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Volume 189, Issue 6
15 September 2012
Issue Cover
ISSN 0022-1767
EISSN 1550-6606

IN THIS ISSUE

In This Issue
J Immunol (2012) 189 (6): 2687–2688.
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BRIEF REVIEWS

Neutrophil Extracellular Traps: Double-Edged Swords of Innate Immunity
Mariana J. Kaplan; Marko Radic
J Immunol (2012) 189 (6): 2689–2695.
View articletitled, Neutrophil Extracellular Traps: Double-Edged Swords of Innate Immunity
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CUTTING EDGE

Cutting Edge: 4-1BB Controls Regulatory Activity in Dendritic Cells through Promoting Optimal Expression of Retinal Dehydrogenase
Seung-Woo Lee; Yunji Park; So-Young Eun; Shravan Madireddi; Hilde Cheroutre; Michael Croft
J Immunol (2012) 189 (6): 2697–2701.
View articletitled, Cutting Edge: 4-1BB Controls Regulatory Activity in Dendritic Cells through Promoting Optimal Expression of Retinal Dehydrogenase
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Cutting Edge: Intravascular Staining Redefines Lung CD8 T Cell Responses
Kristin G. Anderson; Heungsup Sung; Cara N. Skon; Leo Lefrancois; Angela Deisinger; Vaiva Vezys; David Masopust
J Immunol (2012) 189 (6): 2702–2706.
View articletitled, Cutting Edge: Intravascular Staining Redefines Lung CD8 T Cell Responses
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Cutting Edge: IL-6 Is a Marker of Inflammation with No Direct Role in Inflammasome-Mediated Mouse Models
Matthew D. McGeough; Carla A. Pena; James L. Mueller; Derek A. Pociask; Lori Broderick; Hal M. Hoffman; Susannah D. Brydges
J Immunol (2012) 189 (6): 2707–2711.
View articletitled, Cutting Edge: IL-6 Is a Marker of Inflammation with No Direct Role in Inflammasome-Mediated Mouse Models
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Cutting Edge: A Novel Mechanism Bridging Innate and Adaptive Immunity: IL-12 Induction of CD25 To Form High-Affinity IL-2 Receptors on NK Cells
Seung-Hwan Lee; Maria F. Fragoso; Christine A. Biron
J Immunol (2012) 189 (6): 2712–2716.
View articletitled, Cutting Edge: A Novel Mechanism Bridging Innate and Adaptive Immunity: IL-12 Induction of CD25 To Form High-Affinity IL-2 Receptors on NK Cells
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Cutting Edge: TLR13 Is a Receptor for Bacterial RNA
Asa Hidmark; Antonia von Saint Paul; Alexander H. Dalpke
J Immunol (2012) 189 (6): 2717–2721.
View articletitled, Cutting Edge: TLR13 Is a Receptor for Bacterial RNA
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Cutting Edge: Generation of Memory Precursors and Functional Memory CD8+ T Cells Depends on T Cell Factor-1 and Lymphoid Enhancer-Binding Factor-1
Xinyuan Zhou; Hai-Hui Xue
J Immunol (2012) 189 (6): 2722–2726.
View articletitled, Cutting Edge: Generation of Memory Precursors and Functional Memory CD8<sup>+</sup> T Cells Depends on T Cell Factor-1 and Lymphoid Enhancer-Binding Factor-1
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CELLULAR IMMUNOLOGY AND IMMUNE REGULATION

The Adaptor 3BP2 Is Required for Early and Late Events in FcεRI Signaling in Human Mast Cells
Erola Ainsua-Enrich; Damiana Álvarez-Errico; Alasdair M. Gilfillan; César Picado; Joan Sayós; Juan Rivera; Margarita Martín
J Immunol (2012) 189 (6): 2727–2734.
View articletitled, The Adaptor 3BP2 Is Required for Early and Late Events in FcεRI Signaling in Human Mast Cells
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Type III IFNs Are Produced by and Stimulate Human Plasmacytoid Dendritic Cells
Zhiwei Yin; Jihong Dai; Jing Deng; Faruk Sheikh; Mahwish Natalia; Tiffany Shih; Anita Lewis-Antes; Sheela B. Amrute; Ursula Garrigues; Sean Doyle; Raymond P. Donnelly; Sergei V. Kotenko; Patricia Fitzgerald-Bocarsly
J Immunol (2012) 189 (6): 2735–2745.
View articletitled, Type III IFNs Are Produced by and Stimulate Human Plasmacytoid Dendritic Cells
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Host Factor Transcriptional Regulation Contributes to Preferential Expression of HIV Type 1 in IL-4–Producing CD4 T Cells
Mingce Zhang; Adrian Clausell; Tanya Robinson; Jiyi Yin; Eric Chen; Leanne Johnson; Greta Weiss; Steffanie Sabbaj; Robert M. Lowe; Fred H. Wagner; Paul A. Goepfert; Olaf Kutsch; Randy Q. Cron
J Immunol (2012) 189 (6): 2746–2757.
View articletitled, Host Factor Transcriptional Regulation Contributes to Preferential Expression of HIV Type 1 in IL-4–Producing CD4 T Cells
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CD28–B7 Interaction Modulates Short- and Long-Lived Plasma Cell Function
Modesta N. Njau; Jin Hyang Kim; Craig P. Chappell; Rajesh Ravindran; Leela Thomas; Bali Pulendran; Joshy Jacob
J Immunol (2012) 189 (6): 2758–2767.
View articletitled, <em>CD28</em>–B7 Interaction Modulates Short- and Long-Lived Plasma Cell Function
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TIPE2 Controls Innate Immunity to RNA by Targeting the Phosphatidylinositol 3-Kinase–Rac Pathway
Honghong Sun; Guohong Zhuang; Lihui Chai; Zhaojun Wang; Derek Johnson; Yuanfang Ma; Youhai H. Chen
J Immunol (2012) 189 (6): 2768–2773.
View articletitled, TIPE2 Controls Innate Immunity to RNA by Targeting the Phosphatidylinositol 3-Kinase–Rac Pathway
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Identification of Pancreatic Glycoprotein 2 as an Endogenous Immunomodulator of Innate and Adaptive Immune Responses
Lael Werner; Daniela Paclik; Christina Fritz; Dirk Reinhold; Dirk Roggenbuck; Andreas Sturm
J Immunol (2012) 189 (6): 2774–2783.
View articletitled, Identification of Pancreatic Glycoprotein 2 as an Endogenous Immunomodulator of Innate and Adaptive Immune Responses
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Inhibition of JAKs in Macrophages Increases Lipopolysaccharide-Induced Cytokine Production by Blocking IL-10–Mediated Feedback
Michael J. Pattison; Kirsty F. MacKenzie; J. Simon C. Arthur
J Immunol (2012) 189 (6): 2784–2792.
View articletitled, Inhibition of JAKs in Macrophages Increases Lipopolysaccharide-Induced Cytokine Production by Blocking IL-10–Mediated Feedback
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ICOS-Expressing CD4 T Cells Induced via TLR4 in the Nasal Mucosa Are Capable of Inhibiting Experimental Allergic Asthma
Karim H. Shalaby; Taisuke Jo; Emily Nakada; Alexandra Allard-Coutu; Kimitake Tsuchiya; Nobuaki Hirota; Salman T. Qureshi; Karim Maghni; Clément R. Rioux; James G. Martin
J Immunol (2012) 189 (6): 2793–2804.
View articletitled, ICOS-Expressing CD4 T Cells Induced via TLR4 in the Nasal Mucosa Are Capable of Inhibiting Experimental Allergic Asthma
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The Development and Function of Memory Regulatory T Cells after Acute Viral Infections
Ana M. Sanchez; Jiangao Zhu; Xiaopei Huang; Yiping Yang
J Immunol (2012) 189 (6): 2805–2814.
View articletitled, The Development and Function of Memory Regulatory T Cells after Acute Viral Infections
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Vesicles Released by Activated T Cells Induce Both Fas-Mediated RIP-Dependent Apoptotic and Fas-Independent Nonapoptotic Cell Deaths
Gábor Koncz; Anikó Hancz; Krittalak Chakrabandhu; Péter Gogolák; Krisztina Kerekes; Éva Rajnavölgyi; Anne-Odile Hueber
J Immunol (2012) 189 (6): 2815–2823.
View articletitled, Vesicles Released by Activated T Cells Induce Both Fas-Mediated RIP-Dependent Apoptotic and Fas-Independent Nonapoptotic Cell Deaths
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The Chemokine Receptors CXCR1 and CXCR2 Couple to Distinct G Protein-Coupled Receptor Kinases To Mediate and Regulate Leukocyte Functions
Sandeep K. Raghuwanshi; Yingjun Su; Vandana Singh; Katherine Haynes; Ann Richmond; Ricardo M. Richardson
J Immunol (2012) 189 (6): 2824–2832.
View articletitled, The Chemokine Receptors CXCR1 and CXCR2 Couple to Distinct G Protein-Coupled Receptor Kinases To Mediate and Regulate Leukocyte Functions
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Immune Surveillance Properties of Human NK Cell-Derived Exosomes
Luana Lugini; Serena Cecchetti; Veronica Huber; Francesca Luciani; Gianfranco Macchia; Francesca Spadaro; Luisa Paris; Laura Abalsamo; Marisa Colone; Agnese Molinari; Franca Podo; Licia Rivoltini; Carlo Ramoni; Stefano Fais
J Immunol (2012) 189 (6): 2833–2842.
View articletitled, Immune Surveillance Properties of Human NK Cell-Derived Exosomes
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Lung T Lymphocyte Trafficking and Activation during Ischemic Acute Kidney Injury
Mihaela L. Lie; Laura E. White; Rachel J. Santora; Jong M. Park; Hamid Rabb; Heitham T. Hassoun
J Immunol (2012) 189 (6): 2843–2851.
View articletitled, Lung T Lymphocyte Trafficking and Activation during Ischemic Acute Kidney Injury
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Caveolin-1–Mediated Negative Signaling Plays a Critical Role in the Induction of Regulatory Dendritic Cells by DNA and Protein Coimmunization
Jinyao Li; Shuang Geng; Xiaoping Xie; Hu Liu; Guoxing Zheng; Xiaolin Sun; Gan Zhao; Ying Wan; Yuzhang Wu; Xuan Chen; Yiwei Zhong; Bin Wang
J Immunol (2012) 189 (6): 2852–2859.
View articletitled, Caveolin-1–Mediated Negative Signaling Plays a Critical Role in the Induction of Regulatory Dendritic Cells by DNA and Protein Coimmunization
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MyD88 Drives the IFN-β Response to Lactobacillus acidophilus in Dendritic Cells through a Mechanism Involving IRF1, IRF3, and IRF7
Gudrun Weiss; Kristina Maaetoft-Udsen; Sebastian A. Stifter; Paul Hertzog; Stanislas Goriely; Allan R. Thomsen; Søren R. Paludan; Hanne Frøkiær
J Immunol (2012) 189 (6): 2860–2868.
View articletitled, MyD88 Drives the IFN-β Response to <em>Lactobacillus acidophilus</em> in Dendritic Cells through a Mechanism Involving IRF1, IRF3, and IRF7
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Dietary Folic Acid Promotes Survival of Foxp3+ Regulatory T Cells in the Colon
Makoto Kinoshita; Hisako Kayama; Takashi Kusu; Tomoyuki Yamaguchi; Jun Kunisawa; Hiroshi Kiyono; Shimon Sakaguchi; Kiyoshi Takeda
J Immunol (2012) 189 (6): 2869–2878.
View articletitled, Dietary Folic Acid Promotes Survival of Foxp3<sup>+</sup> Regulatory T Cells in the Colon
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Enhanced Tim3 Activity Improves Survival after Influenza Infection
Josalyn L. Cho; Marly I. Roche; Barry Sandall; Abraham L. Brass; Brian Seed; Ramnik J. Xavier; Benjamin D. Medoff
J Immunol (2012) 189 (6): 2879–2889.
View articletitled, Enhanced Tim3 Activity Improves Survival after Influenza Infection
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IFN-γ Production by Allogeneic Foxp3+ Regulatory T Cells Is Essential for Preventing Experimental Graft-versus-Host Disease
Christian Koenecke; Chun-Wei Lee; Kristina Thamm; Lisa Föhse; Matthias Schafferus; Hans-Willi Mittrücker; Stefan Floess; Jochen Huehn; Arnold Ganser; Reinhold Förster; Immo Prinz
J Immunol (2012) 189 (6): 2890–2896.
View articletitled, IFN-γ Production by Allogeneic Foxp3<sup>+</sup> Regulatory T Cells Is Essential for Preventing Experimental Graft-versus-Host Disease
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Myelin Basic Protein-Specific TCR/HLA-DRB5*01:01 Transgenic Mice Support the Etiologic Role of DRB5*01:01 in Multiple Sclerosis
Jacqueline A. Quandt; Jaebong Huh; Mirza Baig; Karen Yao; Naoko Ito; Mark Bryant; Kazuyuki Kawamura; Clemencia Pinilla; Henry F. McFarland; Roland Martin; Kouichi Ito
J Immunol (2012) 189 (6): 2897–2908.
View articletitled, Myelin Basic Protein-Specific TCR/HLA-DRB5*01:01 Transgenic Mice Support the Etiologic Role of DRB5*01:01 in Multiple Sclerosis
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CD28 Promotes CD4+ T Cell Clonal Expansion during Infection Independently of Its YMNM and PYAP Motifs
Antonio J. Pagán; Marion Pepper; H. Hamlet Chu; Jonathan M. Green; Marc K. Jenkins
J Immunol (2012) 189 (6): 2909–2917.
View articletitled, CD28 Promotes CD4<sup>+</sup> T Cell Clonal Expansion during Infection Independently of Its YMNM and PYAP Motifs
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CD5-Dependent CK2 Activation Pathway Regulates Threshold for T Cell Anergy
Christine M. Sestero; Donald J. McGuire; Patrizia De Sarno; Emily C. Brantley; Gloria Soldevila; Robert C. Axtell; Chander Raman
J Immunol (2012) 189 (6): 2918–2930.
View articletitled, CD5-Dependent CK2 Activation Pathway Regulates Threshold for T Cell Anergy
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Cyclin-Dependent Kinase Inhibitor Cdkn2c Deficiency Promotes B1a Cell Expansion and Autoimmunity in a Mouse Model of Lupus
Hari-Hara S. K. Potula; Zhiwei Xu; Leilani Zeumer; Allison Sang; Byron P. Croker; Laurence Morel
J Immunol (2012) 189 (6): 2931–2940.
View articletitled, Cyclin-Dependent Kinase Inhibitor <em>Cdkn2c</em> Deficiency Promotes B1a Cell Expansion and Autoimmunity in a Mouse Model of Lupus
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Leptin-Induced mTOR Activation Defines a Specific Molecular and Transcriptional Signature Controlling CD4+ Effector T Cell Responses
Claudio Procaccini; Veronica De Rosa; Mario Galgani; Fortunata Carbone; Silvana Cassano; Dario Greco; Kui Qian; Petri Auvinen; Gaetano Calì; Giovanni Stallone; Luigi Formisano; Antonio La Cava; Giuseppe Matarese
J Immunol (2012) 189 (6): 2941–2953.
View articletitled, Leptin-Induced mTOR Activation Defines a Specific Molecular and Transcriptional Signature Controlling CD4<sup>+</sup> Effector T Cell Responses
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Tryptophan Depletion and the Kinase GCN2 Mediate IFN-γ–Induced Autophagy
Sophie Fougeray; Iadh Mami; Gildas Bertho; Philippe Beaune; Eric Thervet; Nicolas Pallet
J Immunol (2012) 189 (6): 2954–2964.
View articletitled, Tryptophan Depletion and the Kinase GCN2 Mediate IFN-γ–Induced Autophagy
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Retention of Anergy and Inhibition of Antibody Responses during Acute Gammaherpesvirus 68 Infection
Andrew Getahun; Mia J. Smith; Igor Kogut; Linda F. van Dyk; John C. Cambier
J Immunol (2012) 189 (6): 2965–2974.
View articletitled, Retention of Anergy and Inhibition of Antibody Responses during Acute Gammaherpesvirus 68 Infection
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Autoantigen Recognition Is Required for Recruitment of IGRP206–214-Autoreactive CD8+ T Cells but Is Dispensable for Tolerance
Jinguo Wang; Sue Tsai; Bingye Han; Pankaj Tailor; Pere Santamaria
J Immunol (2012) 189 (6): 2975–2984.
View articletitled, Autoantigen Recognition Is Required for Recruitment of IGRP<sub>206–214</sub>-Autoreactive CD8<sup>+</sup> T Cells but Is Dispensable for Tolerance
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Opposing Roles for Complement Component C5a in Tumor Progression and the Tumor Microenvironment
Lacey Gunn; Chuanlin Ding; Min Liu; Yunfeng Ma; Chunjian Qi; Yihua Cai; Xiaoling Hu; Deep Aggarwal; Huang-ge Zhang; Jun Yan
J Immunol (2012) 189 (6): 2985–2994.
View articletitled, Opposing Roles for Complement Component C5a in Tumor Progression and the Tumor Microenvironment
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Fcγ Receptors Inhibit Mouse and Human Basophil Activation
Lydie Cassard; Friederike Jönsson; Ségolène Arnaud; Marc Daëron
J Immunol (2012) 189 (6): 2995–3006.
View articletitled, Fcγ Receptors Inhibit Mouse and Human Basophil Activation
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MOLECULAR AND STRUCTURAL IMMUNOLOGY

Globosides but Not Isoglobosides Can Impact the Development of Invariant NKT Cells and Their Interaction with Dendritic Cells
Stefan Porubsky; Anneliese O. Speak; Mariolina Salio; Richard Jennemann; Mahnaz Bonrouhi; Rashad Zafarulla; Yogesh Singh; Julian Dyson; Bruno Luckow; Agnes Lehuen; Ernst Malle; Johannes Müthing; Frances M. Platt; Vincenzo Cerundolo; Hermann-Josef Gröne
J Immunol (2012) 189 (6): 3007–3017.
View articletitled, Globosides but Not Isoglobosides Can Impact the Development of Invariant NKT Cells and Their Interaction with Dendritic Cells
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Molecular and Immunological Characterization of Tri a 36, a Low Molecular Weight Glutenin, as a Novel Major Wheat Food Allergen
Alexandra Baar; Sandra Pahr; Claudia Constantin; Sandra Scheiblhofer; Josef Thalhamer; Stavroula Giavi; Nikolaos G. Papadopoulos; Christof Ebner; Adriano Mari; Susanne Vrtala; Rudolf Valenta
J Immunol (2012) 189 (6): 3018–3025.
View articletitled, Molecular and Immunological Characterization of Tri a 36, a Low Molecular Weight Glutenin, as a Novel Major Wheat Food Allergen
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Gcn5 Is Required for PU.1-Dependent IL-9 Induction in Th9 Cells
Ritobrata Goswami; Mark H. Kaplan
J Immunol (2012) 189 (6): 3026–3033.
View articletitled, Gcn5 Is Required for PU.1-Dependent IL-9 Induction in Th9 Cells
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IMMUNOGENETICS

Upstream Stimulating Factors Regulate the Expression of RORγT in Human Lymphocytes
Marcin Ratajewski; Aurelia Walczak-Drzewiecka; Anna Sałkowska; Jarosław Dastych
J Immunol (2012) 189 (6): 3034–3042.
View articletitled, Upstream Stimulating Factors Regulate the Expression of RORγT in Human Lymphocytes
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Genetically Driven Target Tissue Overexpression of CD40: A Novel Mechanism in Autoimmune Disease
Amanda K. Huber; Fred D. Finkelman; Cheuk Wun Li; Erlinda Concepcion; Eric Smith; Eric Jacobson; Rauf Latif; Mehdi Keddache; Weijia Zhang; Yaron Tomer
J Immunol (2012) 189 (6): 3043–3053.
View articletitled, Genetically Driven Target Tissue Overexpression of CD40: A Novel Mechanism in Autoimmune Disease
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HOST DEFENSE

Tissue-Expressed B7x Affects the Immune Response to and Outcome of Lethal Pulmonary Infection
Kimberly A. Hofmeyer; Lisa Scandiuzzi; Kaya Ghosh; Liise-Anne Pirofski; Xingxing Zang
J Immunol (2012) 189 (6): 3054–3063.
View articletitled, Tissue-Expressed B7x Affects the Immune Response to and Outcome of Lethal Pulmonary Infection
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Natural IgM Mediates Complement-Dependent Uptake of Francisella tularensis by Human Neutrophils via Complement Receptors 1 and 3 in Nonimmune Serum
Justin T. Schwartz; Jason H. Barker; Matthew E. Long; Justin Kaufman; Jenna McCracken; Lee-Ann H. Allen
J Immunol (2012) 189 (6): 3064–3077.
View articletitled, Natural IgM Mediates Complement-Dependent Uptake of <em>Francisella tularensis</em> by Human Neutrophils via Complement Receptors 1 and 3 in Nonimmune Serum
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Trefoil Factor 2 Negatively Regulates Type 1 Immunity against Toxoplasma gondii
Cortez McBerry; Charlotte E. Egan; Reena Rani; Yanfen Yang; David Wu; Nicholas Boespflug; Louis Boon; Barbara Butcher; Julie Mirpuri; Simon P. Hogan; Eric Y. Denkers; Julio Aliberti; De’Broski R. Herbert
J Immunol (2012) 189 (6): 3078–3084.
View articletitled, Trefoil Factor 2 Negatively Regulates Type 1 Immunity against <em>Toxoplasma gondii</em>
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Protective Role of Commensals against Clostridium difficile Infection via an IL-1β–Mediated Positive-Feedback Loop
Mizuho Hasegawa; Nobuhiko Kamada; Yizu Jiao; Meng Zhen Liu; Gabriel Núñez; Naohiro Inohara
J Immunol (2012) 189 (6): 3085–3091.
View articletitled, Protective Role of Commensals against <em>Clostridium difficile</em> Infection via an IL-1β–Mediated Positive-Feedback Loop
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Early Secreted Antigenic Target of 6-kDa Protein of Mycobacterium tuberculosis Primes Dendritic Cells To Stimulate Th17 and Inhibit Th1 Immune Responses
Xisheng Wang; Peter F. Barnes; Fangfang Huang; Ivana B. Alvarez; Pierre F. Neuenschwander; David R. Sherman; Buka Samten
J Immunol (2012) 189 (6): 3092–3103.
View articletitled, Early Secreted Antigenic Target of 6-kDa Protein of <em>Mycobacterium tuberculosis</em> Primes Dendritic Cells To Stimulate Th17 and Inhibit Th1 Immune Responses
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The Akt1 Isoform Is Required for Optimal IFN-β Transcription through Direct Phosphorylation of β-Catenin
Benjamin N. Gantner; Huali Jin; Feng Qian; Nissim Hay; Bin He; Richard D. Ye
J Immunol (2012) 189 (6): 3104–3111.
View articletitled, The Akt1 Isoform Is Required for Optimal IFN-β Transcription through Direct Phosphorylation of β-Catenin
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IL-10 Acts As a Developmental Switch Guiding Monocyte Differentiation to Macrophages during a Murine Peritoneal Infection
Huu-Hung Nguyen; Bich-Thu Tran; Werner Muller; Robert S. Jack
J Immunol (2012) 189 (6): 3112–3120.
View articletitled, IL-10 Acts As a Developmental Switch Guiding Monocyte Differentiation to Macrophages during a Murine Peritoneal Infection
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Role of Mincle in Alveolar Macrophage-Dependent Innate Immunity against Mycobacterial Infections in Mice
Friederike Behler; Kathrin Steinwede; Luciana Balboa; Bianca Ueberberg; Regina Maus; Gabriele Kirchhof; Sho Yamasaki; Tobias Welte; Ulrich A. Maus
J Immunol (2012) 189 (6): 3121–3129.
View articletitled, Role of Mincle in Alveolar Macrophage-Dependent Innate Immunity against Mycobacterial Infections in Mice
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INFLAMMATION

Role of Caspases in Cytokine-Induced Barrier Breakdown in Human Brain Endothelial Cells
M. Alejandro Lopez-Ramirez; Roman Fischer; Claudia C. Torres-Badillo; Heather A. Davies; Karen Logan; Klaus Pfizenmaier; David K. Male; Basil Sharrack; Ignacio A. Romero
J Immunol (2012) 189 (6): 3130–3139.
View articletitled, Role of Caspases in Cytokine-Induced Barrier Breakdown in Human Brain Endothelial Cells
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Tc17 CD8+ T Cells Potentiate Th1-Mediated Autoimmune Diabetes in a Mouse Model
Amit Saxena; Sabine Desbois; Nadège Carrié; Myriam Lawand; Lennart T. Mars; Roland S. Liblau
J Immunol (2012) 189 (6): 3140–3149.
View articletitled, Tc17 CD8<sup>+</sup> T Cells Potentiate Th1-Mediated Autoimmune Diabetes in a Mouse Model
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Semaphorin 7A Contributes to West Nile Virus Pathogenesis through TGF-β1/Smad6 Signaling
Hameeda Sultana; Girish Neelakanta; Harald G. Foellmer; Ruth R. Montgomery; John F. Anderson; Raymond A. Koski; Ruslan M. Medzhitov; Erol Fikrig
J Immunol (2012) 189 (6): 3150–3158.
View articletitled, Semaphorin 7A Contributes to West Nile Virus Pathogenesis through TGF-β1/Smad6 Signaling
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Shp2 Plays an Important Role in Acute Cigarette Smoke-Mediated Lung Inflammation
Fen-fen Li; Jian Shen; Hui-juan Shen; Xue Zhang; Rui Cao; Yun Zhang; Qiu Qui; Xi-xi Lin; Yi-cheng Xie; Lin-hui Zhang; Yong-liang Jia; Xin-wei Dong; Jun-xia Jiang; Meng-jing Bao; Shanshan Zhang; Wen-jiang Ma; Xi-mei Wu; Huahao Shen; Qiang-min Xie; Yuehai Ke
J Immunol (2012) 189 (6): 3159–3167.
View articletitled, Shp2 Plays an Important Role in Acute Cigarette Smoke-Mediated Lung Inflammation
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Stabilization of HIF-2α Induces sVEGFR-1 Production from Tumor-Associated Macrophages and Decreases Tumor Growth in a Murine Melanoma Model
Julie M. Roda; Yijie Wang; Laura A. Sumner; Gary S. Phillips; Clay B. Marsh; Timothy D. Eubank
J Immunol (2012) 189 (6): 3168–3177.
View articletitled, Stabilization of HIF-2α Induces sVEGFR-1 Production from Tumor-Associated Macrophages and Decreases Tumor Growth in a Murine Melanoma Model
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Microbial Carriage State of Peripheral Blood Dendritic Cells (DCs) in Chronic Periodontitis Influences DC Differentiation, Atherogenic Potential
Julio Carrion; Elizabeth Scisci; Brodie Miles; Gregory J. Sabino; Amir E. Zeituni; Ying Gu; Adam Bear; Caroline A. Genco; David L. Brown; Christopher W. Cutler
J Immunol (2012) 189 (6): 3178–3187.
View articletitled, Microbial Carriage State of Peripheral Blood Dendritic Cells (DCs) in Chronic Periodontitis Influences DC Differentiation, Atherogenic Potential
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The Ifng Gene Is Essential for Vdr Gene Expression and Vitamin D3-Mediated Reduction of the Pathogenic T Cell Burden in the Central Nervous System in Experimental Autoimmune Encephalomyelitis, a Multiple Sclerosis Model
Justin A. Spanier; Faye E. Nashold; Julie K. Olson; Colleen E. Hayes
J Immunol (2012) 189 (6): 3188–3197.
View articletitled, The <em>Ifng</em> Gene Is Essential for <em>Vdr</em> Gene Expression and Vitamin D<sub>3</sub>-Mediated Reduction of the Pathogenic T Cell Burden in the Central Nervous System in Experimental Autoimmune Encephalomyelitis, a Multiple Sclerosis Model
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CLINICAL IMMUNOLOGY

Expansion of Effector Memory Regulatory T Cells Represents a Novel Prognostic Factor in Lower Risk Myelodysplastic Syndrome
Adam W. Mailloux; Chiharu Sugimori; Rami S. Komrokji; Lili Yang; Jaroslaw P. Maciejewski; Mikkael A. Sekeres; Ronald Paquette; Thomas P. Loughran, Jr.; Alan F. List; Pearlie K. Epling-Burnette
J Immunol (2012) 189 (6): 3198–3208.
View articletitled, Expansion of Effector Memory Regulatory T Cells Represents a Novel Prognostic Factor in Lower Risk Myelodysplastic Syndrome
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Immune Mechanism of the Antitumor Effects Generated by Bortezomib
Chih-Long Chang; Yun-Ting Hsu; Chao-Chih Wu; Yuh-Cheng Yang; Connie Wang; T.-C. Wu; Chien-Fu Hung
J Immunol (2012) 189 (6): 3209–3220.
View articletitled, Immune Mechanism of the Antitumor Effects Generated by Bortezomib
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Shaping of Human Germline IgH Repertoires Revealed by Deep Sequencing
Kevin Larimore; Michael W. McCormick; Harlan S. Robins; Philip D. Greenberg
J Immunol (2012) 189 (6): 3221–3230.
View articletitled, Shaping of Human Germline IgH Repertoires Revealed by Deep Sequencing
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Adiponectin Regulates Cutaneous Wound Healing by Promoting Keratinocyte Proliferation and Migration via the ERK Signaling Pathway
Sayaka Shibata; Yayoi Tada; Yoshihide Asano; Carren S. Hau; Toyoaki Kato; Hidehisa Saeki; Toshimasa Yamauchi; Naoto Kubota; Takashi Kadowaki; Shinichi Sato
J Immunol (2012) 189 (6): 3231–3241.
View articletitled, Adiponectin Regulates Cutaneous Wound Healing by Promoting Keratinocyte Proliferation and Migration via the ERK Signaling Pathway
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Chemical Chaperones Curcumin and 4-Phenylbutyric Acid Improve Secretion of Mutant Factor H R127H by Fibroblasts from a Factor H-Deficient Patient
José Antonio T. Albuquerque; Marcelo L. Lamers; Mónica M. Castiblanco-Valencia; Marinilce dos Santos; Lourdes Isaac
J Immunol (2012) 189 (6): 3242–3248.
View articletitled, Chemical Chaperones Curcumin and 4-Phenylbutyric Acid Improve Secretion of Mutant Factor H R<sub>127</sub>H by Fibroblasts from a Factor H-Deficient Patient
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Novel Humanized and Highly Efficient Bispecific Antibodies Mediate Killing of Prostate Stem Cell Antigen-Expressing Tumor Cells by CD8+ and CD4+ T Cells
Anja Feldmann; Claudia Arndt; Katrin Töpfer; Slava Stamova; Franziska Krone; Marc Cartellieri; Stefanie Koristka; Irene Michalk; Dirk Lindemann; Marc Schmitz; Achim Temme; Martin Bornhäuser; Gerhard Ehninger; Michael Bachmann
J Immunol (2012) 189 (6): 3249–3259.
View articletitled, Novel Humanized and Highly Efficient Bispecific Antibodies Mediate Killing of Prostate Stem Cell Antigen-Expressing Tumor Cells by CD8<sup>+</sup> and CD4<sup>+</sup> T Cells
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LETTERS OF RETRACTION

Retraction: Recombinant Migration Inhibitory Factor Induces Nitric Oxide Synthase in Murine Macrophages
Salvador Moncada; F. Y. Liew
J Immunol (2012) 189 (6): 3260.
View articletitled, Retraction: Recombinant Migration Inhibitory Factor Induces Nitric Oxide Synthase in Murine Macrophages
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Retraction: Human Recombinant Migration Inhibitory Factor Activates Human Macrophages to Kill Leishmania donovani
J Immunol (2012) 189 (6): 3261.
View articletitled, Retraction: Human Recombinant Migration Inhibitory Factor Activates Human Macrophages to Kill Leishmania donovani
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Retraction: Sphingosine Kinase1 Is Pivotal for Fc"RI-Mediated Mast Cell Signaling and Functional Responses In Vitro and In Vivo
Peter N. Pushparaj; Hwee Kee Tay; Josef Pfeilschifter; Andrea Huwiler
J Immunol (2012) 189 (6): 3262.
View articletitled, Retraction: Sphingosine Kinase1 Is Pivotal for Fc"RI-Mediated Mast Cell Signaling and Functional Responses In Vitro and In Vivo
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CORRECTIONS

Correction: Pathogenic Autoreactive B Cells Are Not Negatively Selected toward Matrix Protein Collagen II
Duojia Cao; Ia Khmaladze; Hongwei Jia; Estelle Bajtner; Kutty S. Nandakumar; Thomas Blom; John A. Mo; Rikard Holmdahl
J Immunol (2012) 189 (6): 3263.
View articletitled, Correction: Pathogenic Autoreactive B Cells Are Not Negatively Selected toward Matrix Protein Collagen II
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