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Volume 191, Issue 10
15 November 2013
The Journal of Immunology Cover Image for Volume 191, Issue 10
ISSN 0022-1767
EISSN 1550-6606

IN THIS ISSUE

In This Issue
J Immunol (2013) 191 (10): 4891–4892.
View articletitled, In This Issue
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LETTERS TO THE EDITOR

Comment on “Changes and Regulation of the C5a Receptor on Neutrophils during Septic Shock in Humans”
Andrew Conway Morris; Thomas S. Wilkinson; Timothy S. Walsh; A. John Simpson
J Immunol (2013) 191 (10): 4893.
View articletitled, Comment on “Changes and Regulation of the C5a Receptor on Neutrophils during Septic Shock in Humans”
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BRIEF REVIEWS

Little Peptide, Big Effects: The Role of LL-37 in Inflammation and Autoimmune Disease
J. Michelle Kahlenberg; Mariana J. Kaplan
J Immunol (2013) 191 (10): 4895–4901.
View articletitled, Little Peptide, Big Effects: The Role of LL-37 in Inflammation and Autoimmune Disease
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CUTTING EDGE

Cutting Edge: Identification of the Thymic Stromal Lymphopoietin–Responsive Dendritic Cell Subset Critical for Initiation of Type 2 Contact Hypersensitivity
Masayuki Kitajima; Steven F. Ziegler
J Immunol (2013) 191 (10): 4903–4907.
View articletitled, Cutting Edge: Identification of the Thymic Stromal Lymphopoietin–Responsive Dendritic Cell Subset Critical for Initiation of Type 2 Contact Hypersensitivity
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Cutting Edge: Smad2 and Smad4 Regulate TGF-β–Mediated Il9 Gene Expression via EZH2 Displacement
Aibo Wang; Deng Pan; Young-Hee Lee; Gustavo J. Martinez; Xin-hua Feng; Chen Dong
J Immunol (2013) 191 (10): 4908–4912.
View articletitled, Cutting Edge: Smad2 and Smad4 Regulate TGF-β–Mediated <em>Il9</em> Gene Expression via EZH2 Displacement
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Cutting Edge: Type 1 Diabetes Occurs despite Robust Anergy among Endogenous Insulin-Specific CD4 T Cells in NOD Mice
Kristen E. Pauken; Jonathan L. Linehan; Justin A. Spanier; Nathanael L. Sahli; Lokesh A. Kalekar; Bryce A. Binstadt; James J. Moon; Daniel L. Mueller; Marc K. Jenkins; Brian T. Fife
J Immunol (2013) 191 (10): 4913–4917.
View articletitled, Cutting Edge: Type 1 Diabetes Occurs despite Robust Anergy among Endogenous Insulin-Specific CD4 T Cells in NOD Mice
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ANTIGEN RECOGNITION AND RESPONSES

Evolution of B Cell Responses to Clec9A-Targeted Antigen
Hae-Young Park; Amanda Light; Mireille H. Lahoud; Irina Caminschi; David M. Tarlinton; Ken Shortman
J Immunol (2013) 191 (10): 4919–4925.
View articletitled, Evolution of B Cell Responses to Clec9A-Targeted Antigen
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AUTOIMMUNITY

Molecular Basis of 9G4 B Cell Autoreactivity in Human Systemic Lupus Erythematosus
Christopher Richardson; Asiya Seema Chida; Diana Adlowitz; Lin Silver; Erin Fox; Scott A. Jenks; Elise Palmer; Youliang Wang; Jamie Heimburg-Molinaro; Quan-Zhen Li; Chandra Mohan; Richard Cummings; Christopher Tipton; Ignacio Sanz
J Immunol (2013) 191 (10): 4926–4939.
View articletitled, Molecular Basis of 9G4 B Cell Autoreactivity in Human Systemic Lupus Erythematosus
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Reduced Effectiveness of CD4+Foxp3+ Regulatory T Cells in CD28-Deficient NOD.H-2h4 Mice Leads to Increased Severity of Spontaneous Autoimmune Thyroiditis
Jason S. Ellis; So-Hee Hong; Habib Zaghouani; Helen Braley-Mullen
J Immunol (2013) 191 (10): 4940–4949.
View articletitled, Reduced Effectiveness of CD4<sup>+</sup>Foxp3<sup>+</sup> Regulatory T Cells in CD28-Deficient NOD.H-2h4 Mice Leads to Increased Severity of Spontaneous Autoimmune Thyroiditis
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T Cell–Independent Modulation of Experimental Autoimmune Encephalomyelitis in ADAP-Deficient Mice
Swen Engelmann; Mauro Togni; Anja Thielitz; Peter Reichardt; Stefanie Kliche; Dirk Reinhold; Burkhart Schraven; Annegret Reinhold
J Immunol (2013) 191 (10): 4950–4959.
View articletitled, T Cell–Independent Modulation of Experimental Autoimmune Encephalomyelitis in ADAP-Deficient Mice
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The Role of CD8+ T Cells and Their Local Interaction with CD4+ T Cells in Myelin Oligodendrocyte Glycoprotein35–55–Induced Experimental Autoimmune Encephalomyelitis
Tina Leuenberger; Magdalena Paterka; Eva Reuter; Josephine Herz; Raluca A. Niesner; Helena Radbruch; Tobias Bopp; Frauke Zipp; Volker Siffrin
J Immunol (2013) 191 (10): 4960–4968.
View articletitled, The Role of CD8<sup>+</sup> T Cells and Their Local Interaction with CD4<sup>+</sup> T Cells in Myelin Oligodendrocyte Glycoprotein<sub>35–55</sub>–Induced Experimental Autoimmune Encephalomyelitis
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A Novel Disease-Modifying Antirheumatic Drug, Iguratimod, Ameliorates Murine Arthritis by Blocking IL-17 Signaling, Distinct from Methotrexate and Leflunomide
Qiong Luo; Yang Sun; Wen Liu; Cheng Qian; Biao Jin; Feifei Tao; Yanhong Gu; Xingxin Wu; Yan Shen; Qiang Xu
J Immunol (2013) 191 (10): 4969–4978.
View articletitled, A Novel Disease-Modifying Antirheumatic Drug, Iguratimod, Ameliorates Murine Arthritis by Blocking IL-17 Signaling, Distinct from Methotrexate and Leflunomide
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Reduced T Cell–Dependent Humoral Immune Response in Microsomal Prostaglandin E Synthase-1 Null Mice Is Mediated by Nonhematopoietic Cells
Fumiaki Kojima; Andrey Frolov; Rahul Matnani; Jerold G. Woodward; Leslie J. Crofford
J Immunol (2013) 191 (10): 4979–4988.
View articletitled, Reduced T Cell–Dependent Humoral Immune Response in Microsomal Prostaglandin E Synthase-1 Null Mice Is Mediated by Nonhematopoietic Cells
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CLINICAL AND HUMAN IMMUNOLOGY

A Distinct Subpopulation of Human NK Cells Restricts B Cell Transformation by EBV
Anna Lünemann; Liliana D. Vanoaica; Tarik Azzi; David Nadal; Christian Münz
J Immunol (2013) 191 (10): 4989–4995.
View articletitled, A Distinct Subpopulation of Human NK Cells Restricts B Cell Transformation by EBV
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STAT-3 Activation by Differential Cytokines Is Critical for Human In Vivo–Generated Plasma Cell Survival and Ig Secretion
Beatriz Rodríguez-Bayona; Ana Ramos-Amaya; Rubén López-Blanco; Antonio Campos-Caro; José A. Brieva
J Immunol (2013) 191 (10): 4996–5004.
View articletitled, STAT-3 Activation by Differential Cytokines Is Critical for Human In Vivo–Generated Plasma Cell Survival and Ig Secretion
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IMMUNE REGULATION

Targeting Uptake Receptors on Human Plasmacytoid Dendritic Cells Triggers Antigen Cross-Presentation and Robust Type I IFN Secretion
Jurjen Tel; Simone P. Sittig; Rebecca A. M. Blom; Luis J. Cruz; Gerty Schreibelt; Carl G. Figdor; I. Jolanda M. de Vries
J Immunol (2013) 191 (10): 5005–5012.
View articletitled, Targeting Uptake Receptors on Human Plasmacytoid Dendritic Cells Triggers Antigen Cross-Presentation and Robust Type I IFN Secretion
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Antigen Modulation Confers Protection to Red Blood Cells from Antibody through Fcγ Receptor Ligation
Sean R. Stowell; Justine S. Liepkalns; Jeanne E. Hendrickson; Kathryn R. Girard-Pierce; Nicole H. Smith; C. Maridith Arthur; James C. Zimring
J Immunol (2013) 191 (10): 5013–5025.
View articletitled, Antigen Modulation Confers Protection to Red Blood Cells from Antibody through Fcγ Receptor Ligation
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Exogenous OX40 Stimulation during Lymphocytic Choriomeningitis Virus Infection Impairs Follicular Th Cell Differentiation and Diverts CD4 T Cells into the Effector Lineage by Upregulating Blimp-1
Tobias Boettler; Youn Soo Choi; Shahram Salek-Ardakani; Yang Cheng; Friedrich Moeckel; Michael Croft; Shane Crotty; Matthias von Herrath
J Immunol (2013) 191 (10): 5026–5035.
View articletitled, Exogenous OX40 Stimulation during Lymphocytic Choriomeningitis Virus Infection Impairs Follicular Th Cell Differentiation and Diverts CD4 T Cells into the Effector Lineage by Upregulating Blimp-1
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SOCS3 Deletion in T Lymphocytes Suppresses Development of Chronic Ocular Inflammation via Upregulation of CTLA-4 and Expansion of Regulatory T Cells
Cheng-Rong Yu; Sung-Hye Kim; Rashid M. Mahdi; Charles E. Egwuagu
J Immunol (2013) 191 (10): 5036–5043.
View articletitled, SOCS3 Deletion in T Lymphocytes Suppresses Development of Chronic Ocular Inflammation via Upregulation of CTLA-4 and Expansion of Regulatory T Cells
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IMMUNE SYSTEM DEVELOPMENT

Education of Murine NK Cells Requires Both cis and trans Recognition of MHC Class I Molecules
Stéphanie Bessoles; Georgi S. Angelov; Jonathan Back; Georges Leclercq; Eric Vivier; Werner Held
J Immunol (2013) 191 (10): 5044–5051.
View articletitled, Education of Murine NK Cells Requires Both <em>cis</em> and <em>trans</em> Recognition of MHC Class I Molecules
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Combined Deletion of Id2 and Id3 Genes Reveals Multiple Roles for E Proteins in Invariant NKT Cell Development and Expansion
Jia Li; Di Wu; Ning Jiang; Yuan Zhuang
J Immunol (2013) 191 (10): 5052–5064.
View articletitled, Combined Deletion of <em>Id2</em> and <em>Id3</em> Genes Reveals Multiple Roles for E Proteins in Invariant NKT Cell Development and Expansion
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Increased Level of E Protein Activity during Invariant NKT Development Promotes Differentiation of Invariant NKT2 and Invariant NKT17 Subsets
Taishan Hu; Hongcheng Wang; Amie Simmons; Sandra Bajaña; Ying Zhao; Susan Kovats; Xiao-Hong Sun; Jose Alberola-Ila
J Immunol (2013) 191 (10): 5065–5073.
View articletitled, Increased Level of E Protein Activity during Invariant NKT Development Promotes Differentiation of Invariant NKT2 and Invariant NKT17 Subsets
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IMMUNOTHERAPY AND VACCINES

Small Molecule Inhibitor of Antigen Binding and Presentation by HLA-DR2b as a Therapeutic Strategy for the Treatment of Multiple Sclerosis
Niannian Ji; Animesh Somanaboeina; Aakanksha Dixit; Kazuyuki Kawamura; Neil J. Hayward; Christopher Self; Gary L. Olson; Thomas G. Forsthuber
J Immunol (2013) 191 (10): 5074–5084.
View articletitled, Small Molecule Inhibitor of Antigen Binding and Presentation by HLA-DR2b as a Therapeutic Strategy for the Treatment of Multiple Sclerosis
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Coadministration of Polyinosinic:Polycytidylic Acid and Immunostimulatory Complexes Modifies Antigen Processing in Dendritic Cell Subsets and Enhances HIV Gag-Specific T Cell Immunity
Kylie M. Quinn; Ayako Yamamoto; Andreia Costa; Patricia A. Darrah; Ross W. B. Lindsay; Sonia T. Hegde; Teresa R. Johnson; Barbara J. Flynn; Karin Loré; Robert A. Seder
J Immunol (2013) 191 (10): 5085–5096.
View articletitled, Coadministration of Polyinosinic:Polycytidylic Acid and Immunostimulatory Complexes Modifies Antigen Processing in Dendritic Cell Subsets and Enhances HIV Gag-Specific T Cell Immunity
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Structure-Based Design of Altered MHC Class II–Restricted Peptide Ligands with Heterogeneous Immunogenicity
Shuming Chen; Yili Li; Florence R. Depontieu; Tracee L. McMiller; A. Michelle English; Jeffrey Shabanowitz; Ferdynand Kos; John Sidney; Alessandro Sette; Steven A. Rosenberg; Donald F. Hunt; Roy A. Mariuzza; Suzanne L. Topalian
J Immunol (2013) 191 (10): 5097–5106.
View articletitled, Structure-Based Design of Altered MHC Class II–Restricted Peptide Ligands with Heterogeneous Immunogenicity
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Selective Activation of Antigen-Experienced T Cells by Anti-CD3 Constrained on Nanoparticles
Ying-Chun Lo; Michael A. Edidin; Jonathan D. Powell
J Immunol (2013) 191 (10): 5107–5114.
View articletitled, Selective Activation of Antigen-Experienced T Cells by Anti-CD3 Constrained on Nanoparticles
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INFECTIOUS DISEASE AND HOST RESPONSE

Systemic Disease during Streptococcus pneumoniae Acute Lung Infection Requires 12-Lipoxygenase–Dependent Inflammation
Rudra Bhowmick; Nang H. Tin Maung; Bryan P. Hurley; Elsa Bou Ghanem; Karsten Gronert; Beth A. McCormick; John M. Leong
J Immunol (2013) 191 (10): 5115–5123.
View articletitled, Systemic Disease during <em>Streptococcus pneumoniae</em> Acute Lung Infection Requires 12-Lipoxygenase–Dependent Inflammation
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Asymptomatic HLA-A*02:01–Restricted Epitopes from Herpes Simplex Virus Glycoprotein B Preferentially Recall Polyfunctional CD8+ T Cells from Seropositive Asymptomatic Individuals and Protect HLA Transgenic Mice against Ocular Herpes
Xavier Dervillez; Huma Qureshi; Aziz A. Chentoufi; Arif A. Khan; Elizabeth Kritzer; David C. Yu; Oscar R. Diaz; Chetan Gottimukkala; Mina Kalantari; Maria C. Villacres; Vanessa M. Scarfone; Denise M. McKinney; John Sidney; Alessandro Sette; Anthony B. Nesburn; Steven L. Wechsler; Lbachir BenMohamed
J Immunol (2013) 191 (10): 5124–5138.
View articletitled, Asymptomatic HLA-A*02:01–Restricted Epitopes from Herpes Simplex Virus Glycoprotein B Preferentially Recall Polyfunctional CD8<sup>+</sup> T Cells from Seropositive Asymptomatic Individuals and Protect HLA Transgenic Mice against Ocular Herpes
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Disparate Epitopes Mediating Protective Heterologous Immunity to Unrelated Viruses Share Peptide–MHC Structural Features Recognized by Cross-Reactive T Cells
Zu T. Shen; Tina T. Nguyen; Keith A. Daniels; Raymond M. Welsh; Lawrence J. Stern
J Immunol (2013) 191 (10): 5139–5152.
View articletitled, Disparate Epitopes Mediating Protective Heterologous Immunity to Unrelated Viruses Share Peptide–MHC Structural Features Recognized by Cross-Reactive T Cells
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Influenza A Exacerbates Staphylococcus aureus Pneumonia by Attenuating IL-1β Production in Mice
Keven M. Robinson; Sun Mi Choi; Kevin J. McHugh; Sivanarayana Mandalapu; Richard I. Enelow; Jay K. Kolls; John F. Alcorn
J Immunol (2013) 191 (10): 5153–5159.
View articletitled, Influenza A Exacerbates <em>Staphylococcus aureus</em> Pneumonia by Attenuating IL-1β Production in Mice
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IFN-γ–Induced Priming Maintains Long-Term Strain-Transcending Immunity against Blood-Stage Plasmodium chabaudi Malaria
Henrique Borges da Silva; Érika Machado de Salles; Raquel Hoffmann Panatieri; Silvia Beatriz Boscardin; Sérgio Marcelo Rodríguez-Málaga; José Maria Álvarez; Maria Regina D’Império Lima
J Immunol (2013) 191 (10): 5160–5169.
View articletitled, IFN-γ–Induced Priming Maintains Long-Term Strain-Transcending Immunity against Blood-Stage <em>Plasmodium chabaudi</em> Malaria
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INNATE IMMUNITY AND INFLAMMATION

Novel Regulatory Action of Ribosomal Inactivation on Epithelial Nod2-Linked Proinflammatory Signals in Two Convergent ATF3-Associated Pathways
Seong-Hwan Park; Kee Hun Do; Hye Jin Choi; Juil Kim; Ki-Hyung Kim; Jiyeon Park; Chang Gyu Oh; Yuseok Moon
J Immunol (2013) 191 (10): 5170–5181.
View articletitled, Novel Regulatory Action of Ribosomal Inactivation on Epithelial Nod2-Linked Proinflammatory Signals in Two Convergent ATF3-Associated Pathways
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Wnt6 Is Expressed in Granulomatous Lesions of Mycobacterium tuberculosis–Infected Mice and Is Involved in Macrophage Differentiation and Proliferation
Kolja Schaale; Julius Brandenburg; Andreas Kispert; Michael Leitges; Stefan Ehlers; Norbert Reiling
J Immunol (2013) 191 (10): 5182–5195.
View articletitled, Wnt6 Is Expressed in Granulomatous Lesions of <em>Mycobacterium tuberculosis</em>–Infected Mice and Is Involved in Macrophage Differentiation and Proliferation
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Lipopolysaccharide Stimulates Platelets through an IL-1β Autocrine Loop
G. Thomas Brown; Padmini Narayanan; Wei Li; Roy L. Silverstein; Thomas M. McIntyre
J Immunol (2013) 191 (10): 5196–5203.
View articletitled, Lipopolysaccharide Stimulates Platelets through an IL-1β Autocrine Loop
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Phenotypic Polarization of Activated Astrocytes: The Critical Role of Lipocalin-2 in the Classical Inflammatory Activation of Astrocytes
Eunha Jang; Jong-Heon Kim; Shinrye Lee; Jae-Hong Kim; Jung-Wan Seo; Myungwon Jin; Maan-Gee Lee; Il-Sung Jang; Won-Ha Lee; Kyoungho Suk
J Immunol (2013) 191 (10): 5204–5219.
View articletitled, Phenotypic Polarization of Activated Astrocytes: The Critical Role of Lipocalin-2 in the Classical Inflammatory Activation of Astrocytes
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IL-13 Immunotoxin Accelerates Resolution of Lung Pathological Changes Triggered by Silica Particles in Mice
Tatiana Paula T. Ferreira; Ana Carolina S. de Arantes; Caio Victor M. F. do Nascimento; Priscilla C. Olsen; Patrícia G. Trentin; Patricia R. M. Rocco; Cory M. Hogaboam; Raj K. Puri; Marco Aurélio Martins; Patrícia Machado Rodrigues e Silva
J Immunol (2013) 191 (10): 5220–5229.
View articletitled, IL-13 Immunotoxin Accelerates Resolution of Lung Pathological Changes Triggered by Silica Particles in Mice
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Mitochondrial Reactive Oxygen Species Induces NLRP3-Dependent Lysosomal Damage and Inflammasome Activation
Michelle E. Heid; Peter A. Keyel; Christelle Kamga; Sruti Shiva; Simon C. Watkins; Russell D. Salter
J Immunol (2013) 191 (10): 5230–5238.
View articletitled, Mitochondrial Reactive Oxygen Species Induces NLRP3-Dependent Lysosomal Damage and Inflammasome Activation
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Salmonella Infection Induces Recruitment of Caspase-8 to the Inflammasome To Modulate IL-1β Production
Si Ming Man; Panagiotis Tourlomousis; Lee Hopkins; Tom P. Monie; Katherine A. Fitzgerald; Clare E. Bryant
J Immunol (2013) 191 (10): 5239–5246.
View articletitled, <em>Salmonella</em> Infection Induces Recruitment of Caspase-8 to the Inflammasome To Modulate IL-1β Production
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Targeting F Box Protein Fbxo3 To Control Cytokine-Driven Inflammation
Rama K. Mallampalli; Tiffany A. Coon; Jennifer R. Glasser; Claire Wang; Sarah R. Dunn; Nathaniel M. Weathington; Jing Zhao; Chunbin Zou; Yutong Zhao; Bill B. Chen
J Immunol (2013) 191 (10): 5247–5255.
View articletitled, Targeting F Box Protein Fbxo3 To Control Cytokine-Driven Inflammation
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Genome-Wide siRNA Screen Reveals a New Cellular Partner of NK Cell Receptor KIR2DL4: Heparan Sulfate Directly Modulates KIR2DL4-Mediated Responses
Michael Brusilovsky; Moti Cordoba; Benyamin Rosental; Oren Hershkovitz; Mark D. Andrake; Anna Pecherskaya; Margret B. Einarson; Yan Zhou; Alex Braiman; Kerry S. Campbell; Angel Porgador
J Immunol (2013) 191 (10): 5256–5267.
View articletitled, Genome-Wide siRNA Screen Reveals a New Cellular Partner of NK Cell Receptor KIR2DL4: Heparan Sulfate Directly Modulates KIR2DL4-Mediated Responses
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MOLECULAR AND STRUCTURAL IMMUNOLOGY

MAIT Recognition of a Stimulatory Bacterial Antigen Bound to MR1
Jacinto López-Sagaseta; Charles L. Dulberger; Amanda McFedries; Mark Cushman; Alan Saghatelian; Erin J. Adams
J Immunol (2013) 191 (10): 5268–5277.
View articletitled, MAIT Recognition of a Stimulatory Bacterial Antigen Bound to MR1
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MUCOSAL IMMUNOLOGY

Differential Uptake of Nanoparticles and Microparticles by Pulmonary APC Subsets Induces Discrete Immunological Imprints
Charles L. Hardy; Jeanne S. LeMasurier; Rohimah Mohamud; Jun Yao; Sue D. Xiang; Jennifer M. Rolland; Robyn E. O’Hehir; Magdalena Plebanski
J Immunol (2013) 191 (10): 5278–5290.
View articletitled, Differential Uptake of Nanoparticles and Microparticles by Pulmonary APC Subsets Induces Discrete Immunological Imprints
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TRANSPLANTATION

Induced Regulatory T Cells Promote Tolerance When Stabilized by Rapamycin and IL-2 In Vivo
Ping Zhang; Siok-Keen Tey; Motoko Koyama; Rachel D. Kuns; Stuart D. Olver; Katie E. Lineburg; Mary Lor; Bianca E. Teal; Neil C. Raffelt; Jyothy Raju; Lucie Leveque; Kate A. Markey; Antiopi Varelias; Andrew D. Clouston; Steven W. Lane; Kelli P. A. MacDonald; Geoffrey R. Hill
J Immunol (2013) 191 (10): 5291–5303.
View articletitled, Induced Regulatory T Cells Promote Tolerance When Stabilized by Rapamycin and IL-2 In Vivo
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TUMOR IMMUNOLOGY

Cooperativity of CD44 and CD49d in Leukemia Cell Homing, Migration, and Survival Offers a Means for Therapeutic Attack
Vibuthi Singh; Ulrike Erb; Margot Zöller
J Immunol (2013) 191 (10): 5304–5316.
View articletitled, Cooperativity of CD44 and CD49d in Leukemia Cell Homing, Migration, and Survival Offers a Means for Therapeutic Attack
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CORRECTIONS

Correction: Two phases of inflammatory mediator production defined by the study of IRAK2 and IRAK1 knock-in mice
Eduardo Pauls; Sambit K. Nanda; Hilary Smith; Rachel Toth; J. Simon C. Arthur; Philip Cohen
J Immunol (2013) 191 (10): 5317.
View articletitled, Correction: Two phases of inflammatory mediator production defined by the study of IRAK2 and IRAK1 knock-in mice
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Correction: T cell–derived IL-17 mediates epithelial changes in the airway and drives pulmonary neutrophilia
Laura K. Fogli; Mark S. Sundrud; Swati Goel; Sofia Bajwa; Kari Jensen; Emmanuel Derudder; Amy Sun; Maryaline Coffre; Catherine Uyttenhove; Jacques Van Snick; Marc Schmidt-Supprian; Anjana Rao; Gabriele Grunig; Joan Durbin; Stefano S. Casola; Klaus Rajewsky; Sergei B. Koralov
J Immunol (2013) 191 (10): 5318.
View articletitled, Correction: T cell–derived IL-17 mediates epithelial changes in the airway and drives pulmonary neutrophilia
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Correction: Tumor-infiltrating regulatory T cells inhibit endogenous cytotoxic T cell responses to lung adenocarcinoma
Anusha-Preethi Ganesan; Magnus Johansson; Brian Ruffell; Adam Yagui-Beltrán; Jonathan Lau; David M. Jablons; Lisa M. Coussens
J Immunol (2013) 191 (10): 5319.
View articletitled, Correction: Tumor-infiltrating regulatory T cells inhibit endogenous cytotoxic T cell responses to lung adenocarcinoma
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  • Cover Image

    Cover Image

    issue cover
    On the cover: Targeting Ag to Clec9A on dendritic cells results in early germinal center formation. Histology of a spleen section from a C57BL/6 mouse, 11 d postimmunization with hapten nitrophenol–conjugated anti-Clec9A monoclonal Ab. Immunization results in increased germinal center (blue) formation in the spleen B cell follicles (red). Park, H.-Y., A. Light, M. H. Lahoud, I. Caminschi, D. M. Tarlinton, and K. Shortman. 2013. Evolution of B cell responses to Clec9A-targeted antigen. J. Immunol. 191: 4919–4925.
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