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Issues
15 August 2009
ISSN 0022-1767
EISSN 1550-6606
IN THIS ISSUE
LETTERS TO THE EDITOR
BRIEF REVIEWS
Secondary Lymphoid Organs: Responding to Genetic and Environmental Cues in Ontogeny and the Immune Response1
J Immunol (2009) 183 (4): 2205–2212.
CUTTING EDGE
Cutting Edge: The Chemokine Receptor CXCR3 Retains Invariant NK T Cells in the Thymus1
Michael B. Drennan; Ann-Sophie Franki; Pieter Dewint; Katrien Van Beneden; Sylvie Seeuws; Serge A. van de Pavert; Emma C. Reilly; Gust Verbruggen; Thomas E. Lane; Reina E. Mebius; Dieter Deforce; Dirk Elewaut
J Immunol (2009) 183 (4): 2213–2216.
CELLULAR IMMUNOLOGY AND IMMUNE REGULATION
CD44 Costimulation Promotes FoxP3+ Regulatory T Cell Persistence and Function via Production of IL-2, IL-10, and TGF-β1
Paul L. Bollyky; Ben A. Falk; S. Alice Long; Anton Preisinger; Kathy R. Braun; Rebecca P. Wu; Stephen P. Evanko; Jane H. Buckner; Thomas N. Wight; Gerald T. Nepom
J Immunol (2009) 183 (4): 2232–2241.
Vaccine-Induced Antibody Isotypes Are Skewed by Impaired CD4 T Cell and Invariant NKT Cell Effector Responses in MyD88-Deficient Mice1
Onyinye I. Iweala; Donald W. Smith; Kabir S. Matharu; Isabel Sada-Ovalle; Deanna D. Nguyen; Rosemarie H. DeKruyff; Dale T. Umetsu; Samuel M. Behar; Cathryn R. Nagler
J Immunol (2009) 183 (4): 2252–2260.
Identification of DNA Methyltransferase 3a as a T Cell Receptor-Induced Regulator of Th1 and Th2 Differentiation1
J Immunol (2009) 183 (4): 2267–2276.
Dendritic Cells Require STAT-1 Phosphorylated at Its Transactivating Domain for the Induction of Peptide-Specific CTL1
Andreas Pilz; Wolfgang Kratky; Silvia Stockinger; Olivia Simma; Ulrich Kalinke; Karen Lingnau; Alexander von Gabain; Dagmar Stoiber; Veronika Sexl; Thomas Kolbe; Thomas Rülicke; Mathias Müller; Thomas Decker
J Immunol (2009) 183 (4): 2286–2293.
Novel Generation Mycobacterial Adjuvant Based on Liposome-Encapsulated Monomycoloyl Glycerol from Mycobacterium bovis Bacillus Calmette-Guérin1
Claire A. Swetman Andersen; Ida Rosenkrands; Anja W. Olsen; Pernille Nordly; Dennis Christensen; Roland Lang; Carsten Kirschning; Jessica M. Gomes; Veemal Bhowruth; David E. Minnikin; Gurdyal S. Besra; Frank Follmann; Peter Andersen; Else Marie Agger
J Immunol (2009) 183 (4): 2294–2302.
Helios Deficiency Has Minimal Impact on T Cell Development and Function1
J Immunol (2009) 183 (4): 2303–2311.
Nonredundant Roles for B Cell-Derived IL-10 in Immune Counter-Regulation1
Rajat Madan; Filiz Demircik; Sangeetha Surianarayanan; Jessica L. Allen; Senad Divanovic; Aurelien Trompette; Nir Yogev; Yuanyuan Gu; Marat Khodoun; David Hildeman; Nicholas Boespflug; Mariela B. Fogolin; Lothar Gröbe; Marina Greweling; Fred D. Finkelman; Rhonda Cardin; Markus Mohrs; Werner Müller; Ari Waisman; Axel Roers; Christopher L. Karp
J Immunol (2009) 183 (4): 2312–2320.
TNFR1-Dependent Regulation of Myeloid Cell Function in Experimental Autoimmune Uveoretinitis1
J Immunol (2009) 183 (4): 2321–2329.
Sphingosine 1-Phosphate Enhances Fcγ Receptor-Mediated Neutrophil Activation and Recruitment under Flow Conditions1
J Immunol (2009) 183 (4): 2330–2336.
Telomere Shortening and Oxidative Stress in Aged Macrophages Results in Impaired STAT5a Phosphorylation1
J Immunol (2009) 183 (4): 2356–2364.
Critical Roles of Translationally Controlled Tumor Protein in the Homeostasis and TCR-Mediated Proliferation of Peripheral T Cells1
Peih-Shan Wu; Chia-Yu Yang; Jeffrey Jong-Young Yen; Chiang-Hung Chou; Sung Ho Chen; Chi-Kuang Leo Wang; Yein-Gei Lai; Nan-Shih Liao; Hsin-Fang Yang-Yen
J Immunol (2009) 183 (4): 2373–2381.
The Magnitude of CD4+ T Cell Recall Responses Is Controlled by the Duration of the Secondary Stimulus1
J Immunol (2009) 183 (4): 2382–2389.
Induction of Antigen-Specific Tolerance by Oral Administration of Lactococcus lactis Delivered Immunodominant DQ8-Restricted Gliadin Peptide in Sensitized Nonobese Diabetic Ab° Dq8 Transgenic Mice1
Inge L. Huibregtse; Eric V. Marietta; Shadi Rashtak; Frits Koning; Pieter Rottiers; Chella S. David; Sander J. H. van Deventer; Joseph A. Murray
J Immunol (2009) 183 (4): 2390–2396.
IL-27 Abrogates Receptor Activator of NF-κB Ligand-Mediated Osteoclastogenesis of Human Granulocyte-Macrophage Colony-Forming Unit Cells through STAT1-Dependent Inhibition of c-Fos1
Mitsuru Furukawa; Hironari Takaishi; Jiro Takito; Masaki Yoda; Sadaoki Sakai; Tomohiro Hikata; Akihiro Hakozaki; Shinichi Uchikawa; Morio Matsumoto; Kazuhiro Chiba; Tokuhiro Kimura; Yasunori Okada; Koichi Matsuo; Hiroki Yoshida; Yoshiaki Toyama
J Immunol (2009) 183 (4): 2397–2406.
Immune Sensing of Aspergillus fumigatus Proteins, Glycolipids, and Polysaccharides and the Impact on Th Immunity and Vaccination1
Silvia Bozza; Cecile Clavaud; Gloria Giovannini; Thierry Fontaine; Anne Beauvais; Jacqueline Sarfati; Carmen D'Angelo; Katia Perruccio; Pierluigi Bonifazi; Silvia Zagarella; Silvia Moretti; Francesco Bistoni; Jean-Paul Latgé; Luigina Romani
J Immunol (2009) 183 (4): 2407–2414.
Different Vaccine Vectors Delivering the Same Antigen Elicit CD8+ T Cell Responses with Distinct Clonotype and Epitope Specificity1
Mitsuo Honda; Rui Wang; Wing-Pui Kong; Masaru Kanekiyo; Wataru Akahata; Ling Xu; Kazuhiro Matsuo; Kannan Natarajan; Howard Robinson; Tedi E. Asher; David A. Price; Daniel C. Douek; David H. Margulies; Gary J. Nabel
J Immunol (2009) 183 (4): 2425–2434.
IL-27 Is a Key Regulator of IL-10 and IL-17 Production by Human CD4+ T Cells1
Gopal Murugaiyan; Akanksha Mittal; Rocio Lopez-Diego; Lisa M. Maier; David E. Anderson; Howard L. Weiner
J Immunol (2009) 183 (4): 2435–2443.
IL-10 Suppresses Calcium-Mediated Costimulation of Receptor Activator NF-κB Signaling during Human Osteoclast Differentiation by Inhibiting TREM-2 Expression1
Kyung-Hyun Park-Min; Jong-Dae Ji; Taras Antoniv; Alicia C. Reid; Randi B. Silver; Mary Beth Humphrey; Mary Nakamura; Lionel B. Ivashkiv
J Immunol (2009) 183 (4): 2444–2455.
Functional Modulation of Dendritic Cells and Macrophages by Japanese Encephalitis Virus through MyD88 Adaptor Molecule-Dependent and -Independent Pathways1
Abi G. Aleyas; Junu A. George; Young Woo Han; M. M. Rahman; Seon Ju Kim; Sang Bae Han; Byung Sam Kim; Koanhoi Kim; Seong Kug Eo
J Immunol (2009) 183 (4): 2462–2474.
IDO Activates Regulatory T Cells and Blocks Their Conversion into Th17-Like T Cells1
Babak Baban; Phillip R. Chandler; Madhav D. Sharma; Jeanene Pihkala; Pandelakis A. Koni; David H. Munn; Andrew L. Mellor
J Immunol (2009) 183 (4): 2475–2483.
Thioredoxin-Interacting Protein Regulates Hematopoietic Stem Cell Quiescence and Mobilization under Stress Conditions1
Mira Jeong; Zheng-Hao Piao; Mi Sun Kim; Suk Hyung Lee; Sohyun Yun; Hu-nan Sun; Suk Ran Yoon; Jin Woong Chung; Tae-Don Kim; Jun Ho Jeon; Jiwon Lee; Hyun-Nam Kim; Je-Yong Choi; Inpyo Choi
J Immunol (2009) 183 (4): 2495–2505.
CCR 7 Ligands Are Required for Development of Experimental Autoimmune Encephalomyelitis through Generating IL-23-Dependent Th17 Cells1
Taku Kuwabara; Fumio Ishikawa; Takuwa Yasuda; Kentaro Aritomi; Hideki Nakano; Yuriko Tanaka; Yayoi Okada; Martin Lipp; Terutaka Kakiuchi
J Immunol (2009) 183 (4): 2513–2521.
Poly I:C-Induced Activation of NK Cells by CD8α+ Dendritic Cells via the IPS-1 and TRIF-Dependent Pathways1
Tohru Miyake; Yutaro Kumagai; Hiroki Kato; Zijin Guo; Kazufumi Matsushita; Takashi Satoh; Tatsukata Kawagoe; Himanshu Kumar; Myoung Ho Jang; Taro Kawai; Tohru Tani; Osamu Takeuchi; Shizuo Akira
J Immunol (2009) 183 (4): 2522–2528.
MOLECULAR AND STRUCTURAL IMMUNOLOGY
SCID Dogs: Similar Transplant Potential but Distinct Intra-Uterine Growth Defects and Premature Replicative Senescence Compared with SCID Mice1
Katheryn Meek; Ari Jutkowitz; Lisa Allen; Jillian Glover; Erin Convery; Alisha Massa; Tom Mullaney; Bryden Stanley; Diana Rosenstein; Susan M. Bailey; Cheri Johnson; George Georges
J Immunol (2009) 183 (4): 2529–2536.
Antigen-Driven Evolution of B Lymphocytes in Coronary Atherosclerotic Plaques1
Roberto Burioni; Filippo Canducci; Diego Saita; Mario Perotti; Nicasio Mancini; Donata De Marco; Nicola Clementi; Alaide Chieffo; Maurizio Denaro; Domenico Cianflone; Angelo A. Manfredi; Antonio Colombo; Attilio Maseri; Massimo Clementi
J Immunol (2009) 183 (4): 2537–2544.
The Transcription Factor RFX Protects MHC Class II Genes against Epigenetic Silencing by DNA Methylation1
Queralt Seguín-Estévez; Raffaele De Palma; Michal Krawczyk; Elisa Leimgruber; Jean Villard; Capucine Picard; Augusto Tagliamacco; Gianfranco Abbate; Jack Gorski; Arcangelo Nocera; Walter Reith
J Immunol (2009) 183 (4): 2545–2553.
Structural Basis of the CD8αβ/MHC Class I Interaction: Focused Recognition Orients CD8β to a T Cell Proximal Position12
J Immunol (2009) 183 (4): 2554–2564.
A Molecular Insight into Complement Evasion by the Staphylococcal Complement Inhibitor Protein Family1
Daniel Ricklin; Apostolia Tzekou; Brandon L. Garcia; Michal Hammel; William J. McWhorter; Georgia Sfyroera; You-Qiang Wu; V. Michael Holers; Andrew P. Herbert; Paul N. Barlow; Brian V. Geisbrecht; John D. Lambris
J Immunol (2009) 183 (4): 2565–2574.
Aberrant Selection and Function of Invariant NKT Cells in the Absence of AP-1 Transcription Factor Fra-21
J Immunol (2009) 183 (4): 2575–2584.
TLR4-Mediated Signaling Induces MMP9-Dependent Cleavage of B Cell Surface CD231
J Immunol (2009) 183 (4): 2585–2592.
HOST DEFENSE
Nontypeable Haemophilus influenzae Protein E Binds Vitronectin and Is Important for Serum Resistance1
J Immunol (2009) 183 (4): 2593–2601.
Human Neutrophils Kill Streptococcus pneumoniae via Serine Proteases1
J Immunol (2009) 183 (4): 2602–2609.
NKp44 Receptor Mediates Interaction of the Envelope Glycoproteins from the West Nile and Dengue Viruses with NK Cells1
Oren Hershkovitz; Benyamin Rosental; Lior Ann Rosenberg; Martha Erika Navarro-Sanchez; Sergey Jivov; Alon Zilka; Orly Gershoni-Yahalom; Elodie Brient-Litzler; Hugues Bedouelle; Joanna W. Ho; Kerry S. Campbell; Bracha Rager-Zisman; Philippe Despres; Angel Porgador
J Immunol (2009) 183 (4): 2610–2621.
NK Cells Interfere with the Generation of Resistance against Mycoplasma Respiratory Infection following Nasal-Pulmonary Immunization1
J Immunol (2009) 183 (4): 2622–2631.
Neutrophil Bleaching of GFP-Expressing Staphylococci: Probing the Intraphagosomal Fate of Individual Bacteria1
J Immunol (2009) 183 (4): 2632–2641.
E-Prostanoid 3 Receptor Deletion Improves Pulmonary Host Defense and Protects Mice from Death in Severe Streptococcus pneumoniae Infection1
David M. Aronoff; Casey Lewis; Carlos H. Serezani; Kathryn A. Eaton; Deepti Goel; John C. Phipps; Marc Peters-Golden; Peter Mancuso
J Immunol (2009) 183 (4): 2642–2649.
Leukotriene B4 Potentiates CpG Signaling for Enhanced Cytokine Secretion by Human Leukocytes1
J Immunol (2009) 183 (4): 2650–2658.
TLR4- and TLR2-Mediated B Cell Responses Control the Clearance of the Bacterial Pathogen, Leptospira interrogans1
Cécilia Chassin; Mathieu Picardeau; Jean-Michel Goujon; Pascale Bourhy; Nathalie Quellard; Sylvie Darche; Edgar Badell; Martine Fanton d'Andon; Nathalie Winter; Sonia Lacroix-Lamandé; Dominique Buzoni-Gatel; Alain Vandewalle; Catherine Werts
J Immunol (2009) 183 (4): 2669–2677.
Distinct Responses of Human Monocyte Subsets to Aspergillus fumigatus Conidia1
Natalya V. Serbina; Mathew Cherny; Chao Shi; Sharon A. Bleau; Nancy H. Collins; James W. Young; Eric G. Pamer
J Immunol (2009) 183 (4): 2678–2687.
Intracellular Receptor for Human Host Defense Peptide LL-37 in Monocytes1
Neeloffer Mookherjee; Dustin N. D. Lippert; Pamela Hamill; Reza Falsafi; Anastasia Nijnik; Jason Kindrachuk; Jelena Pistolic; Jennifer Gardy; Pegah Miri; Misbah Naseer; Leonard J. Foster; Robert E. W. Hancock
J Immunol (2009) 183 (4): 2688–2696.
Role of Salmonella enterica Lipopolysaccharide in Activation of Dendritic Cell Functions and Bacterial Containment1
J Immunol (2009) 183 (4): 2697–2707.
HIV-1 Envelope Induces Memory B Cell Responses That Correlate with Plasma Antibody Levels after Envelope gp120 Protein Vaccination or HIV-1 Infection1
Mattia Bonsignori; M. Anthony Moody; Robert J. Parks; T. Matt Holl; Garnett Kelsoe; Charles B. Hicks; Nathan Vandergrift; Georgia D. Tomaras; Barton F. Haynes
J Immunol (2009) 183 (4): 2708–2717.
INFLAMMATION
Human Neutrophils Coordinate Chemotaxis by Differential Activation of Rac1 and Rac21
J Immunol (2009) 183 (4): 2718–2728.
The Peroxisome Proliferator-Activated Receptor γ Agonist Pioglitazone Improves Cardiometabolic Risk and Renal Inflammation in Murine Lupus1
Wenpu Zhao; Seth G. Thacker; Jeffrey B. Hodgin; Hongyu Zhang; Jeffrey H. Wang; James L. Park; Ann Randolph; Emily C. Somers; Subramaniam Pennathur; Matthias Kretzler; Frank C. Brosius, III; Mariana J. Kaplan
J Immunol (2009) 183 (4): 2729–2740.
Blocking TNF-α Attenuates Aneurysm Formation in a Murine Model1
J Immunol (2009) 183 (4): 2741–2746.
Caveolae Facilitate but Are Not Essential for Platelet-Activating Factor-Mediated Calcium Mobilization and Extracellular Signal-Regulated Kinase Activation1
Caroline Poisson; Simon Rollin; Steeve Véronneau; Simon M. Bousquet; Jean-François Larrivée; Christian Le Gouill; Guylain Boulay; Jana Stankova; Marek Rola-Pleszczynski
J Immunol (2009) 183 (4): 2747–2757.
Concomitant Inhalation of Cigarette Smoke and Aerosolized Protein Activates Airway Dendritic Cells and Induces Allergic Airway Inflammation in a TLR-Independent Way1
Lander J. Robays; Ellen A. Lanckacker; Katrien B. Moerloose; Tania Maes; Ken R. Bracke; Guy G. Brusselle; Guy F. Joos; Karim Y. Vermaelen
J Immunol (2009) 183 (4): 2758–2766.
SUMOylation of Tissue Transglutaminase as Link between Oxidative Stress and Inflammation1
Alessandro Luciani; Valeria Rachela Villella; Angela Vasaturo; Ida Giardino; Valeria Raia; Massimo Pettoello-Mantovani; Maria D'Apolito; Stefano Guido; Teresinha Leal; Sonia Quaratino; Luigi Maiuri
J Immunol (2009) 183 (4): 2775–2784.
Peptidoglycan Enhances IL-6 Production in Human Synovial Fibroblasts via TLR2 Receptor, Focal Adhesion Kinase, Akt, and AP-1- Dependent Pathway1
Yung-Cheng Chiu; Ching-Yuang Lin; Chao-Ping Chen; Kui-Chou Huang; Kwok-Man Tong; Chung-Yuh Tzeng; Tu-Sheng Lee; Horng-Chaung Hsu; Chih-Hsin Tang
J Immunol (2009) 183 (4): 2785–2792.
Interactions between Innate Antiviral and Atopic Immunoinflammatory Pathways Precipitate and Sustain Asthma Exacerbations in Children1
Lily S. Subrata; Joelene Bizzintino; Emilie Mamessier; Anthony Bosco; Katherine L. McKenna; Matthew E. Wikström; Jack Goldblatt; Peter D. Sly; Belinda J. Hales; Wayne R. Thomas; Ingrid A. Laing; Peter N. LeSouëf; Patrick G. Holt
J Immunol (2009) 183 (4): 2793–2800.
P2X1 Ion Channels Promote Neutrophil Chemotaxis through Rho Kinase Activation1
Christelle Lecut; Kim Frederix; Daniel M. Johnson; Christophe Deroanne; Marc Thiry; Céline Faccinetto; Raphaël Marée; Richard J. Evans; Paul G. A. Volders; Vincent Bours; Cécile Oury
J Immunol (2009) 183 (4): 2801–2809.
CLINICAL IMMUNOLOGY
Dendritic Cell Anergy Results from Endotoxemia in Severe Malnutrition1
J Immunol (2009) 183 (4): 2818–2826.
High Levels of Human Antigen-Specific CD4+ T Cells in Peripheral Blood Revealed by Stimulated Coexpression of CD25 and CD134 (OX40)1
John J. Zaunders; Mee Ling Munier; Nabila Seddiki; Sarah Pett; Susanna Ip; Michelle Bailey; Yin Xu; Kai Brown; Wayne B. Dyer; Min Kim; Robert de Rose; Stephen J. Kent; Lele Jiang; Samuel N. Breit; Sean Emery; Anthony L. Cunningham; David A. Cooper; Anthony D. Kelleher
J Immunol (2009) 183 (4): 2827–2836.
A Panel of Artificial APCs Expressing Prevalent HLA Alleles Permits Generation of Cytotoxic T Cells Specific for Both Dominant and Subdominant Viral Epitopes for Adoptive Therapy1
Aisha N. Hasan; Wouter J. Kollen; Deepa Trivedi; Annamalai Selvakumar; Bo Dupont; Michel Sadelain; Richard J. O'Reilly
J Immunol (2009) 183 (4): 2837–2850.
Two Compensatory Pathways Maintain Long-Term Stability and Diversity in CD8 T Cell Memory Repertoires12
J Immunol (2009) 183 (4): 2851–2858.
Suppression of Experimental Autoimmune Encephalomyelitis by Ghrelin1
Michael-Mark Theil; Sachiko Miyake; Miho Mizuno; Chiharu Tomi; J. Ludovic Croxford; Hiroshi Hosoda; Julia Theil; Stephan von Hörsten; Hiroaki Yokote; Asako Chiba; Youwei Lin; Shinji Oki; Takashi Akamizu; Kenji Kangawa; Takashi Yamamura
J Immunol (2009) 183 (4): 2859–2866.
Smoking-Dependent Reprogramming of Alveolar Macrophage Polarization: Implication for Pathogenesis of Chronic Obstructive Pulmonary Disease1
Renat Shaykhiev; Anja Krause; Jacqueline Salit; Yael Strulovici-Barel; Ben-Gary Harvey; Timothy P. O'Connor; Ronald G. Crystal
J Immunol (2009) 183 (4): 2867–2883.
CORRECTIONS
Modulating the expression of IFN regulatory factor 8 alters the protumorigenic behavior of CD11b+Gr-1+ myeloid cells
J Immunol (2009) 183 (4): 2884.
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Cover Image
Cover Image
On the cover: Representative light photomicrograph (40× magnification) of Masson trichrome-stained section from kidneys of pioglitazone-treated New Zealand Black/New Zealand White F1 lupus-prone mice at 25 wk of age. In contrast to vehicle-treated mice, the glomeruli of animals receiving pioglitazone had reduction in endocapillary hypercellularity and inflammatory infiltrates. Zhao, W., S. G. Thacker, J. B. Hodgin, H. Zhang, J. H. Wang, J. L. Park, A. Randolph, E. C. Somers, S. Pennathur, M. Kretzler, F. C. Brosius III, and M. J. Kaplan. 2009. The peroxisome proliferator-activated receptor-γ agonist pioglitazone improves cardiometabolic risk and renal inflammation in murine lupus. J. Immunol. 183: 2729–2740.
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