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Volume 193, Issue 12
15 December 2014
Issue Cover
ISSN 0022-1767
EISSN 1550-6606
In this Issue
CD4+ T Cell Epitopes of FliC Conserved between Strains of Burkholderia: Implications for Vaccines against Melioidosis and Cepacia Complex in Cystic Fibrosis
Julie A. Musson; Catherine J. Reynolds; Darawan Rinchai; Arnone Nithichanon; Prasong Khaenam; Emmanuel Favry; Natasha Spink; Karen K. Y. Chu; Anthony De Soyza; Gregory J. Bancroft; Ganjana Lertmemongkolchai; Bernard Maillere; Rosemary J. Boyton; Daniel M. Altmann; John H. Robinson
J Immunol (2014) 193 (12): 6041–6049.
View articletitled, CD4<sup>+</sup> T Cell Epitopes of FliC Conserved between Strains of <em>Burkholderia</em>: Implications for Vaccines against Melioidosis and Cepacia Complex in Cystic Fibrosis
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Cutting Edge: New Chimeric NOD2/TLR2 Adjuvant Drastically Increases Vaccine Immunogenicity
Vincent Pavot; Nicolas Rochereau; Julien Rességuier; Alice Gutjahr; Christian Genin; Gerard Tiraby; Eric Perouzel; Thierry Lioux; Fabienne Vernejoul; Bernard Verrier; Stéphane Paul
J Immunol (2014) 193 (12): 5781–5785.
View articletitled, Cutting Edge: New Chimeric NOD2/TLR2 Adjuvant Drastically Increases Vaccine Immunogenicity
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NK Cells with KIR2DS2 Immunogenotype Have a Functional Activation Advantage To Efficiently Kill Glioblastoma and Prolong Animal Survival
Andrea Gras Navarro; Justyna Kmiecik; Lina Leiss; Mateusz Zelkowski; Agnete Engelsen; Øystein Bruserud; Jacques Zimmer; Per Øyvind Enger; Martha Chekenya
J Immunol (2014) 193 (12): 6192–6206.
View articletitled, NK Cells with KIR2DS2 Immunogenotype Have a Functional Activation Advantage To Efficiently Kill Glioblastoma and Prolong Animal Survival
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CCAAT/Enhancer-Binding Protein α Negatively Regulates IFN-γ Expression in T Cells
Shinya Tanaka; Kentaro Tanaka; Fay Magnusson; Yeonseok Chung; Gustavo J. Martinez; Yi-hong Wang; Roza I. Nurieva; Tomohiro Kurosaki; Chen Dong
J Immunol (2014) 193 (12): 6152–6160.
View articletitled, CCAAT/Enhancer-Binding Protein α Negatively Regulates IFN-γ Expression in T Cells
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Pig Skin Includes Dendritic Cell Subsets Transcriptomically Related to Human CD1a and CD14 Dendritic Cells Presenting Different Migrating Behaviors and T Cell Activation Capacities
Florian Marquet; Thien-Phong Vu Manh; Pauline Maisonnasse; Jamila Elhmouzi-Younes; Céline Urien; Edwige Bouguyon; Luc Jouneau; Mickael Bourge; Gaëlle Simon; Angel Ezquerra; Jérôme Lecardonnel; Michel Bonneau; Marc Dalod; Isabelle Schwartz-Cornil; Nicolas Bertho
J Immunol (2014) 193 (12): 5883–5893.
View articletitled, Pig Skin Includes Dendritic Cell Subsets Transcriptomically Related to Human CD1a and CD14 Dendritic Cells Presenting Different Migrating Behaviors and T Cell Activation Capacities
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B Cell–Intrinsic MyD88 Signaling Is Essential for IgE Responses in Lungs Exposed to Pollen Allergens
Kazufumi Matsushita; Tomohiro Yoshimoto
J Immunol (2014) 193 (12): 5791–5800.
View articletitled, B Cell–Intrinsic MyD88 Signaling Is Essential for IgE Responses in Lungs Exposed to Pollen Allergens
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Infiltrating Regulatory B Cells Control Neuroinflammation following Viral Brain Infection
Manohar B. Mutnal; Shuxian Hu; Scott J. Schachtele; James R. Lokensgard
J Immunol (2014) 193 (12): 6070–6080.
View articletitled, Infiltrating Regulatory B Cells Control Neuroinflammation following Viral Brain Infection
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A Deficiency in the Prostaglandin D2 Receptor CRTH2 Exacerbates Adjuvant-Induced Joint Inflammation
Yoshiki Tsubosaka; Tatsuro Nakamura; Hiroyuki Hirai; Masatoshi Hori; Masataka Nakamura; Hiroshi Ozaki; Takahisa Murata
J Immunol (2014) 193 (12): 5835–5840.
View articletitled, A Deficiency in the Prostaglandin D<sub>2</sub> Receptor CRTH2 Exacerbates Adjuvant-Induced Joint Inflammation
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The Absence or Overexpression of IL-15 Drastically Alters Breast Cancer Metastasis via Effects on NK Cells, CD4 T Cells, and Macrophages
Amy Gillgrass; Navkiran Gill; Artem Babian; Ali A. Ashkar
J Immunol (2014) 193 (12): 6184–6191.
View articletitled, The Absence or Overexpression of IL-15 Drastically Alters Breast Cancer Metastasis via Effects on NK Cells, CD4 T Cells, and Macrophages
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TRAM Is Required for TLR2 Endosomal Signaling to Type I IFN Induction
Julianne Stack; Sarah L. Doyle; Dympna J. Connolly; Line S. Reinert; Kate M. O’Keeffe; Rachel M. McLoughlin; Søren R. Paludan; Andrew G. Bowie
J Immunol (2014) 193 (12): 6090–6102.
View articletitled, TRAM Is Required for TLR2 Endosomal Signaling to Type I IFN Induction
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The Thymic Microenvironment Differentially Regulates Development and Trafficking of Invariant NKT Cell Sublineages
Michael B. Drennan; Srinath Govindarajan; Katelijne De Wilde; Susan M. Schlenner; Carl Ware; Sergei Nedospasov; Hans-Reimer Rodewald; Dirk Elewaut
J Immunol (2014) 193 (12): 5960–5972.
View articletitled, The Thymic Microenvironment Differentially Regulates Development and Trafficking of Invariant NKT Cell Sublineages
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IgG4 and IgE Transcripts in Childhood Allergic Asthma Reflect Divergent Antigen-Driven Selection
Tobias Rogosch; Sebastian Kerzel; Friederike Dey; Johanna-Josophina Wagner; Zhixin Zhang; Rolf F. Maier; Michael Zemlin
J Immunol (2014) 193 (12): 5801–5808.
View articletitled, IgG4 and IgE Transcripts in Childhood Allergic Asthma Reflect Divergent Antigen-Driven Selection
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Rictor Negatively Regulates High-Affinity Receptors for IgE-Induced Mast Cell Degranulation
Daniel Smrz; Glenn Cruse; Michael A. Beaven; Arnold Kirshenbaum; Dean D. Metcalfe; Alasdair M. Gilfillan
J Immunol (2014) 193 (12): 5924–5932.
View articletitled, Rictor Negatively Regulates High-Affinity Receptors for IgE-Induced Mast Cell Degranulation
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Analysis of Relationships between Peptide/MHC Structural Features and Naive T Cell Frequency in Humans
Jean-Baptiste Reiser; François Legoux; Stéphanie Gras; Eric Trudel; Anne Chouquet; Alexandra Léger; Madalen Le Gorrec; Paul Machillot; Marc Bonneville; Xavier Saulquin; Dominique Housset
J Immunol (2014) 193 (12): 5816–5826.
View articletitled, Analysis of Relationships between Peptide/MHC Structural Features and Naive T Cell Frequency in Humans
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CD28–CD80 Interactions Control Regulatory T Cell Motility and Immunological Synapse Formation
Timothy J. Thauland; Yoshinobu Koguchi; Michael L. Dustin; David C. Parker
J Immunol (2014) 193 (12): 5894–5903.
View articletitled, CD28–CD80 Interactions Control Regulatory T Cell Motility and Immunological Synapse Formation
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Borrelia burgdorferi Arthritis–Associated Locus Bbaa1 Regulates Lyme Arthritis and K/B×N Serum Transfer Arthritis through Intrinsic Control of Type I IFN Production
Ying Ma; Kenneth K. C. Bramwell; Robert B. Lochhead; Jackie K. Paquette; James F. Zachary; John H. Weis; Cory Teuscher; Janis J. Weis
J Immunol (2014) 193 (12): 6050–6060.
View articletitled, <em>Borrelia burgdorferi</em> Arthritis–Associated Locus <em>Bbaa1</em> Regulates Lyme Arthritis and K/B×N Serum Transfer Arthritis through Intrinsic Control of Type I IFN Production
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Notch3 Activation Is Sufficient but Not Required for Inducing Human T-Lineage Specification
Els Waegemans; Inge Van de Walle; Jelle De Medts; Magda De Smedt; Tessa Kerre; Bart Vandekerckhove; Georges Leclercq; Tao Wang; Jean Plum; Tom Taghon
J Immunol (2014) 193 (12): 5997–6004.
View articletitled, Notch3 Activation Is Sufficient but Not Required for Inducing Human T-Lineage Specification
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Delta-like 1–Mediated Notch Signaling Enhances the In Vitro Conversion of Human Memory CD4 T Cells into FOXP3-Expressing Regulatory T Cells
Catarina Mota; Vânia Nunes-Silva; Ana R. Pires; Paula Matoso; Rui M. M. Victorino; Ana E. Sousa; Iris Caramalho
J Immunol (2014) 193 (12): 5854–5862.
View articletitled, Delta-like 1–Mediated Notch Signaling Enhances the In Vitro Conversion of Human Memory CD4 T Cells into FOXP3-Expressing Regulatory T Cells
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Intestinal Expression of Fas and Fas Ligand Is Upregulated by Bacterial Signaling through TLR4 and TLR5, with Activation of Fas Modulating Intestinal TLR-Mediated Inflammation
Philana Fernandes; Charlotte O’Donnell; Caitriona Lyons; Jonathan Keane; Tim Regan; Stephen O’Brien; Padraic Fallon; Elizabeth Brint; Aileen Houston
J Immunol (2014) 193 (12): 6103–6113.
View articletitled, Intestinal Expression of Fas and Fas Ligand Is Upregulated by Bacterial Signaling through TLR4 and TLR5, with Activation of Fas Modulating Intestinal TLR-Mediated Inflammation
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In This Issue
J Immunol (2014) 193 (12): 5761–5762.
View articletitled, In This Issue
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Correction: Transcriptional Characterization of the T Cell Population within the Salmonid Interbranchial Lymphoid Tissue
Ida Bergva Aas; Lars Austbø; Melanie König; Mohasina Syed; Knut Falk; Ivar Hordvik; Erling O. Koppang
J Immunol (2014) 193 (12): 6207.
View articletitled, Correction: Transcriptional Characterization of the T Cell Population within the Salmonid Interbranchial Lymphoid Tissue
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Response to Comment on “Intestinal Inflammation Modulates Expression of the Iron-Regulating Hormone Hepcidin Depending on Erythropoietic Activity and the Commensal Microbiota”
Bobby J. Cherayil
J Immunol (2014) 193 (12): 5763.
View articletitled, Response to Comment on “Intestinal Inflammation Modulates Expression of the Iron-Regulating Hormone Hepcidin Depending on Erythropoietic Activity and the Commensal Microbiota”
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Comment on “Intestinal Inflammation Modulates Expression of the Iron-Regulating Hormone Hepcidin Depending on Erythropoietic Activity and the Commensal Microbiota”
Adam Fabisiak; Natalia Murawska; Jakub Fichna
J Immunol (2014) 193 (12): 5763.
View articletitled, Comment on “Intestinal Inflammation Modulates Expression of the Iron-Regulating Hormone Hepcidin Depending on Erythropoietic Activity and the Commensal Microbiota”
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The Extracellular Adherence Protein from Staphylococcus aureus Inhibits the Classical and Lectin Pathways of Complement by Blocking Formation of the C3 Proconvertase
Jordan L. Woehl; Daphne A. C. Stapels; Brandon L. Garcia; Kasra X. Ramyar; Andrew Keightley; Maartje Ruyken; Maria Syriga; Georgia Sfyroera; Alexander B. Weber; Michal Zolkiewski; Daniel Ricklin; John D. Lambris; Suzan H. M. Rooijakkers; Brian V. Geisbrecht
J Immunol (2014) 193 (12): 6161–6171.
View articletitled, The Extracellular Adherence Protein from <em>Staphylococcus aureus</em> Inhibits the Classical and Lectin Pathways of Complement by Blocking Formation of the C3 Proconvertase
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The Plasmacytoid Dendritic Cell as the Swiss Army Knife of the Immune System: Molecular Regulation of Its Multifaceted Functions
Julien J. Karrich; Loes C. M. Jachimowski; Christel H. Uittenbogaart; Bianca Blom
J Immunol (2014) 193 (12): 5772–5778.
View articletitled, The Plasmacytoid Dendritic Cell as the Swiss Army Knife of the Immune System: Molecular Regulation of Its Multifaceted Functions
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Viral MHC Class I–like Molecule Allows Evasion of NK Cell Effector Responses In Vivo
Michal Pyzik; Anne A. Dumaine; Benoît Charbonneau; Nassima Fodil-Cornu; Stipan Jonjic; Silvia M. Vidal
J Immunol (2014) 193 (12): 6061–6069.
View articletitled, Viral MHC Class I–like Molecule Allows Evasion of NK Cell Effector Responses In Vivo
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A Novel Mechanism of B Cell–Mediated Immune Suppression through CD73 Expression and Adenosine Production
Hiroaki Kaku; Kai Fan Cheng; Yousef Al-Abed; Thomas L. Rothstein
J Immunol (2014) 193 (12): 5904–5913.
View articletitled, A Novel Mechanism of B Cell–Mediated Immune Suppression through CD73 Expression and Adenosine Production
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Nonenzymatic Conversion of ADP-Ribosylated Arginines to Ornithine Alters the Biological Activities of Human Neutrophil Peptide-1
Linda A. Stevens; Joseph T. Barbieri; Grzegorz Piszczek; Amy N. Otuonye; Rodney L. Levine; Gang Zheng; Joel Moss
J Immunol (2014) 193 (12): 6144–6151.
View articletitled, Nonenzymatic Conversion of ADP-Ribosylated Arginines to Ornithine Alters the Biological Activities of Human Neutrophil Peptide-1
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PARP-1 Mediates LPS-Induced HMGB1 Release by Macrophages through Regulation of HMGB1 Acetylation
Zhiyong Yang; Li Li; Lijuan Chen; Weiwei Yuan; Liming Dong; Yushun Zhang; Heshui Wu; Chunyou Wang
J Immunol (2014) 193 (12): 6114–6123.
View articletitled, PARP-1 Mediates LPS-Induced HMGB1 Release by Macrophages through Regulation of HMGB1 Acetylation
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Chemokine-Mediated B Cell Trafficking during Early Rabbit GALT Development
Shi-Kang Zhai; Veronica V. Volgina; Periannan Sethupathi; Katherine L. Knight; Dennis K. Lanning
J Immunol (2014) 193 (12): 5951–5959.
View articletitled, Chemokine-Mediated B Cell Trafficking during Early Rabbit GALT Development
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Definition of the Cattle Killer Cell Ig–like Receptor Gene Family: Comparison with Aurochs and Human Counterparts
Nicholas D. Sanderson; Paul J. Norman; Lisbeth A. Guethlein; Shirley A. Ellis; Christina Williams; Matthew Breen; Steven D. E. Park; David A. Magee; Farbod Babrzadeh; Andrew Warry; Mick Watson; Daniel G. Bradley; David E. MacHugh; Peter Parham; John A. Hammond
J Immunol (2014) 193 (12): 6016–6030.
View articletitled, Definition of the Cattle Killer Cell Ig–like Receptor Gene Family: Comparison with Aurochs and Human Counterparts
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TCR Signaling Events Are Required for Maintaining CD4 Regulatory T Cell Numbers and Suppressive Capacities in the Periphery
Arnaud Delpoux; Philippe Yakonowsky; Aurélie Durand; Céline Charvet; Michael Valente; Arnaud Pommier; Nelly Bonilla; Bruno Martin; Cédric Auffray; Bruno Lucas
J Immunol (2014) 193 (12): 5914–5923.
View articletitled, TCR Signaling Events Are Required for Maintaining CD4 Regulatory T Cell Numbers and Suppressive Capacities in the Periphery
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The Specialized Proresolving Mediator 17-HDHA Enhances the Antibody-Mediated Immune Response against Influenza Virus: A New Class of Adjuvant?
Sesquile Ramon; Steven F. Baker; Julie M. Sahler; Nina Kim; Eric A. Feldsott; Charles N. Serhan; Luis Martínez-Sobrido; David J. Topham; Richard P. Phipps
J Immunol (2014) 193 (12): 6031–6040.
View articletitled, The Specialized Proresolving Mediator 17-HDHA Enhances the Antibody-Mediated Immune Response against Influenza Virus: A New Class of Adjuvant?
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Polarized Granzyme Release Is Required for Antigen-Driven Transendothelial Migration of Human Effector Memory CD4 T Cells
Thomas D. Manes; Jordan S. Pober
J Immunol (2014) 193 (12): 5809–5815.
View articletitled, Polarized Granzyme Release Is Required for Antigen-Driven Transendothelial Migration of Human Effector Memory CD4 T Cells
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Glucocorticoid-Induced Leucine Zipper Enhanced Expression in Dendritic Cells Is Sufficient To Drive Regulatory T Cells Expansion In Vivo
Joseph Calmette; Mehdi Ellouze; Thi Tran; Soumaya Karaki; Emilie Ronin; Francis Capel; Marc Pallardy; Françoise Bachelerie; Roman Krzysiek; Dominique Emilie; Géraldine Schlecht-Louf; Véronique Godot
J Immunol (2014) 193 (12): 5863–5872.
View articletitled, Glucocorticoid-Induced Leucine Zipper Enhanced Expression in Dendritic Cells Is Sufficient To Drive Regulatory T Cells Expansion In Vivo
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CD4 T Cells Specific for a Latency-Associated γ-Herpesvirus Epitope Are Polyfunctional and Cytotoxic
Michael L. Freeman; Claire E. Burkum; Tres Cookenham; Alan D. Roberts; Kathleen G. Lanzer; Gail E. Huston; Meghan K. Jensen; John Sidney; Bjoern Peters; Jacob E. Kohlmeier; David L. Woodland; Linda F. van Dyk; Alessandro Sette; Marcia A. Blackman
J Immunol (2014) 193 (12): 5827–5834.
View articletitled, CD4 T Cells Specific for a Latency-Associated γ-Herpesvirus Epitope Are Polyfunctional and Cytotoxic
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Immature Recent Thymic Emigrants Are Eliminated by Complement
Fan-Chi Hsu; Michael J. Shapiro; Meibo W. Chen; Douglas C. McWilliams; Lauren M. Seaburg; Sarah N. Tangen; Virginia Smith Shapiro
J Immunol (2014) 193 (12): 6005–6015.
View articletitled, Immature Recent Thymic Emigrants Are Eliminated by Complement
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Gene Targeting RhoA Reveals Its Essential Role in Coordinating Mitochondrial Function and Thymocyte Development
Shuangmin Zhang; Diamantis G. Konstantinidis; Jun-Qi Yang; Benjamin Mizukawa; Khalid Kalim; Richard A. Lang; Theodosia A. Kalfa; Yi Zheng; Fukun Guo
J Immunol (2014) 193 (12): 5973–5982.
View articletitled, Gene Targeting RhoA Reveals Its Essential Role in Coordinating Mitochondrial Function and Thymocyte Development
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Chloroquine Promotes IL-17 Production by CD4+ T Cells via p38-Dependent IL-23 Release by Monocyte-Derived Langerhans-like Cells
André Said; Stephanie Bock; Trim Lajqi; Gerrit Müller; Günther Weindl
J Immunol (2014) 193 (12): 6135–6143.
View articletitled, Chloroquine Promotes IL-17 Production by CD4<sup>+</sup> T Cells via p38-Dependent IL-23 Release by Monocyte-Derived Langerhans-like Cells
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Histone Deacetylase Inhibitors Upregulate B Cell microRNAs That Silence AID and Blimp-1 Expression for Epigenetic Modulation of Antibody and Autoantibody Responses
Clayton A. White; Egest J. Pone; Tonika Lam; Connie Tat; Ken L. Hayama; Guideng Li; Hong Zan; Paolo Casali
J Immunol (2014) 193 (12): 5933–5950.
View articletitled, Histone Deacetylase Inhibitors Upregulate B Cell microRNAs That Silence AID and Blimp-1 Expression for Epigenetic Modulation of Antibody and Autoantibody Responses
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Diet-Induced Obesity Does Not Impact the Generation and Maintenance of Primary Memory CD8 T Cells
Shaniya H. Khan; Emily A. Hemann; Kevin L. Legge; Lyse A. Norian; Vladimir P. Badovinac
J Immunol (2014) 193 (12): 5873–5882.
View articletitled, Diet-Induced Obesity Does Not Impact the Generation and Maintenance of Primary Memory CD8 T Cells
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Lipocalin 2 Imparts Selective Pressure on Bacterial Growth in the Bladder and Is Elevated in Women with Urinary Tract Infection
Magnus Steigedal; Anne Marstad; Markus Haug; Jan K. Damås; Roland K. Strong; Pacita L. Roberts; Stephanie D. Himpsl; Ann Stapleton; Thomas M. Hooton; Harry L. T. Mobley; Thomas R. Hawn; Trude H. Flo
J Immunol (2014) 193 (12): 6081–6089.
View articletitled, Lipocalin 2 Imparts Selective Pressure on Bacterial Growth in the Bladder and Is Elevated in Women with Urinary Tract Infection
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A Signal Integration Model of Thymic Selection and Natural Regulatory T Cell Commitment
Sahamoddin Khailaie; Philippe A. Robert; Aras Toker; Jochen Huehn; Michael Meyer-Hermann
J Immunol (2014) 193 (12): 5983–5996.
View articletitled, A Signal Integration Model of Thymic Selection and Natural Regulatory T Cell Commitment
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SLAM–SAP Signaling Promotes Differentiation of IL-17–Producing T Cells and Progression of Experimental Autoimmune Encephalomyelitis
Yu-Hsuan Huang; Kevin Tsai; Caixia Ma; Bruce A. Vallance; John J. Priatel; Rusung Tan
J Immunol (2014) 193 (12): 5841–5853.
View articletitled, SLAM–SAP Signaling Promotes Differentiation of IL-17–Producing T Cells and Progression of Experimental Autoimmune Encephalomyelitis
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Correction: Human CD141+ Dendritic Cells Induce CD4+ T Cells To Produce Type 2 Cytokines
Chun I. Yu; Christian Becker; Patrick Metang; Florentina Marches; Yuanyuan Wang; Toshiyuki Hori; Jacques Banchereau; Miriam Merad; A. Karolina Palucka
J Immunol (2014) 193 (12): 6210.
View articletitled, Correction: Human CD141<sup>+</sup> Dendritic Cells Induce CD4<sup>+</sup> T Cells To Produce Type 2 Cytokines
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Correction: Th17 Cells Contribute to Viral Replication in Coxsackievirus B3-Induced Acute Viral Myocarditis
Jing Yuan; Miao Yu; Qiong-Wen Lin; Ai-Lin Cao; Xian Yu; Ji-Hua Dong; Jin-Ping Wang; Jing-Hui Zhang; Min Wang; He-Ping Guo; Xiang Cheng; Yu-Hua Liao
J Immunol (2014) 193 (12): 6208–6209.
View articletitled, Correction: Th17 Cells Contribute to Viral Replication in Coxsackievirus B3-Induced Acute Viral Myocarditis
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Antibody to the gp120 V1/V2 Loops and CD4+ and CD8+ T Cell Responses in Protection from SIVmac251 Vaginal Acquisition and Persistent Viremia
Shari N. Gordon; Melvin N. Doster; Rhonda C. Kines; Brandon F. Keele; Egidio Brocca-Cofano; Yongjun Guan; Poonam Pegu; Namal P. M. Liyanage; Monica Vaccari; Nicolas Cuburu; Christopher B. Buck; Guido Ferrari; David Montefiori; Michael Piatak, Jr.; Jeffrey D. Lifson; Anastasia M. Xenophontos; David Venzon; Marjorie Robert-Guroff; Barney S. Graham; Douglas R. Lowy; John T. Schiller; Genoveffa Franchini
J Immunol (2014) 193 (12): 6172–6183.
View articletitled, Antibody to the gp120 V1/V2 Loops and CD4<sup>+</sup> and CD8<sup>+</sup> T Cell Responses in Protection from SIV<sub>mac251</sub> Vaginal Acquisition and Persistent Viremia
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Functions of Heat Shock Proteins in Pathways of the Innate and Adaptive Immune System
Robert Julian Binder
J Immunol (2014) 193 (12): 5765–5771.
View articletitled, Functions of Heat Shock Proteins in Pathways of the Innate and Adaptive Immune System
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Cutting Edge: Genetic Variation in TLR1 Is Associated with Pam3CSK4-Induced Effector T Cell Resistance to Regulatory T Cell Suppression
Carmen Mikacenic; Anya Schneider; Frank Radella; Jane H. Buckner; Mark M. Wurfel
J Immunol (2014) 193 (12): 5786–5790.
View articletitled, Cutting Edge: Genetic Variation in <em>TLR1</em> Is Associated with Pam<sub>3</sub>CSK<sub>4</sub>-Induced Effector T Cell Resistance to Regulatory T Cell Suppression
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STING-Mediated DNA Sensing Promotes Antitumor and Autoimmune Responses to Dying Cells
Jared Klarquist; Cassandra M. Hennies; Maria A. Lehn; Rachel A. Reboulet; Sonia Feau; Edith M. Janssen
J Immunol (2014) 193 (12): 6124–6134.
View articletitled, STING-Mediated DNA Sensing Promotes Antitumor and Autoimmune Responses to Dying Cells
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  • Cover Image

    Cover Image

    issue cover
    On the cover: Possible tryptophan conformers of the mutated MelanA/Mart1 peptide (ELAI5W), modeled in the ternary complex between TCR Mel5, MHC molecule HLA-A2, and wild-type peptide. The steric clashes suggest that activation of Mart1-specific T cells by the mutated peptide is allowed after structural adaptation of CDRs to fit the larger residue. Reiser, J.-B., F. Legoux, S. Gras, E. Trudel, A. Chouquet, A. Léger, M. Le Gorrec, P. Machillot, M. Bonneville, X. Saulquin, and D. Housset. 2014. Analysis of relationships between peptide/MHC structural features and naive T cell frequency in humans. J. Immunol. 193: 5816–5826.
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