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15 April 2015
ISSN 0022-1767
EISSN 1550-6606
In this Issue
IN THIS ISSUE
LETTERS TO THE EDITOR
BRIEF REVIEWS
Endothelial Actin-Binding Proteins and Actin Dynamics in Leukocyte Transendothelial Migration
J Immunol (2015) 194 (8): 3535–3541.
CUTTING EDGE
Cutting Edge: Identification of Autoreactive CD4+ and CD8+ T Cell Subsets Resistant to PD-1 Pathway Blockade
Kristen E. Pauken; Christine E. Nelson; Tijana Martinov; Justin A. Spanier; James R. Heffernan; Nathanael L. Sahli; Clare F. Quarnstrom; Kevin C. Osum; Jason M. Schenkel; Marc K. Jenkins; Bruce R. Blazar; Vaiva Vezys; Brian T. Fife
J Immunol (2015) 194 (8): 3551–3555.
ALLERGY AND OTHER HYPERSENSITIVITIES
The TNF-Family Ligand TL1A and Its Receptor DR3 Promote T Cell–Mediated Allergic Immunopathology by Enhancing Differentiation and Pathogenicity of IL-9–Producing T Cells
Arianne C. Richard; Cuiyan Tan; Eric T. Hawley; Julio Gomez-Rodriguez; Ritobrata Goswami; Xiang-Ping Yang; Anthony C. Cruz; Pallavi Penumetcha; Erika T. Hayes; Martin Pelletier; Odile Gabay; Matthew Walsh; John R. Ferdinand; Andrea Keane-Myers; Yongwon Choi; John J. O’Shea; Aymen Al-Shamkhani; Mark H. Kaplan; Igal Gery; Richard M. Siegel; Françoise Meylan
J Immunol (2015) 194 (8): 3567–3582.
ANTIGEN RECOGNITION AND RESPONSES
Acidosis Increases MHC Class II–Restricted Presentation of a Protein Endowed with a pH-Dependent Heparan Sulfate–Binding Ability
J Immunol (2015) 194 (8): 3601–3611.
AUTOIMMUNITY
Deletion of Receptor for Advanced Glycation End Products Exacerbates Lymphoproliferative Syndrome and Lupus Nephritis in B6-MRL Fas lpr/j Mice
Antoine Goury; Aïda Meghraoui-Kheddar; Karim Belmokhtar; Vincent Vuiblet; Jeremy Ortillon; Stéphane Jaisson; Jerôme Devy; Richard Le Naour; Thierry Tabary; Jacques H. M. Cohen; Ann-Marie Schmidt; Philippe Rieu; Fatouma Touré
J Immunol (2015) 194 (8): 3612–3622.
Phenotypic Variation in Aicardi–Goutières Syndrome Explained by Cell-Specific IFN-Stimulated Gene Response and Cytokine Release
Eloy Cuadrado; Iliana Michailidou; Emma J. van Bodegraven; Machiel H. Jansen; Jacqueline A. Sluijs; Dirk Geerts; Pierre-Olivier Couraud; Lidia De Filippis; Angelo L. Vescovi; Taco W. Kuijpers; Elly M. Hol
J Immunol (2015) 194 (8): 3623–3633.
Glomerulopathy Induced by Immunization with a Peptide Derived from the Goodpasture Antigen α3IV-NC1
Helmut Hopfer; Stefanie Hünemörder; Julia Treder; Jan-Eric Turner; Hans-Joachim Paust; Catherine Meyer-Schwesinger; Ulrike Hopfer; Marlies Sachs; Anett Peters; Biranda Bucher-Kocaoglu; Stefanie Ahrens; Ulf Panzer; Hans-Willi Mittrücker
J Immunol (2015) 194 (8): 3646–3655.
Caspase-1–Independent IL-1 Release Mediates Blister Formation in Autoantibody-Induced Tissue Injury through Modulation of Endothelial Adhesion Molecules
Hengameh Sadeghi; Anike Lockmann; Anna-Carina Hund; Unni K. S. R. L. Samavedam; Elena Pipi; Katerina Vafia; Eva Hauenschild; Kathrin Kalies; Hendri H. Pas; Marcel F. Jonkman; Hiroaki Iwata; Andreas Recke; Michael P. Schön; Detlef Zillikens; Enno Schmidt; Ralf J. Ludwig
J Immunol (2015) 194 (8): 3656–3663.
Unbiased Modifier Screen Reveals That Signal Strength Determines the Regulatory Role Murine TLR9 Plays in Autoantibody Production
Robyn E. Mills; Viola C. Lam; Allison Tan; Nicole Cresalia; Nir Oksenberg; Julie Zikherman; Mark Anderson; Arthur Weiss; Michelle L. Hermiston
J Immunol (2015) 194 (8): 3675–3686.
CLINICAL AND HUMAN IMMUNOLOGY
Coexpression of TIGIT and FCRL3 Identifies Helios+ Human Memory Regulatory T Cells
Khalid Bin Dhuban; Eva d’Hennezel; Emil Nashi; Amit Bar-Or; Sadiye Rieder; Ethan M. Shevach; Satoshi Nagata; Ciriaco A. Piccirillo
J Immunol (2015) 194 (8): 3687–3696.
Regulation of Pulmonary Graft-versus-Host Disease by IL-26+CD26+CD4 T Lymphocytes
Kei Ohnuma; Ryo Hatano; Thomas M. Aune; Haruna Otsuka; Satoshi Iwata; Nam H. Dang; Taketo Yamada; Chikao Morimoto
J Immunol (2015) 194 (8): 3697–3712.
IMMUNE REGULATION
Deficiency of MALT1 Paracaspase Activity Results in Unbalanced Regulatory and Effector T and B Cell Responses Leading to Multiorgan Inflammation
Frédéric Bornancin; Florian Renner; Ratiba Touil; Heiko Sic; Yeter Kolb; Ismahane Touil-Allaoui; James S. Rush; Paul A. Smith; Marc Bigaud; Ursula Junker-Walker; Christoph Burkhart; Janet Dawson; Satoru Niwa; Andreas Katopodis; Barbara Nuesslein-Hildesheim; Gisbert Weckbecker; Gerhard Zenke; Bernd Kinzel; Elisabetta Traggiai; Dirk Brenner; Anne Brüstle; Michael St. Paul; Natasa Zamurovic; Kathy D. McCoy; Antonius Rolink; Catherine H. Régnier; Tak W. Mak; Pamela S. Ohashi; Dhavalkumar D. Patel; Thomas Calzascia
J Immunol (2015) 194 (8): 3723–3734.
Regulatory T Cell–Derived Adenosine Induces Dendritic Cell Migration through the Epac-Rap1 Pathway
Sabine Ring; Anna Pushkarevskaya; Hansjörg Schild; Hans Christian Probst; Verena Jendrossek; Florian Wirsdörfer; Catherine Ledent; Simon Christopher Robson; Alexander H. Enk; Karsten Mahnke
J Immunol (2015) 194 (8): 3735–3744.
FOXO1 Regulates Dendritic Cell Activity through ICAM-1 and CCR7
Guangyu Dong; Yu Wang; Wenmei Xiao; Sandra Pacios Pujado; Fanxing Xu; Chen Tian; E Xiao; Yongwon Choi; Dana T. Graves
J Immunol (2015) 194 (8): 3745–3755.
CD4+ T Cell–Derived IL-21 and Deprivation of CD40 Signaling Favor the In Vivo Development of Granzyme B–Expressing Regulatory B Cells in HIV Patients
Christof Kaltenmeier; Ali Gawanbacht; Thamara Beyer; Stefanie Lindner; Timo Trzaska; Johannes Andreas van der Merwe; Georg Härter; Beate Grüner; Dorit Fabricius; Ramin Lotfi; Klaus Schwarz; Catharina Schütz; Manfred Hönig; Ansgar Schulz; Peter Kern; Martin Bommer; Hubert Schrezenmeier; Frank Kirchhoff; Bernd Jahrsdörfer
J Immunol (2015) 194 (8): 3768–3777.
NF-κB Downregulates Cbl-b through Binding and Suppressing Cbl-b Promoter in T Cell Activation
J Immunol (2015) 194 (8): 3778–3783.
IMMUNE SYSTEM DEVELOPMENT
Complement Receptor C5aR1/CD88 and Dipeptidyl Peptidase-4/CD26 Define Distinct Hematopoietic Lineages of Dendritic Cells
J Immunol (2015) 194 (8): 3808–3819.
IMMUNOTHERAPY AND VACCINES
INFECTIOUS DISEASE AND HOST RESPONSE
Mast Cells Play an Important Role in Chlamydia pneumoniae Lung Infection by Facilitating Immune Cell Recruitment into the Airway
Norika Chiba; Kenichi Shimada; Shuang Chen; Heather D. Jones; Randa Alsabeh; Anatoly V. Slepenkin; Ellena Peterson; Timothy R. Crother; Moshe Arditi
J Immunol (2015) 194 (8): 3840–3851.
IL-12 Promotes Myeloid-Derived Suppressor Cell Recruitment and Bacterial Persistence during Staphylococcus aureus Orthopedic Implant Infection
J Immunol (2015) 194 (8): 3861–3872.
The Upregulation of LAG-3 on T Cells Defines a Subpopulation with Functional Exhaustion and Correlates with Disease Progression in HIV-Infected Subjects
Xiaoling Tian; Anli Zhang; Chao Qiu; Wei Wang; Yu Yang; Chenli Qiu; Aiping Liu; Lingyan Zhu; Songhua Yuan; Huiliang Hu; Wanhai Wang; Qiang Wei; Xiaoyan Zhang; Jianqing Xu
J Immunol (2015) 194 (8): 3873–3882.
INNATE IMMUNITY AND INFLAMMATION
Type I IFNs and IL-18 Regulate the Antiviral Response of Primary Human γδ T Cells against Dendritic Cells Infected with Dengue Virus
Chen-Yu Tsai; Ka Hang Liong; Matilda Gertrude Gunalan; Na Li; Daniel Say Liang Lim; Dale A. Fisher; Paul A. MacAry; Yee Sin Leo; Siew-Cheng Wong; Kia Joo Puan; Soon Boon Justin Wong
J Immunol (2015) 194 (8): 3890–3900.
IFN-γ Priming of Macrophages Represses a Part of the Inflammatory Program and Attenuates Neutrophil Recruitment
Marten A. Hoeksema; Brendon P. Scicluna; Marieke C. S. Boshuizen; Saskia van der Velden; Annette E. Neele; Jan Van den Bossche; Hanke L. Matlung; Timo K. van den Berg; Pieter Goossens; Menno P. J. de Winther
J Immunol (2015) 194 (8): 3909–3916.
Profiling of the Three Circulating Monocyte Subpopulations in Human Obesity
Estelle F. Devêvre; Mariana Renovato-Martins; Karine Clément; Catherine Sautès-Fridman; Isabelle Cremer; Christine Poitou
J Immunol (2015) 194 (8): 3917–3923.
IL-10/HMOX1 Signaling Modulates Cochlear Inflammation via Negative Regulation of MCP-1/CCL2 Expression in Cochlear Fibrocytes
J Immunol (2015) 194 (8): 3953–3961.
A Critical Role for Dendritic Cells in the Evolution of IL-1β–Mediated Murine Airway Disease
Mitsuo Hashimoto; Haruhiko Yanagisawa; Shunsuke Minagawa; Debasish Sen; Amanda Goodsell; Royce Ma; Catherine Moermans; Kate J. McKnelly; Jody L. Baron; Matthew F. Krummel; Stephen L. Nishimura
J Immunol (2015) 194 (8): 3962–3969.
MOLECULAR AND STRUCTURAL IMMUNOLOGY
A Role for APPL1 in TLR3/4-Dependent TBK1 and IKKε Activation in Macrophages
Tieu-Lan Chau; Serkan Ismail Göktuna; Ayman Rammal; Tomás Casanova; Hong-Quan Duong; Jean-Stéphane Gatot; Pierre Close; Emmanuel Dejardin; Daniel Desmecht; Kateryna Shostak; Alain Chariot
J Immunol (2015) 194 (8): 3970–3983.
Molecular Evolution of Hypoallergenic Hybrid Proteins for Vaccination against Grass Pollen Allergy
Birgit Linhart; Margarete Focke-Tejkl; Milena Weber; Meena Narayanan; Angela Neubauer; Hannes Mayrhofer; Katharina Blatt; Christian Lupinek; Peter Valent; Rudolf Valenta
J Immunol (2015) 194 (8): 4008–4018.
MUCOSAL IMMUNOLOGY
TRANSPLANTATION
Anti–IL-17 Therapy Restricts and Reverses Late-Term Corneal Allorejection
J Immunol (2015) 194 (8): 4029–4038.
DAP12 Expression in Lung Macrophages Mediates Ischemia/Reperfusion Injury by Promoting Neutrophil Extravasation
Jessica H. Spahn; Wenjun Li; Alejandro C. Bribriesco; Jie Liu; Hua Shen; Aida Ibricevic; Jie-Hong Pan; Bernd H. Zinselmeyer; Steven L. Brody; Daniel R. Goldstein; Alexander S. Krupnick; Andrew E. Gelman; Mark J. Miller; Daniel Kreisel
J Immunol (2015) 194 (8): 4039–4048.
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Cover Image
Cover Image
On the cover: DBA/1 mice immunized with the α3IV-NC1 domain of mouse type IV collagen develop membranous glomerulopathy, which progresses to glomerulonephritis. Detail of a mouse glomerulus with membranous glomerulopathy. Granular protein deposits (red) adjacent to swollen podocytes along the glomerular basement membranes (trichrome stain; original magnification ×630). Hopfer, H., S. Hünemörder, J. Treder, J.-E. Turner, H.-J. Paust, C. Meyer-Schwesinger, U. Hopfer, M. Sachs, A. Peters, B. Bucher-Kocaoglu, S. Ahrens, U. Panzer, and H.-W. Mittrücker. 2015. Glomerulopathy induced by immunization with a peptide derived from the Goodpasture antigen α3IV-NC. J. Immunol. 194: 3646–3655.
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