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Volume 194, Issue 10
15 May 2015
Issue Cover
ISSN 0022-1767
EISSN 1550-6606

IN THIS ISSUE

In This Issue
J Immunol (2015) 194 (10): 4593–4594.
View articletitled, In This Issue
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BRIEF REVIEWS

FcRn: The Architect Behind the Immune and Nonimmune Functions of IgG and Albumin
Michal Pyzik; Timo Rath; Wayne I. Lencer; Kristi Baker; Richard S. Blumberg
J Immunol (2015) 194 (10): 4595–4603.
View articletitled, FcRn: The Architect Behind the Immune and Nonimmune Functions of IgG and Albumin
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Cytokines in Graft-versus-Host Disease
Andrea S. Henden; Geoffrey R. Hill
J Immunol (2015) 194 (10): 4604–4612.
View articletitled, Cytokines in Graft-versus-Host Disease
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CUTTING EDGE

Cutting Edge: Differential Regulation of PTEN by TCR, Akt, and FoxO1 Controls CD4+ T Cell Fate Decisions
William F. Hawse; Robert P. Sheehan; Natasa Miskov-Zivanov; Ashley V. Menk; Lawrence P. Kane; James R. Faeder; Penelope A. Morel
J Immunol (2015) 194 (10): 4615–4619.
View articletitled, Cutting Edge: Differential Regulation of PTEN by TCR, Akt, and FoxO1 Controls CD4<sup>+</sup> T Cell Fate Decisions
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ALLERGY AND OTHER HYPERSENSITIVITIES

Integrated Innate Mechanisms Involved in Airway Allergic Inflammation to the Serine Protease Subtilisin
Esther Florsheim; Shuang Yu; Ivan Bragatto; Lucas Faustino; Eliane Gomes; Rodrigo N. Ramos; José Alexandre M. Barbuto; Ruslan Medzhitov; Momtchilo Russo
J Immunol (2015) 194 (10): 4621–4630.
View articletitled, Integrated Innate Mechanisms Involved in Airway Allergic Inflammation to the Serine Protease Subtilisin
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Protective Role of STAT6 in Basophil-Dependent Prurigo-like Allergic Skin Inflammation
Takashi Hashimoto; Takahiro Satoh; Hiroo Yokozeki
J Immunol (2015) 194 (10): 4631–4640.
View articletitled, Protective Role of STAT6 in Basophil-Dependent Prurigo-like Allergic Skin Inflammation
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ANTIGEN RECOGNITION AND RESPONSES

In Vitro and In Vivo Analysis of the Gram-Negative Bacteria–Derived Riboflavin Precursor Derivatives Activating Mouse MAIT Cells
Claire Soudais; Fatoumata Samassa; Manal Sarkis; Lionel Le Bourhis; Stéphanie Bessoles; Didier Blanot; Mireille Hervé; Frédéric Schmidt; Dominique Mengin-Lecreulx; Olivier Lantz
J Immunol (2015) 194 (10): 4641–4649.
View articletitled, In Vitro and In Vivo Analysis of the Gram-Negative Bacteria–Derived Riboflavin Precursor Derivatives Activating Mouse MAIT Cells
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Syk Tyrosine Kinase Is Critical for B Cell Antibody Responses and Memory B Cell Survival
Jochen A. Ackermann; Josquin Nys; Edina Schweighoffer; Scott McCleary; Nicholas Smithers; Victor L. J. Tybulewicz
J Immunol (2015) 194 (10): 4650–4656.
View articletitled, Syk Tyrosine Kinase Is Critical for B Cell Antibody Responses and Memory B Cell Survival
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Impaired NK Cell Responses to Pertussis and H1N1 Influenza Vaccine Antigens in Human Cytomegalovirus-Infected Individuals
Carolyn M. Nielsen; Matthew J. White; Christian Bottomley; Chiara Lusa; Ana Rodríguez-Galán; Scarlett E. G. Turner; Martin R. Goodier; Eleanor M. Riley
J Immunol (2015) 194 (10): 4657–4667.
View articletitled, Impaired NK Cell Responses to Pertussis and H1N1 Influenza Vaccine Antigens in Human Cytomegalovirus-Infected Individuals
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AUTOIMMUNITY

T Cell Cross-Reactivity between a Highly Immunogenic EBV Epitope and a Self-Peptide Naturally Presented by HLA-B*18:01+ Cells
Melissa J. Rist; Kelly M. Hibbert; Nathan P. Croft; Corey Smith; Michelle A. Neller; Jacqueline M. Burrows; John J. Miles; Anthony W. Purcell; Jamie Rossjohn; Stephanie Gras; Scott R. Burrows
J Immunol (2015) 194 (10): 4668–4675.
View articletitled, T Cell Cross-Reactivity between a Highly Immunogenic EBV Epitope and a Self-Peptide Naturally Presented by HLA-B*18:01<sup>+</sup> Cells
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High-Density Lipoprotein Attenuates Th1 and Th17 Autoimmune Responses by Modulating Dendritic Cell Maturation and Function
Ioanna Tiniakou; Elias Drakos; Vaios Sinatkas; Miranda Van Eck; Vassilis I. Zannis; Dimitrios Boumpas; Panayotis Verginis; Dimitris Kardassis
J Immunol (2015) 194 (10): 4676–4687.
View articletitled, High-Density Lipoprotein Attenuates Th1 and Th17 Autoimmune Responses by Modulating Dendritic Cell Maturation and Function
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CLINICAL AND HUMAN IMMUNOLOGY

An NK Cell Population Lacking FcRγ Is Expanded in Chronically Infected HIV Patients
Jingling Zhou; Fathiah S. Amran; Marit Kramski; Tom A. Angelovich; Julian Elliott; Anna C. Hearps; Patricia Price; Anthony Jaworowski
J Immunol (2015) 194 (10): 4688–4697.
View articletitled, An NK Cell Population Lacking FcRγ Is Expanded in Chronically Infected HIV Patients
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Recycled IL-7 Can Be Delivered to Neighboring T Cells
Douglas A. Bazdar; Magdalena Kalinowska; Soumya Panigrahi; Scott F. Sieg
J Immunol (2015) 194 (10): 4698–4704.
View articletitled, Recycled IL-7 Can Be Delivered to Neighboring T Cells
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IMMUNE REGULATION

Macrophage Epoxygenase Determines a Profibrotic Transcriptome Signature
Jacques Behmoaras; Ana Garcia Diaz; Lara Venda; Jeong-Hun Ko; Prashant Srivastava; Alex Montoya; Peter Faull; Zoe Webster; Ben Moyon; Charles D. Pusey; David J. Abraham; Enrico Petretto; Terence H. Cook; Timothy J. Aitman
J Immunol (2015) 194 (10): 4705–4716.
View articletitled, Macrophage Epoxygenase Determines a Profibrotic Transcriptome Signature
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CD28 Promotes Plasma Cell Survival, Sustained Antibody Responses, and BLIMP-1 Upregulation through Its Distal PYAP Proline Motif
Cheryl H. Rozanski; Adam Utley; Louise M. Carlson; Matthew R. Farren; Megan Murray; Lisa M. Russell; Jayakumar R. Nair; ZhengYu Yang; William Brady; Lee Ann Garrett-Sinha; Stephen P. Schoenberger; Jonathan M. Green; Lawrence H. Boise; Kelvin P. Lee
J Immunol (2015) 194 (10): 4717–4728.
View articletitled, CD28 Promotes Plasma Cell Survival, Sustained Antibody Responses, and BLIMP-1 Upregulation through Its Distal PYAP Proline Motif
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Aminoacyl tRNA Synthetase–Interacting Multifunctional Protein 1 Acts as a Novel B Cell–Activating Factor In Vitro and In Vivo
Myun Soo Kim; Tae Sung Kim
J Immunol (2015) 194 (10): 4729–4736.
View articletitled, Aminoacyl tRNA Synthetase–Interacting Multifunctional Protein 1 Acts as a Novel B Cell–Activating Factor In Vitro and In Vivo
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SCARB2/LIMP-2 Regulates IFN Production of Plasmacytoid Dendritic Cells by Mediating Endosomal Translocation of TLR9 and Nuclear Translocation of IRF7
Hao Guo; Jialong Zhang; Xuyuan Zhang; Yanbing Wang; Haisheng Yu; Xiangyun Yin; Jingyun Li; Peishuang Du; Joel Plumas; Laurence Chaperot; Jianzhu Chen; Lishan Su; Yongjun Liu; Liguo Zhang
J Immunol (2015) 194 (10): 4737–4749.
View articletitled, SCARB2/LIMP-2 Regulates IFN Production of Plasmacytoid Dendritic Cells by Mediating Endosomal Translocation of TLR9 and Nuclear Translocation of IRF7
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The Rho GTPase Cdc42 Is Essential for the Activation and Function of Mature B Cells
Natalija Gerasimcik; Carin I. M. Dahlberg; Marisa A. P. Baptista; Michel J. Massaad; Raif S. Geha; Lisa S. Westerberg; Eva Severinson
J Immunol (2015) 194 (10): 4750–4758.
View articletitled, The Rho GTPase Cdc42 Is Essential for the Activation and Function of Mature B Cells
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Tissue-Specific Regulation of p38α-Mediated Inflammation in Con A–Induced Acute Liver Damage
Young Jun Kang; Bo-Ram Bang; Motoyuki Otsuka; Kinya Otsu
J Immunol (2015) 194 (10): 4759–4766.
View articletitled, Tissue-Specific Regulation of p38α-Mediated Inflammation in Con A–Induced Acute Liver Damage
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mTORC2 Deficiency in Myeloid Dendritic Cells Enhances Their Allogeneic Th1 and Th17 Stimulatory Ability after TLR4 Ligation In Vitro and In Vivo
Dàlia Raïch-Regué; Brian R. Rosborough; Alicia R. Watson; Mandy J. McGeachy; Hēth R. Turnquist; Angus W. Thomson
J Immunol (2015) 194 (10): 4767–4776.
View articletitled, mTORC2 Deficiency in Myeloid Dendritic Cells Enhances Their Allogeneic Th1 and Th17 Stimulatory Ability after TLR4 Ligation In Vitro and In Vivo
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IL-33 Reverses an Obesity-Induced Deficit in Visceral Adipose Tissue ST2+ T Regulatory Cells and Ameliorates Adipose Tissue Inflammation and Insulin Resistance
Jonathan M. Han; Dan Wu; Heather C. Denroche; Yu Yao; C. Bruce Verchere; Megan K. Levings
J Immunol (2015) 194 (10): 4777–4783.
View articletitled, IL-33 Reverses an Obesity-Induced Deficit in Visceral Adipose Tissue ST2<sup>+</sup> T Regulatory Cells and Ameliorates Adipose Tissue Inflammation and Insulin Resistance
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IMMUNE SYSTEM DEVELOPMENT

Young, Proliferative Thymic Epithelial Cells Engraft and Function in Aging Thymuses
Mi-Jeong Kim; Christine M. Miller; Jennifer L. Shadrach; Amy J. Wagers; Thomas Serwold
J Immunol (2015) 194 (10): 4784–4795.
View articletitled, Young, Proliferative Thymic Epithelial Cells Engraft and Function in Aging Thymuses
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IMMUNOTHERAPY AND VACCINES

In Vivo Suppression of Heat Shock Protein (HSP)27 and HSP70 Accelerates DMBA-Induced Skin Carcinogenesis by Inducing Antigenic Unresponsiveness to the Initiating Carcinogenic Chemical
Nabiha Yusuf; Tahseen H. Nasti; Israr Ahmad; Sanim Chowdhury; Hasan Mohiuddin; Hui Xu; Mohammad Athar; Laura Timares; Craig A. Elmets
J Immunol (2015) 194 (10): 4796–4803.
View articletitled, In Vivo Suppression of Heat Shock Protein (HSP)27 and HSP70 Accelerates DMBA-Induced Skin Carcinogenesis by Inducing Antigenic Unresponsiveness to the Initiating Carcinogenic Chemical
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DEC205+ Dendritic Cell–Targeted Tolerogenic Vaccination Promotes Immune Tolerance in Experimental Autoimmune Arthritis
Rachel Spiering; Bram Margry; Chantal Keijzer; Cathleen Petzold; Aad Hoek; Josée Wagenaar-Hilbers; Ruurd van der Zee; Willem van Eden; Karsten Kretschmer; Femke Broere
J Immunol (2015) 194 (10): 4804–4813.
View articletitled, DEC205<sup>+</sup> Dendritic Cell–Targeted Tolerogenic Vaccination Promotes Immune Tolerance in Experimental Autoimmune Arthritis
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INFECTIOUS DISEASE AND HOST RESPONSE

T Cell Immunity to the Alkyl Hydroperoxide Reductase of Burkholderia pseudomallei: A Correlate of Disease Outcome in Acute Melioidosis
Catherine Reynolds; Amélie Goudet; Kemajittra Jenjaroen; Manutsanun Sumonwiriya; Darawan Rinchai; Julie Musson; Saskia Overbeek; Julia Makinde; Kathryn Quigley; Jiten Manji; Natasha Spink; Pagnarith Yos; Vanaporn Wuthiekanun; Gregory Bancroft; John Robinson; Ganjana Lertmemongkolchai; Susanna Dunachie; Bernard Maillere; Matthew Holden; Daniel Altmann; Rosemary Boyton
J Immunol (2015) 194 (10): 4814–4824.
View articletitled, T Cell Immunity to the Alkyl Hydroperoxide Reductase of <em>Burkholderia pseudomallei</em>: A Correlate of Disease Outcome in Acute Melioidosis
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Pattern Recognition Receptor–Initiated Innate Antiviral Responses in Mouse Epididymal Epithelial Cells
Weiwei Zhu; Shutao Zhao; Zhenghui Liu; Lijing Cheng; Qing Wang; Keqin Yan; Qiaoyuan Chen; Han Wu; Daishu Han
J Immunol (2015) 194 (10): 4825–4835.
View articletitled, Pattern Recognition Receptor–Initiated Innate Antiviral Responses in Mouse Epididymal Epithelial Cells
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MF59 Mediates Its B Cell Adjuvanticity by Promoting T Follicular Helper Cells and Thus Germinal Center Responses in Adult and Early Life
Beatris Mastelic Gavillet; Christiane S. Eberhardt; Floriane Auderset; Flora Castellino; Anja Seubert; John S. Tregoning; Paul-Henri Lambert; Ennio de Gregorio; Giuseppe Del Giudice; Claire-Anne Siegrist
J Immunol (2015) 194 (10): 4836–4845.
View articletitled, MF59 Mediates Its B Cell Adjuvanticity by Promoting T Follicular Helper Cells and Thus Germinal Center Responses in Adult and Early Life
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Obesity Increases Mortality and Modulates the Lung Metabolome during Pandemic H1N1 Influenza Virus Infection in Mice
J. Justin Milner; Jenny Rebeles; Suraj Dhungana; Delisha A. Stewart; Susan C. J. Sumner; Matthew H. Meyers; Peter Mancuso; Melinda A. Beck
J Immunol (2015) 194 (10): 4846–4859.
View articletitled, Obesity Increases Mortality and Modulates the Lung Metabolome during Pandemic H1N1 Influenza Virus Infection in Mice
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Chemical Attenuation of Plasmodium in the Liver Modulates Severe Malaria Disease Progression
Matthew D. Lewis; Jochen Behrends; Cláudia Sá e Cunha; António M. Mendes; Felix Lasitschka; Julia M. Sattler; Kirsten Heiss; Taco W. A. Kooij; Miguel Prudêncio; Gerhard Bringmann; Friedrich Frischknecht; Ann-Kristin Mueller
J Immunol (2015) 194 (10): 4860–4870.
View articletitled, Chemical Attenuation of <em>Plasmodium</em> in the Liver Modulates Severe Malaria Disease Progression
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IL-33 Enhances Host Tolerance to Candida albicans Kidney Infections through Induction of IL-13 Production by CD4+ T Cells
Vuvi G. Tran; Hye J. Kim; Juyang Kim; Sang W. Kang; U J. Moon; Hong R. Cho; Byungsuk Kwon
J Immunol (2015) 194 (10): 4871–4879.
View articletitled, IL-33 Enhances Host Tolerance to <em>Candida albicans</em> Kidney Infections through Induction of IL-13 Production by CD4<sup>+</sup> T Cells
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INNATE IMMUNITY AND INFLAMMATION

MAVS Promotes Inflammasome Activation by Targeting ASC for K63-Linked Ubiquitination via the E3 Ligase TRAF3
Kai Guan; Congwen Wei; Zirui Zheng; Ting Song; Feixiang Wu; Yanhong Zhang; Ye Cao; Shengli Ma; Wei Chen; Quanbin Xu; Weiwei Xia; Jun Gu; Xiang He; Hui Zhong
J Immunol (2015) 194 (10): 4880–4890.
View articletitled, MAVS Promotes Inflammasome Activation by Targeting ASC for K63-Linked Ubiquitination via the E3 Ligase TRAF3
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Ex Vivo and In Vitro Effect of Serum Amyloid A in the Induction of Macrophage M2 Markers and Efferocytosis of Apoptotic Neutrophils
Lei Sun; Huibin Zhou; Ziyan Zhu; Qian Yan; Lili Wang; Qing Liang; Richard D. Ye
J Immunol (2015) 194 (10): 4891–4900.
View articletitled, Ex Vivo and In Vitro Effect of Serum Amyloid A in the Induction of Macrophage M2 Markers and Efferocytosis of Apoptotic Neutrophils
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Bordetella pertussis Adenylate Cyclase Toxin Blocks Induction of Bactericidal Nitric Oxide in Macrophages through cAMP-Dependent Activation of the SHP-1 Phosphatase
Ondrej Cerny; Jana Kamanova; Jiri Masin; Ilona Bibova; Karolina Skopova; Peter Sebo
J Immunol (2015) 194 (10): 4901–4913.
View articletitled, <em>Bordetella pertussis</em> Adenylate Cyclase Toxin Blocks Induction of Bactericidal Nitric Oxide in Macrophages through cAMP-Dependent Activation of the SHP-1 Phosphatase
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DNA-Mediated Cyclic GMP–AMP Synthase–Dependent and –Independent Regulation of Innate Immune Responses
Kou Motani; Shinji Ito; Shigekazu Nagata
J Immunol (2015) 194 (10): 4914–4923.
View articletitled, DNA-Mediated Cyclic GMP–AMP Synthase–Dependent and –Independent Regulation of Innate Immune Responses
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CCL7 and IRF-7 Mediate Hallmark Inflammatory and IFN Responses following Rhinovirus 1B Infection
Jason Girkin; Luke Hatchwell; Paul Foster; Sebastian L. Johnston; Nathan Bartlett; Adam Collison; Joerg Mattes
J Immunol (2015) 194 (10): 4924–4930.
View articletitled, CCL7 and IRF-7 Mediate Hallmark Inflammatory and IFN Responses following Rhinovirus 1B Infection
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Intestinal Epithelial TLR-4 Activation Is Required for the Development of Acute Lung Injury after Trauma/Hemorrhagic Shock via the Release of HMGB1 from the Gut
Chhinder P. Sodhi; Hongpeng Jia; Yukihiro Yamaguchi; Peng Lu; Misty Good; Charlotte Egan; John Ozolek; Xiaorong Zhu; Timothy R. Billiar; David J. Hackam
J Immunol (2015) 194 (10): 4931–4939.
View articletitled, Intestinal Epithelial TLR-4 Activation Is Required for the Development of Acute Lung Injury after Trauma/Hemorrhagic Shock via the Release of HMGB1 from the Gut
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The Role and Effects of Glucocorticoid-Induced Leucine Zipper in the Context of Inflammation Resolution
Juliana P. Vago; Luciana P. Tavares; Cristiana C. Garcia; Kátia M. Lima; Luiza O. Perucci; Érica L. Vieira; Camila R. C. Nogueira; Frederico M. Soriani; Joilson O. Martins; Patrícia M. R. Silva; Karina B. Gomes; Vanessa Pinho; Stefano Bruscoli; Carlo Riccardi; Elaine Beaulieu; Eric F. Morand; Mauro M. Teixeira; Lirlândia P. Sousa
J Immunol (2015) 194 (10): 4940–4950.
View articletitled, The Role and Effects of Glucocorticoid-Induced Leucine Zipper in the Context of Inflammation Resolution
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DUSP3 Genetic Deletion Confers M2-like Macrophage–Dependent Tolerance to Septic Shock
Pratibha Singh; Lien Dejager; Mathieu Amand; Emilie Theatre; Maud Vandereyken; Tinatin Zurashvili; Maneesh Singh; Matthias Mack; Steven Timmermans; Lucia Musumeci; Emmanuel Dejardin; Tomas Mustelin; Jo A. Van Ginderachter; Michel Moutschen; Cécile Oury; Claude Libert; Souad Rahmouni
J Immunol (2015) 194 (10): 4951–4962.
View articletitled, DUSP3 Genetic Deletion Confers M2-like Macrophage–Dependent Tolerance to Septic Shock
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MOLECULAR AND STRUCTURAL IMMUNOLOGY

Factor H–Related Protein 5 Interacts with Pentraxin 3 and the Extracellular Matrix and Modulates Complement Activation
Ádám I. Csincsi; Anne Kopp; Miklós Zöldi; Zsófia Bánlaki; Barbara Uzonyi; Mario Hebecker; Joseph J. E. Caesar; Matthew C. Pickering; Kenji Daigo; Takao Hamakubo; Susan M. Lea; Elena Goicoechea de Jorge; Mihály Józsi
J Immunol (2015) 194 (10): 4963–4973.
View articletitled, Factor H–Related Protein 5 Interacts with Pentraxin 3 and the Extracellular Matrix and Modulates Complement Activation
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Distinctive Structural Hallmarks and Biological Activities of the Multiple Cathelicidin Antimicrobial Peptides in a Primitive Teleost Fish
Xu-Jie Zhang; Xiang-Yang Zhang; Nu Zhang; Xia Guo; Kai-Song Peng; Han Wu; Long-Feng Lu; Nan Wu; Dan-Dan Chen; Shun Li; Pin Nie; Yong-An Zhang
J Immunol (2015) 194 (10): 4974–4987.
View articletitled, Distinctive Structural Hallmarks and Biological Activities of the Multiple Cathelicidin Antimicrobial Peptides in a Primitive Teleost Fish
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TUMOR IMMUNOLOGY

Cancer-Associated Oxidase ERO1-α Regulates the Expression of MHC Class I Molecule via Oxidative Folding
Kazuharu Kukita; Yasuaki Tamura; Tsutomu Tanaka; Toshimitsu Kajiwara; Goro Kutomi; Keita Saito; Koichi Okuya; Akari Takaya; Takayuki Kanaseki; Tomohide Tsukahara; Yoshihiko Hirohashi; Toshihiko Torigoe; Tomohisa Furuhata; Koichi Hirata; Noriyuki Sato
J Immunol (2015) 194 (10): 4988–4996.
View articletitled, Cancer-Associated Oxidase ERO1-α Regulates the Expression of MHC Class I Molecule via Oxidative Folding
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Intratumoral Delivery of IL-21 Overcomes Anti-Her2/Neu Resistance through Shifting Tumor-Associated Macrophages from M2 to M1 Phenotype
Meng Xu; Mingyue Liu; Xuexiang Du; Sirui Li; Hang Li; Xiaozhu Li; Ying Li; Yang Wang; Zhihai Qin; Yang-Xin Fu; Shengdian Wang
J Immunol (2015) 194 (10): 4997–5006.
View articletitled, Intratumoral Delivery of IL-21 Overcomes Anti-Her2/Neu Resistance through Shifting Tumor-Associated Macrophages from M2 to M1 Phenotype
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Polycomb Repressive Complex 2 Confers BRG1 Dependency on the CIITA Locus
Mohamed Abou El Hassan; Tao Yu; Lan Song; Rod Bremner
J Immunol (2015) 194 (10): 5007–5013.
View articletitled, Polycomb Repressive Complex 2 Confers BRG1 Dependency on the <em>CIITA</em> Locus
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Histamine Promotes the Development of Monocyte-Derived Dendritic Cells and Reduces Tumor Growth by Targeting the Myeloid NADPH Oxidase
Anna Martner; Hanna G. Wiktorin; Brianna Lenox; Frida Ewald Sander; Ebru Aydin; Johan Aurelius; Fredrik B. Thorén; Anders Ståhlberg; Svante Hermodsson; Kristoffer Hellstrand
J Immunol (2015) 194 (10): 5014–5021.
View articletitled, Histamine Promotes the Development of Monocyte-Derived Dendritic Cells and Reduces Tumor Growth by Targeting the Myeloid NADPH Oxidase
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NOVEL IMMUNOLOGICAL METHODS

General Approach for Tetramer-Based Identification of Autoantigen-Reactive B Cells: Characterization of La- and snRNP-Reactive B Cells in Autoimmune BXD2 Mice
Jennie A. Hamilton; Jun Li; Qi Wu; PingAr Yang; Bao Luo; Hao Li; John E. Bradley; Justin J. Taylor; Troy D. Randall; John D. Mountz; Hui-Chen Hsu
J Immunol (2015) 194 (10): 5022–5034.
View articletitled, General Approach for Tetramer-Based Identification of Autoantigen-Reactive B Cells: Characterization of La- and snRNP-Reactive B Cells in Autoimmune BXD2 Mice
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  • Cover Image

    Cover Image

    issue cover

    On the cover: Scanning electron microscopy of spread Cdc42-deficient B cells activated for 2 d with anti-CD40 + IL-4 and incubated on anti-CD44–coated cultures. Note the lack of long protrusions and the presence of brushlike extensions. Pseudo-coloring is used to highlight the cells. Gerasimcik, N., C. I. M. Dahlberg, M. A. P. Baptista, M. J. Massaad, R. S. Geha, L. S. Westerberg, and E. Severinson. 2015. The Rho GTPase Cdc42 is essential for the activation and function of mature B cells. J. Immunol. 194: 4750–4758.

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