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Volume 192, Issue 9
1 May 2014
Issue Cover
ISSN 0022-1767
EISSN 1550-6606
In this Issue
Engineering of a Novel Anti-CD40L Domain Antibody for Treatment of Autoimmune Diseases
Jenny H. Xie; Aaron P. Yamniuk; Virna Borowski; Robert Kuhn; Vojkan Susulic; Sandra Rex-Rabe; Xiaoxia Yang; Xiadi Zhou; Yifan Zhang; Kathleen Gillooly; Ruth Brosius; Rathna Ravishankar; Kimberly Waggie; Kathy Mink; Laura Price; Robert Rehfuss; James Tamura; Yongmi An; Lin Cheng; Bozena Abramczyk; Olga Ignatovich; Philip Drew; Steven Grant; James W. Bryson; Suzanne Suchard; Luisa Salter-Cid; Steven Nadler; Anish Suri
J Immunol (2014) 192 (9): 4083–4092.
View articletitled, Engineering of a Novel Anti-CD40L Domain Antibody for Treatment of Autoimmune Diseases
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Integrin α4β1 Is Necessary for CD4+ T Cell–Mediated Protection against Genital Chlamydia trachomatis Infection
Sergio J. Davila; Andrew J. Olive; Michael N. Starnbach
J Immunol (2014) 192 (9): 4284–4293.
View articletitled, Integrin α<sub>4</sub>β<sub>1</sub> Is Necessary for CD4<sup>+</sup> T Cell–Mediated Protection against Genital <em>Chlamydia trachomatis</em> Infection
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Contrasted Innate Responses to Two Viruses in Zebrafish: Insights into the Ancestral Repertoire of Vertebrate IFN-Stimulated Genes
Valérie Briolat; Luc Jouneau; Ralph Carvalho; Nuno Palha; Christelle Langevin; Philippe Herbomel; Olivier Schwartz; Herman P. Spaink; Jean-Pierre Levraud; Pierre Boudinot
J Immunol (2014) 192 (9): 4328–4341.
View articletitled, Contrasted Innate Responses to Two Viruses in Zebrafish: Insights into the Ancestral Repertoire of Vertebrate IFN-Stimulated Genes
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High Molecular Weight Kininogen Binds Phosphatidylserine and Opsonizes Urokinase Plasminogen Activator Receptor–Mediated Efferocytosis
Aizhen Yang; Jihong Dai; Zhanli Xie; Robert W. Colman; Qingyu Wu; Raymond B. Birge; Yi Wu
J Immunol (2014) 192 (9): 4398–4408.
View articletitled, High Molecular Weight Kininogen Binds Phosphatidylserine and Opsonizes Urokinase Plasminogen Activator Receptor–Mediated Efferocytosis
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Mechanistic Target of Rapamycin Complex 1 Expands Th17 and IL-4+ CD4−CD8− Double-Negative T Cells and Contracts Regulatory T Cells in Systemic Lupus Erythematosus
Hiroshi Kato; Andras Perl
J Immunol (2014) 192 (9): 4134–4144.
View articletitled, Mechanistic Target of Rapamycin Complex 1 Expands Th17 and IL-4<sup>+</sup> CD4<sup>−</sup>CD8<sup>−</sup> Double-Negative T Cells and Contracts Regulatory T Cells in Systemic Lupus Erythematosus
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A Novel Mechanism Underlying the Basic Defensive Response of Macrophages against Mycobacterium Infection
Takuya Iyoda; Muneaki Takada; Yoshinobu Fukatsu; Shunsuke Kumokoshi; Tatsuya Fujisawa; Tomokazu Shimada; Noriko Shimokawa; Takuya Matsunaga; Kimiko Makino; Norio Doi; Hiroshi Terada; Fumio Fukai
J Immunol (2014) 192 (9): 4254–4262.
View articletitled, A Novel Mechanism Underlying the Basic Defensive Response of Macrophages against <em>Mycobacterium</em> Infection
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Conservation of Pathogenic TCR Homology across Class II Restrictions in Anti-Ribonucleoprotein Autoimmunity: Extended Efficacy of T Cell Vaccine Therapy
YunJuan Zang; Laisel Martinez; Irina Fernandez; Judith Pignac-Kobinger; Eric L. Greidinger
J Immunol (2014) 192 (9): 4093–4102.
View articletitled, Conservation of Pathogenic TCR Homology across Class II Restrictions in Anti-Ribonucleoprotein Autoimmunity: Extended Efficacy of T Cell Vaccine Therapy
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Reduced Regulatory T Cell Diversity in NOD Mice Is Linked to Early Events in the Thymus
Cristina Ferreira; Donald Palmer; Kenneth Blake; Oliver A. Garden; Julian Dyson
J Immunol (2014) 192 (9): 4145–4152.
View articletitled, Reduced Regulatory T Cell Diversity in NOD Mice Is Linked to Early Events in the Thymus
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Human Procaspase-1 Variants with Decreased Enzymatic Activity Are Associated with Febrile Episodes and May Contribute to Inflammation via RIP2 and NF-κB Signaling
Michael C. Heymann; Stefan Winkler; Hella Luksch; Silvana Flecks; Marcus Franke; Susanne Ruß; Seza Özen; Engin Yilmaz; Christoph Klein; Tilmann Kallinich; Dirk Lindemann; Sebastian Brenner; Gerd Ganser; Joachim Roesler; Angela Rösen-Wolff; Sigrun R. Hofmann
J Immunol (2014) 192 (9): 4379–4385.
View articletitled, Human Procaspase-1 Variants with Decreased Enzymatic Activity Are Associated with Febrile Episodes and May Contribute to Inflammation via RIP2 and NF-κB Signaling
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Cell Depletion in Mice That Express Diphtheria Toxin Receptor under the Control of SiglecH Encompasses More Than Plasmacytoid Dendritic Cells
Melissa Swiecki; Yaming Wang; Elena Riboldi; Alfred H. J. Kim; Amiran Dzutsev; Susan Gilfillan; William Vermi; Christiane Ruedl; Giorgio Trinchieri; Marco Colonna
J Immunol (2014) 192 (9): 4409–4416.
View articletitled, Cell Depletion in Mice That Express Diphtheria Toxin Receptor under the Control of SiglecH Encompasses More Than Plasmacytoid Dendritic Cells
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CD20+ B Cell Depletion Alters T Cell Homing
Yolanda S. Kap; Nikki van Driel; Jon D. Laman; Paul P. Tak; Bert A. ’t Hart
J Immunol (2014) 192 (9): 4242–4253.
View articletitled, CD20<sup>+</sup> B Cell Depletion Alters T Cell Homing
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TLR4 Ligands Lipopolysaccharide and Monophosphoryl Lipid A Differentially Regulate Effector and Memory CD8+ T Cell Differentiation
Weiguo Cui; Nikhil S. Joshi; Ying Liu; Hailong Meng; Steven H. Kleinstein; Susan M. Kaech
J Immunol (2014) 192 (9): 4221–4232.
View articletitled, TLR4 Ligands Lipopolysaccharide and Monophosphoryl Lipid A Differentially Regulate Effector and Memory CD8<sup>+</sup> T Cell Differentiation
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Synergistic Therapeutic Vascular Cytoprotection against Complement-Mediated Injury Induced via a PKCα-, AMPK-, and CREB-Dependent Pathway
Shahir S. Hamdulay; Bufei Wang; Damien Calay; Allan P. Kiprianos; Jennifer Cole; Odile Dumont; Nicola Dryden; Anna M. Randi; Clare C. Thornton; Fahad Al-Rashed; Caroline Hoong; Aamir Shamsi; Zilei Liu; Vijay R. Holla; Joseph J. Boyle; Dorian O. Haskard; Justin C. Mason
J Immunol (2014) 192 (9): 4316–4327.
View articletitled, Synergistic Therapeutic Vascular Cytoprotection against Complement-Mediated Injury Induced via a PKCα-, AMPK-, and CREB-Dependent Pathway
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The Influenza Virus–Specific CTL Immunodominance Hierarchy in Mice Is Determined by the Relative Frequency of High-Avidity T Cells
Tania Cukalac; Jesseka Chadderton; Weiguang Zeng; Jolie G. Cullen; Wan Ting Kan; Peter C. Doherty; David C. Jackson; Stephen J. Turner; Nicole L. La Gruta
J Immunol (2014) 192 (9): 4061–4068.
View articletitled, The Influenza Virus–Specific CTL Immunodominance Hierarchy in Mice Is Determined by the Relative Frequency of High-Avidity T Cells
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Regulatory CD4+ T Cells Promote B Cell Anergy in Murine Lupus
Yaoyang Liu; Aijing Liu; Noriko Iikuni; Huji Xu; Fu-Dong Shi; Antonio La Cava
J Immunol (2014) 192 (9): 4069–4073.
View articletitled, Regulatory CD4<sup>+</sup> T Cells Promote B Cell Anergy in Murine Lupus
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Molecular Mechanisms of TLR2-Mediated Antigen Cross-Presentation in Dendritic Cells
Kuan-Yin Shen; Ying-Chyi Song; I-Hua Chen; Chih-Hsiang Leng; Hsin-Wei Chen; Hui-Ju Li; Pele Chong; Shih-Jen Liu
J Immunol (2014) 192 (9): 4233–4241.
View articletitled, Molecular Mechanisms of TLR2-Mediated Antigen Cross-Presentation in Dendritic Cells
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Naive Idiotope-Specific B and T Cells Collaborate Efficiently in the Absence of Dendritic Cells
Johanne Jacobsen; Ole-Audun Werner Haabeth; Anders Aune Tveita; Karoline W. Schjetne; Ludvig A. Munthe; Bjarne Bogen
J Immunol (2014) 192 (9): 4174–4183.
View articletitled, Naive Idiotope-Specific B and T Cells Collaborate Efficiently in the Absence of Dendritic Cells
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Multiple CD11c+ Cells Collaboratively Express IL-1β To Modulate Stromal Vascular Endothelial Growth Factor and Lymph Node Vascular–Stromal Growth
Fairouz Benahmed; Susan Chyou; Dragos Dasoveanu; Jingfeng Chen; Varsha Kumar; Yoichiro Iwakura; Theresa T. Lu
J Immunol (2014) 192 (9): 4153–4163.
View articletitled, Multiple CD11c<sup>+</sup> Cells Collaboratively Express IL-1β To Modulate Stromal Vascular Endothelial Growth Factor and Lymph Node Vascular–Stromal Growth
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Congenital Heart Disease Linked to Maternal Autoimmunity against Cardiac Myosin
Charles R. Cole; Katherine E. Yutzey; Anoop K. Brar; Lisa S. Goessling; Sarah J. VanVickle-Chavez; Madeleine W. Cunningham; Pirooz Eghtesady
J Immunol (2014) 192 (9): 4074–4082.
View articletitled, Congenital Heart Disease Linked to Maternal Autoimmunity against Cardiac Myosin
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Age-Enhanced Endoplasmic Reticulum Stress Contributes to Increased Atg9A Inhibition of STING-Mediated IFN-β Production during Streptococcus pneumoniae Infection
Dana N. Mitzel; Virginia Lowry; Anushree C. Shirali; Yushi Liu; Heather W. Stout-Delgado
J Immunol (2014) 192 (9): 4273–4283.
View articletitled, Age-Enhanced Endoplasmic Reticulum Stress Contributes to Increased Atg9A Inhibition of STING-Mediated IFN-β Production during <em>Streptococcus pneumoniae</em> Infection
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SAP Facilitates Recruitment and Activation of LCK at NTB-A Receptors during Restimulation-Induced Cell Death
Gil Katz; Scott M. Krummey; Sasha E. Larsen; Jeffrey R. Stinson; Andrew L. Snow
J Immunol (2014) 192 (9): 4202–4209.
View articletitled, SAP Facilitates Recruitment and Activation of LCK at NTB-A Receptors during Restimulation-Induced Cell Death
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CTLA-4 Is Expressed by Activated Mouse NK Cells and Inhibits NK Cell IFN-γ Production in Response to Mature Dendritic Cells
Ana Stojanovic; Nathalie Fiegler; Monika Brunner-Weinzierl; Adelheid Cerwenka
J Immunol (2014) 192 (9): 4184–4191.
View articletitled, CTLA-4 Is Expressed by Activated Mouse NK Cells and Inhibits NK Cell IFN-γ Production in Response to Mature Dendritic Cells
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Periodontal Pathogens Directly Promote Autoimmune Experimental Arthritis by Inducing a TLR2- and IL-1–Driven Th17 Response
Sabrina G. de Aquino; Shahla Abdollahi-Roodsaz; Marije I. Koenders; Fons A. J. van de Loo; Ger J. M. Pruijn; Renoud J. Marijnissen; Birgitte Walgreen; Monique M. Helsen; Liduine A. van den Bersselaar; Rafael S. de Molon; Mario J. Avila Campos; Fernando Q. Cunha; Joni A. Cirelli; Wim B. van den Berg
J Immunol (2014) 192 (9): 4103–4111.
View articletitled, Periodontal Pathogens Directly Promote Autoimmune Experimental Arthritis by Inducing a TLR2- and IL-1–Driven Th17 Response
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β7 Integrin Controls Mast Cell Recruitment, whereas αE Integrin Modulates the Number and Function of CD8+ T Cells in Immune Complex–Mediated Tissue Injury
Daisuke Yamada; Takafumi Kadono; Yuri Masui; Koichi Yanaba; Shinichi Sato
J Immunol (2014) 192 (9): 4112–4121.
View articletitled, β7 Integrin Controls Mast Cell Recruitment, whereas αE Integrin Modulates the Number and Function of CD8<sup>+</sup> T Cells in Immune Complex–Mediated Tissue Injury
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Wnt5a–Rac1–NF-κB Homeostatic Circuitry Sustains Innate Immune Functions in Macrophages
Debdut Naskar; George Maiti; Arijit Chakraborty; Arunava Roy; Dhrubajyoti Chattopadhyay; Malini Sen
J Immunol (2014) 192 (9): 4386–4397.
View articletitled, Wnt5a–Rac1–NF-κB Homeostatic Circuitry Sustains Innate Immune Functions in Macrophages
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BAFF Suppresses IL-15 Expression in B Cells
Ning Ma; Chen Xing; He Xiao; Youdi He; Gencheng Han; Guojiang Chen; Chunmei Hou; Bernadette Marrero; Yujuan Wang; Shengquan Zhang; Beifen Shen; Yan Li; Renxi Wang
J Immunol (2014) 192 (9): 4192–4201.
View articletitled, BAFF Suppresses IL-15 Expression in B Cells
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JAK2-STAT3 Blockade by AG490 Suppresses Autoimmune Arthritis in Mice via Reciprocal Regulation of Regulatory T Cells and Th17 Cells
Jin-Sil Park; Jennifer Lee; Mi-Ae Lim; Eun-Kyung Kim; Sung-Min Kim; Jun-Geol Ryu; Jae Ho Lee; Seung-Ki Kwok; Kyung-Su Park; Ho-Youn Kim; Sung-Hwan Park; Mi-La Cho
J Immunol (2014) 192 (9): 4417–4424.
View articletitled, JAK2-STAT3 Blockade by AG490 Suppresses Autoimmune Arthritis in Mice via Reciprocal Regulation of Regulatory T Cells and Th17 Cells
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TCR Bias and Affinity Define Two Compartments of the CD1b–Glycolipid-Specific T Cell Repertoire
Ildiko Van Rhijn; Nicholas A. Gherardin; Anne Kasmar; Wilco de Jager; Daniel G. Pellicci; Lyudmila Kostenko; Li Lynn Tan; Mugdha Bhati; Stephanie Gras; Dale I. Godfrey; Jamie Rossjohn; D. Branch Moody
J Immunol (2014) 192 (9): 4054–4060.
View articletitled, TCR Bias and Affinity Define Two Compartments of the CD1b–Glycolipid-Specific T Cell Repertoire
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Immunological Priming Requires Regulatory T Cells and IL-10–Producing Macrophages To Accelerate Resolution from Severe Lung Inflammation
Neil R. Aggarwal; Kenji Tsushima; Yoshiki Eto; Ashutosh Tripathi; Pooja Mandke; Jason R. Mock; Brian T. Garibaldi; Benjamin D. Singer; Venkataramana K. Sidhaye; Maureen R. Horton; Landon S. King; Franco R. D’Alessio
J Immunol (2014) 192 (9): 4453–4464.
View articletitled, Immunological Priming Requires Regulatory T Cells and IL-10–Producing Macrophages To Accelerate Resolution from Severe Lung Inflammation
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HLA-DRα1 Constructs Block CD74 Expression and MIF Effects in Experimental Autoimmune Encephalomyelitis
Roberto Meza-Romero; Gil Benedek; Xiaolin Yu; Jeffery L. Mooney; Rony Dahan; Nerri Duvshani; Richard Bucala; Halina Offner; Yoram Reiter; Gregory G. Burrows; Arthur A. Vandenbark
J Immunol (2014) 192 (9): 4164–4173.
View articletitled, HLA-DRα1 Constructs Block CD74 Expression and MIF Effects in Experimental Autoimmune Encephalomyelitis
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Rab5 Is a Novel Regulator of Mast Cell Secretory Granules: Impact on Size, Cargo, and Exocytosis
Nurit P. Azouz; Neta Zur; Adi Efergan; Norihiko Ohbayashi; Mitsunori Fukuda; Dina Amihai; Ilan Hammel; Marc E. Rothenberg; Ronit Sagi-Eisenberg
J Immunol (2014) 192 (9): 4043–4053.
View articletitled, Rab5 Is a Novel Regulator of Mast Cell Secretory Granules: Impact on Size, Cargo, and Exocytosis
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TLR-Mediated Secretion of Endoplasmic Reticulum Aminopeptidase 1 from Macrophages
Yoshikuni Goto; Kenji Ogawa; Takahiro J. Nakamura; Akira Hattori; Masafumi Tsujimoto
J Immunol (2014) 192 (9): 4443–4452.
View articletitled, TLR-Mediated Secretion of Endoplasmic Reticulum Aminopeptidase 1 from Macrophages
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Differential Ability of Surface and Endosomal TLRs To Induce CD8 T Cell Responses In Vivo
Rajakumar Mandraju; Sean Murray; James Forman; Chandrashekhar Pasare
J Immunol (2014) 192 (9): 4303–4315.
View articletitled, Differential Ability of Surface and Endosomal TLRs To Induce CD8 T Cell Responses In Vivo
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A Critical Role for Thymic Stromal Lymphopoietin in Nickel-Induced Allergy in Mice
Meinar Nur Ashrin; Rieko Arakaki; Akiko Yamada; Tomoyuki Kondo; Mie Kurosawa; Yasusei Kudo; Megumi Watanabe; Tetsuo Ichikawa; Yoshio Hayashi; Naozumi Ishimaru
J Immunol (2014) 192 (9): 4025–4031.
View articletitled, A Critical Role for Thymic Stromal Lymphopoietin in Nickel-Induced Allergy in Mice
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Airway Uric Acid Is a Sensor of Inhaled Protease Allergens and Initiates Type 2 Immune Responses in Respiratory Mucosa
Kenichiro Hara; Koji Iijima; Martha K. Elias; Satoshi Seno; Ichiro Tojima; Takao Kobayashi; Gail M. Kephart; Masahiko Kurabayashi; Hirohito Kita
J Immunol (2014) 192 (9): 4032–4042.
View articletitled, Airway Uric Acid Is a Sensor of Inhaled Protease Allergens and Initiates Type 2 Immune Responses in Respiratory Mucosa
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Heterocomplex Formation between MBL/Ficolin/CL-11–Associated Serine Protease-1 and -3 and MBL/Ficolin/CL-11–Associated Protein-1
Anne Rosbjerg; Lea Munthe-Fog; Peter Garred; Mikkel-Ole Skjoedt
J Immunol (2014) 192 (9): 4352–4360.
View articletitled, Heterocomplex Formation between MBL/Ficolin/CL-11–Associated Serine Protease-1 and -3 and MBL/Ficolin/CL-11–Associated Protein-1
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Engagement of SLAMF2/CD48 Prolongs the Time Frame of Effective T Cell Activation by Supporting Mature Dendritic Cell Survival
Katalin Kis-Toth; George C. Tsokos
J Immunol (2014) 192 (9): 4436–4442.
View articletitled, Engagement of SLAMF2/CD48 Prolongs the Time Frame of Effective T Cell Activation by Supporting Mature Dendritic Cell Survival
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An Overview of the Intrathymic Intricacies of T Cell Development
Divya K. Shah; Juan Carlos Zúñiga-Pflücker
J Immunol (2014) 192 (9): 4017–4023.
View articletitled, An Overview of the Intrathymic Intricacies of T Cell Development
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NKT Cells Determine Titer and Subtype Profile of Virus-Specific IgG Antibodies during Herpes Simplex Virus Infection
Martin J. Raftery; Eike Wolter; Simon Fillatreau; Helga Meisel; Stefan H. E. Kaufmann; Günther Schönrich
J Immunol (2014) 192 (9): 4294–4302.
View articletitled, NKT Cells Determine Titer and Subtype Profile of Virus-Specific IgG Antibodies during Herpes Simplex Virus Infection
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Development and Implementation of Papillomavirus Prophylactic Vaccines
Ian H. Frazer
J Immunol (2014) 192 (9): 4007–4011.
View articletitled, Development and Implementation of Papillomavirus Prophylactic Vaccines
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In This Issue
J Immunol (2014) 192 (9): 3999–4000.
View articletitled, In This Issue
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Interplay between CXCR2 and BLT1 Facilitates Neutrophil Infiltration and Resultant Keratinocyte Activation in a Murine Model of Imiquimod-Induced Psoriasis
Hayakazu Sumida; Keisuke Yanagida; Yoshihiro Kita; Jun Abe; Kouji Matsushima; Motonao Nakamura; Satoshi Ishii; Shinichi Sato; Takao Shimizu
J Immunol (2014) 192 (9): 4361–4369.
View articletitled, Interplay between CXCR2 and BLT1 Facilitates Neutrophil Infiltration and Resultant Keratinocyte Activation in a Murine Model of Imiquimod-Induced Psoriasis
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1,25-Dihydroxyvitamin D3 Promotes Tolerogenic Dendritic Cells with Functional Migratory Properties in NOD Mice
Gabriela B. Ferreira; Conny A. Gysemans; Jocelyne Demengeot; João Paulo M. C. M. da Cunha; An-Sofie Vanherwegen; Lut Overbergh; Tom L. Van Belle; Femke Pauwels; Annemieke Verstuyf; Hannelie Korf; Chantal Mathieu
J Immunol (2014) 192 (9): 4210–4220.
View articletitled, 1,25-Dihydroxyvitamin D<sub>3</sub> Promotes Tolerogenic Dendritic Cells with Functional Migratory Properties in NOD Mice
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Altered Expression of Oligodendrocyte and Neuronal Marker Genes Predicts the Clinical Onset of Autoimmune Encephalomyelitis and Indicates the Effectiveness of Multiple Sclerosis–Directed Therapeutics
Maria Evangelidou; Maria Karamita; Sotiris-Spyros Vamvakas; David E. Szymkowski; Lesley Probert
J Immunol (2014) 192 (9): 4122–4133.
View articletitled, Altered Expression of Oligodendrocyte and Neuronal Marker Genes Predicts the Clinical Onset of Autoimmune Encephalomyelitis and Indicates the Effectiveness of Multiple Sclerosis–Directed Therapeutics
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Pillars Article: Antigen Receptor Tail Clue. Nature. 1989. 338: 383–384
Michael Reth
J Immunol (2014) 192 (9): 4015–4016.
View articletitled, Pillars Article: Antigen Receptor Tail Clue. <em>Nature</em>. 1989. 338: 383–384
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A Clue to Antigen Receptor Tails
Bryan Irving; Arthur Weiss
J Immunol (2014) 192 (9): 4013–4014.
View articletitled, A Clue to Antigen Receptor Tails
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Inhibition of GTPase Rac1 in Endothelium by 6-Mercaptopurine Results in Immunosuppression in Nonimmune Cells: New Target for an Old Drug
Goran Marinković; Jeffrey Kroon; Mark Hoogenboezem; Kees A. Hoeben; Matthijs S. Ruiter; Kondababu Kurakula; Iker Otermin Rubio; Mariska Vos; Carlie J. M. de Vries; Jaap D. van Buul; Vivian de Waard
J Immunol (2014) 192 (9): 4370–4378.
View articletitled, Inhibition of GTPase Rac1 in Endothelium by 6-Mercaptopurine Results in Immunosuppression in Nonimmune Cells: New Target for an Old Drug
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Soluble IFN Receptor Potentiates In Vivo Type I IFN Signaling and Exacerbates TLR4-Mediated Septic Shock
Shamith A. Samarajiwa; Niamh E. Mangan; Matthew P. Hardy; Meri Najdovska; Daphne Dubach; Susie-Jane Braniff; Catherine M. Owczarek; Paul J. Hertzog
J Immunol (2014) 192 (9): 4425–4435.
View articletitled, Soluble IFN Receptor Potentiates In Vivo Type I IFN Signaling and Exacerbates TLR4-Mediated Septic Shock
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NLRP3 Regulates Neutrophil Functions and Contributes to Hepatic Ischemia–Reperfusion Injury Independently of Inflammasomes
Yoshiyuki Inoue; Koumei Shirasuna; Hiroaki Kimura; Fumitake Usui; Akira Kawashima; Tadayoshi Karasawa; Kenji Tago; Katsuya Dezaki; Satoshi Nishimura; Junji Sagara; Tetsuo Noda; Yoichiro Iwakura; Hiroko Tsutsui; Shun’ichiro Taniguchi; Ken Yanagisawa; Toshihiko Yada; Yoshikazu Yasuda; Masafumi Takahashi
J Immunol (2014) 192 (9): 4342–4351.
View articletitled, NLRP3 Regulates Neutrophil Functions and Contributes to Hepatic Ischemia–Reperfusion Injury Independently of Inflammasomes
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Response to Comment on “Killer Ig-like Receptor 2DL4 Does Not Mediate NK Cell IFN-γ Responses to Soluble HLA-G Preparations”
Michael E. L. Le Page; Jodie P. Goodridge; Elisabeth John; Frank T. Christiansen; Campbell S. Witt
J Immunol (2014) 192 (9): 4003–4004.
View articletitled, Response to Comment on “Killer Ig-like Receptor 2DL4 Does Not Mediate NK Cell IFN-γ Responses to Soluble HLA-G Preparations”
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Comment on “Killer Ig-like Receptor 2DL4 Does Not Mediate NK Cell IFN-γ Responses to Soluble HLA-G Preparations”
Sumati Rajagopalan; Eric O. Long
J Immunol (2014) 192 (9): 4003.
View articletitled, Comment on “Killer Ig-like Receptor 2DL4 Does Not Mediate NK Cell IFN-γ Responses to Soluble HLA-G Preparations”
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Mycobacterium tuberculosis Impairs Dendritic Cell Functions through the Serine Hydrolase Hip1
Ranjna Madan-Lala; Jonathan Kevin Sia; Rebecca King; Toidi Adekambi; Leticia Monin; Shabaana A. Khader; Bali Pulendran; Jyothi Rengarajan
J Immunol (2014) 192 (9): 4263–4272.
View articletitled, <em>Mycobacterium tuberculosis</em> Impairs Dendritic Cell Functions through the Serine Hydrolase Hip1
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    On the cover: Three-dimensional reconstructed confocal microscopy of a live rat basophilic leukemia cell that coexpresses a constitutively active Rab5A mutant (green) and the secretory granules marker NPY-mRFP (magenta). Rab5 stimulates secretory granule fusion forming giant secretory granules, part of which appears to be embedded within Rab5A, while others are naked or bridged with Rab5A. Azouz, N. P., N. Zur, A. Efergan, N. Ohbayashi, M. Fukuda, D. Amihai, I. Hammel, M. E. Rothenberg, and R. Sagi-Eisenberg. 2014. Rab5 is a novel regulator of mast cell secretory granules: impact on size, cargo and exocytosis. J. Immunol. 192: 4043–4053.
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  • Online ISSN 1550-6606
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