCR5 and the Human Cytomegalovirus-Encoded Chemokine Receptor US281
Rudolf Richter; Paola Casarosa; Ludger Ständker; Jan Münch; Jean-Yves Springael; Saskia Nijmeijer; Wolf-Georg Forssmann; Henry F. Vischer; Jalal Vakili; Michel Detheux; Marc Parmentier; Rob Leurs; Martine J. Smit
J Immunol (2009) 183 (2): 1229–1237.
IMMUNOGENETICS
Progesterone Inhibits Activation-Induced Deaminase by Binding to the Promoter1
J Immunol (2009) 183 (2): 1238–1244.
HOST DEFENSE
Insufficient TLR Activation Contributes to the Slow Development of CD8+ T Cell Responses in Trypanosoma cruzi Infection1
J Immunol (2009) 183 (2): 1245–1252.
HSV-1-Induced SOCS-1 Expression in Keratinocytes: Use of a SOCS-1 Antagonist to Block a Novel Mechanism of Viral Immune Evasion1
Kenneth G. Frey; Chulbul M. I. Ahmed; Rea Dabelic; Lindsey D. Jager; Ezra N. Noon-Song; S. Mohammad Haider; Howard M. Johnson; Nancy J. Bigley
J Immunol (2009) 183 (2): 1253–1262.
Successful Treatment of Bacterial Infection Hinders Development of Acquired Immunity1
J Immunol (2009) 183 (2): 1263–1270.
MyD88 and Type I Interferon Receptor-Mediated Chemokine Induction and Monocyte Recruitment during Listeria monocytogenes Infection1
J Immunol (2009) 183 (2): 1271–1278.
TLR2 Is a Negative Regulator of Th17 Cells and Tissue Pathology in a Pulmonary Model of Fungal Infection1
J Immunol (2009) 183 (2): 1279–1290.
A MyD88-Dependent Early IL-17 Production Protects Mice against Airway Infection with the Obligate Intracellular Pathogen Chlamydia muridarum1
Xiaoyun Zhang; Lifen Gao; Lei Lei; Youmin Zhong; Peter Dube; Michael T. Berton; Bernard Arulanandam; Jinshun Zhang; Guangming Zhong
J Immunol (2009) 183 (2): 1291–1300.
Autocrine IL-10 Induces Hallmarks of Alternative Activation in Macrophages and Suppresses Antituberculosis Effector Mechanisms without Compromising T Cell Immunity1
Tanja Schreiber; Stefan Ehlers; Lisa Heitmann; Alexandra Rausch; Jörg Mages; Peter J. Murray; Roland Lang; Christoph Hölscher
J Immunol (2009) 183 (2): 1301–1312.
T Cell Responses in the Absence of IFN-γ Exacerbate Uterine Infection with Chlamydia trachomatis
J Immunol (2009) 183 (2): 1313–1319.
INFLAMMATION
The Opposite Effects of Acute and Chronic Alcohol on Lipopolysaccharide-Induced Inflammation Are Linked to IRAK-M in Human Monocytes1
J Immunol (2009) 183 (2): 1320–1327.
Prostaglandin E2 Differentially Modulates Proinflammatory/Prodestructive Effects of TNF-α on Synovial Fibroblasts via Specific E Prostanoid Receptors/cAMP1
Elke Kunisch; Anne Jansen; Fumiaki Kojima; Ivonne Löffler; Mohit Kapoor; Shinichi Kawai; Ignacio Rubio; Leslie J. Crofford; Raimund W. Kinne
J Immunol (2009) 183 (2): 1328–1336.
Mycobacterium bovis Bacillus Calmette-Guérin Infection Induces TLR2-Dependent Peroxisome Proliferator-Activated Receptor γ Expression and Activation: Functions in Inflammation, Lipid Metabolism, and Pathogenesis1
Patrícia E. Almeida; Adriana R. Silva; Clarissa M. Maya-Monteiro; Dániel Töröcsik; Heloisa D′Ávila; Balázs Dezsö; Kelly G. Magalhães; Hugo C. Castro-Faria-Neto; Laszlo Nagy; Patrícia T. Bozza
J Immunol (2009) 183 (2): 1337–1345.
Regulation of Dendritic Cells and Macrophages by an Anti-Apoptotic Cell Natural Antibody that Suppresses TLR Responses and Inhibits Inflammatory Arthritis1
Yifang Chen; Sahil Khanna; Carl S. Goodyear; Yong Beom Park; Eyal Raz; Steffen Thiel; Caroline Grönwall; Jaya Vas; David L. Boyle; Maripat Corr; Dwight H. Kono; Gregg J. Silverman
J Immunol (2009) 183 (2): 1346–1359.
A Subcytotoxic Dose of Subtilase Cytotoxin Prevents Lipopolysaccharide-Induced Inflammatory Responses, Depending on its Capacity to Induce the Unfolded Protein Response1
Daisuke Harama; Kensuke Koyama; Mai Mukai; Naomi Shimokawa; Masanori Miyata; Yuki Nakamura; Yuko Ohnuma; Hideoki Ogawa; Shuji Matsuoka; Adrienne W. Paton; James C. Paton; Masanori Kitamura; Atsuhito Nakao
J Immunol (2009) 183 (2): 1368–1374.
Treatment with a C5aR Antagonist Decreases Pathology and Enhances Behavioral Performance in Murine Models of Alzheimer’s Disease1
Maria I. Fonseca; Rahasson R. Ager; Shu-Hui Chu; Ozkan Yazan; Sam D. Sanderson; Frank M. LaFerla; Stephen M. Taylor; Trent M. Woodruff; Andrea J. Tenner
J Immunol (2009) 183 (2): 1375–1383.
Ubiquitin-Editing Enzyme A20 Promotes Tolerance to Lipopolysaccharide in Enterocytes1
J Immunol (2009) 183 (2): 1384–1392.
Menopause and Ovariectomy Cause a Low Grade of Systemic Inflammation that May Be Prevented by Chronic Treatment with Low Doses of Estrogen or Losartan1
May Abu-Taha; Cristina Rius; Carlos Hermenegildo; Inmaculada Noguera; Jose-Miguel Cerda-Nicolas; Andrew C. Issekutz; Peter J. Jose; Julio Cortijo; Esteban J. Morcillo; Maria-Jesus Sanz
J Immunol (2009) 183 (2): 1393–1402.
Zymosan, but Not Lipopolysaccharide, Triggers Severe and Progressive Peritoneal Injury Accompanied by Complement Activation in a Rat Peritonitis Model1
Masashi Mizuno; Yasuhiko Ito; Natalie Hepburn; Tomohiro Mizuno; Yukihiro Noda; Yukio Yuzawa; Claire L. Harris; B. Paul Morgan; Seiichi Matsuo
J Immunol (2009) 183 (2): 1403–1412.
VAMP8 Is Essential in Anaphylatoxin-Induced Degranulation, TNF-α Secretion, Peritonitis, and Systemic Inflammation
J Immunol (2009) 183 (2): 1413–1418.
Pulmonary Inflammation Triggered by Ricin Toxin Requires Macrophages and IL-1 Signaling1
J Immunol (2009) 183 (2): 1419–1426.
Proteases Induce Production of Thymic Stromal Lymphopoietin by Airway Epithelial Cells through Protease-Activated Receptor-21
J Immunol (2009) 183 (2): 1427–1434.
Annexin-1 Regulates Macrophage IL-6 and TNF via Glucocorticoid-Induced Leucine Zipper1
J Immunol (2009) 183 (2): 1435–1445.
IL-33 Enhances Lipopolysaccharide-Induced Inflammatory Cytokine Production from Mouse Macrophages by Regulating Lipopolysaccharide Receptor Complex1
Quentin Espinassous; Elvira Garcia-de-Paco; Ignacio Garcia-Verdugo; Monique Synguelakis; Sonja von Aulock; Jean-Michel Sallenave; Andrew N. J. McKenzie; Jean Kanellopoulos
J Immunol (2009) 183 (2): 1446–1455.
Pathogen-Induced Interleukin-1β Processing and Secretion Is Regulated by a Biphasic Redox Response1
J Immunol (2009) 183 (2): 1456–1462.
Activation of the Akt-NF-κB Pathway by Subtilase Cytotoxin through the ATF6 Branch of the Unfolded Protein Response1
Hiroaki Yamazaki; Nobuhiko Hiramatsu; Kunihiro Hayakawa; Yasuhiro Tagawa; Maro Okamura; Ryouji Ogata; Tao Huang; Shotaro Nakajima; Jian Yao; Adrienne W. Paton; James C. Paton; Masanori Kitamura
J Immunol (2009) 183 (2): 1480–1487.
CLINICAL IMMUNOLOGY
A20 Attenuates Allergic Airway Inflammation in Mice1
Nam-In Kang; Ha-Yong Yoon; Young-Rae Lee; Minho Won; Myoung Ja Chung; Jin-Woo Park; Gang Min Hur; Hern-Ku Lee; Byung-Hyun Park
J Immunol (2009) 183 (2): 1488–1495.
CORRECTIONS
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Cover Image
Cover Image
On the cover: A20 (green), mucin2 (red) and nuclei (blue) in mouse ileum. Note localization of A20 at the luminal interface of the villi. In addition to its specific activity, the A20 Ab reacts nonspecifically with the mucus in goblet cell cups, which appear yellow/orange on the merged image. Wang, J., Y. Ouyang, Y. Guner, H. R. Ford, and A. V. Grishin. 2009. Ubiquitin-editing enzyme A20 promotes tolerance to LPS in enterocytes. J. Immunol. 183: 1384–1392.
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