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1 October 2014
ISSN 0022-1767
EISSN 1550-6606
In this Issue
IN THIS ISSUE
LETTERS TO THE EDITOR
PILLARS OF IMMUNOLOGY
Macrophage Activation as an Effector Mechanism for Cell-Mediated Immunity
J Immunol (2014) 193 (7): 3183–3184.
Pillars Article: Cellular Resistance to Infection. J. Exp. Med. 1962. 116: 381–406
J Immunol (2014) 193 (7): 3185–3221.
Pillars Article: The Immunological Basis of Acquired Cellular Resistance. J. Exp. Med. 1964. 120: 105–120
J Immunol (2014) 193 (7): 3222–3237.
BRIEF REVIEWS
Helminth Infections Decrease Host Susceptibility to Immune-Mediated Diseases
J Immunol (2014) 193 (7): 3239–3247.
Putting J Chain Back on the Map: How Might Its Expression Define Plasma Cell Development?
J Immunol (2014) 193 (7): 3248–3255.
CUTTING EDGE
Cutting Edge: The UNC93B1 Tyrosine-Based Motif Regulates Trafficking and TLR Responses via Separate Mechanisms
Karin Pelka; Kshiti Phulphagar; Jana Zimmermann; Rainer Stahl; Jonathan L. Schmid-Burgk; Tobias Schmidt; Jan-Hendrik Spille; Larisa I. Labzin; Sudhir Agrawal; Ekambar R. Kandimalla; Jean-Laurent Casanova; Veit Hornung; Ann Marshak-Rothstein; Stefan Höning; Eicke Latz
J Immunol (2014) 193 (7): 3257–3261.
ANTIGEN RECOGNITION AND RESPONSES
Bispecificity for Myelin and Neuronal Self-Antigens Is a Common Feature of CD4 T Cells in C57BL/6 Mice
Liliana E. Lucca; Sabine Desbois; Abdulraouf Ramadan; Avraham Ben-Nun; Miriam Eisenstein; Nadège Carrié; Jean-Charles Guéry; Alessandro Sette; Phuong Nguyen; Terrence L. Geiger; Lennart T. Mars; Roland S. Liblau
J Immunol (2014) 193 (7): 3267–3277.
AUTOIMMUNITY
Inhibition of TYK2 and JAK1 Ameliorates Imiquimod-Induced Psoriasis-like Dermatitis by Inhibiting IL-22 and the IL-23/IL-17 Axis
Melissa G. Works; Fangfang Yin; Catherine C. Yin; Ying Yiu; Kenneth Shew; Thanh-Thuy Tran; Nahoko Dunlap; Jennifer Lam; Tim Mitchell; John Reader; Paul L. Stein; Annalisa D’Andrea
J Immunol (2014) 193 (7): 3278–3287.
Complement Component C5a Permits the Coexistence of Pathogenic Th17 Cells and Type I IFN in Lupus
Sudesh Pawaria; Kritika Ramani; Kelly Maers; Youhua Liu; Lawrence P. Kane; Marc C. Levesque; Partha S. Biswas
J Immunol (2014) 193 (7): 3288–3295.
The Cross-Priming Capacity and Direct Presentation Potential of an Autoantigen Are Separable and Inversely Related Properties
Jinguo Wang; Roopa Hebbandi Nanjundappa; Afshin Shameli; Xavier Clemente-Casares; Jun Yamanouchi; John F. Elliott; Robyn Slattery; Pau Serra; Pere Santamaria
J Immunol (2014) 193 (7): 3296–3307.
Fungal β-Glucan, a Dectin-1 Ligand, Promotes Protection from Type 1 Diabetes by Inducing Regulatory Innate Immune Response
J Immunol (2014) 193 (7): 3308–3321.
CLINICAL AND HUMAN IMMUNOLOGY
IL-21 Is a Central Memory T Cell–Associated Cytokine That Inhibits the Generation of Pathogenic Th1/17 Effector Cells
Ilko Kastirr; Stefano Maglie; Moira Paroni; Johanna Sophie Alfen; Giulia Nizzoli; Elisa Sugliano; Maria-Cristina Crosti; Monica Moro; Bodo Steckel; Svenja Steinfelder; Katharina Stölzel; Chiara Romagnani; Fiorenzo Botti; Flavio Caprioli; Massimilliano Pagani; Sergio Abrignani; Jens Geginat
J Immunol (2014) 193 (7): 3322–3331.
Identification of Immunogenic Antigens from Aspergillus fumigatus by Direct Multiparameter Characterization of Specific Conventional and Regulatory CD4+ T Cells
Petra Bacher; Olaf Kniemeyer; Janka Teutschbein; Marcel Thön; Martin Vödisch; Dirk Wartenberg; Daniel H. Scharf; Nora Koester-Eiserfunke; Mark Schütte; Stefan Dübel; Mario Assenmacher; Axel A. Brakhage; Alexander Scheffold
J Immunol (2014) 193 (7): 3332–3343.
Monocyte-Induced Development of Th17 Cells and the Release of S100 Proteins Are Involved in the Pathogenesis of Graft-versus-Host Disease
Katharina Reinhardt; Dirk Foell; Thomas Vogl; Markus Mezger; Helmut Wittkowski; Falko Fend; Birgit Federmann; Christian Gille; Tobias Feuchtinger; Peter Lang; Rupert Handgretinger; Wolfgang Andreas Bethge; Ursula Holzer
J Immunol (2014) 193 (7): 3355–3365.
CD39 and CD161 Modulate Th17 Responses in Crohn's Disease
Aiping Bai; Alan Moss; Efi Kokkotou; Anny Usheva; Xiaofeng Sun; Adam Cheifetz; Yi Zheng; Maria Serena Longhi; Wenda Gao; Yan Wu; Simon C. Robson
J Immunol (2014) 193 (7): 3366–3377.
IMMUNE REGULATION
TGF-β–Induced CD4+Foxp3+ T Cells Attenuate Acute Graft-versus-Host Disease by Suppressing Expansion and Killing of Effector CD8+ Cells
Jian Gu; Ling Lu; Maogen Chen; Lili Xu; Qin Lan; Qiang Li; Zhongmin Liu; Guihua Chen; Ping Wang; Xuehao Wang; David Brand; Nancy Olsen; Song Guo Zheng
J Immunol (2014) 193 (7): 3388–3397.
TLR9 Transcriptional Regulation in Response to Double-Stranded DNA Viruses
Claudia Zannetti; Peggy Parroche; Marine Panaye; Guillaume Roblot; Henri Gruffat; Evelyne Manet; Anne Laure Debaud; Joel Plumas; Nelly Vey; Christophe Caux; Nathalie Bendriss-Vermare; Uzma Ayesha Hasan
J Immunol (2014) 193 (7): 3398–3408.
Immunoregulation of Dendritic Cells by the Receptor T cell Ig and Mucin Protein-3 via Bruton’s Tyrosine Kinase and c-Src
J Immunol (2014) 193 (7): 3417–3425.
Systemic C3 Modulates CD8+ T Cell Contraction after Listeria monocytogenes Infection
J Immunol (2014) 193 (7): 3426–3435.
Adenosine Deaminase Acting on RNA 1 Limits RIG-I RNA Detection and Suppresses IFN Production Responding to Viral and Endogenous RNAs
Shengyong Yang; Peng Deng; Zhaowei Zhu; Jianzhong Zhu; Guoliang Wang; Liyong Zhang; Alex F. Chen; Tony Wang; Saumendra N. Sarkar; Timothy R. Billiar; Qingde Wang
J Immunol (2014) 193 (7): 3436–3445.
IMMUNE SYSTEM DEVELOPMENT
Transcriptional Characterization of the T Cell Population within the Salmonid Interbranchial Lymphoid Tissue
Ida Bergva Aas; Lars Austbø; Melanie König; Mohasina Syed; Knut Falk; Ivar Hordvik; Erling O. Koppang
J Immunol (2014) 193 (7): 3463–3469.
GATA-3 Dose-Dependent Checkpoints in Early T Cell Commitment
Deirdre D. Scripture-Adams; Sagar S. Damle; Long Li; Koorosh J. Elihu; Shuyang Qin; Alexandra M. Arias; Robert R. Butler, III; Ameya Champhekar; Jingli A. Zhang; Ellen V. Rothenberg
J Immunol (2014) 193 (7): 3470–3491.
IMMUNOGENETICS
The Mouse Idd2 Locus Is Linked to the Proportion of Immunoregulatory Double-Negative T Cells, a Trait Associated with Autoimmune Diabetes Resistance
J Immunol (2014) 193 (7): 3503–3512.
IMMUNOTHERAPY AND VACCINES
Characterization of Cross-Protection by Genetically Modified Live-Attenuated Leishmania donovani Parasites against Leishmania mexicana
Ranadhir Dey; Gayathri Natarajan; Parna Bhattacharya; Hannah Cummings; Pradeep K. Dagur; César Terrazas; Angamuthu Selvapandiyan; John P. McCoy, Jr.; Robert Duncan; Abhay R. Satoskar; Hira L. Nakhasi
J Immunol (2014) 193 (7): 3513–3527.
Circulating CXCR5+PD-1+ Response Predicts Influenza Vaccine Antibody Responses in Young Adults but not Elderly Adults
Ramin Sedaghat Herati; Morgan A. Reuter; Douglas V. Dolfi; Kathleen D. Mansfield; Htin Aung; Osama Z. Badwan; Raj K. Kurupati; Senthil Kannan; Hildegund Ertl; Kenneth E. Schmader; Michael R. Betts; David H. Canaday; E. John Wherry
J Immunol (2014) 193 (7): 3528–3537.
INFECTIOUS DISEASE AND HOST RESPONSE
Helicobacter pylori–Induced IL-1β Secretion in Innate Immune Cells Is Regulated by the NLRP3 Inflammasome and Requires the Cag Pathogenicity Island
Raphaela P. Semper; Raquel Mejías-Luque; Christina Groß; Florian Anderl; Anne Müller; Michael Vieth; Dirk H. Busch; Clarissa Prazeres da Costa; Jürgen Ruland; Olaf Groß; Markus Gerhard
J Immunol (2014) 193 (7): 3566–3576.
T Cell–Derived IL-4/IL-13 Protects Mice against Fatal Schistosoma mansoni Infection Independently of Basophils
J Immunol (2014) 193 (7): 3590–3599.
Type I IFN Induces IL-10 Production in an IL-27–Independent Manner and Blocks Responsiveness to IFN-γ for Production of IL-12 and Bacterial Killing in Mycobacterium tuberculosis–Infected Macrophages
Finlay W. McNab; John Ewbank; Ashleigh Howes; Lucia Moreira-Teixeira; Anna Martirosyan; Nico Ghilardi; Margarida Saraiva; Anne O’Garra
J Immunol (2014) 193 (7): 3600–3612.
Pegylated Bisacycloxypropylcysteine, a Diacylated Lipopeptide Ligand of TLR6, Plays a Host-Protective Role against Experimental Leishmania major Infection
Surya Prakash Pandey; Himanshu Singh Chandel; Sunit Srivastava; Sathishkumar Selvaraj; Mukesh Kumar Jha; Divanshu Shukla; Thomas Ebensen; Carlos A. Guzman; Bhaskar Saha
J Immunol (2014) 193 (7): 3632–3643.
SHP-1 Plays a Crucial Role in CD40 Signaling Reciprocity
Tabish Hasan Khan; Neetu Srivastava; Ankita Srivastava; Archana Sareen; Ram K. Mathur; Ajit G. Chande; Krishnasastry V. Musti; Somenath Roy; Robin Mukhopadhyaya; Bhaskar Saha
J Immunol (2014) 193 (7): 3644–3653.
INNATE IMMUNITY AND INFLAMMATION
Plasmin Induces In Vivo Monocyte Recruitment through Protease-Activated Receptor-1–, MEK/ERK-, and CCR2-Mediated Signaling
Aline A. F. Carmo; Bruno R. C. Costa; Juliana P. Vago; Leonardo C. de Oliveira; Luciana P. Tavares; Camila R. C. Nogueira; Ana Luíza C. Ribeiro; Cristiana C. Garcia; Alan S. Barbosa; Bruno S. A. F. Brasil; Luci M. Dusse; Lucíola S. Barcelos; Cláudio A. Bonjardim; Mauro M. Teixeira; Lirlândia P. Sousa
J Immunol (2014) 193 (7): 3654–3663.
Differential Control of Mincle-Dependent Cord Factor Recognition and Macrophage Responses by the Transcription Factors C/EBPβ and HIF1α
Hanne Schoenen; Alexandra Huber; Nada Sonda; Stephanie Zimmermann; Jonathan Jantsch; Bernd Lepenies; Vincenzo Bronte; Roland Lang
J Immunol (2014) 193 (7): 3664–3675.
The E3 Ubiquitin Ligase Tripartite Motif 33 Is Essential for Cytosolic RNA–Induced NLRP3 Inflammasome Activation
J Immunol (2014) 193 (7): 3676–3682.
Microbe-Specific Unconventional T Cells Induce Human Neutrophil Differentiation into Antigen Cross-Presenting Cells
Martin S. Davey; Matt P. Morgan; Anna Rita Liuzzi; Christopher J. Tyler; Mohd Wajid A. Khan; Tamas Szakmany; Judith E. Hall; Bernhard Moser; Matthias Eberl
J Immunol (2014) 193 (7): 3704–3716.
Basophils Promote Innate Lymphoid Cell Responses in Inflamed Skin
Brian S. Kim; Kelvin Wang; Mark C. Siracusa; Steven A. Saenz; Jonathan R. Brestoff; Laurel A. Monticelli; Mario Noti; Elia D. Tait Wojno; Thomas C. Fung; Masato Kubo; David Artis
J Immunol (2014) 193 (7): 3717–3725.
TLR-Mediated Inflammatory Responses to Streptococcus pneumoniae Are Highly Dependent on Surface Expression of Bacterial Lipoproteins
Gillian Tomlinson; Suneeta Chimalapati; Tracey Pollard; Thabo Lapp; Jonathan Cohen; Emilie Camberlein; Sian Stafford; Jimstan Periselneris; Christine Aldridge; Waldemar Vollmer; Capucine Picard; Jean-Laurent Casanova; Mahdad Noursadeghi; Jeremy Brown
J Immunol (2014) 193 (7): 3736–3745.
MOLECULAR AND STRUCTURAL IMMUNOLOGY
A Major Deletion in the Vκ–Jκ Intervening Region Results in Hyperelevated Transcription of Proximal Vκ Genes and a Severely Restricted Repertoire
J Immunol (2014) 193 (7): 3746–3754.
Blockade of IL-6 Trans Signaling Attenuates Pulmonary Fibrosis
Thanh-Thuy T. Le; Harry Karmouty-Quintana; Ernestina Melicoff; Thanh-Truc T. Le; Tingting Weng; Ning-Yuan Chen; Mesias Pedroza; Yang Zhou; Jonathan Davies; Kemly Philip; Jose Molina; Fayong Luo; Anuh T. George; Luis J. Garcia-Morales; Raquel R. Bunge; Brian A. Bruckner; Matthias Loebe; Harish Seethamraju; Sandeep K. Agarwal; Michael R. Blackburn
J Immunol (2014) 193 (7): 3755–3768.
MUCOSAL IMMUNOLOGY
STAT3 Activation in Th17 and Th22 Cells Controls IL-22–Mediated Epithelial Host Defense during Infectious Colitis
Ingo Backert; Sergei B. Koralov; Stefan Wirtz; Vera Kitowski; Ulrike Billmeier; Eva Martini; Katharina Hofmann; Kai Hildner; Nadine Wittkopf; Katrin Brecht; Maximilian Waldner; Klaus Rajewsky; Markus F. Neurath; Christoph Becker; Clemens Neufert
J Immunol (2014) 193 (7): 3779–3791.
TRANSPLANTATION
IL-33–Induced Hematopoietic Stem and Progenitor Cell Mobilization Depends upon CCR2
Juyang Kim; Wonyoung Kim; Hongnga T. Le; U J. Moon; Vuvi G. Tran; Hyun J. Kim; Soyeon Jung; Quang-Tam Nguyen; Byung-Sam Kim; Jae-Bum Jun; Hong R. Cho; Byungsuk Kwon
J Immunol (2014) 193 (7): 3792–3802.
Identification of Activators of ERK5 Transcriptional Activity by High-Throughput Screening and the Role of Endothelial ERK5 in Vasoprotective Effects Induced by Statins and Antimalarial Agents
Nhat-Tu Le; Yuichiro Takei; Yuki Izawa-Ishizawa; Kyung-Sun Heo; Hakjoo Lee; Alan V. Smrcka; Benjamin L. Miller; Kyung Ae Ko; Sara Ture; Craig Morrell; Keigi Fujiwara; Masashi Akaike; Jun-ichi Abe
J Immunol (2014) 193 (7): 3803–3815.
Novel CD8 T Cell Alloreactivities in CCR5-Deficient Recipients of Class II MHC Disparate Kidney Grafts
Daisuke Ishii; Joshua M. Rosenblum; Taiji Nozaki; Austin D. Schenk; Kiyoshi Setoguchi; Charles A. Su; Victoria Gorbacheva; William M. Baldwin, III; Anna Valujskikh; Robert L. Fairchild
J Immunol (2014) 193 (7): 3816–3824.
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Cover Image
Cover Image
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On the cover: This image shows α-smooth muscle actin staining (pink) of myofibroblasts together with nuclear staining of phosphorylated STAT-3 (brown) in a lung section from a patient with idiopathic pulmonary fibrosis. Le and colleagues demonstrate that IL-6 trans signaling activates this pathway and plays a role in pulmonary fibrosis. Le, T.-T. T., H. Karmouty-Quintana, E. Melicoff, T.-T. T. Le, T. Weng, N.-Y. Chen, M. Pedroza, Y. Zhou, J. Davies, K. Philip, J. Molina, F. Luo, A. T. George, L. J. Garcia-Morales, R. R. Bunge, B. A. Bruckner, M. Loebe, H. Seethamraju, S. K. Agarwal, and M. R. Blackburn. 2014. Blockade of IL-6 trans signaling attenuates pulmonary fibrosis. J. Immunol. 193: 3755–3768.
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