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Volume 188, Issue 11
1 June 2012
The Journal of Immunology Cover Image for Volume 188, Issue 11
ISSN 0022-1767
EISSN 1550-6606

IN THIS ISSUE

In This Issue
J Immunol (2012) 188 (11): 5201–5202.
View articletitled, In This Issue
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LETTERS TO THE EDITOR

Comment on “Cutting Edge: Regulatory T Cells Do Not Mediate Suppression via Programmed Cell Death Pathways”
Pushpa Pandiyan; Michael Lenardo
J Immunol (2012) 188 (11): 5203–5204.
View articletitled, Comment on “Cutting Edge: Regulatory T Cells Do Not Mediate Suppression via Programmed Cell Death Pathways”
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Response to Comment on “Cutting Edge: Regulatory T Cells Do Not Mediate Suppression via Programmed Cell Death Pathways”
Andrea L. Szymczak-Workman; Greg M. Delgoffe; Douglas R. Green; Dario A. A. Vignali
J Immunol (2012) 188 (11): 5204–5205.
View articletitled, Response to Comment on “Cutting Edge: Regulatory T Cells Do Not Mediate Suppression via Programmed Cell Death Pathways”
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Comment on “Frequency of Epitope-Specific Naive CD4+ T Cells Correlates with Immunodominance in the Human Memory Repertoire”
Stephanie Ascough; Rebecca J. Ingram; Gökhan Metan; Bernard Maillere; Mehmet Doganay; Yusuf Ozkul; Louise U. Kim; Les Ballie; Steven Moore; Theresa B. Huwar; Shiranee Sriskandan; Daniel M. Altmann
J Immunol (2012) 188 (11): 5205–5206.
View articletitled, Comment on “Frequency of Epitope-Specific Naive CD4<sup>+</sup> T Cells Correlates with Immunodominance in the Human Memory Repertoire”
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Response to Comment on “Frequency of Epitope-Specific Naive CD4+ T Cells Correlates with Immunodominance in the Human Memory Repertoire”
William W. Kwok; Eddie A. James
J Immunol (2012) 188 (11): 5206.
View articletitled, Response to Comment on “Frequency of Epitope-Specific Naive CD4<sup>+</sup> T Cells Correlates with Immunodominance in the Human Memory Repertoire”
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PILLARS OF IMMUNOLOGY

How Discovery of Toll-Mediated Innate Immunity in Drosophila Impacted Our Understanding of TLR Signaling (and Vice Versa)
Stefanie N. Vogel
J Immunol (2012) 188 (11): 5207–5209.
View articletitled, How Discovery of Toll-Mediated Innate Immunity in <em>Drosophila</em> Impacted Our Understanding of TLR Signaling (and Vice Versa)
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Pillars Article: The Dorsoventral Regulatory Gene Cassette spätzle/Toll/cactus Controls the Potent Antifungal Response in Drosophila Adults. Cell. 1996. 86: 973-983
Bruno Lemaitre; Emmanuelle Nicolas; Lydia Michaut; Jean-Marc Reichhart; Jules A. Hoffmann
J Immunol (2012) 188 (11): 5210–5220.
View articletitled, Pillars Article: The Dorsoventral Regulatory Gene Cassette <em>spätzle/Toll/cactus</em> Controls the Potent Antifungal Response in <em>Drosophila</em> Adults. Cell. 1996. 86: 973-983
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CUTTING EDGE

Cutting Edge: In the Absence of Regulatory T Cells, a Unique Th Cell Population Expands and Leads to a Loss of B Cell Anergy
Steven M. Leonardo; Jessica L. De Santis; Laurent P. Malherbe; Stephen B. Gauld
J Immunol (2012) 188 (11): 5223–5226.
View articletitled, Cutting Edge: In the Absence of Regulatory T Cells, a Unique Th Cell Population Expands and Leads to a Loss of B Cell Anergy
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CELLULAR IMMUNOLOGY AND IMMUNE REGULATION

IL-27 Production and STAT3-Dependent Upregulation of B7-H1 Mediate Immune Regulatory Functions of Liver Plasmacytoid Dendritic Cells
Benjamin M. Matta; Giorgio Raimondi; Brian R. Rosborough; Tina L. Sumpter; Angus W. Thomson
J Immunol (2012) 188 (11): 5227–5237.
View articletitled, IL-27 Production and STAT3-Dependent Upregulation of B7-H1 Mediate Immune Regulatory Functions of Liver Plasmacytoid Dendritic Cells
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Structurally Identical Capsular Polysaccharide Expressed by Intact Group B Streptococcus versus Streptococcus pneumoniae Elicits Distinct Murine Polysaccharide-Specific IgG Responses In Vivo
Swadhinya Arjunaraja; Lawrence C. Paoletti; Clifford M. Snapper
J Immunol (2012) 188 (11): 5238–5246.
View articletitled, Structurally Identical Capsular Polysaccharide Expressed by Intact Group B <em>Streptococcus</em> versus <em>Streptococcus pneumoniae</em> Elicits Distinct Murine Polysaccharide-Specific IgG Responses In Vivo
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Fyn Promotes Th17 Differentiation by Regulating the Kinetics of RORγt and Foxp3 Expression
Aki Ueda; Liang Zhou; Paul L. Stein
J Immunol (2012) 188 (11): 5247–5256.
View articletitled, Fyn Promotes Th17 Differentiation by Regulating the Kinetics of RORγt and Foxp3 Expression
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Chronic Spinal Cord Injury Impairs Primary Antibody Responses but Spares Existing Humoral Immunity in Mice
Michael A. Oropallo; Katherine S. Held; Radhika Goenka; Sifat A. Ahmad; Patrick J. O’Neill; Oswald Steward; Thomas E. Lane; Michael P. Cancro
J Immunol (2012) 188 (11): 5257–5266.
View articletitled, Chronic Spinal Cord Injury Impairs Primary Antibody Responses but Spares Existing Humoral Immunity in Mice
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PTPN22 Alters the Development of Regulatory T Cells in the Thymus
Christian J. Maine; Emma E. Hamilton-Williams; Jocelyn Cheung; Stephanie M. Stanford; Nunzio Bottini; Linda S. Wicker; Linda A. Sherman
J Immunol (2012) 188 (11): 5267–5275.
View articletitled, PTPN22 Alters the Development of Regulatory T Cells in the Thymus
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1,25-Dihyroxyvitamin D3 Promotes FOXP3 Expression via Binding to Vitamin D Response Elements in Its Conserved Noncoding Sequence Region
Seong Wook Kang; Sang Hyun Kim; Naeun Lee; Won-Woo Lee; Kyung-A Hwang; Min Sun Shin; Seung-Hyun Lee; Wan-Uk Kim; Insoo Kang
J Immunol (2012) 188 (11): 5276–5282.
View articletitled, 1,25-Dihyroxyvitamin D<sub>3</sub> Promotes <em>FOXP3</em> Expression via Binding to Vitamin D Response Elements in Its Conserved Noncoding Sequence Region
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Two Preferentially Expressed Proteins Protect Vascular Endothelial Cells from an Attack by Peptide-Specific CTL
Daniela S. Thommen; Heiko Schuster; Mario Keller; Sarika Kapoor; Andreas O. Weinzierl; Cuddapah S. Chennakesava; Xueya Wang; Lucia Rohrer; Arnold von Eckardstein; Stefan Stevanovic; Barbara C. Biedermann
J Immunol (2012) 188 (11): 5283–5292.
View articletitled, Two Preferentially Expressed Proteins Protect Vascular Endothelial Cells from an Attack by Peptide-Specific CTL
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Integrin CD11b Negatively Regulates TLR9-Triggered Dendritic Cell Cross-Priming by Upregulating microRNA-146a
Yi Bai; Cheng Qian; Li Qian; Feng Ma; Jin Hou; Yongjian Chen; Qingqing Wang; Xuetao Cao
J Immunol (2012) 188 (11): 5293–5302.
View articletitled, Integrin CD11b Negatively Regulates TLR9-Triggered Dendritic Cell Cross-Priming by Upregulating microRNA-146a
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Prostaglandin E2 Affects T Cell Responses through Modulation of CD46 Expression
Karoline Kickler; Kathryn Maltby; Siobhán Ni Choileain; Jillian Stephen; Sheila Wright; David A. Hafler; Henry N. Jabbour; Anne L. Astier
J Immunol (2012) 188 (11): 5303–5310.
View articletitled, Prostaglandin E<sub>2</sub> Affects T Cell Responses through Modulation of CD46 Expression
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Tripartite Motif-Containing Protein 38 Negatively Regulates TLR3/4- and RIG-I–Mediated IFN-β Production and Antiviral Response by Targeting NAP1
Wei Zhao; Lijuan Wang; Meng Zhang; Peng Wang; Chao Yuan; Jianni Qi; Hong Meng; Chengjiang Gao
J Immunol (2012) 188 (11): 5311–5318.
View articletitled, Tripartite Motif-Containing Protein 38 Negatively Regulates TLR3/4- and RIG-I–Mediated IFN-β Production and Antiviral Response by Targeting NAP1
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Dendritic Cells Activated by IFN-γ/STAT1 Express IL-31 Receptor and Release Proinflammatory Mediators upon IL-31 Treatment
Jutta Horejs-Hoeck; Harald Schwarz; Sebastian Lamprecht; Elisabeth Maier; Stefan Hainzl; Maria Schmittner; Gernot Posselt; Angelika Stoecklinger; Thomas Hawranek; Albert Duschl
J Immunol (2012) 188 (11): 5319–5326.
View articletitled, Dendritic Cells Activated by IFN-γ/STAT1 Express IL-31 Receptor and Release Proinflammatory Mediators upon IL-31 Treatment
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ATP Binding Cassette Transporter G1 Deletion Induces IL-17–Dependent Dysregulation of Pulmonary Adaptive Immunity
David W. Draper; Kymberly M. Gowdy; Jennifer H. Madenspacher; Rhonda H. Wilson; Gregory S. Whitehead; Hideki Nakano; Arun R. Pandiri; Julie F. Foley; Alan T. Remaley; Donald N. Cook; Michael B. Fessler
J Immunol (2012) 188 (11): 5327–5336.
View articletitled, ATP Binding Cassette Transporter G1 Deletion Induces IL-17–Dependent Dysregulation of Pulmonary Adaptive Immunity
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Protein Kinase C-θ Inhibits Inducible Regulatory T Cell Differentiation via an AKT-Foxo1/3a–Dependent Pathway
Jian Ma; Yan Ding; Xianfeng Fang; Ruiqing Wang; Zuoming Sun
J Immunol (2012) 188 (11): 5337–5347.
View articletitled, Protein Kinase C-θ Inhibits Inducible Regulatory T Cell Differentiation via an AKT-Foxo1/3a–Dependent Pathway
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IRF5 Risk Polymorphisms Contribute to Interindividual Variance in Pattern Recognition Receptor-Mediated Cytokine Secretion in Human Monocyte-Derived Cells
Matija Hedl; Clara Abraham
J Immunol (2012) 188 (11): 5348–5356.
View articletitled, <em>IRF5</em> Risk Polymorphisms Contribute to Interindividual Variance in Pattern Recognition Receptor-Mediated Cytokine Secretion in Human Monocyte-Derived Cells
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Polyinosinic-Polycytidylic Acid Limits Tumor Outgrowth in a Mouse Model of Metastatic Lung Cancer
Giovanni Forte; Alessia Rega; Silvana Morello; Antonio Luciano; Claudio Arra; Aldo Pinto; Rosalinda Sorrentino
J Immunol (2012) 188 (11): 5357–5364.
View articletitled, Polyinosinic-Polycytidylic Acid Limits Tumor Outgrowth in a Mouse Model of Metastatic Lung Cancer
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Tumor-Expressed Inducible Nitric Oxide Synthase Controls Induction of Functional Myeloid-Derived Suppressor Cells through Modulation of Vascular Endothelial Growth Factor Release
Padmini Jayaraman; Falguni Parikh; Esther Lopez-Rivera; Yared Hailemichael; Amelia Clark; Ge Ma; David Cannan; Marcel Ramacher; Masashi Kato; Willem W. Overwijk; Shu-Hsia Chen; Viktor Y. Umansky; Andrew G. Sikora
J Immunol (2012) 188 (11): 5365–5376.
View articletitled, Tumor-Expressed Inducible Nitric Oxide Synthase Controls Induction of Functional Myeloid-Derived Suppressor Cells through Modulation of Vascular Endothelial Growth Factor Release
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Alternative Splicing Controlled by Heterogeneous Nuclear Ribonucleoprotein L Regulates Development, Proliferation, and Migration of Thymic Pre-T Cells
Marie-Claude Gaudreau; Florian Heyd; Rachel Bastien; Brian Wilhelm; Tarik Möröy
J Immunol (2012) 188 (11): 5377–5388.
View articletitled, Alternative Splicing Controlled by Heterogeneous Nuclear Ribonucleoprotein L Regulates Development, Proliferation, and Migration of Thymic Pre-T Cells
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Long-Lived Bone Marrow Plasma Cells Are Induced Early in Response to T Cell-Independent or T Cell-Dependent Antigens
Alexandra Bortnick; Irene Chernova; William J. Quinn, III; Monica Mugnier; Michael P. Cancro; David Allman
J Immunol (2012) 188 (11): 5389–5396.
View articletitled, Long-Lived Bone Marrow Plasma Cells Are Induced Early in Response to T Cell-Independent or T Cell-Dependent Antigens
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Dendritic Cell-Specific Ablation of the Protein Tyrosine Phosphatase Shp1 Promotes Th1 Cell Differentiation and Induces Autoimmunity
Tetsuya Kaneko; Yasuyuki Saito; Takenori Kotani; Hideki Okazawa; Hiroko Iwamura; Miho Sato-Hashimoto; Yoshitake Kanazawa; Satoshi Takahashi; Keiju Hiromura; Shinya Kusakari; Yoriaki Kaneko; Yoji Murata; Hiroshi Ohnishi; Yoshihisa Nojima; Kenji Takagishi; Takashi Matozaki
J Immunol (2012) 188 (11): 5397–5407.
View articletitled, Dendritic Cell-Specific Ablation of the Protein Tyrosine Phosphatase Shp1 Promotes Th1 Cell Differentiation and Induces Autoimmunity
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Runx1 Deficiency in CD4+ T Cells Causes Fatal Autoimmune Inflammatory Lung Disease Due to Spontaneous Hyperactivation of Cells
Won Fen Wong; Kazuyoshi Kohu; Akira Nakamura; Masahito Ebina; Toshiaki Kikuchi; Ryushi Tazawa; Keisuke Tanaka; Shunsuke Kon; Tomo Funaki; Akiko Sugahara-Tobinai; Chung Yeng Looi; Shota Endo; Ryo Funayama; Mineo Kurokawa; Sonoko Habu; Naoto Ishii; Manabu Fukumoto; Koh Nakata; Toshiyuki Takai; Masanobu Satake
J Immunol (2012) 188 (11): 5408–5420.
View articletitled, <em>Runx1</em> Deficiency in CD4<sup>+</sup> T Cells Causes Fatal Autoimmune Inflammatory Lung Disease Due to Spontaneous Hyperactivation of Cells
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Stathmin Regulates Microtubule Dynamics and Microtubule Organizing Center Polarization in Activated T Cells
Erin L. Filbert; Marie Le Borgne; Joseph Lin; John E. Heuser; Andrey S. Shaw
J Immunol (2012) 188 (11): 5421–5427.
View articletitled, Stathmin Regulates Microtubule Dynamics and Microtubule Organizing Center Polarization in Activated T Cells
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Stem Cell Factor Programs the Mast Cell Activation Phenotype
Tomonobu Ito; Daniel Smrž; Mi-Yeon Jung; Geethani Bandara; Avanti Desai; Šárka Smržová; Hye Sun Kuehn; Michael A. Beaven; Dean D. Metcalfe; Alasdair M. Gilfillan
J Immunol (2012) 188 (11): 5428–5437.
View articletitled, Stem Cell Factor Programs the Mast Cell Activation Phenotype
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Human Th17 Cells Express High Levels of Enzymatically Active Dipeptidylpeptidase IV (CD26)
Bertram Bengsch; Bianca Seigel; Tobias Flecken; Julia Wolanski; Hubert E. Blum; Robert Thimme
J Immunol (2012) 188 (11): 5438–5447.
View articletitled, Human Th17 Cells Express High Levels of Enzymatically Active Dipeptidylpeptidase IV (CD26)
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Wnt5a Induces a Tolerogenic Phenotype of Macrophages in Sepsis and Breast Cancer Patients
Caroline Bergenfelz; Catharina Medrek; Elin Ekström; Karin Jirström; Helena Janols; Marlene Wullt; Anders Bredberg; Karin Leandersson
J Immunol (2012) 188 (11): 5448–5458.
View articletitled, Wnt5a Induces a Tolerogenic Phenotype of Macrophages in Sepsis and Breast Cancer Patients
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Kinetics and Activation Requirements of Contact-Dependent Immune Suppression by Human Regulatory T Cells
Morten Hagness; Karen Henjum; Johannes Landskron; Kristoffer Watten Brudvik; Bjørn Atle Bjørnbeth; Aksel Foss; Kjetil Taskén; Einar Martin Aandahl
J Immunol (2012) 188 (11): 5459–5466.
View articletitled, Kinetics and Activation Requirements of Contact-Dependent Immune Suppression by Human Regulatory T Cells
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Strong Impact of CD4+Foxp3+ Regulatory T Cells and Limited Effect of T Cell-Derived IL-10 on Pathogen Clearance during Plasmodium yoelii Infection
Simone Abel; Nadja Lückheide; Astrid M. Westendorf; Robert Geffers; Axel Roers; Werner Müller; Tim Sparwasser; Kai Matuschewski; Jan Buer; Wiebke Hansen
J Immunol (2012) 188 (11): 5467–5477.
View articletitled, Strong Impact of CD4<sup>+</sup>Foxp3<sup>+</sup> Regulatory T Cells and Limited Effect of T Cell-Derived IL-10 on Pathogen Clearance during <em>Plasmodium yoelii</em> Infection
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IL-10+CTLA-4+ Th2 Inhibitory Cells Form in a Foxp3-Independent, IL-2–Dependent Manner from Th2 Effectors during Chronic Inflammation
John A. Altin; Chris C. Goodnow; Matthew C. Cook
J Immunol (2012) 188 (11): 5478–5488.
View articletitled, IL-10<sup>+</sup>CTLA-4<sup>+</sup> Th2 Inhibitory Cells Form in a Foxp3-Independent, IL-2–Dependent Manner from Th2 Effectors during Chronic Inflammation
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CD13 Regulates Dendritic Cell Cross-Presentation and T Cell Responses by Inhibiting Receptor-Mediated Antigen Uptake
Mallika Ghosh; Beata McAuliffe; Jaganathan Subramani; Sreyashi Basu; Linda H. Shapiro
J Immunol (2012) 188 (11): 5489–5499.
View articletitled, CD13 Regulates Dendritic Cell Cross-Presentation and T Cell Responses by Inhibiting Receptor-Mediated Antigen Uptake
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MicroRNA-494 Is Required for the Accumulation and Functions of Tumor-Expanded Myeloid-Derived Suppressor Cells via Targeting of PTEN
Yang Liu; Lihua Lai; Qingyun Chen; Yinjing Song; Sheng Xu; Feng Ma; Xiaojian Wang; Jianli Wang; Hai Yu; Xuetao Cao; Qingqing Wang
J Immunol (2012) 188 (11): 5500–5510.
View articletitled, MicroRNA-494 Is Required for the Accumulation and Functions of Tumor-Expanded Myeloid-Derived Suppressor Cells via Targeting of PTEN
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MOLECULAR AND STRUCTURAL IMMUNOLOGY

Crystal Structure of Cell Adhesion Molecule Nectin-2/CD112 and Its Binding to Immune Receptor DNAM-1/CD226
Jun Liu; Xiaomin Qian; Zhujun Chen; Xiang Xu; Feng Gao; Shuijun Zhang; Rongguang Zhang; Jianxun Qi; George F. Gao; Jinghua Yan
J Immunol (2012) 188 (11): 5511–5520.
View articletitled, Crystal Structure of Cell Adhesion Molecule Nectin-2/CD112 and Its Binding to Immune Receptor DNAM-1/CD226
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CD40 Stimulates a “Feed-Forward” NF-κB–Driven Molecular Pathway That Regulates IFN-β Expression in Carcinoma Cells
Aristides Moschonas; Marina Ioannou; Aristides G. Eliopoulos
J Immunol (2012) 188 (11): 5521–5527.
View articletitled, CD40 Stimulates a “Feed-Forward” NF-κB–Driven Molecular Pathway That Regulates IFN-β Expression in Carcinoma Cells
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Altered Ig Hypermutation Pattern and Frequency in Complementary Mouse Models of DNA Polymerase ζ Activity
Janssen Daly; Katarzyna Bebenek; Danielle L. Watt; Kathleen Richter; Chuancang Jiang; Ming-Lang Zhao; Madhumita Ray; W. Glenn McGregor; Thomas A. Kunkel; Marilyn Diaz
J Immunol (2012) 188 (11): 5528–5537.
View articletitled, Altered Ig Hypermutation Pattern and Frequency in Complementary Mouse Models of DNA Polymerase ζ Activity
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Incorporation of Transmembrane Hydrophobic Mutations in the TCR Enhance Its Surface Expression and T Cell Functional Avidity
Astar Haga-Friedman; Miryam Horovitz-Fried; Cyrille J. Cohen
J Immunol (2012) 188 (11): 5538–5546.
View articletitled, Incorporation of Transmembrane Hydrophobic Mutations in the TCR Enhance Its Surface Expression and T Cell Functional Avidity
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E2A and CBP/p300 Act in Synergy To Promote Chromatin Accessibility of the Immunoglobulin κ Locus
Shuji Sakamoto; Kousho Wakae; Yuki Anzai; Kiyohito Murai; Nobuyuki Tamaki; Masaki Miyazaki; Kazuko Miyazaki; William J. Romanow; Tomokatsu Ikawa; Daisuke Kitamura; Itaru Yanagihara; Nagahiro Minato; Cornelis Murre; Yasutoshi Agata
J Immunol (2012) 188 (11): 5547–5560.
View articletitled, E2A and CBP/p300 Act in Synergy To Promote Chromatin Accessibility of the Immunoglobulin κ Locus
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IMMUNOGENETICS

The Size of the Plasmacytoid Dendritic Cell Compartment Is a Multigenic Trait Dominated by a Locus on Mouse Chromosome 7
Adam-Nicolas Pelletier; Fanny Guimont-Desrochers; Michelle P. Ashton; Thomas C. Brodnicki; Sylvie Lesage
J Immunol (2012) 188 (11): 5561–5570.
View articletitled, The Size of the Plasmacytoid Dendritic Cell Compartment Is a Multigenic Trait Dominated by a Locus on Mouse Chromosome 7
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Essential Role of IL-4 and IL-4Rα Interaction in Adaptive Immunity of Zebrafish: Insight into the Origin of Th2-like Regulatory Mechanism in Ancient Vertebrates
Lv-yun Zhu; Ping-ping Pan; Wei Fang; Jian-zhong Shao; Li-xin Xiang
J Immunol (2012) 188 (11): 5571–5584.
View articletitled, Essential Role of IL-4 and IL-4Rα Interaction in Adaptive Immunity of Zebrafish: Insight into the Origin of Th2-like Regulatory Mechanism in Ancient Vertebrates
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HOST DEFENSE

Soluble Trem-like Transcript-1 Regulates Leukocyte Activation and Controls Microbial Sepsis
Marc Derive; Youcef Bouazza; Nacira Sennoun; Sandra Marchionni; Laura Quigley; Valance Washington; Frédéric Massin; Jean-Pierre Max; Jill Ford; Corentine Alauzet; Bruno Levy; Daniel W. McVicar; Sébastien Gibot
J Immunol (2012) 188 (11): 5585–5592.
View articletitled, Soluble Trem-like Transcript-1 Regulates Leukocyte Activation and Controls Microbial Sepsis
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Mycobacterium tuberculosis Modulates Macrophage Lipid-Sensing Nuclear Receptors PPARγ and TR4 for Survival
Sahil Mahajan; H. Kitdorlang Dkhar; Vemika Chandra; Sandeep Dave; Ravikanth Nanduri; Ashok Kumar Janmeja; Javed N. Agrewala; Pawan Gupta
J Immunol (2012) 188 (11): 5593–5603.
View articletitled, <em>Mycobacterium tuberculosis</em> Modulates Macrophage Lipid-Sensing Nuclear Receptors PPARγ and TR4 for Survival
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Mast Cell TLR2 Signaling Is Crucial for Effective Killing of Francisella tularensis
Annette R. Rodriguez; Jieh-Juen Yu; M. Neal Guentzel; Christopher S. Navara; Karl E. Klose; Thomas G. Forsthuber; James P. Chambers; Michael T. Berton; Bernard P. Arulanandam
J Immunol (2012) 188 (11): 5604–5611.
View articletitled, Mast Cell TLR2 Signaling Is Crucial for Effective Killing of <em>Francisella tularensis</em>
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Delays and Diversions Mark the Development of B Cell Responses to Borrelia burgdorferi Infection
Christine J. Hastey; Rebecca A. Elsner; Stephen W. Barthold; Nicole Baumgarth
J Immunol (2012) 188 (11): 5612–5622.
View articletitled, Delays and Diversions Mark the Development of B Cell Responses to <em>Borrelia burgdorferi</em> Infection
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NLRC4 Inflammasome-Mediated Production of IL-1β Modulates Mucosal Immunity in the Lung against Gram-Negative Bacterial Infection
Shanshan Cai; Sanjay Batra; Nobuko Wakamatsu; Pal Pacher; Samithamby Jeyaseelan
J Immunol (2012) 188 (11): 5623–5635.
View articletitled, NLRC4 Inflammasome-Mediated Production of IL-1β Modulates Mucosal Immunity in the Lung against Gram-Negative Bacterial Infection
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A Novel Th Cell Epitope of Candida albicans Mediates Protection from Fungal Infection
Eva Bär; André Gladiator; Sonia Bastidas; Bernd Roschitzki; Hans Acha-Orbea; Annette Oxenius; Salomé LeibundGut-Landmann
J Immunol (2012) 188 (11): 5636–5643.
View articletitled, A Novel Th Cell Epitope of <em>Candida albicans</em> Mediates Protection from Fungal Infection
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Dectin-1 Stimulation Induces Suppressor of Cytokine Signaling 1, Thereby Modulating TLR Signaling and T Cell Responses
Mariel E. Eberle; Alexander H. Dalpke
J Immunol (2012) 188 (11): 5644–5654.
View articletitled, Dectin-1 Stimulation Induces Suppressor of Cytokine Signaling 1, Thereby Modulating TLR Signaling and T Cell Responses
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CRTH2 Is A Critical Regulator of Neutrophil Migration and Resistance to Polymicrobial Sepsis
Makoto Ishii; Koichiro Asano; Ho Namkoong; Sadatomo Tasaka; Kosuke Mizoguchi; Takahiro Asami; Hirofumi Kamata; Yoshifumi Kimizuka; Hiroshi Fujiwara; Yohei Funatsu; Shizuko Kagawa; Jun Miyata; Ken Ishii; Masataka Nakamura; Hiroyuki Hirai; Kinya Nagata; Steven L. Kunkel; Naoki Hasegawa; Tomoko Betsuyaku
J Immunol (2012) 188 (11): 5655–5664.
View articletitled, CRTH2 Is A Critical Regulator of Neutrophil Migration and Resistance to Polymicrobial Sepsis
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INFLAMMATION

Regulation of Cytosolic Phospholipase A2 Phosphorylation by Proteolytic Cleavage of Annexin A1 in Activated Mast Cells
Joon Hyun Kwon; Jea Hwang Lee; Ki Soon Kim; Youn Wook Chung; Ick Young Kim
J Immunol (2012) 188 (11): 5665–5673.
View articletitled, Regulation of Cytosolic Phospholipase A<sub>2</sub> Phosphorylation by Proteolytic Cleavage of Annexin A1 in Activated Mast Cells
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Severe Impairment of Leukocyte Recruitment in ppGalNAcT-1–Deficient Mice
Helena Block; Klaus Ley; Alexander Zarbock
J Immunol (2012) 188 (11): 5674–5681.
View articletitled, Severe Impairment of Leukocyte Recruitment in ppGalNAcT-1–Deficient Mice
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Complement Protein C1q Directs Macrophage Polarization and Limits Inflammasome Activity during the Uptake of Apoptotic Cells
Marie E. Benoit; Elizabeth V. Clarke; Pedro Morgado; Deborah A. Fraser; Andrea J. Tenner
J Immunol (2012) 188 (11): 5682–5693.
View articletitled, Complement Protein C1q Directs Macrophage Polarization and Limits Inflammasome Activity during the Uptake of Apoptotic Cells
Supplementary data
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Complement C3a-Induced IL-17 Plays a Critical Role in an IgE-Mediated Late-Phase Asthmatic Response and Airway Hyperresponsiveness via Neutrophilic Inflammation in Mice
Nobuaki Mizutani; Hirofumi Goshima; Takeshi Nabe; Shin Yoshino
J Immunol (2012) 188 (11): 5694–5705.
View articletitled, Complement C3a-Induced IL-17 Plays a Critical Role in an IgE-Mediated Late-Phase Asthmatic Response and Airway Hyperresponsiveness via Neutrophilic Inflammation in Mice
Supplementary data
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TLR9 Provokes Inflammation in Response to Fetal DNA: Mechanism for Fetal Loss in Preterm Birth and Preeclampsia
Andrea Scharfe-Nugent; Sinéad C. Corr; Susan B. Carpenter; Louise Keogh; Brendan Doyle; Cara Martin; Katherine A. Fitzgerald; Sean Daly; John J. O’Leary; Luke A. J. O’Neill
J Immunol (2012) 188 (11): 5706–5712.
View articletitled, TLR9 Provokes Inflammation in Response to Fetal DNA: Mechanism for Fetal Loss in Preterm Birth and Preeclampsia
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A2A Adenosine Receptor Signaling in Lymphocytes and the Central Nervous System Regulates Inflammation during Experimental Autoimmune Encephalomyelitis
Jeffrey H. Mills; Do-Geun Kim; Antje Krenz; Jiang-Fan Chen; Margaret S. Bynoe
J Immunol (2012) 188 (11): 5713–5722.
View articletitled, A2A Adenosine Receptor Signaling in Lymphocytes and the Central Nervous System Regulates Inflammation during Experimental Autoimmune Encephalomyelitis
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Ceramide Synthase 6 Plays a Critical Role in the Development of Experimental Autoimmune Encephalomyelitis
Susanne Schiffmann; Nerea Ferreiros; Kerstin Birod; Max Eberle; Yannick Schreiber; Waltraud Pfeilschifter; Ulf Ziemann; Sandra Pierre; Klaus Scholich; Sabine Grösch; Gerd Geisslinger
J Immunol (2012) 188 (11): 5723–5733.
View articletitled, Ceramide Synthase 6 Plays a Critical Role in the Development of Experimental Autoimmune Encephalomyelitis
Supplementary data
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Protective Role of Reactive Oxygen Species in Endotoxin-Induced Lung Inflammation through Modulation of IL-10 Expression
Jing Deng; Xuerong Wang; Feng Qian; Stephen Vogel; Lei Xiao; Ravi Ranjan; Hyesuk Park; Manjula Karpurapu; Richard D. Ye; Gye Young Park; John W. Christman
J Immunol (2012) 188 (11): 5734–5740.
View articletitled, Protective Role of Reactive Oxygen Species in Endotoxin-Induced Lung Inflammation through Modulation of IL-10 Expression
Supplementary data
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TRPV1 Deletion Enhances Local Inflammation and Accelerates the Onset of Systemic Inflammatory Response Syndrome
Elizabeth S. Fernandes; Lihuan Liang; Sarah-Jane Smillie; Frank Kaiser; Robert Purcell; Damian W. Rivett; Saydul Alam; Sarah Howat; Helen Collins; Stephen J. Thompson; Julie E. Keeble; Yanira Riffo-Vasquez; Kenneth D. Bruce; Susan D. Brain
J Immunol (2012) 188 (11): 5741–5751.
View articletitled, TRPV1 Deletion Enhances Local Inflammation and Accelerates the Onset of Systemic Inflammatory Response Syndrome
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Defining GM-CSF– and Macrophage-CSF–Dependent Macrophage Responses by In Vitro Models
Derek C. Lacey; Adrian Achuthan; Andrew J. Fleetwood; Hang Dinh; John Roiniotis; Glen M. Scholz; Melody W. Chang; Sandra K. Beckman; Andrew D. Cook; John A. Hamilton
J Immunol (2012) 188 (11): 5752–5765.
View articletitled, Defining GM-CSF– and Macrophage-CSF–Dependent Macrophage Responses by In Vitro Models
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CLINICAL IMMUNOLOGY

Beyond HLA-A*0201: New HLA-Transgenic Nonobese Diabetic Mouse Models of Type 1 Diabetes Identify the Insulin C-Peptide as a Rich Source of CD8+ T Cell Epitopes
Zoltan Antal; Jason C. Baker; Carla Smith; Irene Jarchum; Jeffrey Babad; Gayatri Mukherjee; Yang Yang; John Sidney; Alessandro Sette; Pere Santamaria; Teresa P. DiLorenzo
J Immunol (2012) 188 (11): 5766–5775.
View articletitled, Beyond HLA-A*0201: New HLA-Transgenic Nonobese Diabetic Mouse Models of Type 1 Diabetes Identify the Insulin C-Peptide as a Rich Source of CD8<sup>+</sup> T Cell Epitopes
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Cyr61 Induces IL-6 Production by Fibroblast-like Synoviocytes Promoting Th17 Differentiation in Rheumatoid Arthritis
Jinpiao Lin; Zhou Zhou; Rongfen Huo; Lianbo Xiao; Guilin Ouyang; Li Wang; Yue Sun; Baihua Shen; Dangsheng Li; Ningli Li
J Immunol (2012) 188 (11): 5776–5784.
View articletitled, Cyr61 Induces IL-6 Production by Fibroblast-like Synoviocytes Promoting Th17 Differentiation in Rheumatoid Arthritis
Supplementary data
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Role of CD25+ Dendritic Cells in the Generation of Th17 Autoreactive T Cells in Autoimmune Experimental Uveitis
Dongchun Liang; Aijun Zuo; Hui Shao; Willi K. Born; Rebecca L. O’Brien; Henry J. Kaplan; Deming Sun
J Immunol (2012) 188 (11): 5785–5791.
View articletitled, Role of CD25<sup>+</sup> Dendritic Cells in the Generation of Th17 Autoreactive T Cells in Autoimmune Experimental Uveitis
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Antibodies to Pathogenic Epitopes on Type XVII Collagen Cause Skin Fragility in a Complement-Dependent and -Independent Manner
Ken Natsuga; Wataru Nishie; Satoru Shinkuma; Hideyuki Ujiie; Machiko Nishimura; Daisuke Sawamura; Hiroshi Shimizu
J Immunol (2012) 188 (11): 5792–5799.
View articletitled, Antibodies to Pathogenic Epitopes on Type XVII Collagen Cause Skin Fragility in a Complement-Dependent and -Independent Manner
Supplementary data
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LETTERS OF RETRACTION

Retraction: CD226 Expression Deficiency Causes High Sensitivity to Apoptosis in NK T Cells from Patients with Systemic Lupus Erythematosus
Deng Tao; Liu Shangwu; Liu Yan; Liu Junyan; Gong Feili; Jin Boquan; Tan Jinquan
J Immunol (2012) 188 (11): 5800.
View articletitled, Retraction: CD226 Expression Deficiency Causes High Sensitivity to Apoptosis in NK T Cells from Patients with Systemic Lupus Erythematosus
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Retraction: Vα24-Invariant NKT Cells from Patients with Allergic Asthma Express CCR9 at High Frequency and Induce Th2 Bias of CD3+ T Cells upon CD226 Engagement
Yang Sen; Bi Yongyi; He Yuling; Xie Luokun; He Li; Xiong Jie; Deng Tao; Zhou Gang; Liu Junyan; Hu Chunsong; Zhang Xuejun; Jin Youxin; Gong Feili; Jin Boquan; Tan Jinquan
J Immunol (2012) 188 (11): 5801.
View articletitled, Retraction: Vα24-Invariant NKT Cells from Patients with Allergic Asthma Express CCR9 at High Frequency and Induce Th2 Bias of CD3<sup>+</sup> T Cells upon CD226 Engagement
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CORRECTIONS

Correction: TREM2 and β-catenin regulate bone homeostasis by controlling the rate of osteoclastogenesis
Karel Otero; Masahiro Shinohara; Haibo Zhao; Marina Cella; Susan Gilfillan; Angela Colucci; Roberta Faccio; F. Patrick Ross; Steve L. Teitelbaum; Hiroshi Takayanagi; Marco Colonna
J Immunol (2012) 188 (11): 5802.
View articletitled, Correction: TREM2 and β-catenin regulate bone homeostasis by controlling the rate of osteoclastogenesis
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  • Cover Image

    Cover Image

    issue cover
    On the cover: Heat map of significantly modulated genes by complement protein C1q in LPS-stimulated human macrophages after uptake of apoptotic cells. Ingestion of autologous apoptotic lymphocytes with bound C1q suppresses proinflammatory gene expression induced by 10 ng/ml LPS in human monocyte-derived macrophages. Benoit, M. E., E. V. Clarke, P. Morgado, D. A. Fraser, and A. J. Tenner. 2012. Complement protein C1q directs macrophage polarization and limits inflammasome activity during the uptake of apoptotic cells. J. Immunol. 188: 5682–5693.
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