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Issues
15 October 2014
ISSN 0022-1767
EISSN 1550-6606
PRESIDENT'S ADDRESS
IN THIS ISSUE
BRIEF REVIEWS
The Programmed Death-1 Immune-Suppressive Pathway: Barrier to Antitumor Immunity
J Immunol (2014) 193 (8): 3835–3841.
Innate Receptors and Cellular Defense against Pulmonary Infections
J Immunol (2014) 193 (8): 3842–3850.
ANTIGEN RECOGNITION AND RESPONSES
SAP-Regulated T Cell–APC Adhesion and Ligation-Dependent and -Independent Ly108–CD3ζ Interactions
Coco Chu; Yifeng Wang; Xu Zhang; Xinya Ni; Junxia Cao; Wan Xu; Zhongjun Dong; Pengfei Yuan; Wensheng Wei; Yuanwu Ma; Lianfeng Zhang; Longyan Wu; Hai Qi
J Immunol (2014) 193 (8): 3860–3871.
AUTOIMMUNITY
Autoimmune Predisposition in Down Syndrome May Result from a Partial Central Tolerance Failure due to Insufficient Intrathymic Expression of AIRE and Peripheral Antigens
Mireia Giménez-Barcons; Anna Casteràs; Maria del Pilar Armengol; Eduard Porta; Paula A. Correa; Ana Marín; Ricardo Pujol-Borrell; Roger Colobran
J Immunol (2014) 193 (8): 3872–3879.
Clinical and Serologic Parallels to APS-I in Patients with Thymomas and Autoantigen Transcripts in Their Tumors
Anette S. B. Wolff; Jaanika Kärner; Jone F. Owe; Bergithe E. V. Oftedal; Nils Erik Gilhus; Martina M. Erichsen; Olle Kämpe; Anthony Meager; Pärt Peterson; Kai Kisand; Nick Willcox; Eystein S. Husebye
J Immunol (2014) 193 (8): 3880–3890.
Mucosal-Associated Invariant T Cell Deficiency in Systemic Lupus Erythematosus
Young-Nan Cho; Seung-Jung Kee; Tae-Jong Kim; Hye Mi Jin; Moon-Ju Kim; Hyun-Ju Jung; Ki-Jeong Park; Sung-Ji Lee; Shin-Seok Lee; Yong-Soo Kwon; Hae Jin Kee; Nacksung Kim; Yong-Wook Park
J Immunol (2014) 193 (8): 3891–3901.
CLINICAL AND HUMAN IMMUNOLOGY
Ligation of TLR5 Promotes Myeloid Cell Infiltration and Differentiation into Mature Osteoclasts in Rheumatoid Arthritis and Experimental Arthritis
Seung-jae Kim; Zhenlong Chen; Nathan D. Chamberlain; Abdul B. Essani; Michael V. Volin; M. Asif Amin; Suncica Volkov; Ellen M. Gravallese; Shiva Arami; William Swedler; Nancy E. Lane; Anjali Mehta; Nadera Sweiss; Shiva Shahrara
J Immunol (2014) 193 (8): 3902–3913.
IMMUNE REGULATION
IL-17A Enhances the Expression of Profibrotic Genes through Upregulation of the TGF-β Receptor on Hepatic Stellate Cells in a JNK-Dependent Manner
J Immunol (2014) 193 (8): 3925–3933.
Restriction of IL-22–Producing T Cell Responses and Differential Regulation of Regulatory T Cell Compartments by Zinc Finger Transcription Factor Ikaros
Jennifer J. Heller; Hilde Schjerven; Shiyang Li; Aileen Lee; Ju Qiu; Zong-Ming E. Chen; Stephen T. Smale; Liang Zhou
J Immunol (2014) 193 (8): 3934–3946.
Immunophilins Control T Lymphocyte Adhesion and Migration by Regulating CrkII Binding to C3G
J Immunol (2014) 193 (8): 3966–3977.
Alpha-1 Antitrypsin Augmentation Therapy Corrects Accelerated Neutrophil Apoptosis in Deficient Individuals
Killian Hurley; Noreen Lacey; Ciara A. O’Dwyer; David A. Bergin; Oliver J. McElvaney; M. Emmet O’Brien; Oisín F. McElvaney; Emer P. Reeves; Noel G. McElvaney
J Immunol (2014) 193 (8): 3978–3991.
IL-18 Synergizes with IL-7 To Drive Slow Proliferation of Naive CD8 T Cells by Costimulating Self-Peptide–Mediated TCR Signals
J Immunol (2014) 193 (8): 3992–4001.
Long-Acting Glucose-Dependent Insulinotropic Polypeptide Ameliorates Obesity-Induced Adipose Tissue Inflammation
Chen Varol; Isabel Zvibel; Lior Spektor; Fernanda Dana Mantelmacher; Milena Vugman; Tamar Thurm; Marian Khatib; Elinor Elmaliah; Zamir Halpern; Sigal Fishman
J Immunol (2014) 193 (8): 4002–4009.
IMMUNE SYSTEM DEVELOPMENT
IMMUNOTHERAPY AND VACCINES
INFECTIOUS DISEASE AND HOST RESPONSE
Production and Differentiation of Myeloid Cells Driven by Proinflammatory Cytokines in Response to Acute Pneumovirus Infection in Mice
Steven Maltby; Nicole G. Hansbro; Hock L. Tay; Jessica Stewart; Maximilian Plank; Bianca Donges; Helene F. Rosenberg; Paul S. Foster
J Immunol (2014) 193 (8): 4072–4082.
Imipramine Exploits Histone Deacetylase 11 To Increase the IL-12/IL-10 Ratio in Macrophages Infected with Antimony-Resistant Leishmania donovani and Clears Organ Parasites in Experimental Infection
Sandip Mukherjee; Budhaditya Mukherjee; Rupkatha Mukhopadhyay; Kshudiram Naskar; Shyam Sundar; Jean-Claude Dujardin; Syamal Roy
J Immunol (2014) 193 (8): 4083–4094.
IL-1R1 Signaling Regulates CXCL12-Mediated T Cell Localization and Fate within the Central Nervous System during West Nile Virus Encephalitis
J Immunol (2014) 193 (8): 4095–4106.
Early or Late IL-10 Blockade Enhances Th1 and Th17 Effector Responses and Promotes Fungal Clearance in Mice with Cryptococcal Lung Infection
Benjamin J. Murdock; Seagal Teitz-Tennenbaum; Gwo-Hsiao Chen; Anthony J. Dils; Antoni N. Malachowski; Jeffrey L. Curtis; Michal A. Olszewski; John J. Osterholzer
J Immunol (2014) 193 (8): 4107–4116.
IFN-Stimulated Gene LY6E in Monocytes Regulates the CD14/TLR4 Pathway but Inadequately Restrains the Hyperactivation of Monocytes during Chronic HIV-1 Infection
Xuan Xu; Chao Qiu; Lingyan Zhu; Jun Huang; Lishuang Li; Weihui Fu; Linxia Zhang; Jun Wei; Ying Wang; Yunqi Geng; Xiaoyan Zhang; Wentao Qiao; Jianqing Xu
J Immunol (2014) 193 (8): 4125–4136.
Serine Cluster Phosphorylation Liberates the C-Terminal Helix of IFN Regulatory Factor 7 To Bind Histone Acetyltransferase p300
J Immunol (2014) 193 (8): 4137–4148.
MCPIP1 Suppresses Hepatitis C Virus Replication and Negatively Regulates Virus-Induced Proinflammatory Cytokine Responses
Ren-Jye Lin; Jan-Show Chu; Hsu-Ling Chien; Chung-Hsin Tseng; Pin-Chen Ko; Yung-Yu Mei; Wei-Chun Tang; Yu-Ting Kao; Hui-Ying Cheng; Yu-Chih Liang; Shyr-Yi Lin
J Immunol (2014) 193 (8): 4159–4168.
Eosinophil-Derived IL-10 Supports Chronic Nematode Infection
Lu Huang; Nebiat G. Gebreselassie; Lucille F. Gagliardo; Maura C. Ruyechan; Nancy A. Lee; James J. Lee; Judith A. Appleton
J Immunol (2014) 193 (8): 4178–4187.
The Two Human CXCR4 Isoforms Display Different HIV Receptor Activities: Consequences for the Emergence of X4 Strains
Charline Duquenne; Christina Psomas; Sandrine Gimenez; Adeline Guigues; Marie-Josée Carles; Claudine Barbuat; Jean-Philippe Lavigne; Albert Sotto; Jacques Reynes; Paul Guglielmi; Clément Mettling; Vincent François; Pierre Corbeau
J Immunol (2014) 193 (8): 4188–4194.
NFκB2/p100 Is a Key Factor for Endotoxin Tolerance in Human Monocytes: A Demonstration Using Primary Human Monocytes from Patients with Sepsis
Carolina Cubillos-Zapata; Enrique Hernández-Jiménez; Víctor Toledano; Laura Esteban-Burgos; Irene Fernández-Ruíz; Vanesa Gómez-Piña; Carlos del Fresno; María Siliceo; Patricia Prieto-Chinchiña; Rebeca Pérez de Diego; Lisardo Boscá; Manuel Fresno; Francisco Arnalich; Eduardo López-Collazo
J Immunol (2014) 193 (8): 4195–4202.
INNATE IMMUNITY AND INFLAMMATION
TLR2-Dependent Activation of β-Catenin Pathway in Dendritic Cells Induces Regulatory Responses and Attenuates Autoimmune Inflammation
Indumathi Manoharan; Yuan Hong; Amol Suryawanshi; Melinda L. Angus-Hill; Zuoming Sun; Andrew L. Mellor; David H. Munn; Santhakumar Manicassamy
J Immunol (2014) 193 (8): 4203–4213.
Cytosolic Double-Stranded RNA Activates the NLRP3 Inflammasome via MAVS-Induced Membrane Permeabilization and K+ Efflux
Luigi Franchi; Tatjana Eigenbrod; Raúl Muñoz-Planillo; Ulas Ozkurede; Yun-Gi Kim; Arindam Chakrabarti; Michael Gale, Jr.; Robert H. Silverman; Marco Colonna; Shizuo Akira; Gabriel Núñez
J Immunol (2014) 193 (8): 4214–4222.
TRIF Signaling Drives Homeostatic Intestinal Epithelial Antimicrobial Peptide Expression
Silvia Stockinger; Claudia U. Duerr; Marcus Fulde; Tamas Dolowschiak; Johanna Pott; Ines Yang; Daniel Eibach; Fredrik Bäckhed; Shizuo Akira; Sebastian Suerbaum; Martijn Brugman; Mathias W. Hornef
J Immunol (2014) 193 (8): 4223–4234.
Aging Delays Resolution of Acute Inflammation in Mice: Reprogramming the Host Response with Novel Nano-Proresolving Medicines
J Immunol (2014) 193 (8): 4235–4244.
Resident Alveolar Macrophages Suppress, whereas Recruited Monocytes Promote, Allergic Lung Inflammation in Murine Models of Asthma
Zbigniew Zasłona; Sally Przybranowski; Carol Wilke; Nico van Rooijen; Seagal Teitz-Tennenbaum; John J. Osterholzer; John E. Wilkinson; Bethany B. Moore; Marc Peters-Golden
J Immunol (2014) 193 (8): 4245–4253.
TUMOR IMMUNOLOGY
Fc-Optimized NKG2D–Fc Constructs Induce NK Cell Antibody-Dependent Cellular Cytotoxicity against Breast Cancer Cells Independently of HER2/neu Expression Status
Stefanie Raab; Julia Steinbacher; Benjamin J. Schmiedel; Philaretos C. Kousis; Alexander Steinle; Gundram Jung; Ludger Grosse-Hovest; Helmut R. Salih
J Immunol (2014) 193 (8): 4261–4272.
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Cover Image
Cover Image
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On the cover: Immunostaining for Reg3γ (red) of small intestinal tissue from TRIF mutant mice treated i.p. with TNF. Counterstaining was performed with E-cadherin (green) and DAPI (blue). Original magnification ×400. TNF treatment overcomes the reduced level of Reg3γ expression observed in TRIF mutant mice under homeostatic conditions. Stockinger, S., C. U. Duerr, M. Fulde, T. Dolowschiak, J. Pott, I. Yang, D. Eibach, F. Bäckhed, S. Akira, S. Suerbaum, M. Brugman, and M. W. Hornef. 2014. TRIF signalling drives homeostatic intestinal epithelial antimicrobial peptide expression. J. Immunol. 193: 4223–4234. - PDF Icon PDF LinkFront Matter
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