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Volume 194, Issue 4
15 February 2015
The Journal of Immunology Cover Image for Volume 194, Issue 4
ISSN 0022-1767
EISSN 1550-6606

IN THIS ISSUE

In This Issue
J Immunol (2015) 194 (4): 1387–1388.
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BRIEF REVIEWS

Fibroblastic Reticular Cells: Organization and Regulation of the T Lymphocyte Life Cycle
Flavian D. Brown; Shannon J. Turley
J Immunol (2015) 194 (4): 1389–1394.
View articletitled, Fibroblastic Reticular Cells: Organization and Regulation of the T Lymphocyte Life Cycle
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B10 Cells: A Functionally Defined Regulatory B Cell Subset
Thomas F. Tedder
J Immunol (2015) 194 (4): 1395–1401.
View articletitled, B10 Cells: A Functionally Defined Regulatory B Cell Subset
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CUTTING EDGE

Cutting Edge: DNase II Deficiency Prevents Activation of Autoreactive B Cells by Double-Stranded DNA Endogenous Ligands
Sudesh Pawaria; Krishna Moody; Patricia Busto; Kerstin Nündel; Chee-Ho Choi; Tariq Ghayur; Ann Marshak-Rothstein
J Immunol (2015) 194 (4): 1403–1407.
View articletitled, Cutting Edge: DNase II Deficiency Prevents Activation of Autoreactive B Cells by Double-Stranded DNA Endogenous Ligands
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Cutting Edge: Stage-Specific Requirement of IL-18 for Antiviral NK Cell Expansion
Sharline Madera; Joseph C. Sun
J Immunol (2015) 194 (4): 1408–1412.
View articletitled, Cutting Edge: Stage-Specific Requirement of IL-18 for Antiviral NK Cell Expansion
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Cutting Edge: The BTLA–HVEM Regulatory Pathway Interferes with Protective Immunity to Intestinal Helminth Infection
Minka Breloer; Wiebke Hartmann; Birte Blankenhaus; Marie-Luise Eschbach; Klaus Pfeffer; Thomas Jacobs
J Immunol (2015) 194 (4): 1413–1416.
View articletitled, Cutting Edge: The BTLA–HVEM Regulatory Pathway Interferes with Protective Immunity to Intestinal Helminth Infection
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Cutting Edge: Identification of Neutrophil PGLYRP1 as a Ligand for TREM-1
Christine B. Read; Joseph L. Kuijper; Siv A. Hjorth; Mark D. Heipel; Xiaoting Tang; Andrew J. Fleetwood; Jeffrey L. Dantzler; Susanne N. Grell; Jesper Kastrup; Camilla Wang; Cameron S. Brandt; Anker J. Hansen; Nicolai R. Wagtmann; Wenfeng Xu; Vibeke W. Stennicke
J Immunol (2015) 194 (4): 1417–1421.
View articletitled, Cutting Edge: Identification of Neutrophil PGLYRP1 as a Ligand for TREM-1
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ALLERGY AND OTHER HYPERSENSITIVITIES

Neurturin Influences Inflammatory Responses and Airway Remodeling in Different Mouse Asthma Models
Marion Mauffray; Olivia Domingues; François Hentges; Jacques Zimmer; Daniel Hanau; Tatiana Michel
J Immunol (2015) 194 (4): 1423–1433.
View articletitled, Neurturin Influences Inflammatory Responses and Airway Remodeling in Different Mouse Asthma Models
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ANTIGEN RECOGNITION AND RESPONSES

Elevation of c-MYC Disrupts HLA Class II–Mediated Immune Recognition of Human B Cell Tumors
Jason M. God; Christine Cameron; Janette Figueroa; Shereen Amria; Azim Hossain; Bettina Kempkes; Georg W. Bornkamm; Robert K. Stuart; Janice S. Blum; Azizul Haque
J Immunol (2015) 194 (4): 1434–1445.
View articletitled, Elevation of c-MYC Disrupts HLA Class II–Mediated Immune Recognition of Human B Cell Tumors
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Macronutrient Deprivation Modulates Antigen Trafficking and Immune Recognition through HSC70 Accessibility
Sarah N. Deffit; Janice S. Blum
J Immunol (2015) 194 (4): 1446–1453.
View articletitled, Macronutrient Deprivation Modulates Antigen Trafficking and Immune Recognition through HSC70 Accessibility
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AUTOIMMUNITY

Selective Blockade of CD28-Mediated T Cell Costimulation Protects Rhesus Monkeys against Acute Fatal Experimental Autoimmune Encephalomyelitis
Krista G. Haanstra; Karin Dijkman; Noun Bashir; Jan Bauer; Caroline Mary; Nicolas Poirier; Paul Baker; Linda Scobie; Bert A. ’t Hart; Bernard Vanhove
J Immunol (2015) 194 (4): 1454–1466.
View articletitled, Selective Blockade of CD28-Mediated T Cell Costimulation Protects Rhesus Monkeys against Acute Fatal Experimental Autoimmune Encephalomyelitis
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IRF5 Deficiency Ameliorates Lupus but Promotes Atherosclerosis and Metabolic Dysfunction in a Mouse Model of Lupus-Associated Atherosclerosis
Amanda A. Watkins; Kei Yasuda; Gabriella E. Wilson; Tamar Aprahamian; Yao Xie; Elena Maganto-Garcia; Prachi Shukla; Lillian Oberlander; Bari Laskow; Hanni Menn-Josephy; Yuanyuan Wu; Pierre Duffau; Susan K. Fried; Andrew H. Lichtman; Ramon G. Bonegio; Ian R. Rifkin
J Immunol (2015) 194 (4): 1467–1479.
View articletitled, IRF5 Deficiency Ameliorates Lupus but Promotes Atherosclerosis and Metabolic Dysfunction in a Mouse Model of Lupus-Associated Atherosclerosis
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JNK Regulatory Molecule G5PR Induces IgG Autoantibody–Producing Plasmablasts from Peritoneal B1a Cells
Masahiro Kitabatake; Miho Soma; Tianli Zhang; Kazuhiko Kuwahara; Yoshimi Fukushima; Takuya Nojima; Daisuke Kitamura; Nobuo Sakaguchi
J Immunol (2015) 194 (4): 1480–1488.
View articletitled, JNK Regulatory Molecule G5PR Induces IgG Autoantibody–Producing Plasmablasts from Peritoneal B1a Cells
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Natural IgM Prevents Autoimmunity by Enforcing B Cell Central Tolerance Induction
Trang T. T. Nguyen; Rebecca A. Elsner; Nicole Baumgarth
J Immunol (2015) 194 (4): 1489–1502.
View articletitled, Natural IgM Prevents Autoimmunity by Enforcing B Cell Central Tolerance Induction
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Expansion of an Atypical NK Cell Subset in Mouse Models of Systemic Lupus Erythematosus
Elisaveta N. Voynova; Jeffrey Skinner; Silvia Bolland
J Immunol (2015) 194 (4): 1503–1513.
View articletitled, Expansion of an Atypical NK Cell Subset in Mouse Models of Systemic Lupus Erythematosus
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CLINICAL AND HUMAN IMMUNOLOGY

Defective Selection of Thymic Regulatory T Cells Accompanies Autoimmunity and Pulmonary Infiltrates in Tcra-Deficient Mice Double Transgenic for Human La/Sjögren’s Syndrome-B and Human La-Specific TCR
Jane C. Yaciuk; Yujun Pan; Karen Schwarz; Zi-jian Pan; Jacen S. Maier-Moore; Stanley D. Kosanke; Christina Lawrence; A. Darise Farris
J Immunol (2015) 194 (4): 1514–1522.
View articletitled, Defective Selection of Thymic Regulatory T Cells Accompanies Autoimmunity and Pulmonary Infiltrates in <em>Tcra</em>-Deficient Mice Double Transgenic for Human La/Sjögren’s Syndrome-B and Human La-Specific TCR
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IMMUNE REGULATION

Duox1-Derived H2O2 Modulates Cxcl8 Expression and Neutrophil Recruitment via JNK/c-JUN/AP-1 Signaling and Chromatin Modifications
Sofia de Oliveira; Pierre Boudinot; Ângelo Calado; Victoriano Mulero
J Immunol (2015) 194 (4): 1523–1533.
View articletitled, Duox1-Derived H<sub>2</sub>O<sub>2</sub> Modulates Cxcl8 Expression and Neutrophil Recruitment via JNK/c-JUN/AP-1 Signaling and Chromatin Modifications
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The Human Fetal Placenta Promotes Tolerance against the Semiallogeneic Fetus by Inducing Regulatory T Cells and Homeostatic M2 Macrophages
Judit Svensson-Arvelund; Ratnesh B. Mehta; Robert Lindau; Elahe Mirrasekhian; Heriberto Rodriguez-Martinez; Göran Berg; Gendie E. Lash; Maria C. Jenmalm; Jan Ernerudh
J Immunol (2015) 194 (4): 1534–1544.
View articletitled, The Human Fetal Placenta Promotes Tolerance against the Semiallogeneic Fetus by Inducing Regulatory T Cells and Homeostatic M2 Macrophages
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Positive Feedback Regulation of Type I IFN Production by the IFN-Inducible DNA Sensor cGAS
Feng Ma; Bing Li; Su-yang Liu; Shankar S. Iyer; Yongxin Yu; Aiping Wu; Genhong Cheng
J Immunol (2015) 194 (4): 1545–1554.
View articletitled, Positive Feedback Regulation of Type I IFN Production by the IFN-Inducible DNA Sensor cGAS
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A Novel Regulatory Macrophage Induced by a Helminth Molecule Instructs IL-10 in CD4+ T Cells and Protects against Mucosal Inflammation
Thomas Ziegler; Sebastian Rausch; Svenja Steinfelder; Christian Klotz; Matthew R. Hepworth; Anja A. Kühl; Paul-Christian Burda; Richard Lucius; Susanne Hartmann
J Immunol (2015) 194 (4): 1555–1564.
View articletitled, A Novel Regulatory Macrophage Induced by a Helminth Molecule Instructs IL-10 in CD4<sup>+</sup> T Cells and Protects against Mucosal Inflammation
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Defining CD4 T Cell Memory by the Epigenetic Landscape of CpG DNA Methylation
H. Kiyomi Komori; Traver Hart; Sarah A. LaMere; Pamela V. Chew; Daniel R. Salomon
J Immunol (2015) 194 (4): 1565–1579.
View articletitled, Defining CD4 T Cell Memory by the Epigenetic Landscape of CpG DNA Methylation
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In Vivo 4-1BB Deficiency in Myeloid Cells Enhances Peripheral T Cell Proliferation by Increasing IL-15
Beom K. Choi; Young H. Kim; Don G. Lee; Ho S. Oh; Kwang H. Kim; Sang H. Park; Jinsun Lee; Dass S. Vinay; Byoung S. Kwon
J Immunol (2015) 194 (4): 1580–1590.
View articletitled, In Vivo 4-1BB Deficiency in Myeloid Cells Enhances Peripheral T Cell Proliferation by Increasing IL-15
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The D0 Ig-like Domain Plays a Central Role in the Stronger Binding of KIR3DL2 to B27 Free H Chain Dimers
Hiroko Hatano; Jacqueline Shaw; Kaitlin Marquardt; Zhiyong Zhang; Laurent Gauthier; Stephanie Chanteux; Benjamin Rossi; Demin Li; Julie Mitchell; Simon Kollnberger
J Immunol (2015) 194 (4): 1591–1601.
View articletitled, The D0 Ig-like Domain Plays a Central Role in the Stronger Binding of KIR3DL2 to B27 Free H Chain Dimers
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Tim-1 Is Essential for Induction and Maintenance of IL-10 in Regulatory B Cells and Their Regulation of Tissue Inflammation
Sheng Xiao; Craig R. Brooks; Raymond A. Sobel; Vijay K. Kuchroo
J Immunol (2015) 194 (4): 1602–1608.
View articletitled, Tim-1 Is Essential for Induction and Maintenance of IL-10 in Regulatory B Cells and Their Regulation of Tissue Inflammation
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Alterations in Antigen-Specific Naive CD4 T Cell Precursors after Sepsis Impairs Their Responsiveness to Pathogen Challenge
Javier Cabrera-Perez; Stephanie A. Condotta; Britnie R. James; Sakeen W. Kashem; Erik L. Brincks; Deepa Rai; Tamara A. Kucaba; Vladimir P. Badovinac; Thomas S. Griffith
J Immunol (2015) 194 (4): 1609–1620.
View articletitled, Alterations in Antigen-Specific Naive CD4 T Cell Precursors after Sepsis Impairs Their Responsiveness to Pathogen Challenge
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Engulfment of Activated Apoptotic Cells Abolishes TGF-β–Mediated Immunoregulation via the Induction of IL-6
Clare A. Notley; Mark A. Brown; Jenny L. McGovern; Christine K. Jordan; Michael R. Ehrenstein
J Immunol (2015) 194 (4): 1621–1627.
View articletitled, Engulfment of Activated Apoptotic Cells Abolishes TGF-β–Mediated Immunoregulation via the Induction of IL-6
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CX3CR1 Reduces Kidney Fibrosis by Inhibiting Local Proliferation of Profibrotic Macrophages
Daniel R. Engel; Torsten A. Krause; Sarah L. Snelgrove; Stephanie Thiebes; Michael J. Hickey; Peter Boor; A. Richard Kitching; Christian Kurts
J Immunol (2015) 194 (4): 1628–1638.
View articletitled, CX<sub>3</sub>CR1 Reduces Kidney Fibrosis by Inhibiting Local Proliferation of Profibrotic Macrophages
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E3 Ubiquitin Ligase Cbl-b Regulates Thymic-Derived CD4+CD25+ Regulatory T Cell Development by Targeting Foxp3 for Ubiquitination
Yixia Zhao; Hui Guo; Guilin Qiao; Mark Zucker; Wallace Y. Langdon; Jian Zhang
J Immunol (2015) 194 (4): 1639–1645.
View articletitled, E3 Ubiquitin Ligase Cbl-b Regulates Thymic-Derived CD4<sup>+</sup>CD25<sup>+</sup> Regulatory T Cell Development by Targeting Foxp3 for Ubiquitination
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5-Lipoxygenase Is a Direct Target of miR-19a-3p and miR-125b-5p
Saskia Busch; Eileen Auth; Friederike Scholl; Sabine Huenecke; Ulrike Koehl; Beatrix Suess; Dieter Steinhilber
J Immunol (2015) 194 (4): 1646–1653.
View articletitled, 5-Lipoxygenase Is a Direct Target of miR-19a-3p and miR-125b-5p
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IMMUNE SYSTEM DEVELOPMENT

PP6 Controls T Cell Development and Homeostasis by Negatively Regulating Distal TCR Signaling
Jian Ye; Hao Shi; Ye Shen; Chao Peng; Yan Liu; Chenyu Li; Kejing Deng; Jianguo Geng; Tian Xu; Yuan Zhuang; Biao Zheng; Wufan Tao
J Immunol (2015) 194 (4): 1654–1664.
View articletitled, <em>PP6</em> Controls T Cell Development and Homeostasis by Negatively Regulating Distal TCR Signaling
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ShcA Regulates Late Stages of T Cell Development and Peripheral CD4+ T Cell Numbers
Monica W. Buckley; Paul C. Trampont; Sanja Arandjelovic; Aaron M. Fond; Ignacio J. Juncadella; Kodi S. Ravichandran
J Immunol (2015) 194 (4): 1665–1676.
View articletitled, ShcA Regulates Late Stages of T Cell Development and Peripheral CD4<sup>+</sup> T Cell Numbers
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Heme Exporter FLVCR Is Required for T Cell Development and Peripheral Survival
Mary Philip; Scott A. Funkhouser; Edison Y. Chiu; Susan R. Phelps; Jeffrey J. Delrow; James Cox; Pamela J. Fink; Janis L. Abkowitz
J Immunol (2015) 194 (4): 1677–1685.
View articletitled, Heme Exporter FLVCR Is Required for T Cell Development and Peripheral Survival
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IMMUNOTHERAPY AND VACCINES

Alternatively Spliced Myeloid Differentiation Protein-2 Inhibits TLR4-Mediated Lung Inflammation
Gantsetseg Tumurkhuu; Jargalsaikhan Dagvadorj; Heather D. Jones; Shuang Chen; Kenichi Shimada; Timothy R. Crother; Moshe Arditi
J Immunol (2015) 194 (4): 1686–1694.
View articletitled, Alternatively Spliced Myeloid Differentiation Protein-2 Inhibits TLR4-Mediated Lung Inflammation
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Bortezomib Reduces Pre-Existing Antibodies to Recombinant Immunotoxins in Mice
Michael L. Manning; Emily Mason-Osann; Masanori Onda; Ira Pastan
J Immunol (2015) 194 (4): 1695–1701.
View articletitled, Bortezomib Reduces Pre-Existing Antibodies to Recombinant Immunotoxins in Mice
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A Nonhuman Primate Scrub Typhus Model: Protective Immune Responses Induced by pKarp47 DNA Vaccination in Cynomolgus Macaques
Daniel H. Paris; Suchismita Chattopadhyay; Ju Jiang; Pruksa Nawtaisong; John S. Lee; Esterlina Tan; Eduardo Dela Cruz; Jasmin Burgos; Rodolfo Abalos; Stuart D. Blacksell; Eric Lombardini; Gareth D. Turner; Nicholas P. J. Day; Allen L. Richards
J Immunol (2015) 194 (4): 1702–1716.
View articletitled, A Nonhuman Primate Scrub Typhus Model: Protective Immune Responses Induced by pKarp47 DNA Vaccination in Cynomolgus Macaques
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Vaccine Adjuvant MF59 Promotes Retention of Unprocessed Antigen in Lymph Node Macrophage Compartments and Follicular Dendritic Cells
Rocco Cantisani; Alfredo Pezzicoli; Rossella Cioncada; Carmine Malzone; Ennio De Gregorio; Ugo D’Oro; Diego Piccioli
J Immunol (2015) 194 (4): 1717–1725.
View articletitled, Vaccine Adjuvant MF59 Promotes Retention of Unprocessed Antigen in Lymph Node Macrophage Compartments and Follicular Dendritic Cells
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Memory T Cells Specific for Murine Cytomegalovirus Re-Emerge after Multiple Challenges and Recapitulate Immunity in Various Adoptive Transfer Scenarios
Michael Quinn; Holly Turula; Mayank Tandon; Berthony Deslouches; Toktam Moghbeli; Christopher M. Snyder
J Immunol (2015) 194 (4): 1726–1736.
View articletitled, Memory T Cells Specific for Murine Cytomegalovirus Re-Emerge after Multiple Challenges and Recapitulate Immunity in Various Adoptive Transfer Scenarios
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The Inducible Costimulator Augments Tc17 Cell Responses to Self and Tumor Tissue
Michelle H. Nelson; Sreenath Kundimi; Jacob S. Bowers; Carolyn E. Rogers; Logan W. Huff; Kristina M. Schwartz; Krishnamurthy Thyagarajan; Elizabeth C. Little; Shikhar Mehrotra; David J. Cole; Mark P. Rubinstein; Chrystal M. Paulos
J Immunol (2015) 194 (4): 1737–1747.
View articletitled, The Inducible Costimulator Augments Tc17 Cell Responses to Self and Tumor Tissue
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INFECTIOUS DISEASE AND HOST RESPONSE

Cytotoxic Mediators in Paradoxical HIV–Tuberculosis Immune Reconstitution Inflammatory Syndrome
Katalin A. Wilkinson; Naomi F. Walker; Graeme Meintjes; Armin Deffur; Mark P. Nicol; Keira H. Skolimowska; Kerryn Matthews; Rebecca Tadokera; Ronnett Seldon; Gary Maartens; Molebogeng X. Rangaka; Gurdyal S. Besra; Robert J. Wilkinson
J Immunol (2015) 194 (4): 1748–1754.
View articletitled, Cytotoxic Mediators in Paradoxical HIV–Tuberculosis Immune Reconstitution Inflammatory Syndrome
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Protective Efficacy of Individual CD8+ T Cell Specificities in Chronic Viral Infection
Susan Johnson; Andreas Bergthaler; Frederik Graw; Lukas Flatz; Weldy V. Bonilla; Claire-Anne Siegrist; Paul-Henri Lambert; Roland R. Regoes; Daniel D. Pinschewer
J Immunol (2015) 194 (4): 1755–1762.
View articletitled, Protective Efficacy of Individual CD8<sup>+</sup> T Cell Specificities in Chronic Viral Infection
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Neutrophil IL-1β Processing Induced by Pneumolysin Is Mediated by the NLRP3/ASC Inflammasome and Caspase-1 Activation and Is Dependent on K+ Efflux
Mausita Karmakar; Michael Katsnelson; Hesham A. Malak; Neil G. Greene; Scott J. Howell; Amy G. Hise; Andrew Camilli; Aras Kadioglu; George R. Dubyak; Eric Pearlman
J Immunol (2015) 194 (4): 1763–1775.
View articletitled, Neutrophil IL-1β Processing Induced by Pneumolysin Is Mediated by the NLRP3/ASC Inflammasome and Caspase-1 Activation and Is Dependent on K<sup>+</sup> Efflux
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High-Mobility Group Box 1: A Novel Target for Treatment of Pseudomonas aeruginosa Keratitis
Sharon McClellan; Xiaoyu Jiang; Ronald Barrett; Linda D. Hazlett
J Immunol (2015) 194 (4): 1776–1787.
View articletitled, High-Mobility Group Box 1: A Novel Target for Treatment of <em>Pseudomonas aeruginosa</em> Keratitis
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β-Defensin 1 Plays a Role in Acute Mucosal Defense against Candida albicans
Jeffrey Tomalka; Elaheh Azodi; Hema P. Narra; Krupen Patel; Samantha O’Neill; Cisley Cardwell; Brian A. Hall; James M. Wilson; Amy G. Hise
J Immunol (2015) 194 (4): 1788–1795.
View articletitled, β-Defensin 1 Plays a Role in Acute Mucosal Defense against <em>Candida albicans</em>
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The Unappreciated Intracellular Lifestyle of Blastomyces dermatitidis
Alana K. Sterkel; Robert Mettelman; Marcel Wüthrich; Bruce S. Klein
J Immunol (2015) 194 (4): 1796–1805.
View articletitled, The Unappreciated Intracellular Lifestyle of <em>Blastomyces dermatitidis</em>
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Deficiency of Antigen-Specific B Cells Results in Decreased Trypanosoma cruzi Systemic but Not Mucosal Immunity Due to CD8 T Cell Exhaustion
Nicole L. Sullivan; Christopher S. Eickhoff; John Sagartz; Daniel F. Hoft
J Immunol (2015) 194 (4): 1806–1818.
View articletitled, Deficiency of Antigen-Specific B Cells Results in Decreased <em>Trypanosoma cruzi</em> Systemic but Not Mucosal Immunity Due to CD8 T Cell Exhaustion
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Evasion of Innate Cytosolic DNA Sensing by a Gammaherpesvirus Facilitates Establishment of Latent Infection
Chenglong Sun; Stefan A. Schattgen; Prapaporn Pisitkun; Joan P. Jorgensen; Adam T. Hilterbrand; Lucas J. Wang; John A. West; Kathrine Hansen; Kristy A. Horan; Martin R. Jakobsen; Peter O’Hare; Heiko Adler; Ren Sun; Hidde L. Ploegh; Blossom Damania; Jason W. Upton; Katherine A. Fitzgerald; Søren R. Paludan
J Immunol (2015) 194 (4): 1819–1831.
View articletitled, Evasion of Innate Cytosolic DNA Sensing by a Gammaherpesvirus Facilitates Establishment of Latent Infection
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INNATE IMMUNITY AND INFLAMMATION

PTEN Is a Negative Regulator of NK Cell Cytolytic Function
Edward L. Briercheck; Rossana Trotta; Li Chen; Alex S. Hartlage; Jordan P. Cole; Tyler D. Cole; Charlene Mao; Pinaki P. Banerjee; Hsiang-Ting Hsu; Emily M. Mace; David Ciarlariello; Bethany L. Mundy-Bosse; Isabel Garcia-Cao; Steven D. Scoville; Lianbo Yu; Robert Pilarski; William E. Carson, III; Gustavo Leone; Pier Paolo Pandolfi; Jianhua Yu; Jordan S. Orange; Michael A. Caligiuri
J Immunol (2015) 194 (4): 1832–1840.
View articletitled, PTEN Is a Negative Regulator of NK Cell Cytolytic Function
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Monitoring and Cell-Specific Deletion of C5aR1 Using a Novel Floxed GFP-C5aR1 Reporter Knock-in Mouse
Christian M. Karsten; Yves Laumonnier; Benjamin Eurich; Fanny Ender; Katharina Bröker; Sreeja Roy; Anna Czabanska; Tillman Vollbrandt; Julia Figge; Jörg Köhl
J Immunol (2015) 194 (4): 1841–1855.
View articletitled, Monitoring and Cell-Specific Deletion of C5aR1 Using a Novel Floxed GFP-C5aR1 Reporter Knock-in Mouse
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Antibody-Opsonized Bacteria Evoke an Inflammatory Dendritic Cell Phenotype and Polyfunctional Th Cells by Cross-Talk between TLRs and FcRs
Jantine E. Bakema; Cornelis W. Tuk; Sandra J. van Vliet; Sven C. Bruijns; Joost B. Vos; Sophia Letsiou; Christien D. Dijkstra; Yvette van Kooyk; Arjan B. Brenkman; Marjolein van Egmond
J Immunol (2015) 194 (4): 1856–1866.
View articletitled, Antibody-Opsonized Bacteria Evoke an Inflammatory Dendritic Cell Phenotype and Polyfunctional Th Cells by Cross-Talk between TLRs and FcRs
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β-arrestin1 Is Critical for the Full Activation of NLRP3 and NLRC4 Inflammasomes
Kairui Mao; Shuzhen Chen; Yan Wang; Yan Zeng; Yonglei Ma; Yu Hu; Hong Zhang; Shuhui Sun; Xiaodong Wu; Guangxun Meng; Gang Pei; Bing Sun
J Immunol (2015) 194 (4): 1867–1873.
View articletitled, β-arrestin1 Is Critical for the Full Activation of NLRP3 and NLRC4 Inflammasomes
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Loss of Mouse P2Y4 Nucleotide Receptor Protects against Myocardial Infarction through Endothelin-1 Downregulation
Michael Horckmans; Hrag Esfahani; Christophe Beauloye; Sophie Clouet; Larissa di Pietrantonio; Bernard Robaye; Jean-Luc Balligand; Jean-Marie Boeynaems; Chantal Dessy; Didier Communi
J Immunol (2015) 194 (4): 1874–1881.
View articletitled, Loss of Mouse P2Y<sub>4</sub> Nucleotide Receptor Protects against Myocardial Infarction through Endothelin-1 Downregulation
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Porcine β-Defensin 2 Attenuates Inflammation and Mucosal Lesions in Dextran Sodium Sulfate–Induced Colitis
Feifei Han; Haiwen Zhang; Xi Xia; Haitao Xiong; Deguang Song; Xin Zong; Yizhen Wang
J Immunol (2015) 194 (4): 1882–1893.
View articletitled, Porcine β-Defensin 2 Attenuates Inflammation and Mucosal Lesions in Dextran Sodium Sulfate–Induced Colitis
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IRAK-M Promotes Alternative Macrophage Activation and Fibroproliferation in Bleomycin-Induced Lung Injury
Megan N. Ballinger; Michael W. Newstead; Xianying Zeng; Urvashi Bhan; Xiaokui M. Mo; Steven L. Kunkel; Bethany B. Moore; Richard Flavell; John W. Christman; Theodore J. Standiford
J Immunol (2015) 194 (4): 1894–1904.
View articletitled, IRAK-M Promotes Alternative Macrophage Activation and Fibroproliferation in Bleomycin-Induced Lung Injury
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Recombinant Thrombomodulin Inhibits Lipopolysaccharide-Induced Inflammatory Response by Blocking the Functions of CD14
Chih-Yuan Ma; Wei-En Chang; Guey-Yueh Shi; Bi-Ying Chang; Sheng-En Cheng; Yun-Tai Shih; Hua-Lin Wu
J Immunol (2015) 194 (4): 1905–1915.
View articletitled, Recombinant Thrombomodulin Inhibits Lipopolysaccharide-Induced Inflammatory Response by Blocking the Functions of CD14
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miR-24, miR-30b, and miR-142-3p Regulate Phagocytosis in Myeloid Inflammatory Cells
Afsar Raza Naqvi; Jezrom B. Fordham; Salvador Nares
J Immunol (2015) 194 (4): 1916–1927.
View articletitled, miR-24, miR-30b, and miR-142-3p Regulate Phagocytosis in Myeloid Inflammatory Cells
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TAM Receptor–Dependent Regulation of SOCS3 and MAPKs Contributes to Proinflammatory Cytokine Downregulation following Chronic NOD2 Stimulation of Human Macrophages
Shasha Zheng; Matija Hedl; Clara Abraham
J Immunol (2015) 194 (4): 1928–1937.
View articletitled, TAM Receptor–Dependent Regulation of SOCS3 and MAPKs Contributes to Proinflammatory Cytokine Downregulation following Chronic NOD2 Stimulation of Human Macrophages
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A RIPK3–Caspase 8 Complex Mediates Atypical Pro–IL-1β Processing
Kenta Moriwaki; John Bertin; Peter J. Gough; Francis Ka-Ming Chan
J Immunol (2015) 194 (4): 1938–1944.
View articletitled, A RIPK3–Caspase 8 Complex Mediates Atypical Pro–IL-1β Processing
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Acquisition of Activation Receptor Ligand by Trogocytosis Renders NK Cells Hyporesponsive
Cathrine A. Miner; Tusar K. Giri; Claire E. Meyer; Mark Shabsovich; Sandeep K. Tripathy
J Immunol (2015) 194 (4): 1945–1953.
View articletitled, Acquisition of Activation Receptor Ligand by Trogocytosis Renders NK Cells Hyporesponsive
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Activation-Specific Metabolic Requirements for NK Cell IFN-γ Production
Molly P. Keppel; Nermina Saucier; Annelise Y. Mah; Tiphanie P. Vogel; Megan A. Cooper
J Immunol (2015) 194 (4): 1954–1962.
View articletitled, Activation-Specific Metabolic Requirements for NK Cell IFN-γ Production
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MOLECULAR AND STRUCTURAL IMMUNOLOGY

NFAT1 and JunB Cooperatively Regulate IL-31 Gene Expression in CD4+ T Cells in Health and Disease
Ji Sun Hwang; Gi-Cheon Kim; EunBee Park; Jung-Eun Kim; Chang-Suk Chae; Won Hwang; Changhon Lee; Sung-Min Hwang; Hui Sun Wang; Chang-Duk Jun; Dipayan Rudra; Sin-Hyeog Im
J Immunol (2015) 194 (4): 1963–1974.
View articletitled, NFAT1 and JunB Cooperatively Regulate <em>IL-31</em> Gene Expression in CD4<sup>+</sup> T Cells in Health and Disease
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Unique Ligand-Binding Property of the Human IgM Fc Receptor
Kazuhito Honjo; Yoshiki Kubagawa; John F. Kearney; Hiromi Kubagawa
J Immunol (2015) 194 (4): 1975–1982.
View articletitled, Unique Ligand-Binding Property of the Human IgM Fc Receptor
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MUCOSAL IMMUNOLOGY

TLR Signaling Modulates Side Effects of Anticancer Therapy in the Small Intestine
Magdalena Frank; Eva Maria Hennenberg; Annette Eyking; Michael Rünzi; Guido Gerken; Paul Scott; Julian Parkhill; Alan W. Walker; Elke Cario
J Immunol (2015) 194 (4): 1983–1995.
View articletitled, TLR Signaling Modulates Side Effects of Anticancer Therapy in the Small Intestine
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TRANSPLANTATION

Transplanted Bone Marrow–Derived Circulating PDGFRα+ Cells Restore Type VII Collagen in Recessive Dystrophic Epidermolysis Bullosa Mouse Skin Graft
Shin Iinuma; Eriko Aikawa; Katsuto Tamai; Ryo Fujita; Yasushi Kikuchi; Takenao Chino; Junichi Kikuta; John A. McGrath; Jouni Uitto; Masaru Ishii; Hajime Iizuka; Yasufumi Kaneda
J Immunol (2015) 194 (4): 1996–2003.
View articletitled, Transplanted Bone Marrow–Derived Circulating PDGFRα<sup>+</sup> Cells Restore Type VII Collagen in Recessive Dystrophic Epidermolysis Bullosa Mouse Skin Graft
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TUMOR IMMUNOLOGY

Cancer-Associated Oxidoreductase ERO1-α Drives the Production of Tumor-Promoting Myeloid-Derived Suppressor Cells via Oxidative Protein Folding
Tsutomu Tanaka; Toshimitsu Kajiwara; Toshihiko Torigoe; Yoshiharu Okamoto; Noriyuki Sato; Yasuaki Tamura
J Immunol (2015) 194 (4): 2004–2010.
View articletitled, Cancer-Associated Oxidoreductase ERO1-α Drives the Production of Tumor-Promoting Myeloid-Derived Suppressor Cells via Oxidative Protein Folding
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Alkylating Agent Melphalan Augments the Efficacy of Adoptive Immunotherapy Using Tumor-Specific CD4+ T Cells
Xiaoyun Lu; Zhi-Chun Ding; Yang Cao; Chufeng Liu; Tsadik Habtetsion; Miao Yu; Henrique Lemos; Huda Salman; Hongyan Xu; Andrew L. Mellor; Gang Zhou
J Immunol (2015) 194 (4): 2011–2021.
View articletitled, Alkylating Agent Melphalan Augments the Efficacy of Adoptive Immunotherapy Using Tumor-Specific CD4<sup>+</sup> T Cells
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NOVEL IMMUNOLOGICAL METHODS

Barcoding of Live Human Peripheral Blood Mononuclear Cells for Multiplexed Mass Cytometry
Henrik E. Mei; Michael D. Leipold; Axel Ronald Schulz; Cariad Chester; Holden T. Maecker
J Immunol (2015) 194 (4): 2022–2031.
View articletitled, Barcoding of Live Human Peripheral Blood Mononuclear Cells for Multiplexed Mass Cytometry
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CORRECTIONS

Correction: A238L Inhibits NF-ATc2, NF-κB, and c-Jun Activation through a Novel Mechanism Involving Protein Kinase C-θ-Mediated Up-Regulation of the Amino-Terminal Transactivation Domain of p300
Aitor G. Granja; Neil D. Perkins; Yolanda Revilla
J Immunol (2015) 194 (4): 2032.
View articletitled, Correction: A238L Inhibits NF-ATc2, NF-κB, and c-Jun Activation through a Novel Mechanism Involving Protein Kinase C-θ-Mediated Up-Regulation of the Amino-Terminal Transactivation Domain of p300
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Correction: Dual Function of CD70 in Viral Infection: Modulator of Early Cytokine Responses and Activator of Adaptive Responses
Atef Allam; Melissa Swiecki; William Vermi; Jonathan D. Ashwell; Marco Colonna
J Immunol (2015) 194 (4): 2033.
View articletitled, Correction: Dual Function of CD70 in Viral Infection: Modulator of Early Cytokine Responses and Activator of Adaptive Responses
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  • Cover Image

    Cover Image

    issue cover

    On the cover: Sirius red staining of the renal cortex of a CX3CR1-deficient mouse 7 d after unilateral ureter ligation, a model of kidney fibrosis. This staining illustrates the expanded extracellular matrix, in particular collagens, indicative of aggravated interstitial fibrosis in the absence of CX3CR1. Engel, D. R., T. A. Krause, S. L. Snelgrove, S. Thiebes, M. J. Hickey, P. Boor, A. R. Kitching, and C. Kurts. 2015. CX3CR1 reduces kidney fibrosis by inhibiting local proliferation of profibrotic macrophages. J. Immunol. 194: 1628–1638.

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