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Issues
1 April 2015
ISSN 0022-1767
EISSN 1550-6606
In this Issue
IN THIS ISSUE
PILLARS OF IMMUNOLOGY
BRIEF REVIEWS
The Role of PTPN22 Risk Variant in the Development of Autoimmunity: Finding Common Ground between Mouse and Human
J Immunol (2015) 194 (7): 2977–2984.
CUTTING EDGE
Cutting Edge: An In Vivo Reporter Reveals Active B Cell Receptor Signaling in the Germinal Center
J Immunol (2015) 194 (7): 2993–2997.
ANTIGEN RECOGNITION AND RESPONSES
IL-4–Secreting Secondary T Follicular Helper (Tfh) Cells Arise from Memory T Cells, Not Persisting Tfh Cells, through a B Cell–Dependent Mechanism
Keke C. Fairfax; Bart Everts; Eyal Amiel; Amber M. Smith; Gabriele Schramm; Helmut Haas; Gwendalyn J. Randolph; Justin J. Taylor; Edward J. Pearce
J Immunol (2015) 194 (7): 2999–3010.
AUTOIMMUNITY
Egress of Mature Murine Regulatory T Cells from the Thymus Requires RelA
J Immunol (2015) 194 (7): 3020–3028.
Functional Analysis of a Complement Polymorphism (rs17611) Associated with Rheumatoid Arthritis
J Immunol (2015) 194 (7): 3029–3034.
CLINICAL AND HUMAN IMMUNOLOGY
TLR7- and TLR9-Responsive Human B Cells Share Phenotypic and Genetic Characteristics
J Immunol (2015) 194 (7): 3035–3044.
A Novel Thymoma-Associated Immunodeficiency with Increased Naive T Cells and Reduced CD247 Expression
Petros Christopoulos; Elaine P. Dopfer; Miroslav Malkovsky; Philipp R. Esser; Hans-Eckart Schaefer; Alexander Marx; Sylvia Kock; Nicole Rupp; Myriam R. Lorenz; Klaus Schwarz; Jan Harder; Stefan F. Martin; Martin Werner; Christian Bogdan; Wolfgang W. A. Schamel; Paul Fisch
J Immunol (2015) 194 (7): 3045–3053.
IMMUNE REGULATION
Cellular Mechanisms of CCL22-Mediated Attenuation of Autoimmune Diabetes
Loraine Bischoff; Sigrid Alvarez; Derek L. Dai; Galina Soukhatcheva; Paul C. Orban; C. Bruce Verchere
J Immunol (2015) 194 (7): 3054–3064.
B Cell Rab7 Mediates Induction of Activation-Induced Cytidine Deaminase Expression and Class-Switching in T-Dependent and T-Independent Antibody Responses
Egest J. Pone; Tonika Lam; Zheng Lou; Rui Wang; Yuhui Chen; Dongfang Liu; Aimee L. Edinger; Zhenming Xu; Paolo Casali
J Immunol (2015) 194 (7): 3065–3078.
Alcohol-Induced miR-27a Regulates Differentiation and M2 Macrophage Polarization of Normal Human Monocytes
J Immunol (2015) 194 (7): 3079–3087.
MAPK Phosphatase 7 Regulates T Cell Differentiation via Inhibiting ERK-Mediated IL-2 Expression
Yongliang Zhang; Kalyan C. Nallaparaju; Xin Liu; Huipeng Jiao; Joseph M. Reynolds; Zhi-Xin Wang; Chen Dong
J Immunol (2015) 194 (7): 3088–3095.
FcμR Interacts and Cooperates with the B Cell Receptor To Promote B Cell Survival
J Immunol (2015) 194 (7): 3096–3101.
HSV-2 Immediate-Early Protein US1 Inhibits IFN-β Production by Suppressing Association of IRF-3 with IFN-β Promoter
Mudan Zhang; Yalan Liu; Ping Wang; Xinmeng Guan; Siyi He; Sukun Luo; Chang Li; Kai Hu; Wei Jin; Tao Du; Yan Yan; Zhenfeng Zhang; Zhenhua Zheng; Hanzhong Wang; Qinxue Hu
J Immunol (2015) 194 (7): 3102–3115.
Demethylation of the RORC2 and IL17A in Human CD4+ T Lymphocytes Defines Th17 Origin of Nonclassic Th1 Cells
Alessio Mazzoni; Veronica Santarlasci; Laura Maggi; Manuela Capone; Maria Caterina Rossi; Valentina Querci; Raffaele De Palma; Hyun-Dong Chang; Andreas Thiel; Rolando Cimaz; Francesco Liotta; Lorenzo Cosmi; Enrico Maggi; Andreas Radbruch; Sergio Romagnani; Jun Dong; Francesco Annunziato
J Immunol (2015) 194 (7): 3116–3126.
Ultraviolet Radiation Signaling through TLR4/MyD88 Constrains DNA Repair and Plays a Role in Cutaneous Immunosuppression
J Immunol (2015) 194 (7): 3127–3135.
TCAIM Decreases T Cell Priming Capacity of Dendritic Cells by Inhibiting TLR-Induced Ca2+ Influx and IL-2 Production
Simone Z. Vogel; Stephan Schlickeiser; Karsten Jürchott; Levent Akyuez; Julia Schumann; Christine Appelt; Katrin Vogt; Martina Schröder; Martin Vaeth; Friederike Berberich-Siebelt; Manfred B. Lutz; Gerald Grütz; Birgit Sawitzki
J Immunol (2015) 194 (7): 3136–3146.
Therapeutic Regulatory T Cells Subvert Effector T Cell Function in Inflamed Islets To Halt Autoimmune Diabetes
J Immunol (2015) 194 (7): 3147–3155.
Collagen Induces Maturation of Human Monocyte-Derived Dendritic Cells by Signaling through Osteoclast-Associated Receptor
Heidi S. Schultz; Louise M. Nitze; Louise H. Zeuthen; Pernille Keller; Albrecht Gruhler; Jesper Pass; Jianhe Chen; Li Guo; Andrew J. Fleetwood; John A. Hamilton; Martin W. Berchtold; Svetlana Panina
J Immunol (2015) 194 (7): 3169–3179.
IMMUNE SYSTEM DEVELOPMENT
IMMUNOTHERAPY AND VACCINES
DAP12-Based Activating Chimeric Antigen Receptor for NK Cell Tumor Immunotherapy
Katrin Töpfer; Marc Cartellieri; Susanne Michen; Ralf Wiedemuth; Nadja Müller; Dirk Lindemann; Michael Bachmann; Monika Füssel; Gabriele Schackert; Achim Temme
J Immunol (2015) 194 (7): 3201–3212.
Liver-Resident CD103+ Dendritic Cells Prime Antiviral CD8+ T Cells In Situ
J Immunol (2015) 194 (7): 3213–3222.
INFECTIOUS DISEASE AND HOST RESPONSE
Ly6Chigh Monocytes Control Cerebral Toxoplasmosis
Aindrila Biswas; Dunja Bruder; Susanne A. Wolf; Andreas Jeron; Matthias Mack; Markus M. Heimesaat; Ildiko Rita Dunay
J Immunol (2015) 194 (7): 3223–3235.
cGAS and Ifi204 Cooperate To Produce Type I IFNs in Response to Francisella Infection
J Immunol (2015) 194 (7): 3236–3245.
Buprenorphine Decreases the CCL2-Mediated Chemotactic Response of Monocytes
Loreto Carvallo; Lillie Lopez; Fa-Yun Che; Jihyeon Lim; Eliseo A. Eugenin; Dionna W. Williams; Edward Nieves; Tina M. Calderon; Carlos Madrid-Aliste; Andras Fiser; Louis Weiss; Ruth Hogue Angeletti; Joan W. Berman
J Immunol (2015) 194 (7): 3246–3258.
Myeloid HIF-1 Is Protective in Helicobacter pylori–Mediated Gastritis
Pavle Matak; Mylène Heinis; Jacques R. R. Mathieu; Ross Corriden; Sylvain Cuvellier; Stéphanie Delga; Rémi Mounier; Alexandre Rouquette; Josette Raymond; Dominique Lamarque; Jean-François Emile; Victor Nizet; Eliette Touati; Carole Peyssonnaux
J Immunol (2015) 194 (7): 3259–3266.
Proinflammatory Responses and Higher IL-10 Production by T Cells Correlate with Protection against Malaria during Pregnancy and Delivery Outcomes
Pilar Requena; Diana Barrios; Leanne J. Robinson; Paula Samol; Alexandra J. Umbers; Regina Wangnapi; Maria Ome-Kaius; Anna Rosanas-Urgell; Alfredo Mayor; Marta López; Elisa de Lazzari; Myriam Arévalo-Herrera; Carmen Fernández-Becerra; Hernando del Portillo; Chetan E. Chitnis; Peter M. Siba; Stephen Rogerson; Ivo Mueller; Azucena Bardají; Clara Menéndez; Carlota Dobaño
J Immunol (2015) 194 (7): 3275–3285.
INNATE IMMUNITY AND INFLAMMATION
CIKS/DDX3X Interaction Controls the Stability of the Zc3h12a mRNA Induced by IL-17
Domenico Somma; Paola Mastrovito; Marianeve Grieco; Alfonso Lavorgna; Angelica Pignalosa; Luigi Formisano; Anna Maria Salzano; Andrea Scaloni; Francesco Pacifico; Ulrich Siebenlist; Antonio Leonardi
J Immunol (2015) 194 (7): 3286–3294.
Canonical Wnt Signaling in Dendritic Cells Regulates Th1/Th17 Responses and Suppresses Autoimmune Neuroinflammation
Amol Suryawanshi; Indumathi Manoharan; Yuan Hong; Daniel Swafford; Tanmay Majumdar; M. Mark Taketo; Balaji Manicassamy; Pandelakis A. Koni; Muthusamy Thangaraju; Zuoming Sun; Andrew L. Mellor; David H. Munn; Santhakumar Manicassamy
J Immunol (2015) 194 (7): 3295–3304.
Rare Loss-of-Function Mutation in Complement Component C3 Provides Insight into Molecular and Pathophysiological Determinants of Complement Activity
Georgia Sfyroera; Daniel Ricklin; Edimara S. Reis; Hui Chen; Emilia L. Wu; Yiannis N. Kaznessis; Kristina N. Ekdahl; Bo Nilsson; John D. Lambris
J Immunol (2015) 194 (7): 3305–3316.
OSCAR Is a Receptor for Surfactant Protein D That Activates TNF-α Release from Human CCR2+ Inflammatory Monocytes
Alexander D. Barrow; Yaseelan Palarasah; Mattia Bugatti; Alex S. Holehouse; Derek E. Byers; Michael J. Holtzman; William Vermi; Karsten Skjødt; Erika Crouch; Marco Colonna
J Immunol (2015) 194 (7): 3317–3326.
Basal Cells Contribute to Innate Immunity of the Airway Epithelium through Production of the Antimicrobial Protein RNase 7
Gimano D. Amatngalim; Yolanda van Wijck; Yvonne de Mooij-Eijk; Renate M. Verhoosel; Jürgen Harder; Annemarie N. Lekkerkerker; Richard A. J. Janssen; Pieter S. Hiemstra
J Immunol (2015) 194 (7): 3340–3350.
WNT-Inflammasome Signaling Mediates NOD2-Induced Development of Acute Arthritis in Mice
J Immunol (2015) 194 (7): 3351–3360.
Extracellular Vesicles Derived from Gram-Negative Bacteria, such as Escherichia coli, Induce Emphysema Mainly via IL-17A–Mediated Neutrophilic Inflammation
You-Sun Kim; Won-Hee Lee; Eun-Jeong Choi; Jun-Pyo Choi; Young Joo Heo; Yong Song Gho; Young-Koo Jee; Yeon-Mok Oh; Yoon-Keun Kim
J Immunol (2015) 194 (7): 3361–3368.
Biased Agonism as a Novel Strategy To Harness the Proresolving Properties of Melanocortin Receptors without Eliciting Melanogenic Effects
J Immunol (2015) 194 (7): 3381–3388.
Myeloid HIFs Are Dispensable for Resolution of Inflammation during Skeletal Muscle Regeneration
Julien Gondin; Marine Théret; Guillaume Duhamel; Katarina Pegan; Jacques R. R. Mathieu; Carole Peyssonnaux; Sylvain Cuvellier; Claire Latroche; Bénédicte Chazaud; David Bendahan; Rémi Mounier
J Immunol (2015) 194 (7): 3389–3399.
CXCL10 Triggers Early Microglial Activation in the Cuprizone Model
Tim Clarner; Katharina Janssen; Lara Nellessen; Martin Stangel; Thomas Skripuletz; Barbara Krauspe; Franz-Martin Hess; Bernd Denecke; Clara Beutner; Bettina Linnartz-Gerlach; Harald Neumann; Luc Vallières; Sandra Amor; Kim Ohl; Klaus Tenbrock; Cordian Beyer; Markus Kipp
J Immunol (2015) 194 (7): 3400–3413.
MOLECULAR AND STRUCTURAL IMMUNOLOGY
Transcription-Dependent Generation of a Specialized Chromatin Structure at the TCRβ Locus
Joaquin Zacarías-Cabeza; Mohamed Belhocine; Laurent Vanhille; Pierre Cauchy; Frederic Koch; Aleksandra Pekowska; Romain Fenouil; Aurélie Bergon; Marta Gut; Ivo Gut; Dirk Eick; Jean Imbert; Pierre Ferrier; Jean-Christophe Andrau; Salvatore Spicuglia
J Immunol (2015) 194 (7): 3432–3443.
c-FLIP Protects T Lymphocytes from Apoptosis in the Intrinsic Pathway
J Immunol (2015) 194 (7): 3444–3451.
TUMOR IMMUNOLOGY
Differential Response of Myeloid-Derived Suppressor Cells to the Nonsteroidal Anti-Inflammatory Agent Indomethacin in Tumor-Associated and Tumor-Free Microenvironments
Ada G. Blidner; Mariana Salatino; Ivan D. Mascanfroni; Miriam J. Diament; Elisa Bal de Kier Joffé; Maria A. Jasnis; Slobodanka M. Klein; Gabriel A. Rabinovich
J Immunol (2015) 194 (7): 3452–3462.
Macrophage Migration Inhibitory Factor–CXCR4 Is the Dominant Chemotactic Axis in Human Mesenchymal Stem Cell Recruitment to Tumors
J Immunol (2015) 194 (7): 3463–3474.
CD8+CD103+ Tumor–Infiltrating Lymphocytes Are Tumor-Specific Tissue-Resident Memory T Cells and a Prognostic Factor for Survival in Lung Cancer Patients
Fayçal Djenidi; Julien Adam; Aïcha Goubar; Aurélie Durgeau; Guillaume Meurice; Vincent de Montpréville; Pierre Validire; Benjamin Besse; Fathia Mami-Chouaib
J Immunol (2015) 194 (7): 3475–3486.
Specific Roles of Each TCR Hemichain in Generating Functional Chain-Centric TCR
Munehide Nakatsugawa; Yuki Yamashita; Toshiki Ochi; Shinya Tanaka; Kenji Chamoto; Tingxi Guo; Marcus O. Butler; Naoto Hirano
J Immunol (2015) 194 (7): 3487–3500.
Modeling the Specific CD4+ T Cell Response against a Tumor Neoantigen
Héloïse Flament; Ruby Alonso Ramirez; Virginie Prémel; Nathalie T. Joncker; Alexandra Jacquet; Suzy Scholl; Olivier Lantz
J Immunol (2015) 194 (7): 3501–3512.
NOVEL IMMUNOLOGICAL METHODS
Predominant Development of Mature and Functional Human NK Cells in a Novel Human IL-2–Producing Transgenic NOG Mouse
Ikumi Katano; Takeshi Takahashi; Ryoji Ito; Tsutomu Kamisako; Takuma Mizusawa; Yuyo Ka; Tomoyuki Ogura; Hiroshi Suemizu; Yutaka Kawakami; Mamoru Ito
J Immunol (2015) 194 (7): 3513–3525.
CORRECTIONS
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Cover Image
Cover Image
On the cover: High macrophage infiltration (DAB staining) following Helicobacter pylori–induced gastritis in mice with specific deletion of hypoxia inducible factor-1 (HIF-1) in the myeloid lineage. This figure illustrates a global increase in inflammation, which leads to the worsening of the gastritis in the absence of myeloid HIF-1. Image credit: Andrija Matak. Matak, P., M. Heinis, J. R. R. Mathieu, R. Corriden, S. Cuvellier, S. Delga, R. Mounier, A. Rouquette, J. Raymond, D. Lamarque, J.-F. Emile, V. Nizet, E. Touati, and C. Peyssonnaux. 2015. Myeloid HIF-1 is protective in Helicobacter pylori–mediated gastritis. J. Immunol. 194: 3259–3266.
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