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Issues
1 September 2013
ISSN 0022-1767
EISSN 1550-6606
In this Issue
IN THIS ISSUE
PILLARS OF IMMUNOLOGY
The Carrier Effect and T Cell/B Cell Cooperation in the Antibody Response
J Immunol (2013) 191 (5): 2025–2027.
BRIEF REVIEWS
Immune Dysfunction and Bacterial Coinfections following Influenza
J Immunol (2013) 191 (5): 2047–2052.
ALLERGY AND OTHER HYPERSENSITIVITIES
ANTIGEN RECOGNITION AND RESPONSES
AUTOIMMUNITY
Plasma B Lymphocyte Stimulator and B Cell Differentiation in Idiopathic Pulmonary Fibrosis Patients
Jianmin Xue; Daniel J. Kass; Jessica Bon; Louis Vuga; Jiangning Tan; Eva Csizmadia; Leo Otterbein; Makoto Soejima; Marc C. Levesque; Kevin F. Gibson; Naftali Kaminski; Joseph M. Pilewski; Michael Donahoe; Frank C. Sciurba; Steven R. Duncan
J Immunol (2013) 191 (5): 2089–2095.
A Small Shared Epitope–Mimetic Compound Potently Accelerates Osteoclast-Mediated Bone Damage in Autoimmune Arthritis
Jiaqi Fu; Song Ling; Ying Liu; Jianyi Yang; Shirly Naveh; Margaret Hannah; Chaim Gilon; Yang Zhang; Joseph Holoshitz
J Immunol (2013) 191 (5): 2096–2103.
Overexpression of Membrane-Bound Fas Ligand (CD95L) Exacerbates Autoimmune Disease and Renal Pathology in Pristane-Induced Lupus
Lukas Bossaller; Vijay A. K. Rathinam; Ramon Bonegio; Ping-I Chiang; Patricia Busto; Adam R. Wespiser; Daniel R. Caffrey; Quan-Zhen Li; Chandra Mohan; Katherine A. Fitzgerald; Eicke Latz; Ann Marshak-Rothstein
J Immunol (2013) 191 (5): 2104–2114.
Preventive and Therapeutic Effects of Adenanthin on Experimental Autoimmune Encephalomyelitis by Inhibiting NF-κB Signaling
Qian-Qian Yin; Chuan-Xu Liu; Ying-Li Wu; Shao-Fang Wu; Yan Wang; Xia Zhang; Xiao-Juan Hu; Jian-Xin Pu; Ying Lu; Hu-Chen Zhou; Hong-Lin Wang; Hong Nie; Han-Dong Sun; Guo-Qiang Chen
J Immunol (2013) 191 (5): 2115–2125.
Antimitochondrial Antibody Recognition and Structural Integrity of the Inner Lipoyl Domain of the E2 Subunit of Pyruvate Dehydrogenase Complex
Jinjun Wang; Madhu S. Budamagunta; John C. Voss; Mark J. Kurth; Kit S. Lam; Ling Lu; Thomas P. Kenny; Christopher Bowlus; Kentaro Kikuchi; Ross L. Coppel; Aftab A. Ansari; M. Eric Gershwin; Patrick S. C. Leung
J Immunol (2013) 191 (5): 2126–2133.
PTPN22 Modulates Macrophage Polarization and Susceptibility to Dextran Sulfate Sodium–Induced Colitis
Hui-Hsin Chang; Shi-Chuen Miaw; William Tseng; Yi-Wei Sun; Chih-Chun Liu; Hsiao-Wei Tsao; I-Cheng Ho
J Immunol (2013) 191 (5): 2134–2143.
Paradoxical Effect of Cortistatin Treatment and Its Deficiency on Experimental Autoimmune Encephalomyelitis
Luciana Souza-Moreira; Maria Morell; Virginia Delgado-Maroto; Marta Pedreño; Laura Martinez-Escudero; Marta Caro; Francisco O’Valle; Raul Luque; Milagros Gallo; Luis de Lecea; Justo P. Castaño; Elena Gonzalez-Rey
J Immunol (2013) 191 (5): 2144–2154.
Spontaneous Loss of Tolerance of Autoreactive B Cells in Act1-Deficient Rheumatoid Factor Transgenic Mice
J Immunol (2013) 191 (5): 2155–2163.
CLINICAL AND HUMAN IMMUNOLOGY
Mucosal Th17 Cell Function Is Altered during HIV Infection and Is an Independent Predictor of Systemic Immune Activation
Connie J. Kim; Lyle R. McKinnon; Colin Kovacs; Gabor Kandel; Sanja Huibner; Duncan Chege; Kamnoosh Shahabi; Erika Benko; Mona Loutfy; Mario Ostrowski; Rupert Kaul
J Immunol (2013) 191 (5): 2164–2173.
Bacterial CD1d–Restricted Glycolipids Induce IL-10 Production by Human Regulatory T Cells upon Cross-Talk with Invariant NKT Cells
J Immunol (2013) 191 (5): 2174–2183.
Programmed Death-1 Is a Marker for Abnormal Distribution of Naive/Memory T Cell Subsets in HIV-1 Infection
Gaëlle Breton; Nicolas Chomont; Hiroshi Takata; Rémi Fromentin; Jeffrey Ahlers; Abdelali Filali-Mouhim; Catherine Riou; Mohamed-Rachid Boulassel; Jean-Pierre Routy; Bader Yassine-Diab; Rafick-Pierre Sékaly
J Immunol (2013) 191 (5): 2194–2204.
A Restricted Role for TYK2 Catalytic Activity in Human Cytokine Responses Revealed by Novel TYK2-Selective Inhibitors
Sue J. Sohn; Kathy Barrett; Anne Van Abbema; Christine Chang; Pawan Bir Kohli; Hidenobu Kanda; Janice Smith; Yingjie Lai; Aihe Zhou; Birong Zhang; Wenqian Yang; Karen Williams; Calum Macleod; Christopher A. Hurley; Janusz J. Kulagowski; Nicholas Lewin-Koh; Hart S. Dengler; Adam R. Johnson; Nico Ghilardi; Mark Zak; Jun Liang; Wade S. Blair; Steven Magnuson; Lawren C. Wu
J Immunol (2013) 191 (5): 2205–2216.
Phenotype and Function of T Cells Infiltrating Visceral Metastases from Gastrointestinal Cancers and Melanoma: Implications for Adoptive Cell Transfer Therapy
Simon Turcotte; Alena Gros; Katherine Hogan; Eric Tran; Christian S. Hinrichs; John R. Wunderlich; Mark E. Dudley; Steven A. Rosenberg
J Immunol (2013) 191 (5): 2217–2225.
Uterine NK Cells Regulate Endometrial Bleeding in Women and Are Suppressed by the Progesterone Receptor Modulator Asoprisnil
Julia Wilkens; Victoria Male; Peter Ghazal; Thorsten Forster; Douglas A. Gibson; Alistair R. W. Williams; Savita L. Brito-Mutunayagam; Marie Craigon; Paula Lourenco; Iain T. Cameron; Kristof Chwalisz; Ashley Moffett; Hilary O. D. Critchley
J Immunol (2013) 191 (5): 2226–2235.
Mechanistic Target of Rapamycin Activation Triggers IL-4 Production and Necrotic Death of Double-Negative T Cells in Patients with Systemic Lupus Erythematosus
Zhi-Wei Lai; Rebecca Borsuk; Ashwini Shadakshari; Jianghong Yu; Maha Dawood; Ricardo Garcia; Lisa Francis; Hajra Tily; Adam Bartos; Stephen V. Faraone; Paul Phillips; Andras Perl
J Immunol (2013) 191 (5): 2236–2246.
IMMUNE REGULATION
TWEAK Inhibits TRAF2-Mediated CD40 Signaling by Destabilization of CD40 Signaling Complexes
Steffen Salzmann; Isabell Lang; Alevtina Rosenthal; Viktoria Schäfer; Daniela Weisenberger; José Antonio Carmona Arana; Johannes Trebing; Daniela Siegmund; Manfred Neumann; Harald Wajant
J Immunol (2013) 191 (5): 2308–2318.
Serine Protease Inhibitor 6 Plays a Critical Role in Protecting Murine Granzyme B–Producing Regulatory T Cells
Jamil Azzi; Nikolaos Skartsis; Marwan Mounayar; Ciara N. Magee; Ibrahim Batal; Christopher Ting; Robert Moore; Leonardo V. Riella; Shunsuke Ohori; Rozita Abdoli; Brian Smith; Paolo Fiorina; Dean Heathcote; Tannous Bakhos; Philip G. Ashton-Rickardt; Reza Abdi
J Immunol (2013) 191 (5): 2319–2327.
Notch Signaling Regulates Follicular Helper T Cell Differentiation
Floriane Auderset; Steffen Schuster; Nicolas Fasnacht; Manuel Coutaz; Mélanie Charmoy; Ute Koch; Stéphanie Favre; Anne Wilson; François Trottein; James Alexander; Sanjiv A. Luther; H. Robson MacDonald; Freddy Radtke; Fabienne Tacchini-Cottier
J Immunol (2013) 191 (5): 2344–2350.
Transcription Factor Early Growth Response 3 Is Associated with the TGF-β1 Expression and the Regulatory Activity of CD4-Positive T Cells In Vivo
Shuji Sumitomo; Keishi Fujio; Tomohisa Okamura; Kaoru Morita; Kazuyoshi Ishigaki; Keigo Suzukawa; Kaori Kanaya; Kenji Kondo; Tatsuya Yamasoba; Asayo Furukawa; Noburou Kitahara; Hirofumi Shoda; Mihoko Shibuya; Akiko Okamoto; Kazuhiko Yamamoto
J Immunol (2013) 191 (5): 2351–2359.
Smad2/3 and IRF4 Play a Cooperative Role in IL-9–Producing T Cell Induction
Taiga Tamiya; Kenji Ichiyama; Hitoshi Kotani; Tomohiro Fukaya; Takashi Sekiya; Takashi Shichita; Kiri Honma; Katsuyuki Yui; Toshifumi Matsuyama; Takako Nakao; Satoru Fukuyama; Hiromasa Inoue; Masatoshi Nomura; Akihiko Yoshimura
J Immunol (2013) 191 (5): 2360–2371.
Multistage T Cell–Dendritic Cell Interactions Control Optimal CD4 T Cell Activation through the ADAP-SKAP55–Signaling Module
J Immunol (2013) 191 (5): 2372–2383.
IMMUNE SYSTEM DEVELOPMENT
Differential Postselection Proliferation Dynamics of αβ T Cells, Foxp3+ Regulatory T Cells, and Invariant NKT Cells Monitored by Genetic Pulse Labeling
Lisa Föhse; Annika Reinhardt; Linda Oberdörfer; Susanne Schmitz; Reinhold Förster; Bernard Malissen; Immo Prinz
J Immunol (2013) 191 (5): 2384–2392.
IMMUNOGENETICS
Deep Sequencing of the Murine Igh Repertoire Reveals Complex Regulation of Nonrandom V Gene Rearrangement Frequencies
Nancy M. Choi; Salvatore Loguercio; Jiyoti Verma-Gaur; Stephanie C. Degner; Ali Torkamani; Andrew I. Su; Eugene M. Oltz; Maxim Artyomov; Ann J. Feeney
J Immunol (2013) 191 (5): 2393–2402.
IMMUNOTHERAPY AND VACCINES
Immunization with a Chimera Consisting of the B Subunit of Shiga Toxin Type 2 and Brucella Lumazine Synthase Confers Total Protection against Shiga Toxins in Mice
María P. Mejias; Giselle Ghersi; Patricio O. Craig; Cecilia A. Panek; Leticia V. Bentancor; Ariela Baschkier; Fernando A. Goldbaum; Vanesa Zylberman; Marina S. Palermo
J Immunol (2013) 191 (5): 2403–2411.
Tick-Borne Encephalitis (TBE) and Hepatitis B Nonresponders Feature Different Immunologic Mechanisms in Response to TBE and Influenza Vaccination with Involvement of Regulatory T and B Cells and IL-10
Erika Garner-Spitzer; Angelika Wagner; Maria Paulke-Korinek; Herwig Kollaritsch; Franz X. Heinz; Monika Redlberger-Fritz; Karin Stiasny; Gottfried F. Fischer; Michael Kundi; Ursula Wiedermann
J Immunol (2013) 191 (5): 2426–2436.
Synergistic Chemoimmunotherapy of Epithelial Ovarian Cancer Using ErbB-Retargeted T Cells Combined with Carboplatin
Ana C. Parente-Pereira; Lynsey M. Whilding; Nancy Brewig; Sjoukje J. C. van der Stegen; David M. Davies; Scott Wilkie; May C. I. van Schalkwyk; Sadaf Ghaem-Maghami; John Maher
J Immunol (2013) 191 (5): 2437–2445.
INFECTIOUS DISEASE AND HOST RESPONSE
IL-4–, TGF-β–, and IL-1–Dependent Expansion of Parasite Antigen-Specific Th9 Cells Is Associated with Clinical Pathology in Human Lymphatic Filariasis
Rajamanickam Anuradha; Parakkal Jovvian George; Luke E. Hanna; Vedachalam Chandrasekaran; Paul Kumaran; Thomas B. Nutman; Subash Babu
J Immunol (2013) 191 (5): 2466–2473.
Protection against Tuberculosis with Homologous or Heterologous Protein/Vector Vaccine Approaches Is Not Dependent on CD8+ T Cells
Susan L. Baldwin; Lance K. Ching; Samuel O. Pine; Magdalini Moutaftsi; Elyse Lucas; Aarthy Vallur; Mark T. Orr; Sylvie Bertholet; Steven G. Reed; Rhea N. Coler
J Immunol (2013) 191 (5): 2514–2525.
Induction of HIV-1 Broad Neutralizing Antibodies in 2F5 Knock-in Mice: Selection against Membrane Proximal External Region–Associated Autoreactivity Limits T-Dependent Responses
Laurent Verkoczy; Yao Chen; Jinsong Zhang; Hilary Bouton-Verville; Amanda Newman; Bradley Lockwood; Richard M. Scearce; David C. Montefiori; S. Moses Dennison; Shi-Mao Xia; Kwan-Ki Hwang; Hua-Xin Liao; S. Munir Alam; Barton F. Haynes
J Immunol (2013) 191 (5): 2538–2550.
Negative Charges in the Flexible N-Terminal Domain of Rho GDP-Dissociation Inhibitors (RhoGDIs) Regulate the Targeting of the RhoGDI–Rac1 Complex to Membranes
Takehiko Ueyama; Jeonghyun Son; Takeshi Kobayashi; Takeshi Hamada; Takashi Nakamura; Hirofumi Sakaguchi; Toshihiko Shirafuji; Naoaki Saito
J Immunol (2013) 191 (5): 2560–2569.
Selective Induction of CTL Helper Rather Than Killer Activity by Natural Epitope Variants Promotes Dendritic Cell–Mediated HIV-1 Dissemination
Robbie B. Mailliard; Kellie N. Smith; Ronald J. Fecek; Giovanna Rappocciolo; Eduardo J. M. Nascimento; Ernesto T. Marques; Simon C. Watkins; James I. Mullins; Charles R. Rinaldo
J Immunol (2013) 191 (5): 2570–2580.
INNATE IMMUNITY AND INFLAMMATION
YB-1 Is an Early and Central Mediator of Bacterial and Sterile Inflammation In Vivo
Lydia Hanssen; Christina Alidousty; Sonja Djudjaj; Björn C. Frye; Thomas Rauen; Peter Boor; Peter R. Mertens; Claudia R. van Roeyen; Frank Tacke; Felix Heymann; Andre P. Tittel; Alexander Koch; Jürgen Floege; Tammo Ostendorf; Ute Raffetseder
J Immunol (2013) 191 (5): 2604–2613.
Enhancer of Zeste Homolog 2 Is a Negative Regulator of Mitochondria-Mediated Innate Immune Responses
Shuai Chen; Chunjie Sheng; Dong Liu; Chen Yao; Shijuan Gao; Liping Song; Wei Jiang; Jiandong Li; Wenlin Huang
J Immunol (2013) 191 (5): 2614–2623.
Role of Ribonuclease L in Viral Pathogen-Associated Molecular Pattern/Influenza Virus and Cigarette Smoke–Induced Inflammation and Remodeling
J Immunol (2013) 191 (5): 2637–2646.
Macrophage Clearance of Neutrophil Extracellular Traps Is a Silent Process
J Immunol (2013) 191 (5): 2647–2656.
TLR2 Signaling in Tubular Epithelial Cells Regulates NK Cell Recruitment in Kidney Ischemia–Reperfusion Injury
Hye J. Kim; Jong S. Lee; Ahra Kim; Sumi Koo; Hee J. Cha; Jae-A Han; Yoonkyung Do; Kyung M. Kim; Byoung S. Kwon; Robert S. Mittler; Hong R. Cho; Byungsuk Kwon
J Immunol (2013) 191 (5): 2657–2664.
Histones Activate the NLRP3 Inflammasome in Kupffer Cells during Sterile Inflammatory Liver Injury
Hai Huang; Hui-Wei Chen; John Evankovich; Wei Yan; Brian R. Rosborough; Gary W. Nace; Qing Ding; Patricia Loughran; Donna Beer-Stolz; Timothy R. Billiar; Charles T. Esmon; Allan Tsung
J Immunol (2013) 191 (5): 2665–2679.
Kinase AKT1 Negatively Controls Neutrophil Recruitment and Function in Mice
Guangwei Liu; Yujing Bi; Ruoning Wang; Bo Shen; Yan Zhang; Hui Yang; Xiao Wang; Huanrong Liu; Yun Lu; Fei Han
J Immunol (2013) 191 (5): 2680–2690.
Amplified NKG2C+ NK Cells in Cytomegalovirus (CMV) Infection Preferentially Express Killer Cell Ig-like Receptor 2DL: Functional Impact in Controlling CMV-Infected Dendritic Cells
Zakia Djaoud; Gaëlle David; Céline Bressollette; Catherine Willem; Pauline Rettman; Katia Gagne; Nolwenn Legrand; Souad Mehlal; Anne Cesbron; Berthe-Marie Imbert-Marcille; Christelle Retière
J Immunol (2013) 191 (5): 2708–2716.
MOLECULAR AND STRUCTURAL IMMUNOLOGY
Differential Roles of CXCL2 and CXCL3 and Their Receptors in Regulating Normal and Asthmatic Airway Smooth Muscle Cell Migration
Laila A. Al-Alwan; Ying Chang; Andrea Mogas; Andrew J. Halayko; Carolyn J. Baglole; James G. Martin; Simon Rousseau; David H. Eidelman; Qutayba Hamid
J Immunol (2013) 191 (5): 2731–2741.
MUCOSAL IMMUNOLOGY
Proinflammatory Vδ2+ T Cells Populate the Human Intestinal Mucosa and Enhance IFN-γ Production by Colonic αβ T Cells
Neil E. McCarthy; Zora Bashir; Anna Vossenkämper; Charlotte R. Hedin; Edward M. Giles; Shaumick Bhattacharjee; Sabrina G. Brown; Theodore J. Sanders; Kevin Whelan; Thomas T. MacDonald; James O. Lindsay; Andrew J. Stagg
J Immunol (2013) 191 (5): 2752–2763.
Activation of p38α in T Cells Regulates the Intestinal Host Defense against Attaching and Effacing Bacterial Infections
Eun-Jin Shim; Bo-Ram Bang; Seung-Goo Kang; Jianhui Ma; Motoyuki Otsuka; Jiman Kang; Martin Stahl; Jiahuai Han; Changchun Xiao; Bruce A. Vallance; Young Jun Kang
J Immunol (2013) 191 (5): 2764–2770.
TRANSPLANTATION
Identification of the Tetraspanin CD82 as a New Barrier to Xenotransplantation
Soad M. Saleh; Ranjit S. Parhar; Reem S. Al-Hejailan; Razan H. Bakheet; Hala S. Khaleel; Hanif G. Khalak; Anason S. Halees; Marya Z. Zaidi; Brian F. Meyer; Gisella P. Yung; Jörg D. Seebach; Walter Conca; Khalid S. Khabar; Kate S. Collison; Futwan A. Al-Mohanna
J Immunol (2013) 191 (5): 2796–2805.
In Kidney Transplant Patients, Alemtuzumab but Not Basiliximab/Low-Dose Rabbit Anti-Thymocyte Globulin Induces B Cell Depletion and Regeneration, Which Associates with a High Incidence of De Novo Donor-Specific Anti-HLA Antibody Development
Marta Todeschini; Monica Cortinovis; Norberto Perico; Francesca Poli; Annalisa Innocente; Regiane Aparecida Cavinato; Eliana Gotti; Piero Ruggenenti; Flavio Gaspari; Marina Noris; Giuseppe Remuzzi; Federica Casiraghi
J Immunol (2013) 191 (5): 2818–2828.
TUMOR IMMUNOLOGY
Soluble CD80 Restores T Cell Activation and Overcomes Tumor Cell Programmed Death Ligand 1–Mediated Immune Suppression
J Immunol (2013) 191 (5): 2829–2836.
Proteasome Inhibition by Bortezomib Increases IL-8 Expression in Androgen-Independent Prostate Cancer Cells: The Role of IKKα
Subrata Manna; Bipradeb Singha; Sai Aung Phyo; Himavanth Reddy Gatla; Tzu-Pei Chang; Shannon Sanacora; Sitharam Ramaswami; Ivana Vancurova
J Immunol (2013) 191 (5): 2837–2846.
CORRECTIONS
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Cover Image
Cover Image
![issue cover]()
On the cover: An electron micrograph (6000×) capturing the interaction of an HIV-1–specific CTL (center) with a dendritic cell (DC) expressing cross-reactive HIV-1 variant Ag. The bidirectional activation of both cell types results in dramatic morphological changes in the DC, highlighted by the appearance of interconnected web-like extensions. (Courtesy of Colleen Zaccard and Donna Stolz.) Mailliard, R. B., K. N. Smith, R. J. Fecek, G. Rappocciolo, E. J. M. Nascimento, E. T. Marques, S. C. Watkins, J. I. Mullins, and C. R. Rinaldo. 2013. Selective induction of CTL helper rather than killer activity by natural epitope variants promotes dendritic cell–mediated HIV-1 dissemination. J. Immunol. 191: 2570–2580.
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