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Volume 195, Issue 10
15 November 2015
Issue Cover
ISSN 0022-1767
EISSN 1550-6606
In this Issue
Sensor Function for Butyrophilin 3A1 in Prenyl Pyrophosphate Stimulation of Human Vγ2Vδ2 T Cells
Hong Wang; Craig T. Morita
J Immunol (2015) 195 (10): 4583–4594.
View articletitled, Sensor Function for Butyrophilin 3A1 in Prenyl Pyrophosphate Stimulation of Human Vγ2Vδ2 T Cells
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Limited Internodal Migration of T Follicular Helper Cells after Peripheral Infection with Herpes Simplex Virus-1
Sanda Stankovic; Christopher M. Harpur; Bethany L. Macleod; Paul G. Whitney; Thomas Gebhardt; Andrew G. Brooks
J Immunol (2015) 195 (10): 4892–4899.
View articletitled, Limited Internodal Migration of T Follicular Helper Cells after Peripheral Infection with Herpes Simplex Virus-1
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Oral Immunization with a Recombinant Lactococcus lactis–Expressing HIV-1 Antigen on Group A Streptococcus Pilus Induces Strong Mucosal Immunity in the Gut
Venkateswarlu Chamcha; Andrew Jones; Bernard R. Quigley; June R. Scott; Rama Rao Amara
J Immunol (2015) 195 (10): 5025–5034.
View articletitled, Oral Immunization with a Recombinant <em>Lactococcus lactis</em>–Expressing HIV-1 Antigen on Group A <em>Streptococcus</em> Pilus Induces Strong Mucosal Immunity in the Gut
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Antigen Specificity of Type I NKT Cells Is Governed by TCR β-Chain Diversity
Garth Cameron; Daniel G. Pellicci; Adam P. Uldrich; Gurdyal S. Besra; Petr Illarionov; Spencer J. Williams; Nicole L. La Gruta; Jamie Rossjohn; Dale I. Godfrey
J Immunol (2015) 195 (10): 4604–4614.
View articletitled, Antigen Specificity of Type I NKT Cells Is Governed by TCR β-Chain Diversity
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Internalized Cryptococcus neoformans Activates the Canonical Caspase-1 and the Noncanonical Caspase-8 Inflammasomes
Mingkuan Chen; Yue Xing; Ailing Lu; Wei Fang; Bing Sun; Changbin Chen; Wanqing Liao; Guangxun Meng
J Immunol (2015) 195 (10): 4962–4972.
View articletitled, Internalized <em>Cryptococcus neoformans</em> Activates the Canonical Caspase-1 and the Noncanonical Caspase-8 Inflammasomes
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IL-25 or IL-17E Protects against High-Fat Diet–Induced Hepatic Steatosis in Mice Dependent upon IL-13 Activation of STAT6
An-Jiang Wang; Zhonghan Yang; Viktoriya Grinchuk; Allen Smith; Bolin Qin; Nonghua Lu; Duan Wang; Hongbing Wang; Thirumalai R. Ramalingam; Thomas A. Wynn; Joseph F. Urban, Jr.; Terez Shea-Donohue; Aiping Zhao
J Immunol (2015) 195 (10): 4771–4780.
View articletitled, IL-25 or IL-17E Protects against High-Fat Diet–Induced Hepatic Steatosis in Mice Dependent upon IL-13 Activation of STAT6
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Cutting Edge: Inhibiting TBK1 by Compound II Ameliorates Autoimmune Disease in Mice
Maroof Hasan; Nicole Dobbs; Shaheen Khan; Michael A. White; Edward K. Wakeland; Quan-Zhen Li; Nan Yan
J Immunol (2015) 195 (10): 4573–4577.
View articletitled, Cutting Edge: Inhibiting TBK1 by Compound II Ameliorates Autoimmune Disease in Mice
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Enhancing the Quality of Antibodies to HIV-1 Envelope by GagPol-Specific Th Cells
Michael Storcksdieck genannt Bonsmann; Thomas Niezold; Vladimir Temchura; Franco Pissani; Katrin Ehrhardt; Eric P. Brown; Nana Yaw Osei-Owusu; Drew Hannaman; Hartmut Hengel; Margaret E. Ackerman; Hendrik Streeck; Ghulam Nabi; Matthias Tenbusch; Klaus Überla
J Immunol (2015) 195 (10): 4861–4872.
View articletitled, Enhancing the Quality of Antibodies to HIV-1 Envelope by GagPol-Specific Th Cells
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UNC-45A Is a Nonmuscle Myosin IIA Chaperone Required for NK Cell Cytotoxicity via Control of Lytic Granule Secretion
Yoshie Iizuka; Frank Cichocki; Andrew Sieben; Fabio Sforza; Razaul Karim; Kathleen Coughlin; Rachel Isaksson Vogel; Riccardo Gavioli; Valarie McCullar; Todd Lenvik; Michael Lee; Jeffrey Miller; Martina Bazzaro
J Immunol (2015) 195 (10): 4760–4770.
View articletitled, UNC-45A Is a Nonmuscle Myosin IIA Chaperone Required for NK Cell Cytotoxicity via Control of Lytic Granule Secretion
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Bee Venom Phospholipase A2, a Novel Foxp3+ Regulatory T Cell Inducer, Protects Dopaminergic Neurons by Modulating Neuroinflammatory Responses in a Mouse Model of Parkinson’s Disease
Eun Sook Chung; Gihyun Lee; Chanju Lee; Minsook Ye; Hwan-suck Chung; Hyunseong Kim; Sung-joo S. Bae; Deok-Sang Hwang; Hyunsu Bae
J Immunol (2015) 195 (10): 4853–4860.
View articletitled, Bee Venom Phospholipase A<sub>2</sub>, a Novel Foxp3<sup>+</sup> Regulatory T Cell Inducer, Protects Dopaminergic Neurons by Modulating Neuroinflammatory Responses in a Mouse Model of Parkinson’s Disease
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Authentic GITR Signaling Fails To Induce Tumor Regression unless Foxp3+ Regulatory T Cells Are Depleted
Young H. Kim; Su M. Shin; Beom K. Choi; Ho S. Oh; Chang H. Kim; Seung J. Lee; Kwang H. Kim; Don G. Lee; Sang H. Park; Byoung S. Kwon
J Immunol (2015) 195 (10): 4721–4729.
View articletitled, Authentic GITR Signaling Fails To Induce Tumor Regression unless Foxp3<sup>+</sup> Regulatory T Cells Are Depleted
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In This Issue
J Immunol (2015) 195 (10): 4547–4548.
View articletitled, In This Issue
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T Cell Responses against Mycobacterial Lipids and Proteins Are Poorly Correlated in South African Adolescents
Chetan Seshadri; Lin Lin; Thomas J. Scriba; Glenna Peterson; David Freidrich; Nicole Frahm; Stephen C. DeRosa; D. Branch Moody; Jacques Prandi; Martine Gilleron; Hassan Mahomed; Wenxin Jiang; Greg Finak; Willem A. Hanekom; Raphael Gottardo; M. Juliana McElrath; Thomas R. Hawn
J Immunol (2015) 195 (10): 4595–4603.
View articletitled, T Cell Responses against Mycobacterial Lipids and Proteins Are Poorly Correlated in South African Adolescents
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Oncogenic Transformation of Dendritic Cells and Their Precursors Leads to Rapid Cancer Development in Mice
Jan P. Böttcher; Santiago Zelenay; Neil C. Rogers; Julie Helft; Barbara U. Schraml; Caetano Reis e Sousa
J Immunol (2015) 195 (10): 5066–5076.
View articletitled, Oncogenic Transformation of Dendritic Cells and Their Precursors Leads to Rapid Cancer Development in Mice
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NK Cell Proliferation Induced by IL-15 Transpresentation Is Negatively Regulated by Inhibitory Receptors
Olga M. Anton; Susina Vielkind; Mary E. Peterson; Yutaka Tagaya; Eric O. Long
J Immunol (2015) 195 (10): 4810–4821.
View articletitled, NK Cell Proliferation Induced by IL-15 Transpresentation Is Negatively Regulated by Inhibitory Receptors
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Novel Role of TRPML2 in the Regulation of the Innate Immune Response
Lu Sun; Yinan Hua; Silvia Vergarajauregui; Heba I. Diab; Rosa Puertollano
J Immunol (2015) 195 (10): 4922–4932.
View articletitled, Novel Role of TRPML2 in the Regulation of the Innate Immune Response
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TNFR2 Deficiency Acts in Concert with Gut Microbiota To Precipitate Spontaneous Sex-Biased Central Nervous System Demyelinating Autoimmune Disease
Patrick G. Miller; Michael B. Bonn; Craig L. Franklin; Aaron C. Ericsson; Susan C. McKarns
J Immunol (2015) 195 (10): 4668–4684.
View articletitled, TNFR2 Deficiency Acts in Concert with Gut Microbiota To Precipitate Spontaneous Sex-Biased Central Nervous System Demyelinating Autoimmune Disease
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NK Cell Functional Impairment after Allogeneic Hematopoietic Stem Cell Transplantation Is Associated with Reduced Levels of T-bet and Eomesodermin
Federico Simonetta; Amandine Pradier; Carine Bosshard; Stavroula Masouridi-Levrat; Yves Chalandon; Eddy Roosnek
J Immunol (2015) 195 (10): 4712–4720.
View articletitled, NK Cell Functional Impairment after Allogeneic Hematopoietic Stem Cell Transplantation Is Associated with Reduced Levels of T-bet and Eomesodermin
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SARM1, Not MyD88, Mediates TLR7/TLR9-Induced Apoptosis in Neurons
Piyali Mukherjee; Clayton W. Winkler; Katherine G. Taylor; Tyson A. Woods; Vinod Nair; Burhan A. Khan; Karin E. Peterson
J Immunol (2015) 195 (10): 4913–4921.
View articletitled, SARM1, Not MyD88, Mediates TLR7/TLR9-Induced Apoptosis in Neurons
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Regulatory B Cells with a Partial Defect in CD40 Signaling and Overexpressing Granzyme B Transfer Allograft Tolerance in Rodents
Justine Durand; Virginie Huchet; Emmanuel Merieau; Claire Usal; Melanie Chesneau; Severine Remy; Michele Heslan; Ignacio Anegon; Maria-Cristina Cuturi; Sophie Brouard; Elise Chiffoleau
J Immunol (2015) 195 (10): 5035–5044.
View articletitled, Regulatory B Cells with a Partial Defect in CD40 Signaling and Overexpressing Granzyme B Transfer Allograft Tolerance in Rodents
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Ptpn22 and Cd2 Variations Are Associated with Altered Protein Expression and Susceptibility to Type 1 Diabetes in Nonobese Diabetic Mice
Heather I. Fraser; Sarah Howlett; Jan Clark; Daniel B. Rainbow; Stephanie M. Stanford; Dennis J. Wu; Yi-Wen Hsieh; Christian J. Maine; Mikkel Christensen; Vijay Kuchroo; Linda A. Sherman; Patricia L. Podolin; John A. Todd; Charles A. Steward; Laurence B. Peterson; Nunzio Bottini; Linda S. Wicker
J Immunol (2015) 195 (10): 4841–4852.
View articletitled, <em>Ptpn22</em> and <em>Cd2</em> Variations Are Associated with Altered Protein Expression and Susceptibility to Type 1 Diabetes in Nonobese Diabetic Mice
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Response to Comment on “Primary Central Nervous System (CNS) Lymphoma B Cell Receptors Recognize CNS Proteins”
Manuel Montesinos-Rongen; Frauke Purschke; Anna Brunn; Martina Deckert
J Immunol (2015) 195 (10): 4550–4551.
View articletitled, Response to Comment on “Primary Central Nervous System (CNS) Lymphoma B Cell Receptors Recognize CNS Proteins”
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CD Nomenclature 2015: Human Leukocyte Differentiation Antigen Workshops as a Driving Force in Immunology
Pablo Engel; Laurence Boumsell; Robert Balderas; Armand Bensussan; Valter Gattei; Vaclav Horejsi; Bo-Quan Jin; Fabio Malavasi; Frank Mortari; Reinhard Schwartz-Albiez; Hannes Stockinger; Menno C. van Zelm; Heddy Zola; Georgina Clark
J Immunol (2015) 195 (10): 4555–4563.
View articletitled, CD Nomenclature 2015: Human Leukocyte Differentiation Antigen Workshops as a Driving Force in Immunology
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Targeting Anti-Insulin B Cell Receptors Improves Receptor Editing in Type 1 Diabetes–Prone Mice
Rachel H. Bonami; James W. Thomas
J Immunol (2015) 195 (10): 4730–4741.
View articletitled, Targeting Anti-Insulin B Cell Receptors Improves Receptor Editing in Type 1 Diabetes–Prone Mice
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Endoplasmic Reticulum Stress of Neutrophils Is Required for Ischemia/Reperfusion–Induced Acute Lung Injury
Rong Hu; Zhi-Feng Chen; Jia Yan; Qi-Fang Li; Yan Huang; Hui Xu; Xiao-Ping Zhang; Hong Jiang
J Immunol (2015) 195 (10): 4802–4809.
View articletitled, Endoplasmic Reticulum Stress of Neutrophils Is Required for Ischemia/Reperfusion–Induced Acute Lung Injury
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Comment on “Deficient NLRP3 and AIM2 Inflammasome Function in Autoimmune NZB Mice”
Divaker Choubey; Ravichandran Panchanathan
J Immunol (2015) 195 (10): 4551–4552.
View articletitled, Comment on “Deficient NLRP3 and AIM2 Inflammasome Function in Autoimmune NZB Mice”
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A Small Molecule Inhibitor of ITK and RLK Impairs Th1 Differentiation and Prevents Colitis Disease Progression
Hyoung-Soo Cho; Hyun Mu Shin; Helena Haberstock-Debic; Yan Xing; Timothy D. Owens; Jens Oliver Funk; Ronald J. Hill; J. Michael Bradshaw; Leslie J. Berg
J Immunol (2015) 195 (10): 4822–4831.
View articletitled, A Small Molecule Inhibitor of ITK and RLK Impairs Th1 Differentiation and Prevents Colitis Disease Progression
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The Quantity of Autocrine IL-2 Governs the Expansion Potential of CD8+ T Cells
Anke Redeker; Suzanne P. M. Welten; Miranda R. M. Baert; Sandra A. Vloemans; Machteld M. Tiemessen; Frank J. T. Staal; Ramon Arens
J Immunol (2015) 195 (10): 4792–4801.
View articletitled, The Quantity of Autocrine IL-2 Governs the Expansion Potential of CD8<sup>+</sup> T Cells
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A Central Role for HLA-DR3 in Anti-Smith Antibody Responses and Glomerulonephritis in a Transgenic Mouse Model of Spontaneous Lupus
Vaidehi R. Chowdhary; Chao Dai; Ashenafi Y. Tilahun; Julie A. Hanson; Michele K. Smart; Joseph P. Grande; Govindarajan Rajagopalan; Shu-Man Fu; Chella S. David
J Immunol (2015) 195 (10): 4660–4667.
View articletitled, A Central Role for HLA-DR3 in Anti-Smith Antibody Responses and Glomerulonephritis in a Transgenic Mouse Model of Spontaneous Lupus
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Tissue-Resident NK Cells Mediate Ischemic Kidney Injury and Are Not Depleted by Anti–Asialo-GM1 Antibody
Francisco Victorino; Dorothy K. Sojka; Kelley S. Brodsky; Eoin N. McNamee; Joanne C. Masterson; Dirk Homann; Wayne M. Yokoyama; Holger K. Eltzschig; Eric T. Clambey
J Immunol (2015) 195 (10): 4973–4985.
View articletitled, Tissue-Resident NK Cells Mediate Ischemic Kidney Injury and Are Not Depleted by Anti–Asialo-GM1 Antibody
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Dynamics and Transcriptomics of Skin Dendritic Cells and Macrophages in an Imiquimod-Induced, Biphasic Mouse Model of Psoriasis
Dorothea Terhorst; Rabie Chelbi; Christian Wohn; Camille Malosse; Samira Tamoutounour; Audrey Jorquera; Marc Bajenoff; Marc Dalod; Bernard Malissen; Sandrine Henri
J Immunol (2015) 195 (10): 4953–4961.
View articletitled, Dynamics and Transcriptomics of Skin Dendritic Cells and Macrophages in an Imiquimod-Induced, Biphasic Mouse Model of Psoriasis
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Responsiveness of Developing T Cells to IL-7 Signals Is Sustained by miR-17∼92
Malte Regelin; Jonas Blume; Jens Pommerencke; Ramin Vakilzadeh; Katrin Witzlau; Marcin Łyszkiewicz; Natalia Ziętara; Namita Saran; Axel Schambach; Andreas Krueger
J Immunol (2015) 195 (10): 4832–4840.
View articletitled, Responsiveness of Developing T Cells to IL-7 Signals Is Sustained by miR-17∼92
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Comment on “Primary Central Nervous System (CNS) Lymphoma B Cell Receptors Recognize CNS Proteins”
Elmar Spies; Michael Fichtner; Fabian Müller; Susanne Krasemann; Gerald Illerhaus; Markus Glatzel; Mascha Binder; Martin Trepel
J Immunol (2015) 195 (10): 4549–4550.
View articletitled, Comment on “Primary Central Nervous System (CNS) Lymphoma B Cell Receptors Recognize CNS Proteins”
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Response to Comment on “Deficient NLRP3 and AIM2 Inflammasome Function in Autoimmune NZB Mice”
David P. Sester; Katryn J. Stacey
J Immunol (2015) 195 (10): 4552–4553.
View articletitled, Response to Comment on “Deficient NLRP3 and AIM2 Inflammasome Function in Autoimmune NZB Mice”
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Dectin-1 Activation by a Natural Product β-Glucan Converts Immunosuppressive Macrophages into an M1-like Phenotype
Min Liu; Fengling Luo; Chuanlin Ding; Sabrin Albeituni; Xiaoling Hu; Yunfeng Ma; Yihua Cai; Lacey McNally; Mary Ann Sanders; Dharamvir Jain; Goetz Kloecker; Michael Bousamra, II; Huang-ge Zhang; Richard M. Higashi; Andrew N. Lane; Teresa W.-M. Fan; Jun Yan
J Immunol (2015) 195 (10): 5055–5065.
View articletitled, Dectin-1 Activation by a Natural Product β-Glucan Converts Immunosuppressive Macrophages into an M1-like Phenotype
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Cutting Edge: Plasmacytoid Dendritic Cells in Late-Stage Lupus Mice Defective in Producing IFN-α
Xiaofeng Liao; Song Li; Robert E. Settlage; Sha Sun; Jingjing Ren; Alec M. Reihl; Husen Zhang; Saikumar V. Karyala; Christopher M. Reilly; S. Ansar Ahmed; Xin M. Luo
J Immunol (2015) 195 (10): 4578–4582.
View articletitled, Cutting Edge: Plasmacytoid Dendritic Cells in Late-Stage Lupus Mice Defective in Producing IFN-α
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Housing Temperature–Induced Stress Is Suppressing Murine Graft-versus-Host Disease through β2-Adrenergic Receptor Signaling
Nicholas D. Leigh; Kathleen M. Kokolus; Rachel E. O’Neill; Wei Du; Jason W.-L. Eng; Jingxin Qiu; George L. Chen; Philip L. McCarthy; J. David Farrar; Xuefang Cao; Elizabeth A. Repasky
J Immunol (2015) 195 (10): 5045–5054.
View articletitled, Housing Temperature–Induced Stress Is Suppressing Murine Graft-versus-Host Disease through β<sub>2</sub>-Adrenergic Receptor Signaling
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Identification of the SLAM Adapter Molecule EAT-2 as a Lupus-Susceptibility Gene That Acts through Impaired Negative Regulation of Dendritic Cell Signaling
Nafiseh Talaei; Tao Yu; Kieran Manion; Rod Bremner; Joan E. Wither
J Immunol (2015) 195 (10): 4623–4631.
View articletitled, Identification of the SLAM Adapter Molecule EAT-2 as a Lupus-Susceptibility Gene That Acts through Impaired Negative Regulation of Dendritic Cell Signaling
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miR-155 Upregulation in Dendritic Cells Is Sufficient To Break Tolerance In Vivo by Negatively Regulating SHIP1
Evan F. Lind; Douglas G. Millar; Dilan Dissanayake; Jonathan C. Savage; Natasha K. Grimshaw; William G. Kerr; Pamela S. Ohashi
J Immunol (2015) 195 (10): 4632–4640.
View articletitled, miR-155 Upregulation in Dendritic Cells Is Sufficient To Break Tolerance In Vivo by Negatively Regulating SHIP1
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Preferential Destruction of Interstitial Macrophages over Alveolar Macrophages as a Cause of Pulmonary Disease in Simian Immunodeficiency Virus–Infected Rhesus Macaques
Yanhui Cai; Chie Sugimoto; Mariluz Arainga; Cecily C. Midkiff; David Xianhong Liu; Xavier Alvarez; Andrew A. Lackner; Woong-Ki Kim; Elizabeth S. Didier; Marcelo J. Kuroda
J Immunol (2015) 195 (10): 4884–4891.
View articletitled, Preferential Destruction of Interstitial Macrophages over Alveolar Macrophages as a Cause of Pulmonary Disease in Simian Immunodeficiency Virus–Infected Rhesus Macaques
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Phenotypic and Morphological Properties of Germinal Center Dark Zone Cxcl12-Expressing Reticular Cells
Lauren B. Rodda; Oliver Bannard; Burkhard Ludewig; Takashi Nagasawa; Jason G. Cyster
J Immunol (2015) 195 (10): 4781–4791.
View articletitled, Phenotypic and Morphological Properties of Germinal Center Dark Zone <em>Cxcl12</em>-Expressing Reticular Cells
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Cholesterol-Independent Suppression of Lymphocyte Activation, Autoimmunity, and Glomerulonephritis by Apolipoprotein A-I in Normocholesterolemic Lupus-Prone Mice
Leland L. Black; Roshni Srivastava; Trenton R. Schoeb; Ray D. Moore; Stephen Barnes; Janusz H. Kabarowski
J Immunol (2015) 195 (10): 4685–4698.
View articletitled, Cholesterol-Independent Suppression of Lymphocyte Activation, Autoimmunity, and Glomerulonephritis by Apolipoprotein A-I in Normocholesterolemic Lupus-Prone Mice
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Sos1 Regulates Macrophage Podosome Assembly and Macrophage Invasive Capacity
Anna Baruzzi; Sabrina Remelli; Erika Lorenzetto; Michela Sega; Roberto Chignola; Giorgio Berton
J Immunol (2015) 195 (10): 4900–4912.
View articletitled, Sos1 Regulates Macrophage Podosome Assembly and Macrophage Invasive Capacity
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Lipopolysaccharide Regulation of Intestinal Tight Junction Permeability Is Mediated by TLR4 Signal Transduction Pathway Activation of FAK and MyD88
Shuhong Guo; Meghali Nighot; Rana Al-Sadi; Tarik Alhmoud; Prashant Nighot; Thomas Y. Ma
J Immunol (2015) 195 (10): 4999–5010.
View articletitled, Lipopolysaccharide Regulation of Intestinal Tight Junction Permeability Is Mediated by TLR4 Signal Transduction Pathway Activation of FAK and MyD88
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Intestinal Epithelial Cell Tyrosine Kinase 2 Transduces IL-22 Signals To Protect from Acute Colitis
Eva Hainzl; Silvia Stockinger; Isabella Rauch; Susanne Heider; David Berry; Caroline Lassnig; Clarissa Schwab; Felix Rosebrock; Gabriel Milinovich; Michaela Schlederer; Michael Wagner; Christa Schleper; Alexander Loy; Tim Urich; Lukas Kenner; Xiaonan Han; Thomas Decker; Birgit Strobl; Mathias Müller
J Immunol (2015) 195 (10): 5011–5024.
View articletitled, Intestinal Epithelial Cell Tyrosine Kinase 2 Transduces IL-22 Signals To Protect from Acute Colitis
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Cellular Dynamics of Memory B Cell Populations: IgM+ and IgG+ Memory B Cells Persist Indefinitely as Quiescent Cells
Derek D. Jones; Joel R. Wilmore; David Allman
J Immunol (2015) 195 (10): 4753–4759.
View articletitled, Cellular Dynamics of Memory B Cell Populations: IgM<sup>+</sup> and IgG<sup>+</sup> Memory B Cells Persist Indefinitely as Quiescent Cells
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Polarization of Monocytic Myeloid-Derived Suppressor Cells by Hepatitis B Surface Antigen Is Mediated via ERK/IL-6/STAT3 Signaling Feedback and Restrains the Activation of T Cells in Chronic Hepatitis B Virus Infection
Zhong Fang; Jin Li; Xiaoyu Yu; Dandan Zhang; Guangxu Ren; Bisheng Shi; Cong Wang; Anna D. Kosinska; Sen Wang; Xiaohui Zhou; Maya Kozlowski; Yunwen Hu; Zhenghong Yuan
J Immunol (2015) 195 (10): 4873–4883.
View articletitled, Polarization of Monocytic Myeloid-Derived Suppressor Cells by Hepatitis B Surface Antigen Is Mediated via ERK/IL-6/STAT3 Signaling Feedback and Restrains the Activation of T Cells in Chronic Hepatitis B Virus Infection
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A Lymphotoxin/Type I IFN Axis Programs CD8+ T Cells To Infiltrate a Self-Tissue and Propagate Immunopathology
Dennis Ng; Blandine Maître; Derek Cummings; Albert Lin; Lesley A. Ward; Ramtin Rahbar; Karen L. Mossman; Pamela S. Ohashi; Jennifer L. Gommerman
J Immunol (2015) 195 (10): 4650–4659.
View articletitled, A Lymphotoxin/Type I IFN Axis Programs CD8<sup>+</sup> T Cells To Infiltrate a Self-Tissue and Propagate Immunopathology
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Low Thymic Activity and Dendritic Cell Numbers Are Associated with the Immune Response to Primary Viral Infection in Elderly Humans
Axel Ronald Schulz; Julia Nora Mälzer; Cristina Domingo; Karsten Jürchott; Andreas Grützkau; Nina Babel; Mikalai Nienen; Tomas Jelinek; Matthias Niedrig; Andreas Thiel
J Immunol (2015) 195 (10): 4699–4711.
View articletitled, Low Thymic Activity and Dendritic Cell Numbers Are Associated with the Immune Response to Primary Viral Infection in Elderly Humans
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Mechanistic Target of Rapamycin Complex 1/S6 Kinase 1 Signals Influence T Cell Activation Independently of Ribosomal Protein S6 Phosphorylation
Robert J. Salmond; Rebecca J. Brownlie; Oded Meyuhas; Rose Zamoyska
J Immunol (2015) 195 (10): 4615–4622.
View articletitled, Mechanistic Target of Rapamycin Complex 1/S6 Kinase 1 Signals Influence T Cell Activation Independently of Ribosomal Protein S6 Phosphorylation
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A Complement-Optimized EGFR Antibody Improves Cytotoxic Functions of Polymorphonuclear Cells against Tumor Cells
Stefanie Derer; Michael Cossham; Thies Rösner; Christian Kellner; Frank J. Beurskens; Ralf Schwanbeck; Stefan Lohse; Christian Sina; Matthias Peipp; Thomas Valerius
J Immunol (2015) 195 (10): 5077–5087.
View articletitled, A Complement-Optimized EGFR Antibody Improves Cytotoxic Functions of Polymorphonuclear Cells against Tumor Cells
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Eomesodermin Expression in CD4+ T Cells Restricts Peripheral Foxp3 Induction
Ekaterina Lupar; Maria Brack; Laure Garnier; Sophie Laffont; Katharina S. Rauch; Kristina Schachtrup; Sebastian J. Arnold; Jean-Charles Guéry; Ana Izcue
J Immunol (2015) 195 (10): 4742–4752.
View articletitled, Eomesodermin Expression in CD4<sup>+</sup> T Cells Restricts Peripheral Foxp3 Induction
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APOBEC3 Proteins in Viral Immunity
Spyridon Stavrou; Susan R. Ross
J Immunol (2015) 195 (10): 4565–4570.
View articletitled, APOBEC3 Proteins in Viral Immunity
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Cytosolic Low Molecular Weight FGF2 Orchestrates RIG-I–Mediated Innate Immune Response
Xin Liu; Deyan Luo; Ning Yang
J Immunol (2015) 195 (10): 4943–4952.
View articletitled, Cytosolic Low Molecular Weight FGF2 Orchestrates RIG-I–Mediated Innate Immune Response
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Ectopic Aire Expression in the Thymic Cortex Reveals Inherent Properties of Aire as a Tolerogenic Factor within the Medulla
Hitoshi Nishijima; Satsuki Kitano; Hitoshi Miyachi; Junko Morimoto; Hiroshi Kawano; Fumiko Hirota; Ryoko Morita; Yasuhiro Mouri; Kiyoshi Masuda; Issei Imoto; Koichi Ikuta; Mitsuru Matsumoto
J Immunol (2015) 195 (10): 4641–4649.
View articletitled, Ectopic Aire Expression in the Thymic Cortex Reveals Inherent Properties of Aire as a Tolerogenic Factor within the Medulla
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LRRC59 Regulates Trafficking of Nucleic Acid–Sensing TLRs from the Endoplasmic Reticulum via Association with UNC93B1
Megumi Tatematsu; Kenji Funami; Noriko Ishii; Tsukasa Seya; Chikashi Obuse; Misako Matsumoto
J Immunol (2015) 195 (10): 4933–4942.
View articletitled, LRRC59 Regulates Trafficking of Nucleic Acid–Sensing TLRs from the Endoplasmic Reticulum via Association with UNC93B1
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Complement Evasion Mediated by Enhancement of Captured Factor H: Implications for Protection of Self-Surfaces from Complement
Andrew P. Herbert; Elisavet Makou; Zhuo A. Chen; Heather Kerr; Anna Richards; Juri Rappsilber; Paul N. Barlow
J Immunol (2015) 195 (10): 4986–4998.
View articletitled, Complement Evasion Mediated by Enhancement of Captured Factor H: Implications for Protection of Self-Surfaces from Complement
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  • Cover Image

    Cover Image

    issue cover

    On the cover: Butyrophilin 3A1 structure with an IgV:IgC extracellular dimer, a B30.2 intracellular dimer, and a model of the coiled coil domain. (E)-hydroxy-2-methyl-butenyl pyrophosphate produced by microbes (left) and endogenous isopentenyl pyrophosphate (right) bind to the B30.2 domain rather than the IgV site, suggesting that butyrophilin 3A1 functions as a sensor molecule. Wang, H., and C. T. Morita. 2015. Sensor function for butyrophilin 3A1 in prenyl pyrophosphate stimulation of human Vγ2Vδ2 T cells. J. Immunol. 195: 4583–4594.

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