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Issues
1 November 2010
ISSN 0022-1767
EISSN 1550-6606
IN THIS ISSUE
LETTERS TO THE EDITOR
Response to Comment on “Cutting Edge: FcR-Like 6 Is an MHC Class II Receptor”
J Immunol (2010) 185 (9): 4965–4966.
PILLARS OF IMMUNOLOGY
CRACking the Code without Rosetta: Molecular Regulation of Calcium-Stimulated Gene Transcription after T Cell Activation
J Immunol (2010) 185 (9): 4969–4971.
Pillars Article: Identification of a Putative Regulator of Early T Cell Activation Genes. Science. 1988. 241: 202–205
J Immunol (2010) 185 (9): 4972–4975.
BRIEF REVIEWS
CUTTING EDGE
CELLULAR IMMUNOLOGY AND IMMUNE REGULATION
Tolerogenic Dendritic Cells Induce CD4+CD25hiFoxp3+ Regulatory T Cell Differentiation from CD4+CD25−/loFoxp3− Effector T Cells
J Immunol (2010) 185 (9): 5003–5010.
Leishmania Exosomes Modulate Innate and Adaptive Immune Responses through Effects on Monocytes and Dendritic Cells
Judith Maxwell Silverman; Joachim Clos; Eva Horakova; Adele Y. Wang; Martina Wiesgigl; Isabelle Kelly; Miriam A. Lynn; W. Robert McMaster; Leonard J. Foster; Megan K. Levings; Neil E. Reiner
J Immunol (2010) 185 (9): 5011–5022.
Autoamplification of Notch Signaling in Macrophages by TLR-Induced and RBP-J–Dependent Induction of Jagged1
Julia Foldi; Allen Y. Chung; Haixia Xu; Jimmy Zhu; Hasina H. Outtz; Jan Kitajewski; Yueming Li; Xiaoyu Hu; Lionel B. Ivashkiv
J Immunol (2010) 185 (9): 5023–5031.
Murine B Cells Regulate Serum IgE Levels in a CD23-Dependent Manner
J Immunol (2010) 185 (9): 5040–5047.
Differential Suppression of Tumor-Specific CD8+ T Cells by Regulatory T Cells
Edward James; Alex Yeh; Cathy King; Firouzeh Korangy; Ian Bailey; Denise S. Boulanger; Benoît J. Van den Eynde; Nicholas Murray; Tim J. Elliott
J Immunol (2010) 185 (9): 5048–5055.
IL-32: A Host Proinflammatory Factor against Influenza Viral Replication Is Upregulated by Aberrant Epigenetic Modifications during Influenza A Virus Infection
Wei Li; Wei Sun; Li Liu; Fang Yang; Yongkui Li; Yanni Chen; Jiali Fang; Wenjing Zhang; Jianguo Wu; Ying Zhu
J Immunol (2010) 185 (9): 5056–5065.
Blockade of Programmed Death-1 Pathway Rescues the Effector Function of Tumor-Infiltrating T Cells and Enhances the Antitumor Efficacy of Lentivector Immunization
Qifeng Zhou; Haiyan Xiao; Yanjun Liu; Yibing Peng; Yuan Hong; Hideo Yagita; Phillip Chandler; David H. Munn; Andrew Mellor; Ning Fu; Yukai He
J Immunol (2010) 185 (9): 5082–5092.
Does Cytolysis by CD8+ T Cells Drive Immune Escape in HIV Infection?
Mehala Balamurali; Janka Petravic; Liyen Loh; Sheilajen Alcantara; Stephen J. Kent; Miles P. Davenport
J Immunol (2010) 185 (9): 5093–5101.
Inhibition of Immune Synapse by Altered Dendritic Cell Actin Distribution: A New Pathway of Mesenchymal Stem Cell Immune Regulation
Alessandra Aldinucci; Lisa Rizzetto; Laura Pieri; Daniele Nosi; Paolo Romagnoli; Tiziana Biagioli; Benedetta Mazzanti; Riccardo Saccardi; Luca Beltrame; Luca Massacesi; Duccio Cavalieri; Clara Ballerini
J Immunol (2010) 185 (9): 5102–5110.
The Protein Tyrosine Kinase Tec Regulates a CD44highCD62L− Th17 Subset
Nicole Boucheron; Omar Sharif; Alexandra Schebesta; Andrew Croxford; Julia Raberger; Uwe Schmidt; Benjamin Vigl; Jan Bauer; Rashmi Bankoti; Hans Lassmann; Michelle M. Epstein; Sylvia Knapp; Ari Waisman; Wilfried Ellmeier
J Immunol (2010) 185 (9): 5111–5119.
Adjuvant Immunotherapy Increases β Cell Regenerative Factor Reg2 in the Pancreas of Diabetic Mice
Katrina Huszarik; Benjamin Wright; Christina Keller; Enayat Nikoopour; Olga Krougly; Edwin Lee-Chan; Hui-Yu Qin; Mark J. Cameron; Werner K. Gurr; David J. Hill; Robert S. Sherwin; David J. Kelvin; Bhagirath Singh
J Immunol (2010) 185 (9): 5120–5129.
CXCR7 Protein Is Not Expressed on Human or Mouse Leukocytes
Robert D. Berahovich; Brian A. Zabel; Mark E. T. Penfold; Susanna Lewén; Yu Wang; Zhenhua Miao; Lin Gan; Jaime Pereda; Jessica Dias; Igor I. Slukvin; Kathleen E. McGrath; Juan C. Jaen; Thomas J. Schall
J Immunol (2010) 185 (9): 5130–5139.
IL-2 mRNA Stabilization upon PMA Stimulation Is Dependent on NF90-Ser647 Phosphorylation by Protein Kinase CβI
Ping Zhu; Wei Jiang; Lihuan Cao; Wenbo Yu; Yuan Pei; Xianmei Yang; Bo Wan; Jun O. Liu; Qing Yi; Long Yu
J Immunol (2010) 185 (9): 5140–5149.
A Peptide Inhibitor of FOXP3 Impairs Regulatory T Cell Activity and Improves Vaccine Efficacy in Mice
Noelia Casares; Francesc Rudilla; Laura Arribillaga; Diana Llopiz; José Ignacio Riezu-Boj; Teresa Lozano; Jacinto López-Sagaseta; Laura Guembe; Pablo Sarobe; Jesús Prieto; Francisco Borrás-Cuesta; Juan José Lasarte
J Immunol (2010) 185 (9): 5150–5159.
Intra- and Intercompartmental Movement of γδ T Cells: Intestinal Intraepithelial and Peripheral γδ T Cells Represent Exclusive Nonoverlapping Populations with Distinct Migration Characteristics
Vijaykumar Chennupati; Tim Worbs; Xiaosun Liu; Frano H. Malinarich; Susanne Schmitz; Jan D. Haas; Bernard Malissen; Reinhold Förster; Immo Prinz
J Immunol (2010) 185 (9): 5160–5168.
Disruption of Intestinal CD4+ T Cell Homeostasis Is a Key Marker of Systemic CD4+ T Cell Activation in HIV-Infected Individuals
Shari N. Gordon; Barbara Cervasi; Pamela Odorizzi; Randee Silverman; Faten Aberra; Gregory Ginsberg; Jacob D. Estes; Mirko Paiardini; Ian Frank; Guido Silvestri
J Immunol (2010) 185 (9): 5169–5179.
Critical Role of Pcid2 in B Cell Survival through the Regulation of MAD2 Expression
Teruo Nakaya; Kazuhiko Kuwahara; Kazutaka Ohta; Masahiro Kitabatake; Teppei Toda; Naoki Takeda; Tokio Tani; Eisaku Kondo; Nobuo Sakaguchi
J Immunol (2010) 185 (9): 5180–5187.
Th Cells Act Via Two Synergistic Pathways To Promote Antiviral CD8+ T Cell Responses
Melanie Wiesel; Nicole Joller; Anna-Katharina Ehlert; Josh Crouse; Roman Spörri; Martin F. Bachmann; Annette Oxenius
J Immunol (2010) 185 (9): 5188–5197.
Mechanism of Induction of NK Activation by 2B4 (CD244) via Its Cognate Ligand
J Immunol (2010) 185 (9): 5205–5210.
Monocyte 15-Lipoxygenase Gene Expression Requires ERK1/2 MAPK Activity
J Immunol (2010) 185 (9): 5211–5224.
Apoptotic Cells Activate NKT Cells through T Cell Ig-Like Mucin-Like–1 Resulting in Airway Hyperreactivity
Hyun-Hee Lee; Everett H. Meyer; Sho Goya; Muriel Pichavant; Hye Young Kim; Xia Bu; Sarah E. Umetsu; Jennifer C. Jones; Paul B. Savage; Yoichiro Iwakura; Jose M. Casasnovas; Gerardo Kaplan; Gordon J. Freeman; Rosemarie H. DeKruyff; Dale T. Umetsu
J Immunol (2010) 185 (9): 5225–5235.
Human Plasma Membrane-Derived Vesicles Halt Proliferation and Induce Differentiation of THP-1 Acute Monocytic Leukemia Cells
Ephraim A. Ansa-Addo; Sigrun Lange; Dan Stratton; Samuel Antwi-Baffour; Igor Cestari; Marcel I. Ramirez; Maria V. McCrossan; Jameel M. Inal
J Immunol (2010) 185 (9): 5236–5246.
NADPH Oxidase Deficiency Regulates Th Lineage Commitment and Modulates Autoimmunity
Hubert M. Tse; Terri C. Thayer; Chad Steele; Carla M. Cuda; Laurence Morel; Jon D. Piganelli; Clayton E. Mathews
J Immunol (2010) 185 (9): 5247–5258.
Dendritic Cells Recruit T Cell Exosomes via Exosomal LFA-1 Leading to Inhibition of CD8+ CTL Responses through Downregulation of Peptide/MHC Class I and Fas Ligand-Mediated Cytotoxicity
Yufeng Xie; Haifeng Zhang; Wei Li; Yulin Deng; Manjunatha Ankathatti Munegowda; Rajni Chibbar; Mabood Qureshi; Jim Xiang
J Immunol (2010) 185 (9): 5268–5278.
Naive Human T Cells Are Activated and Proliferate in Response to the Heme Oxygenase-1 Inhibitor Tin Mesoporphyrin
J Immunol (2010) 185 (9): 5279–5288.
Efficient Induction of CCR9 on T Cells Requires Coactivation of Retinoic Acid Receptors and Retinoid X Receptors (RXRs): Exaggerated T Cell Homing to the Intestine by RXR Activation with Organotins
Hajime Takeuchi; Aya Yokota; Yoshiharu Ohoka; Hiroyuki Kagechika; Chieko Kato; Si-Young Song; Makoto Iwata
J Immunol (2010) 185 (9): 5289–5299.
Differential Localization of Effector and Memory CD8 T Cell Subsets in Lymphoid Organs during Acute Viral Infection
J Immunol (2010) 185 (9): 5315–5325.
MOLECULAR AND STRUCTURAL IMMUNOLOGY
TGF-β1 Accelerates Dendritic Cell Differentiation from Common Dendritic Cell Progenitors and Directs Subset Specification toward Conventional Dendritic Cells
Piritta Felker; Kristin Seré; Qiong Lin; Christiane Becker; Mihail Hristov; Thomas Hieronymus; Martin Zenke
J Immunol (2010) 185 (9): 5326–5335.
Error-Prone DNA Repair Activity during Somatic Hypermutation in Shark B Lymphocytes
J Immunol (2010) 185 (9): 5336–5347.
Stress-Regulated Targeting of the NKG2D Ligand Mult1 by a Membrane-Associated RING-CH Family E3 Ligase
J Immunol (2010) 185 (9): 5369–5376.
Rapid Generation of Rotavirus-Specific Human Monoclonal Antibodies from Small-Intestinal Mucosa
Roberto Di Niro; Luka Mesin; Melinda Raki; Nai-Ying Zheng; Fridtjof Lund-Johansen; Knut E. A. Lundin; Annie Charpilienne; Didier Poncet; Patrick C. Wilson; Ludvig M. Sollid
J Immunol (2010) 185 (9): 5377–5383.
IMMUNOGENETICS
Genetic Susceptibility to the Delayed Sequelae of Neonatal Respiratory Syncytial Virus Infection Is MHC Dependent
John S. Tregoning; Yuko Yamaguchi; Belinda Wang; Dagmar Mihm; James A. Harker; Ellen S. C. Bushell; Ming Zheng; Guochun Liao; Gary Peltz; Peter J. M. Openshaw
J Immunol (2010) 185 (9): 5384–5391.
Gender-Associated Differences of Perforin Polymorphisms in the Susceptibility to Multiple Sclerosis
Montse Camiña-Tato; Carlos Morcillo-Suárez; Marta F. Bustamante; Israel Ortega; Arcadi Navarro; Aura Muntasell; Miguel López-Botet; Alex Sánchez; Paco Carmona; Eva Julià; María Teresa Tortola; Laura Audí; Jorge R. Oksenberg; Roland Martin; Xavier Montalban; Manuel Comabella
J Immunol (2010) 185 (9): 5392–5404.
HOST DEFENSE
CD4+ T Cells Are Not Required for the Induction of Dengue Virus-Specific CD8+ T Cell or Antibody Responses but Contribute to Protection after Vaccination
Lauren E. Yauch; Tyler R. Prestwood; Monica M. May; Malika M. Morar; Raphaël M. Zellweger; Bjoern Peters; Alessandro Sette; Sujan Shresta
J Immunol (2010) 185 (9): 5405–5416.
Host Genes Associated with HIV-1 Replication in Lymphatic Tissue
Anthony J. Smith; Qingsheng Li; Stephen W. Wietgrefe; Timothy W. Schacker; Cavan S. Reilly; Ashley T. Haase
J Immunol (2010) 185 (9): 5417–5424.
Identification of an Autophagy Defect in Smokers’ Alveolar Macrophages
Martha M. Monick; Linda S. Powers; Katherine Walters; Nina Lovan; Michael Zhang; Alicia Gerke; Sif Hansdottir; Gary W. Hunninghake
J Immunol (2010) 185 (9): 5425–5435.
In Vivo Molecular Imaging Analysis of a Nasal Vaccine That Induces Protective Immunity against Botulism in Nonhuman Primates
Yoshikazu Yuki; Tomonori Nochi; Norihiro Harada; Yuko Katakai; Hiroaki Shibata; Mio Mejima; Tomoko Kohda; Daisuke Tokuhara; Shiho Kurokawa; Yuko Takahashi; Fumiko Ono; Shunji Kozaki; Keiji Terao; Hideo Tsukada; Hiroshi Kiyono
J Immunol (2010) 185 (9): 5436–5443.
Steroid Receptor Coactivator 3 Is Required for Clearing Bacteria and Repressing Inflammatory Response in Escherichia coli-Induced Septic Peritonitis
J Immunol (2010) 185 (9): 5444–5452.
IL-23 and IL-17A, but Not IL-12 and IL-22, Are Required for Optimal Skin Host Defense against Candida albicans
J Immunol (2010) 185 (9): 5453–5462.
Neutrophil Elastase Mediates Pathogenic Effects of Anthrax Lethal Toxin in the Murine Intestinal Tract
J Immunol (2010) 185 (9): 5463–5467.
Deletion of ripA Alleviates Suppression of the Inflammasome and MAPK by Francisella tularensis
Max Tze-Han Huang; Brittany L. Mortensen; Debra J. Taxman; Robin R. Craven; Sharon Taft-Benz; Todd M. Kijek; James R. Fuller; Beckley K. Davis; Irving Coy Allen; Willie June Brickey; Denis Gris; Haitao Wen; Thomas H. Kawula; Jenny Pan-Yun Ting
J Immunol (2010) 185 (9): 5476–5485.
INFLAMMATION
Heparan Sulfate, Including That in Bruch’s Membrane, Inhibits the Complement Alternative Pathway: Implications for Age-Related Macular Degeneration
Una Kelly; Ling Yu; Pallavi Kumar; Jin-Dong Ding; Haixiang Jiang; Gregory S. Hageman; Vadim Y. Arshavsky; Michael M. Frank; Michael A. Hauser; Catherine Bowes Rickman
J Immunol (2010) 185 (9): 5486–5494.
Caspase-12 Dampens the Immune Response to Malaria Independently of the Inflammasome by Targeting NF-κB Signaling
Katherine Labbé; Jenny Miu; Garabet Yeretssian; Lena Serghides; Mifong Tam; Constance A. Finney; Laura K. Erdman; Marie-Line Goulet; Kevin C. Kain; Mary M. Stevenson; Maya Saleh
J Immunol (2010) 185 (9): 5495–5502.
Although IL-6 Trans-Signaling Is Sufficient To Drive Local Immune Responses, Classical IL-6 Signaling Is Obligate for the Induction of T Cell-Mediated Autoimmunity
Rami Lissilaa; Vanessa Buatois; Giovanni Magistrelli; Anwen S. Williams; Gareth W. Jones; Suzanne Herren; Limin Shang; Pauline Malinge; Florence Guilhot; Laurence Chatel; Eric Hatterer; Simon A. Jones; Marie H. Kosco-Vilbois; Walter G. Ferlin
J Immunol (2010) 185 (9): 5512–5521.
Repression of Peroxisome Proliferator-Activated Receptor γ by Mucosal Ribotoxic Insult-Activated CCAAT/Enhancer-Binding Protein Homologous Protein
J Immunol (2010) 185 (9): 5522–5530.
IL-22 Induces an Acute-Phase Response
Spencer C. Liang; Cheryl Nickerson-Nutter; Debra D. Pittman; Yijun Carrier; Debra G. Goodwin; Kathleen M. Shields; Andre-Jean Lambert; Scott H. Schelling; Quintus G. Medley; Hak-Ling Ma; Mary Collins; Kyriaki Dunussi-Joannopoulos; Lynette A. Fouser
J Immunol (2010) 185 (9): 5531–5538.
Reduced Immunoproteasome Formation and Accumulation of Immunoproteasomal Precursors in the Brains of Lymphocytic Choriomeningitis Virus-Infected Mice
Marcel Kremer; Anja Henn; Cornelia Kolb; Michael Basler; Jacqueline Moebius; Benoît Guillaume; Marcel Leist; Benoît J. Van den Eynde; Marcus Groettrup
J Immunol (2010) 185 (9): 5549–5560.
β7 Integrin Deficiency Suppresses B Cell Homing and Attenuates Chronic Ileitis in SAMP1/YitFc Mice
Gezahegn Gorfu; Jesus Rivera-Nieves; Sharon Hoang; Derek W. Abbott; Keely Arbenz-Smith; David W. Azar; Theresa T. Pizarro; Fabio Cominelli; Marcia McDuffie; Klaus Ley
J Immunol (2010) 185 (9): 5561–5568.
Anti-Inflammatory Effects of the Activation of the Angiotensin-(1–7) Receptor, Mas, in Experimental Models of Arthritis
Kátia Daniela da Silveira; Fernanda Matos Coelho; Angélica Thomáz Vieira; Daniela Sachs; Lívia Corrêa Barroso; Vivian Vasconcelos Costa; Thales Lages Bicalho Bretas; Michael Bader; Lirlândia Pires de Sousa; Tarcília Aparecida da Silva; Robson Augusto Souza dos Santos; Ana Cristina Simões e Silva; Mauro Martins Teixeira
J Immunol (2010) 185 (9): 5569–5576.
LRRK2 Is Involved in the IFN-γ Response and Host Response to Pathogens
Agnès Gardet; Yair Benita; Chun Li; Bruce E. Sands; Isabel Ballester; Christine Stevens; Joshua R. Korzenik; John D. Rioux; Mark J. Daly; Ramnik J. Xavier; Daniel K. Podolsky
J Immunol (2010) 185 (9): 5577–5585.
Anti-Inflammatory Effects of the Neurotransmitter Agonist Honokiol in a Mouse Model of Allergic Asthma
J Immunol (2010) 185 (9): 5586–5597.
Essential Role of Complement Mannose-Binding Lectin-Associated Serine Proteases-1/3 in the Murine Collagen Antibody-Induced Model of Inflammatory Arthritis
Nirmal K. Banda; Minoru Takahashi; Brandt Levitt; Magdalena Glogowska; Jessica Nicholas; Kazue Takahashi; Gregory L. Stahl; Teizo Fujita; William P. Arend; V. Michael Holers
J Immunol (2010) 185 (9): 5598–5606.
IL-17A Is Proatherogenic in High-Fat Diet-Induced and Chlamydia pneumoniae Infection-Accelerated Atherosclerosis in Mice
J Immunol (2010) 185 (9): 5619–5627.
CLINICAL IMMUNOLOGY
Molecular Intercommunication between the Complement and Coagulation Systems
Umme Amara; Michael A. Flierl; Daniel Rittirsch; Andreas Klos; Hui Chen; Barbara Acker; Uwe B. Brückner; Bo Nilsson; Florian Gebhard; John D. Lambris; Markus Huber-Lang
J Immunol (2010) 185 (9): 5628–5636.
Distinct Roles of Vascular Endothelial Growth Factor Receptor-1– and Receptor-2–Mediated Signaling in T Cell Priming and Th17 Polarization to Lipopolysaccharide-Containing Allergens in the Lung
You-Sun Kim; Seng-Jin Choi; You-Me Tae; Byung-Jae Lee; Seong Gyu Jeon; Sun-Young Oh; Yong Song Gho; Zhou Zhu; Yoon-Keun Kim
J Immunol (2010) 185 (9): 5648–5655.
Naturally Occurring CD4+CD25+ Regulatory T Cells Prevent but Do Not Improve Experimental Myasthenia Gravis
Valeria Nessi; Sara Nava; Chiara Ruocco; Chiara Toscani; Renato Mantegazza; Carlo Antozzi; Fulvio Baggi
J Immunol (2010) 185 (9): 5656–5667.
CORRECTIONS
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Cover Image
Cover Image
![issue cover]()
On the cover: HIV infection induces chronic immune activation; this activation manifests as increased proliferation of lymphocytes in mucosal tissues. The representative image shows immunohistochemical staining for Ki67, a nuclear Ag whose expression is increased in proliferating cells, within the lamina propria of the colon. Gordon, S. N., B. Cervasi, P. Odorizzi, R. Silverman, F. Aberra, G. Ginsberg, J. D. Estes, M. Paiardini, I. Frank, and G. Silvestri. 2010. Disruption of intestinal CD4+ T cell homeostasis is a key marker of systemic CD4+ T cell activation in HIV-infected individuals. J. Immunol. 185: 5169–5179.
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