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Volume 193, Issue 4
15 August 2014
Issue Cover
ISSN 0022-1767
EISSN 1550-6606

IN THIS ISSUE

In This Issue
J Immunol (2014) 193 (4): 1517–1518.
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TRANSLATING IMMUNOLOGY

Translational Medicine in Action: Anti-CD20 Therapy in Lymphoma
Sean H. Lim; Ronald Levy
J Immunol (2014) 193 (4): 1519–1524.
View articletitled, Translational Medicine in Action: Anti-CD20 Therapy in Lymphoma
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BRIEF REVIEWS

Too Much of a Good Thing? Tim-3 and TCR Signaling in T Cell Exhaustion
Robert L. Ferris; Binfeng Lu; Lawrence P. Kane
J Immunol (2014) 193 (4): 1525–1530.
View articletitled, Too Much of a Good Thing? Tim-3 and TCR Signaling in T Cell Exhaustion
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Dendritic Cells and B Cells: Unexpected Partners in Th2 Development
Beatriz León; André Ballesteros-Tato; Frances E. Lund
J Immunol (2014) 193 (4): 1531–1537.
View articletitled, Dendritic Cells and B Cells: Unexpected Partners in Th2 Development
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CUTTING EDGE

Cutting Edge: RIPK1 Kinase Inactive Mice Are Viable and Protected from TNF-Induced Necroptosis In Vivo
Apostolos Polykratis; Nicole Hermance; Matija Zelic; Justine Roderick; Chun Kim; Trieu-My Van; Thomas H. Lee; Francis K. M. Chan; Manolis Pasparakis; Michelle A. Kelliher
J Immunol (2014) 193 (4): 1539–1543.
View articletitled, Cutting Edge: RIPK1 Kinase Inactive Mice Are Viable and Protected from TNF-Induced Necroptosis In Vivo
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Cutting Edge: An Antibody Recognizing Ancestral Endogenous Virus Glycoproteins Mediates Antibody-Dependent Cellular Cytotoxicity on HIV-1–Infected Cells
Henri-Alexandre Michaud; Devi SenGupta; Miguel de Mulder; Steven G. Deeks; Jeffrey N. Martin; James J. Kobie; Jonah B. Sacha; Douglas F. Nixon
J Immunol (2014) 193 (4): 1544–1548.
View articletitled, Cutting Edge: An Antibody Recognizing Ancestral Endogenous Virus Glycoproteins Mediates Antibody-Dependent Cellular Cytotoxicity on HIV-1–Infected Cells
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ALLERGY AND OTHER HYPERSENSITIVITIES

IL-33 and Thymic Stromal Lymphopoietin Mediate Immune Pathology in Response to Chronic Airborne Allergen Exposure
Koji Iijima; Takao Kobayashi; Kenichiro Hara; Gail M. Kephart; Steven F. Ziegler; Andrew N. McKenzie; Hirohito Kita
J Immunol (2014) 193 (4): 1549–1559.
View articletitled, IL-33 and Thymic Stromal Lymphopoietin Mediate Immune Pathology in Response to Chronic Airborne Allergen Exposure
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ANTIGEN RECOGNITION AND RESPONSES

Targeted Delivery of Mycobacterial Antigens to Human Dendritic Cells via Siglec-7 Induces Robust T Cell Activation
Norihito Kawasaki; Cory D. Rillahan; Tan-Yun Cheng; Ildiko Van Rhijn; Matthew S. Macauley; D. Branch Moody; James C. Paulson
J Immunol (2014) 193 (4): 1560–1566.
View articletitled, Targeted Delivery of Mycobacterial Antigens to Human Dendritic Cells via Siglec-7 Induces Robust T Cell Activation
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Clonotypic Composition of the CD4+ T Cell Response to a Vectored Retroviral Antigen Is Determined by Its Speed
Georgina Thorborn; Mickaël J. Ploquin; Urszula Eksmond; Rebecca Pike; Wibke Bayer; Ulf Dittmer; Kim J. Hasenkrug; Marion Pepper; George Kassiotis
J Immunol (2014) 193 (4): 1567–1577.
View articletitled, Clonotypic Composition of the CD4<sup>+</sup> T Cell Response to a Vectored Retroviral Antigen Is Determined by Its Speed
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Cowpox Virus Protein CPXV012 Eludes CTLs by Blocking ATP Binding to TAP
Rutger D. Luteijn; Hanneke Hoelen; Elisabeth Kruse; Wouter F. van Leeuwen; Jennine Grootens; Daniëlle Horst; Martijn Koorengevel; Jan W. Drijfhout; Elisabeth Kremmer; Klaus Früh; Jacques J. Neefjes; Antoinette Killian; Robert Jan Lebbink; Maaike E. Ressing; Emmanuel J. H. J. Wiertz
J Immunol (2014) 193 (4): 1578–1589.
View articletitled, Cowpox Virus Protein CPXV012 Eludes CTLs by Blocking ATP Binding to TAP
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AUTOIMMUNITY

The Differential Regulation of Human ACT1 Isoforms by Hsp90 in IL-17 Signaling
Ling Wu; Chenhui Wang; Bertrand Boisson; Saurav Misra; Patricia Rayman; James H. Finke; Anne Puel; Jean-Laurent Casanova; Xiaoxia Li
J Immunol (2014) 193 (4): 1590–1599.
View articletitled, The Differential Regulation of Human ACT1 Isoforms by Hsp90 in IL-17 Signaling
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Recombinant Human IgA1 and IgA2 Autoantibodies to Type VII Collagen Induce Subepidermal Blistering Ex Vivo
Andreas Recke; Luisa M. Trog; Hendri H. Pas; Artem Vorobyev; Aida Abadpour; Marcel F. Jonkman; Ger van Zandbergen; Claudia Kauderer; Detlef Zillikens; Gestur Vidarsson; Ralf J. Ludwig
J Immunol (2014) 193 (4): 1600–1608.
View articletitled, Recombinant Human IgA1 and IgA2 Autoantibodies to Type VII Collagen Induce Subepidermal Blistering Ex Vivo
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Activation of Rheumatoid Factor–Specific B Cells Is Antigen Dependent and Occurs Preferentially Outside of Germinal Centers in the Lupus-Prone NZM2410 Mouse Model
Allison Sang; Haitao Niu; Jaime Cullen; Seung Chul Choi; Ying Yi Zheng; Haowei Wang; Mark J. Shlomchik; Laurence Morel
J Immunol (2014) 193 (4): 1609–1621.
View articletitled, Activation of Rheumatoid Factor–Specific B Cells Is Antigen Dependent and Occurs Preferentially Outside of Germinal Centers in the Lupus-Prone NZM2410 Mouse Model
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CLINICAL AND HUMAN IMMUNOLOGY

Human XCR1+ Dendritic Cells Derived In Vitro from CD34+ Progenitors Closely Resemble Blood Dendritic Cells, Including Their Adjuvant Responsiveness, Contrary to Monocyte-Derived Dendritic Cells
Sreekumar Balan; Vincent Ollion; Nicholas Colletti; Rabie Chelbi; Frédéric Montanana-Sanchis; Hong Liu; Thien-Phong Vu Manh; Cindy Sanchez; Juliette Savoret; Ivan Perrot; Anne-Claire Doffin; Even Fossum; Didier Bechlian; Christian Chabannon; Bjarne Bogen; Carine Asselin-Paturel; Michael Shaw; Timothy Soos; Christophe Caux; Jenny Valladeau-Guilemond; Marc Dalod
J Immunol (2014) 193 (4): 1622–1635.
View articletitled, Human XCR1<sup>+</sup> Dendritic Cells Derived In Vitro from CD34<sup>+</sup> Progenitors Closely Resemble Blood Dendritic Cells, Including Their Adjuvant Responsiveness, Contrary to Monocyte-Derived Dendritic Cells
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IMMUNE REGULATION

Lymph Node Stromal Cells Negatively Regulate Antigen-Specific CD4+ T Cell Responses
Jun Abe; Shigeyuki Shichino; Satoshi Ueha; Shin-ichi Hashimoto; Michio Tomura; Yutaka Inagaki; Jens V. Stein; Kouji Matsushima
J Immunol (2014) 193 (4): 1636–1644.
View articletitled, Lymph Node Stromal Cells Negatively Regulate Antigen-Specific CD4<sup>+</sup> T Cell Responses
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γδT Cells Drive Myeloid-Derived Suppressor Cell–Mediated CD8+ T Cell Exhaustion in Hepatitis B Virus–Induced Immunotolerance
Xiaohui Kong; Rui Sun; Yongyan Chen; Haiming Wei; Zhigang Tian
J Immunol (2014) 193 (4): 1645–1653.
View articletitled, γδT Cells Drive Myeloid-Derived Suppressor Cell–Mediated CD8<sup>+</sup> T Cell Exhaustion in Hepatitis B Virus–Induced Immunotolerance
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The NKG2D Ligand ULBP2 Is Specifically Regulated through an Invariant Chain–Dependent Endosomal Pathway
Franziska Uhlenbrock; Michael Hagemann-Jensen; Stephanie Kehlet; Lars Andresen; Silvia Pastorekova; Søren Skov
J Immunol (2014) 193 (4): 1654–1665.
View articletitled, The NKG2D Ligand ULBP2 Is Specifically Regulated through an Invariant Chain–Dependent Endosomal Pathway
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Regulation of Intestinal IgA Responses by Dietary Palmitic Acid and Its Metabolism
Jun Kunisawa; Eri Hashimoto; Asuka Inoue; Risa Nagasawa; Yuji Suzuki; Izumi Ishikawa; Shiori Shikata; Makoto Arita; Junken Aoki; Hiroshi Kiyono
J Immunol (2014) 193 (4): 1666–1671.
View articletitled, Regulation of Intestinal IgA Responses by Dietary Palmitic Acid and Its Metabolism
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Deltex1 Promotes Protein Kinase Cθ Degradation and Sustains Casitas B-Lineage Lymphoma Expression
Tzu-Sheng Hsu; Huey-Wen Hsiao; Pei-Jung Wu; Wen-Hsien Liu; Ming-Zong Lai
J Immunol (2014) 193 (4): 1672–1680.
View articletitled, Deltex1 Promotes Protein Kinase Cθ Degradation and Sustains Casitas B-Lineage Lymphoma Expression
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Marginal Zone B Cells Transport IgG3-Immune Complexes to Splenic Follicles
Lu Zhang; Zhoujie Ding; Hui Xu; Birgitta Heyman
J Immunol (2014) 193 (4): 1681–1689.
View articletitled, Marginal Zone B Cells Transport IgG3-Immune Complexes to Splenic Follicles
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Repression of Arginase-2 Expression in Dendritic Cells by MicroRNA-155 Is Critical for Promoting T Cell Proliferation
Isabelle Dunand-Sauthier; Magali Irla; Stéphanie Carnesecchi; Queralt Seguín-Estévez; Charles E. Vejnar; Evgeny M. Zdobnov; Marie-Laure Santiago-Raber; Walter Reith
J Immunol (2014) 193 (4): 1690–1700.
View articletitled, Repression of Arginase-2 Expression in Dendritic Cells by MicroRNA-155 Is Critical for Promoting T Cell Proliferation
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Distinct Fcγ Receptors Mediate the Effect of Serum Amyloid P on Neutrophil Adhesion and Fibrocyte Differentiation
Nehemiah Cox; Darrell Pilling; Richard H. Gomer
J Immunol (2014) 193 (4): 1701–1708.
View articletitled, Distinct Fcγ Receptors Mediate the Effect of Serum Amyloid P on Neutrophil Adhesion and Fibrocyte Differentiation
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Increased Antitumor Effects Using IL-2 with Anti–TGF-β Reveals Competition between Mouse NK and CD8 T Cells
Maite Alvarez; Myriam N. Bouchlaka; Gail D. Sckisel; Can M. Sungur; Mingyi Chen; William J. Murphy
J Immunol (2014) 193 (4): 1709–1716.
View articletitled, Increased Antitumor Effects Using IL-2 with Anti–TGF-β Reveals Competition between Mouse NK and CD8 T Cells
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Macrophage PTEN Regulates Expression and Secretion of Arginase I Modulating Innate and Adaptive Immune Responses
Emine Sahin; Stefan Haubenwallner; Mario Kuttke; Isabella Kollmann; Angela Halfmann; Alexander B. Dohnal; Li Chen; Paul Cheng; Bastian Hoesel; Elisa Einwallner; Julia Brunner; Julia B. Kral; Waltraud C. Schrottmaier; Kathrin Thell; Victoria Saferding; Stephan Blüml; Gernot Schabbauer
J Immunol (2014) 193 (4): 1717–1727.
View articletitled, Macrophage PTEN Regulates Expression and Secretion of Arginase I Modulating Innate and Adaptive Immune Responses
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Lnk/Sh2b3 Controls the Production and Function of Dendritic Cells and Regulates the Induction of IFN-γ–Producing T Cells
Taizo Mori; Yukiko Iwasaki; Yoichi Seki; Masanori Iseki; Hiroko Katayama; Kazuhiko Yamamoto; Kiyoshi Takatsu; Satoshi Takaki
J Immunol (2014) 193 (4): 1728–1736.
View articletitled, <em>Lnk/Sh2b3</em> Controls the Production and Function of Dendritic Cells and Regulates the Induction of IFN-γ–Producing T Cells
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Leukocyte β7 Integrin Targeted by Krüppel-like Factors
Melanie Alles; Gleb Turchinovich; Pumin Zhang; Wolfgang Schuh; Fabien Agenès; Jörg Kirberg
J Immunol (2014) 193 (4): 1737–1746.
View articletitled, Leukocyte β<sub>7</sub> Integrin Targeted by Krüppel-like Factors
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IMMUNE SYSTEM DEVELOPMENT

Adipocyte IL-15 Regulates Local and Systemic NK Cell Development
Yae-Huei Liou; Szu-Wen Wang; Chin-Ling Chang; Po-Lin Huang; Mau-Sheng Hou; Yein-Gei Lai; Gilbert Aaron Lee; Si-Tse Jiang; Ching-Yen Tsai; Nan-Shih Liao
J Immunol (2014) 193 (4): 1747–1758.
View articletitled, Adipocyte IL-15 Regulates Local and Systemic NK Cell Development
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Mammalian Target of Rapamycin Complex 1 Orchestrates Invariant NKT Cell Differentiation and Effector Function
Lianjun Zhang; Benjamin O. Tschumi; Stéphanie Corgnac; Markus A. Rüegg; Michael N. Hall; Jean-Pierre Mach; Pedro Romero; Alena Donda
J Immunol (2014) 193 (4): 1759–1765.
View articletitled, Mammalian Target of Rapamycin Complex 1 Orchestrates Invariant NKT Cell Differentiation and Effector Function
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A Reporter Mouse Reveals Lineage-Specific and Heterogeneous Expression of IRF8 during Lymphoid and Myeloid Cell Differentiation
Hongsheng Wang; Ming Yan; Jiafang Sun; Shweta Jain; Ryusuke Yoshimi; Sanaz Momben Abolfath; Keiko Ozato; William G. Coleman, Jr.; Ashley P. Ng; Donald Metcalf; Ladina DiRago; Stephen L. Nutt; Herbert C. Morse, III
J Immunol (2014) 193 (4): 1766–1777.
View articletitled, A Reporter Mouse Reveals Lineage-Specific and Heterogeneous Expression of IRF8 during Lymphoid and Myeloid Cell Differentiation
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The Ability To Rearrange Dual TCRs Enhances Positive Selection, Leading to Increased Allo- and Autoreactive T Cell Repertoires
Peggy P. Ni; Benjamin Solomon; Chyi-Song Hsieh; Paul M. Allen; Gerald P. Morris
J Immunol (2014) 193 (4): 1778–1786.
View articletitled, The Ability To Rearrange Dual TCRs Enhances Positive Selection, Leading to Increased Allo- and Autoreactive T Cell Repertoires
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IMMUNOTHERAPY AND VACCINES

Antigen Targeting to CD11b+ Dendritic Cells in Association with TLR4/TRIF Signaling Promotes Strong CD8+ T Cell Responses
Gilles Dadaglio; Catherine Fayolle; Xiaoming Zhang; Bernard Ryffel; Marine Oberkampf; Tristan Felix; Sandra Hervas-Stubbs; Radim Osicka; Peter Sebo; Daniel Ladant; Claude Leclerc
J Immunol (2014) 193 (4): 1787–1798.
View articletitled, Antigen Targeting to CD11b<sup>+</sup> Dendritic Cells in Association with TLR4/TRIF Signaling Promotes Strong CD8<sup>+</sup> T Cell Responses
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Aerosol Vaccination with AERAS-402 Elicits Robust Cellular Immune Responses in the Lungs of Rhesus Macaques but Fails To Protect against High-Dose Mycobacterium tuberculosis Challenge
Patricia A. Darrah; Diane L. Bolton; Andrew A. Lackner; Deepak Kaushal; Pyone Pyone Aye; Smriti Mehra; James L. Blanchard; Peter J. Didier; Chad J. Roy; Srinivas S. Rao; David A. Hokey; Charles A. Scanga; Donata R. Sizemore; Jerald C. Sadoff; Mario Roederer; Robert A. Seder
J Immunol (2014) 193 (4): 1799–1811.
View articletitled, Aerosol Vaccination with AERAS-402 Elicits Robust Cellular Immune Responses in the Lungs of Rhesus Macaques but Fails To Protect against High-Dose <em>Mycobacterium tuberculosis</em> Challenge
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T Cell Antigen Discovery Using Soluble Vaccinia Proteome Reveals Recognition of Antigens with Both Virion and Nonvirion Association
D. Huw Davies; Sookhee Chun; Gary Hermanson; Jo Anne Tucker; Aarti Jain; Rie Nakajima; Jozelyn Pablo; Philip L. Felgner; Xiaowu Liang
J Immunol (2014) 193 (4): 1812–1827.
View articletitled, T Cell Antigen Discovery Using Soluble Vaccinia Proteome Reveals Recognition of Antigens with Both Virion and Nonvirion Association
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Fcγ Receptor Dependency of Agonistic CD40 Antibody in Lymphoma Therapy Can Be Overcome through Antibody Multimerization
Ann L. White; Lang Dou; H. T. Claude Chan; Vikki L. Field; C. Ian Mockridge; Kane Moss; Emily L. Williams; Steven G. Booth; Ruth R. French; Elizabeth A. Potter; Cherié Butts; Aymen Al-Shamkhani; Mark S. Cragg; J. Sjef Verbeek; Peter W. M. Johnson; Martin J. Glennie; Stephen A. Beers
J Immunol (2014) 193 (4): 1828–1835.
View articletitled, Fcγ Receptor Dependency of Agonistic CD40 Antibody in Lymphoma Therapy Can Be Overcome through Antibody Multimerization
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The Effect of Adjuvanting Cancer Vaccines with Herpes Simplex Virus Glycoprotein D on Melanoma-Driven CD8+ T Cell Exhaustion
Ying Zhang; Hildegund C. J. Ertl
J Immunol (2014) 193 (4): 1836–1846.
View articletitled, The Effect of Adjuvanting Cancer Vaccines with Herpes Simplex Virus Glycoprotein D on Melanoma-Driven CD8<sup>+</sup> T Cell Exhaustion
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IL-2 Induction of Blimp-1 Is a Key In Vivo Signal for CD8+ Short-Lived Effector T Cell Differentiation
Salix Boulet; Jean-François Daudelin; Nathalie Labrecque
J Immunol (2014) 193 (4): 1847–1854.
View articletitled, IL-2 Induction of Blimp-1 Is a Key In Vivo Signal for CD8<sup>+</sup> Short-Lived Effector T Cell Differentiation
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INFECTIOUS DISEASE AND HOST RESPONSE

Inhibition of the Classical Pathway of Complement by Meningococcal Capsular Polysaccharides
Sarika Agarwal; Shreekant Vasudhev; Rosane B. DeOliveira; Sanjay Ram
J Immunol (2014) 193 (4): 1855–1863.
View articletitled, Inhibition of the Classical Pathway of Complement by Meningococcal Capsular Polysaccharides
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Platelet Activation and Apoptosis Modulate Monocyte Inflammatory Responses in Dengue
Eugenio D. Hottz; Isabel M. Medeiros-de-Moraes; Adriana Vieira-de-Abreu; Edson F. de Assis; Rogério Vals-de-Souza; Hugo C. Castro-Faria-Neto; Andrew S. Weyrich; Guy A. Zimmerman; Fernando A. Bozza; Patrícia T. Bozza
J Immunol (2014) 193 (4): 1864–1872.
View articletitled, Platelet Activation and Apoptosis Modulate Monocyte Inflammatory Responses in Dengue
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Antigen-Specific Naive CD8+ T Cells Produce a Single Pulse of IFN-γ In Vivo within Hours of Infection, but without Antiviral Effect
Martin P. Hosking; Claudia T. Flynn; J. Lindsay Whitton
J Immunol (2014) 193 (4): 1873–1885.
View articletitled, Antigen-Specific Naive CD8<sup>+</sup> T Cells Produce a Single Pulse of IFN-γ In Vivo within Hours of Infection, but without Antiviral Effect
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Does β-Hexosaminidase Function Only as a Degranulation Indicator in Mast Cells? The Primary Role of β-Hexosaminidase in Mast Cell Granules
Nobuyuki Fukuishi; Shinya Murakami; Akane Ohno; Naoya Yamanaka; Nobuaki Matsui; Kenji Fukutsuji; Sakuo Yamada; Kouji Itoh; Masaaki Akagi
J Immunol (2014) 193 (4): 1886–1894.
View articletitled, Does β-Hexosaminidase Function Only as a Degranulation Indicator in Mast Cells? The Primary Role of β-Hexosaminidase in Mast Cell Granules
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CCR5 Knockout Prevents Neuronal Injury and Behavioral Impairment Induced in a Transgenic Mouse Model by a CXCR4-Using HIV-1 Glycoprotein 120
Ricky Maung; Melanie M. Hoefer; Ana B. Sanchez; Natalia E. Sejbuk; Kathryn E. Medders; Maya K. Desai; Irene C. Catalan; Cari C. Dowling; Cyrus M. de Rozieres; Gwenn A. Garden; Rossella Russo; Amanda J. Roberts; Roy Williams; Marcus Kaul
J Immunol (2014) 193 (4): 1895–1910.
View articletitled, CCR5 Knockout Prevents Neuronal Injury and Behavioral Impairment Induced in a Transgenic Mouse Model by a CXCR4-Using HIV-1 Glycoprotein 120
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INNATE IMMUNITY AND INFLAMMATION

TRIL Is Involved in Cytokine Production in the Brain following Escherichia coli Infection
Paulina Wochal; Vijay A. K. Rathinam; Aisling Dunne; Thaddeus Carlson; Wen Kuang; Katherine J. Seidl; J. Perry Hall; Lih-Ling Lin; Mary Collins; Stefan A. Schattgen; Christopher R. MacKay; Caio T. Fagundes; Susan Carpenter; Katherine A. Fitzgerald; Luke A. J. O’Neill
J Immunol (2014) 193 (4): 1911–1919.
View articletitled, TRIL Is Involved in Cytokine Production in the Brain following <em>Escherichia coli</em> Infection
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Enhancement of Adaptive Immunity by the Human Vaccine Adjuvant AS01 Depends on Activated Dendritic Cells
Arnaud M. Didierlaurent; Catherine Collignon; Patricia Bourguignon; Sandrine Wouters; Kaat Fierens; Michel Fochesato; Najoua Dendouga; Christelle Langlet; Bernard Malissen; Bart N. Lambrecht; Nathalie Garçon; Marcelle Van Mechelen; Sandra Morel
J Immunol (2014) 193 (4): 1920–1930.
View articletitled, Enhancement of Adaptive Immunity by the Human Vaccine Adjuvant AS01 Depends on Activated Dendritic Cells
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Differential Role for p120-Catenin in Regulation of TLR4 Signaling in Macrophages
Zhiyong Yang; Dong Sun; Zhibo Yan; Albert B. Reynolds; John W. Christman; Richard D. Minshall; Asrar B. Malik; Yang Zhang; Guochang Hu
J Immunol (2014) 193 (4): 1931–1941.
View articletitled, Differential Role for p120-Catenin in Regulation of TLR4 Signaling in Macrophages
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Myeloid-Derived Suppressor Cells Are Involved in Lysosomal Acid Lipase Deficiency–Induced Endothelial Cell Dysfunctions
Ting Zhao; Xinchun Ding; Hong Du; Cong Yan
J Immunol (2014) 193 (4): 1942–1953.
View articletitled, Myeloid-Derived Suppressor Cells Are Involved in Lysosomal Acid Lipase Deficiency–Induced Endothelial Cell Dysfunctions
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Immobilized Immune Complexes Induce Neutrophil Extracellular Trap Release by Human Neutrophil Granulocytes via FcγRIIIB and Mac-1
Martina Behnen; Christoph Leschczyk; Sonja Möller; Tobit Batel; Matthias Klinger; Werner Solbach; Tamás Laskay
J Immunol (2014) 193 (4): 1954–1965.
View articletitled, Immobilized Immune Complexes Induce Neutrophil Extracellular Trap Release by Human Neutrophil Granulocytes via FcγRIIIB and Mac-1
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Neutrophils Exhibit Differential Requirements for Homing Molecules in Their Lymphatic and Blood Trafficking into Draining Lymph Nodes
Carolina V. Gorlino; Romina P. Ranocchia; María F. Harman; Iris A. García; María I. Crespo; Gabriel Morón; Belkys A. Maletto; María C. Pistoresi-Palencia
J Immunol (2014) 193 (4): 1966–1974.
View articletitled, Neutrophils Exhibit Differential Requirements for Homing Molecules in Their Lymphatic and Blood Trafficking into Draining Lymph Nodes
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Moderate Alcohol Induces Stress Proteins HSF1 and hsp70 and Inhibits Proinflammatory Cytokines Resulting in Endotoxin Tolerance
Sujatha Muralidharan; Aditya Ambade; Melissa A. Fulham; Janhavee Deshpande; Donna Catalano; Pranoti Mandrekar
J Immunol (2014) 193 (4): 1975–1987.
View articletitled, Moderate Alcohol Induces Stress Proteins HSF1 and hsp70 and Inhibits Proinflammatory Cytokines Resulting in Endotoxin Tolerance
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Cell Cycle Control and HIV-1 Susceptibility Are Linked by CDK6-Dependent CDK2 Phosphorylation of SAMHD1 in Myeloid and Lymphoid Cells
Eduardo Pauls; Alba Ruiz; Roger Badia; Marc Permanyer; Albert Gubern; Eva Riveira-Muñoz; Javier Torres-Torronteras; Mar Álvarez; Beatriz Mothe; Christian Brander; Manel Crespo; Luis Menéndez-Arias; Bonaventura Clotet; Oliver T. Keppler; Ramon Martí; Francesc Posas; Ester Ballana; José A. Esté
J Immunol (2014) 193 (4): 1988–1997.
View articletitled, Cell Cycle Control and HIV-1 Susceptibility Are Linked by CDK6-Dependent CDK2 Phosphorylation of SAMHD1 in Myeloid and Lymphoid Cells
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MOLECULAR AND STRUCTURAL IMMUNOLOGY

Structure of the Superantigen Staphylococcal Enterotoxin B in Complex with TCR and Peptide–MHC Demonstrates Absence of TCR–Peptide Contacts
Karin E. J. Rödström; Karin Elbing; Karin Lindkvist-Petersson
J Immunol (2014) 193 (4): 1998–2004.
View articletitled, Structure of the Superantigen Staphylococcal Enterotoxin B in Complex with TCR and Peptide–MHC Demonstrates Absence of TCR–Peptide Contacts
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TRANSPLANTATION

MHC-Mismatched Chimerism Is Required for Induction of Transplantation Tolerance in Autoimmune Nonobese Diabetic Recipients
Miao Wang; Jeremy Racine; Mingfeng Zhang; Tao Wu; Ruishu Deng; Heather Johnston; Christine Shen; Kathleen Siswanto; Defu Zeng
J Immunol (2014) 193 (4): 2005–2015.
View articletitled, MHC-Mismatched Chimerism Is Required for Induction of Transplantation Tolerance in Autoimmune Nonobese Diabetic Recipients
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TUMOR IMMUNOLOGY

NK Cells Are the Crucial Antitumor Mediators When STAT3-Mediated Immunosuppression Is Blocked in Hepatocellular Carcinoma
Qiangjun Sui; Jian Zhang; Xiaoxia Sun; Cai Zhang; Qiuju Han; Zhigang Tian
J Immunol (2014) 193 (4): 2016–2023.
View articletitled, NK Cells Are the Crucial Antitumor Mediators When STAT3-Mediated Immunosuppression Is Blocked in Hepatocellular Carcinoma
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Therapy of Peritoneally Disseminated Colon Cancer by TAP-Deficient Embryonic Stem Cell–Derived Macrophages in Allogeneic Recipients
Eriko Haga; Yuko Endo; Miwa Haruta; Chihiro Koba; Keiko Matsumura; Koutaro Takamatsu; Tokunori Ikeda; Yasuharu Nishimura; Satoru Senju
J Immunol (2014) 193 (4): 2024–2033.
View articletitled, Therapy of Peritoneally Disseminated Colon Cancer by TAP-Deficient Embryonic Stem Cell–Derived Macrophages in Allogeneic Recipients
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    On the cover: Localization of BrdU+ (red) gp38+ (blue) fibroblastic reticular cells relative to blood vessels (green) on day 14 postinfection by OVA-expressing recombinant vaccinia virus. Continuous BrdU labeling allowed identification of the fibroblastic reticular cells replaced by the day of analysis. Abe, J., S. Shichino, S. Ueha, S.-i. Hashimoto, M. Tomura, Y. Inagaki, J. V. Stein, and K. Matsushima. 2014. Lymph node stromal cells negatively regulate antigen-specific CD4+ T cell responses. J. Immunol. 193: 1636–1644.
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