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1 June 2010
ISSN 0022-1767
EISSN 1550-6606
IN THIS ISSUE
PILLARS OF IMMUNOLOGY
Pillars Article: Interaction between CD4 and Class II MHC Molecules Mediates Cell Adhesion. Nature. 1987. 330: 256–259
J Immunol (2010) 184 (11): 5935–5938.
BRIEF REVIEWS
CUTTING EDGE
Cutting Edge: Delay and Reversal of T Cell Tolerance by Intratumoral Injection of Antigen-Loaded Dendritic Cells in an Autochthonous Tumor Model
J Immunol (2010) 184 (11): 5954–5958.
Cutting Edge: Mechanical Forces Acting on T Cells Immobilized via the TCR Complex Can Trigger TCR Signaling
Ya-Chen Li; Bing-Mae Chen; Pei-Chun Wu; Tian-Lu Cheng; Lung-Sen Kao; Mi-Hua Tao; Andre Lieber; Steve R. Roffler
J Immunol (2010) 184 (11): 5959–5963.
Cutting Edge: Rag Deletion in Peripheral T Cells Blocks TCR Revision
J Immunol (2010) 184 (11): 5964–5968.
CELLULAR IMMUNOLOGY AND IMMUNE REGULATION
APC Activation by IFN-α Decreases Regulatory T Cell and Enhances Th Cell Functions
Luigia Pace; Sara Vitale; Beatrice Dettori; Cecilia Palombi; Valentina La Sorsa; Filippo Belardelli; Enrico Proietti; Gino Doria
J Immunol (2010) 184 (11): 5969–5979.
Hemoglobin Transforms Anti-Inflammatory Salmonella typhi Virulence Polysaccharide into a TLR-2 Agonist
J Immunol (2010) 184 (11): 5980–5987.
Both CD4 and CD8 T Cells Mediate Equally Effective In Vivo Tumor Treatment When Engineered with a Highly Avid TCR Targeting Tyrosinase
Timothy L. Frankel; William R. Burns; Peter D. Peng; Zhiya Yu; Dhanalakshmi Chinnasamy; Jennifer A. Wargo; Zhili Zheng; Nicholas P. Restifo; Steven A. Rosenberg; Richard A. Morgan
J Immunol (2010) 184 (11): 5988–5998.
CD28 Facilitates the Generation of Foxp3− Cytokine Responsive Regulatory T Cell Precursors
J Immunol (2010) 184 (11): 6007–6013.
Sex Steroid Ablation Enhances Immune Reconstitution Following Cytotoxic Antineoplastic Therapy in Young Mice
Gabrielle L. Goldberg; Jarrod A. Dudakov; Jessica J. Reiseger; Natalie Seach; Tomoo Ueno; Katerina Vlahos; Maree V. Hammett; Lauren F. Young; Tracy S. P. Heng; Richard L. Boyd; Ann P. Chidgey
J Immunol (2010) 184 (11): 6014–6024.
Neuronal Nitric Oxide Synthase Modulates Maturation of Human Dendritic Cells
Henric S. Adler; Alexandra Simon; Edith Graulich; Alice Habermeier; Nicole Bacher; Andreas Friebe; Ellen I. Closs; Kerstin Steinbrink
J Immunol (2010) 184 (11): 6025–6034.
Targeting Neural-Restrictive Silencer Factor Sensitizes Tumor Cells to Antibody-Based Cancer Immunotherapy In Vitro via Multiple Mechanisms
J Immunol (2010) 184 (11): 6035–6042.
Krüppel-Like Factor 2 Regulates Trafficking and Homeostasis of γδ T Cells
J Immunol (2010) 184 (11): 6060–6066.
Allergic Conjunctivitis Exacerbates Corneal Allograft Rejection by Activating Th1 and Th2 Alloimmune Responses
J Immunol (2010) 184 (11): 6076–6083.
Transcription Factor E2F1 Suppresses Dendritic Cell Maturation
Fang Fang; Yan Wang; Rui Li; Ying Zhao; Yang Guo; Ming Jiang; Jie Sun; Yang Ma; Zijia Ren; Zhigang Tian; Feng Wei; De Yang; Weihua Xiao
J Immunol (2010) 184 (11): 6084–6091.
Gender-Specific Expression of β1 Integrin of VLA-4 in Myelin Basic Protein-Primed T Cells: Implications for Gender Bias in Multiple Sclerosis
J Immunol (2010) 184 (11): 6103–6113.
The Role of the CCL2/CCR2 Axis in Mouse Mast Cell Migration In Vitro and In Vivo
Sarah J. Collington; Jenny Hallgren; James E. Pease; Tatiana G. Jones; Barrett J. Rollins; John Westwick; K. Frank Austen; Timothy J. Williams; Michael F. Gurish; Charlotte L. Weller
J Immunol (2010) 184 (11): 6114–6123.
Erbb2 DNA Vaccine Combined with Regulatory T Cell Deletion Enhances Antibody Response and Reveals Latent Low-Avidity T Cells: Potential and Limits of Its Therapeutic Efficacy
Simona Rolla; Francesco Ria; Sergio Occhipinti; Gabriele Di Sante; Manuela Iezzi; Michela Spadaro; Chiara Nicolò; Elena Ambrosino; Irene Fiore Merighi; Piero Musiani; Guido Forni; Federica Cavallo
J Immunol (2010) 184 (11): 6124–6132.
Foxa2 Programs Th2 Cell-Mediated Innate Immunity in the Developing Lung
Gang Chen; Huajing Wan; Fengming Luo; Liqian Zhang; Yan Xu; Ian Lewkowich; Marsha Wills-Karp; Jeffrey A. Whitsett
J Immunol (2010) 184 (11): 6133–6141.
Expanded CD23+/CD21hi B Cells in Inflamed Lymph Nodes Are Associated with the Onset of Inflammatory-Erosive Arthritis in TNF-Transgenic Mice and Are Targets of Anti-CD20 Therapy
Jie Li; Igor Kuzin; Safiehkhatoon Moshkani; Steven T. Proulx; Lianping Xing; Denise Skrombolas; Robert Dunn; Iñaki Sanz; Edward M. Schwarz; Andrea Bottaro
J Immunol (2010) 184 (11): 6142–6150.
Antigen-Specific Immunity and Cross-Priming by Epithelial Ovarian Carcinoma-Induced CD11b+Gr-1+ Cells
Kei Tomihara; Miao Guo; Takako Shin; Xiuhua Sun; Sara M. Ludwig; Michael J. Brumlik; Bin Zhang; Tyler J. Curiel; Tahiro Shin
J Immunol (2010) 184 (11): 6151–6160.
RORC2 Is Involved in T Cell Polarization through Interaction with the FOXP3 Promoter
Simone Burgler; Pierre-Yves Mantel; Claudio Bassin; Nadia Ouaked; Cezmi A. Akdis; Carsten B. Schmidt-Weber
J Immunol (2010) 184 (11): 6161–6169.
Reporter Alleles that Inform on Differences in Cre Recombinase Expression
J Immunol (2010) 184 (11): 6170–6176.
MOLECULAR AND STRUCTURAL IMMUNOLOGY
Genome-Wide RNA Interference in Drosophila Cells Identifies G Protein-Coupled Receptor Kinase 2 as a Conserved Regulator of NF-κB Signaling
Susanna Valanne; Henna Myllymäki; Jenni Kallio; Martin Rudolf Schmid; Anni Kleino; Astrid Murumägi; Laura Airaksinen; Tapio Kotipelto; Meri Kaustio; Johanna Ulvila; Shiva Seyedoleslami Esfahani; Ylva Engström; Olli Silvennoinen; Dan Hultmark; Mataleena Parikka; Mika Rämet
J Immunol (2010) 184 (11): 6188–6198.
HLA-F Complex without Peptide Binds to MHC Class I Protein in the Open Conformer Form
J Immunol (2010) 184 (11): 6199–6208.
Vγ2Vδ2 T Cell Receptor Recognition of Prenyl Pyrophosphates Is Dependent on All CDRs
J Immunol (2010) 184 (11): 6209–6222.
Minimal Amino Acid Exchange in Human TCR Constant Regions Fosters Improved Function of TCR Gene-Modified T Cells
J Immunol (2010) 184 (11): 6223–6231.
Selected Murine Residues Endow Human TCR with Enhanced Tumor Recognition
J Immunol (2010) 184 (11): 6232–6241.
Switch Region Identity Plays an Important Role in Ig Class Switch Recombination
J Immunol (2010) 184 (11): 6242–6248.
The E3 Ubiquitin Ligase RNF5 Targets Virus-Induced Signaling Adaptor for Ubiquitination and Degradation
J Immunol (2010) 184 (11): 6249–6255.
IMMUNOGENETICS
HOST DEFENSE
Monocyte Trafficking to Hepatic Sites of Bacterial Infection Is Chemokine Independent and Directed by Focal Intercellular Adhesion Molecule-1 Expression
J Immunol (2010) 184 (11): 6266–6274.
Diabetic Mice Display a Delayed Adaptive Immune Response to Mycobacterium tuberculosis
J Immunol (2010) 184 (11): 6275–6282.
Specificity of Staphylococcal Superantigen-Like Protein 10 toward the Human IgG1 Fc Domain
J Immunol (2010) 184 (11): 6283–6292.
Immune Complex-Mediated Enhancement of Secondary Antibody Responses
J Immunol (2010) 184 (11): 6293–6298.
A Role for IL-1 Receptor-Associated Kinase-M in Prostaglandin E2-Induced Immunosuppression Post-Bone Marrow Transplantation
Leah L. N. Hubbard; Megan N. Ballinger; Peedikayil E. Thomas; Carol A. Wilke; Theodore J. Standiford; Koichi S. Kobayashi; Richard A. Flavell; Bethany B. Moore
J Immunol (2010) 184 (11): 6299–6308.
Lack of Original Antigenic Sin in Recall CD8+ T Cell Responses
J Immunol (2010) 184 (11): 6320–6326.
INFLAMMATION
Mouse and Human Eosinophils Degranulate in Response to Platelet-Activating Factor (PAF) and LysoPAF via a PAF-Receptor–Independent Mechanism: Evidence for a Novel Receptor
Kimberly D. Dyer; Caroline M. Percopo; Zhihui Xie; Zhao Yang; John Dongil Kim; Francis Davoine; Paige Lacy; Kirk M. Druey; Redwan Moqbel; Helene F. Rosenberg
J Immunol (2010) 184 (11): 6327–6334.
(1,3)-β-Glucans Activate Both Dectin-1 and NLRP3 Inflammasome in Human Macrophages
J Immunol (2010) 184 (11): 6335–6342.
Surfactant Protein D-Mediated Decrease of Allergen-Induced Inflammation Is Dependent upon CTLA4
J Immunol (2010) 184 (11): 6343–6349.
Human Eosinophils Recognize Endogenous Danger Signal Crystalline Uric Acid and Produce Proinflammatory Cytokines Mediated by Autocrine ATP
J Immunol (2010) 184 (11): 6350–6358.
Identification of a Novel Human MD-2 Splice Variant That Negatively Regulates Lipopolysaccharide-Induced TLR4 Signaling
Pearl Gray; Kathrin S. Michelsen; Cherilyn M. Sirois; Emily Lowe; Kenichi Shimada; Timothy R. Crother; Shuang Chen; Constantinos Brikos; Yonca Bulut; Eicke Latz; David Underhill; Moshe Arditi
J Immunol (2010) 184 (11): 6359–6366.
IL-17A–Producing γδ T and Th17 Lymphocytes Mediate Lung Inflammation but Not Fibrosis in Experimental Silicosis
Sandra Lo Re; Laure Dumoutier; Isabelle Couillin; Charlotte Van Vyve; Yousof Yakoub; Francine Uwambayinema; Benoît Marien; Sybille van den Brûle; Jacques Van Snick; Catherine Uyttenhove; Bernard Ryffel; Jean-Christophe Renauld; Dominique Lison; François Huaux
J Immunol (2010) 184 (11): 6367–6377.
Identifying the Cells Breaching Self-Tolerance in Autoimmunity
Robert A. Benson; Agapitos Patakas; Paola Conigliaro; Catherine M. Rush; Paul Garside; Iain B. McInnes; James M. Brewer
J Immunol (2010) 184 (11): 6378–6385.
Membrane-Type I Matrix Metalloproteinase-Dependent Regulation of Rheumatoid Arthritis Synoviocyte Function
J Immunol (2010) 184 (11): 6396–6406.
CD93/AA4.1: A Novel Regulator of Inflammation in Murine Focal Cerebral Ischemia
Denise Harhausen; Vincent Prinz; Gina Ziegler; Karen Gertz; Matthias Endres; Hans Lehrach; Philippe Gasque; Marina Botto; Philip F. Stahel; Ulrich Dirnagl; Wilfried Nietfeld; George Trendelenburg
J Immunol (2010) 184 (11): 6407–6417.
Acute Serum Amyloid A Induces Migration, Angiogenesis, and Inflammation in Synovial Cells In Vitro and in a Human Rheumatoid Arthritis/SCID Mouse Chimera Model
Mary Connolly; Alessandra Marrelli; Mark Blades; Jennifer McCormick; Paola Maderna; Catherine Godson; Ronan Mullan; Oliver FitzGerald; Barry Bresnihan; Costantino Pitzalis; Douglas J. Veale; Ursula Fearon
J Immunol (2010) 184 (11): 6427–6437.
Arginase I Suppresses IL-12/IL-23p40–Driven Intestinal Inflammation during Acute Schistosomiasis
De’Broski R. Herbert; Tatyana Orekov; Amanda Roloson; Monica Ilies; Charles Perkins; William O’Brien; Stephen Cederbaum; David W. Christianson; Nives Zimmermann; Marc E. Rothenberg; Fred D. Finkelman
J Immunol (2010) 184 (11): 6438–6446.
Scaffolding Adaptor Protein Gab1 Is Required for TLR3/4- and RIG-I–Mediated Production of Proinflammatory Cytokines and Type I IFN in Macrophages
J Immunol (2010) 184 (11): 6447–6456.
CLINICAL IMMUNOLOGY
Treatment of Autoimmune Arthritis Using RNA Interference-Modulated Dendritic Cells
Xiufen Zheng; Motohiko Suzuki; Thomas E. Ichim; Xusheng Zhang; Hongtao Sun; Fei Zhu; Aminah Shunnar; Bertha Garcia; Robert D. Inman; Weiping Min
J Immunol (2010) 184 (11): 6457–6464.
Blockade of Notch1 Signaling Alleviates Murine Lupus via Blunting Macrophage Activation and M2b Polarization
J Immunol (2010) 184 (11): 6465–6478.
Surfactant Protein-A as an Anti-Inflammatory Component in the Amnion: Implications for Human Pregnancy
Deug-Chan Lee; Roberto Romero; Chong Jai Kim; Tinnakorn Chaiworapongsa; Adi L. Tarca; JoonHo Lee; Yeon-Lim Suh; Shali Mazaki-Tovi; Edi Vaisbuch; Pooja Mittal; Sorin Draghici; Offer Erez; Juan Pedro Kusanovic; Sonia S. Hassan; Jung-Sun Kim
J Immunol (2010) 184 (11): 6479–6491.
Mycobacterium tuberculosis Upregulates Microglial Matrix Metalloproteinase-1 and -3 Expression and Secretion via NF-κB– and Activator Protein-1–Dependent Monocyte Networks
Justin A. Green; Paul T. Elkington; Caroline J. Pennington; Federico Roncaroli; Shruti Dholakia; Rachel C. Moores; Anwen Bullen; Joanna C. Porter; Dan Agranoff; Dylan R. Edwards; Jon S. Friedland
J Immunol (2010) 184 (11): 6492–6503.
Cytotoxic Potential of Lung CD8+ T Cells Increases with Chronic Obstructive Pulmonary Disease Severity and with In Vitro Stimulation by IL-18 or IL-15
Christine M. Freeman; MeiLan K. Han; Fernando J. Martinez; Susan Murray; Lyrica X. Liu; Stephen W. Chensue; Timothy J. Polak; Joanne Sonstein; Jill C. Todt; Theresa M. Ames; Douglas A. Arenberg; Catherine A. Meldrum; Christi Getty; Lisa McCloskey; Jeffrey L. Curtis
J Immunol (2010) 184 (11): 6504–6513.
Conditional Superagonist CTL Ligands for the Promotion of Tumor-Specific CTL Responses
J Immunol (2010) 184 (11): 6514–6521.
DAP12 Is Required for Macrophage Recruitment to the Lung in Response to Cigarette Smoke and Chemotaxis toward CCL2
Laura L. Koth; C.J. Cambier; Almut Ellwanger; Margaret Solon; Lydia Hou; Lewis L. Lanier; Clare L. Abram; Jessica A. Hamerman; Prescott G. Woodruff
J Immunol (2010) 184 (11): 6522–6528.
Novel SHP-1 Inhibitors Tyrosine Phosphatase Inhibitor-1 and Analogs with Preclinical Anti-Tumor Activities as Tolerated Oral Agents
J Immunol (2010) 184 (11): 6529–6536.
Polyfunctional CD4+ and CD8+ T Cell Responses to Tuberculosis Antigens in HIV-1–Infected Patients before and after Anti-Retroviral Treatment
Jayne S. Sutherland; James M. Young; Kevin L. Peterson; Bakary Sanneh; Hilton C. Whittle; Sarah L. Rowland-Jones; Richard A. Adegbola; Assan Jaye; Martin O. C. Ota
J Immunol (2010) 184 (11): 6537–6544.
LAG-3 Expression Defines a Subset of CD4+CD25highFoxp3+ Regulatory T Cells That Are Expanded at Tumor Sites
Chiara Camisaschi; Chiara Casati; Francesca Rini; Michela Perego; Annamaria De Filippo; Frédéric Triebel; Giorgio Parmiani; Filiberto Belli; Licia Rivoltini; Chiara Castelli
J Immunol (2010) 184 (11): 6545–6551.
LETTERS OF RETRACTION
Retraction: Naturally Occurring Human IgM Antibody That Binds B7-DC and Potentiates T Cell Stimulation by Dendritic Cells
Loc T. Nguyen; Bogoljub Ciric; Daren R. Ure; Bin Zhou; Koji Tamada; Su-Yi Tseng; Tahiro Shin; Lieping Chen; Haidong Dong; Robert A. Kyle; Moses Rodriguez; Larry R. Pease
J Immunol (2010) 184 (11): 6552.
Retraction: B7-DC/PD-L2 Cross-Linking Induces NF-κB-Dependent Protection of Dendritic Cells from Cell Death
J Immunol (2010) 184 (11): 6554.
Retraction: Induction of a Th1 Response from Th2-Polarized T Cells by Activated Dendritic Cells: Dependence on TCR:Peptide-MHC Interaction, ICAM-1, IL-12, and IFN-γ
Karla R. Wiehagen; Vesna Pulko; Virginia Van Keulen; William A. Faubion; Keith L. Knutson; Larry R. Pease
J Immunol (2010) 184 (11): 6555.
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Cover Image
Cover Image
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On the cover: The structure of the Vγ2Vδ2 T cell Ag receptor is shown with the CDRs colored. Alanine mutations in all CDR loops altered recognition of prenyl pyrophosphates with strong contributions from germline elements of CDR3δ (green residues) but minimal contributions from CDR3δ (yellow residues). These results show that prenyl pyrophosphate recognition primarily involves germline-encoded regions of the γδ TCR, allowing a high proportion of Vγ2Vδ2 TCRs to respond. The large footprint strongly supports the existence of a presenting molecule for these Ags. Wang, H., Z. Fang, and C. T. Morita. 2010. Vγ2Vδ2 T cell receptor recognition of prenyl pyrophosphates is dependent on all CDRs. J. Immunol. 184: 6209–6222.
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