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Volume 196, Issue 12
15 June 2016
The Journal of Immunology Cover Image for Volume 196, Issue 12
ISSN 0022-1767
EISSN 1550-6606

IN THIS ISSUE

In This Issue
J Immunol (2016) 196 (12): 4837–4838.
View articletitled, In This Issue
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BRIEF REVIEWS

The Lung Microbiome, Immunity, and the Pathogenesis of Chronic Lung Disease
David N. O’Dwyer; Robert P. Dickson; Bethany B. Moore
J Immunol (2016) 196 (12): 4839–4847.
View articletitled, The Lung Microbiome, Immunity, and the Pathogenesis of Chronic Lung Disease
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What Happens in the Thymus Does Not Stay in the Thymus: How T Cells Recycle the CD4+–CD8+ Lineage Commitment Transcriptional Circuitry To Control Their Function
Melanie S. Vacchio; Rémy Bosselut
J Immunol (2016) 196 (12): 4848–4856.
View articletitled, What Happens in the Thymus Does Not Stay in the Thymus: How T Cells Recycle the CD4<sup>+</sup>–CD8<sup>+</sup> Lineage Commitment Transcriptional Circuitry To Control Their Function
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CUTTING EDGE

Cutting Edge: Skin CCR10+ CD8+ T Cells Support Resident Regulatory T Cells through the B7.2/Receptor Axis To Regulate Local Immune Homeostasis and Response
Yaoyao Fu; Jie Yang; Na Xiong
J Immunol (2016) 196 (12): 4859–4864.
View articletitled, Cutting Edge: Skin CCR10<sup>+</sup> CD8<sup>+</sup> T Cells Support Resident Regulatory T Cells through the B7.2/Receptor Axis To Regulate Local Immune Homeostasis and Response
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ALLERGY AND OTHER HYPERSENSITIVITIES

IL-10 Enhances IgE-Mediated Mast Cell Responses and Is Essential for the Development of Experimental Food Allergy in IL-10–Deficient Mice
Stephanie H. Polukort; Jeffrey Rovatti; Logan Carlson; Chelsea Thompson; Jennifer Ser-Dolansky; Shannon R. M. Kinney; Sallie S. Schneider; Clinton B. Mathias
J Immunol (2016) 196 (12): 4865–4876.
View articletitled, IL-10 Enhances IgE-Mediated Mast Cell Responses and Is Essential for the Development of Experimental Food Allergy in IL-10–Deficient Mice
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Impaired P2X1 Receptor–Mediated Adhesion in Eosinophils from Asthmatic Patients
Adam Wright; Martyn Mahaut-Smith; Fiona Symon; Nicolas Sylvius; Shaun Ran; Mona Bafadhel; Michelle Muessel; Peter Bradding; Andrew Wardlaw; Catherine Vial
J Immunol (2016) 196 (12): 4877–4884.
View articletitled, Impaired P2X1 Receptor–Mediated Adhesion in Eosinophils from Asthmatic Patients
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Unlike in Children with Allergic Asthma, IgE Transcripts from Preschool Children with Atopic Dermatitis Display Signs of Superantigen-Driven Activation
Sebastian Kerzel; Tobias Rogosch; Benjamin Struecker; Rolf F. Maier; Michael Kabesch; Michael Zemlin
J Immunol (2016) 196 (12): 4885–4892.
View articletitled, Unlike in Children with Allergic Asthma, IgE Transcripts from Preschool Children with Atopic Dermatitis Display Signs of Superantigen-Driven Activation
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AUTOIMMUNITY

Tbet or Continued RORγt Expression Is Not Required for Th17-Associated Immunopathology
Verena Brucklacher-Waldert; Cristina Ferreira; Silvia Innocentin; Shraddha Kamdar; David R. Withers; Marika C. Kullberg; Marc Veldhoen
J Immunol (2016) 196 (12): 4893–4904.
View articletitled, Tbet or Continued RORγt Expression Is Not Required for Th17-Associated Immunopathology
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Preferential Use of Public TCR during Autoimmune Encephalomyelitis
Yunqian Zhao; Phuong Nguyen; Jing Ma; Tianhua Wu; Lindsay L. Jones; Deqing Pei; Cheng Cheng; Terrence L. Geiger
J Immunol (2016) 196 (12): 4905–4914.
View articletitled, Preferential Use of Public TCR during Autoimmune Encephalomyelitis
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Decreased SAP Expression in T Cells from Patients with Systemic Lupus Erythematosus Contributes to Early Signaling Abnormalities and Reduced IL-2 Production
Maria P. Karampetsou; Denis Comte; Katalin Kis-Toth; Cox Terhorst; Vasileios C. Kyttaris; George C. Tsokos
J Immunol (2016) 196 (12): 4915–4924.
View articletitled, Decreased SAP Expression in T Cells from Patients with Systemic Lupus Erythematosus Contributes to Early Signaling Abnormalities and Reduced IL-2 Production
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Piperlongumine Suppresses Dendritic Cell Maturation by Reducing Production of Reactive Oxygen Species and Has Therapeutic Potential for Rheumatoid Arthritis
Youjun Xiao; Maohua Shi; Qian Qiu; Mingcheng Huang; Shan Zeng; Yaoyao Zou; Zhongping Zhan; Liuqin Liang; Xiuyan Yang; Hanshi Xu
J Immunol (2016) 196 (12): 4925–4934.
View articletitled, Piperlongumine Suppresses Dendritic Cell Maturation by Reducing Production of Reactive Oxygen Species and Has Therapeutic Potential for Rheumatoid Arthritis
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CD275-Independent IL-17–Producing T Follicular Helper–like Cells in Lymphopenic Autoimmune-Prone Mice
Christopher Smith; Janet E. Buhlmann; Xiaogan Wang; Amber Bartlett; Bing Lim; Robert A. Barrington
J Immunol (2016) 196 (12): 4935–4946.
View articletitled, CD275-Independent IL-17–Producing T Follicular Helper–like Cells in Lymphopenic Autoimmune-Prone Mice
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ERβ in CD4+ T Cells Is Crucial for Ligand-Mediated Suppression of Central Nervous System Autoimmunity
Maria Aggelakopoulou; Evangelia Kourepini; Nikolaos Paschalidis; Vily Panoutsakopoulou
J Immunol (2016) 196 (12): 4947–4956.
View articletitled, ERβ in CD4<sup>+</sup> T Cells Is Crucial for Ligand-Mediated Suppression of Central Nervous System Autoimmunity
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CLINICAL AND HUMAN IMMUNOLOGY

Heightened Immune Activation in Fetuses with Gastroschisis May Be Blocked by Targeting IL-5
Michela Frascoli; Cerine Jeanty; Shannon Fleck; Patriss W. Moradi; Sheila Keating; Aras N. Mattis; Qizhi Tang; Tippi C. MacKenzie
J Immunol (2016) 196 (12): 4957–4966.
View articletitled, Heightened Immune Activation in Fetuses with Gastroschisis May Be Blocked by Targeting IL-5
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IMMUNE REGULATION

HNRNPR Regulates the Expression of Classical and Nonclassical MHC Class I Proteins
Adi Reches; Daphna Nachmani; Orit Berhani; Alexandra Duev-Cohen; Dorin Shreibman; Yael Ophir; Barbara Seliger; Ofer Mandelboim
J Immunol (2016) 196 (12): 4967–4976.
View articletitled, HNRNPR Regulates the Expression of Classical and Nonclassical MHC Class I Proteins
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RBP-J–Regulated miR-182 Promotes TNF-α–Induced Osteoclastogenesis
Christine H. Miller; Sinead M. Smith; Mahmoud Elguindy; Tuo Zhang; Jenny Z. Xiang; Xiaoyu Hu; Lionel B. Ivashkiv; Baohong Zhao
J Immunol (2016) 196 (12): 4977–4986.
View articletitled, RBP-J–Regulated miR-182 Promotes TNF-α–Induced Osteoclastogenesis
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IMMUNE SYSTEM DEVELOPMENT

NKAP Regulates Invariant NKT Cell Proliferation and Differentiation into ROR-γt–Expressing NKT17 Cells
Puspa Thapa; Meibo W. Chen; Douglas C. McWilliams; Paul Belmonte; Megan Constans; Derek B. Sant’Angelo; Virginia Smith Shapiro
J Immunol (2016) 196 (12): 4987–4998.
View articletitled, NKAP Regulates Invariant NKT Cell Proliferation and Differentiation into ROR-γt–Expressing NKT17 Cells
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The Hayflick Limit May Determine the Effective Clonal Diversity of Naive T Cells
Wilfred Ndifon; Jonathan Dushoff
J Immunol (2016) 196 (12): 4999–5004.
View articletitled, The Hayflick Limit May Determine the Effective Clonal Diversity of Naive T Cells
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IMMUNOGENETICS

Dynamics of Individual T Cell Repertoires: From Cord Blood to Centenarians
Olga V. Britanova; Mikhail Shugay; Ekaterina M. Merzlyak; Dmitriy B. Staroverov; Ekaterina V. Putintseva; Maria A. Turchaninova; Ilgar Z. Mamedov; Mikhail V. Pogorelyy; Dmitriy A. Bolotin; Mark Izraelson; Alexey N. Davydov; Evgeny S. Egorov; Sofya A. Kasatskaya; Denis V. Rebrikov; Sergey Lukyanov; Dmitriy M. Chudakov
J Immunol (2016) 196 (12): 5005–5013.
View articletitled, Dynamics of Individual T Cell Repertoires: From Cord Blood to Centenarians
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IMMUNOTHERAPY AND VACCINES

Aerosol Delivery of a Candidate Universal Influenza Vaccine Reduces Viral Load in Pigs Challenged with Pandemic H1N1 Virus
Sophie B. Morgan; Johanneke D. Hemmink; Emily Porter; Ross Harley; Holly Shelton; Mario Aramouni; Helen E. Everett; Sharon M. Brookes; Michael Bailey; Alain M. Townsend; Bryan Charleston; Elma Tchilian
J Immunol (2016) 196 (12): 5014–5023.
View articletitled, Aerosol Delivery of a Candidate Universal Influenza Vaccine Reduces Viral Load in Pigs Challenged with Pandemic H1N1 Virus
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IL-3 Decreases Cartilage Degeneration by Downregulating Matrix Metalloproteinases and Reduces Joint Destruction in Osteoarthritic Mice
Supinder Kour; Manasa G. Garimella; Divya A. Shiroor; Suhas T. Mhaske; Snehal R. Joshi; Kanupriya Singh; Subhashis Pal; Monika Mittal; Hari B. Krishnan; Naibedya Chattopadhyay; Anil H. Ulemale; Mohan R. Wani
J Immunol (2016) 196 (12): 5024–5035.
View articletitled, IL-3 Decreases Cartilage Degeneration by Downregulating Matrix Metalloproteinases and Reduces Joint Destruction in Osteoarthritic Mice
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Regulatory T Cell Dysfunction Acquiesces to BTLA+ Regulatory B Cells Subsequent to Oral Intervention in Experimental Autoimmune Encephalomyelitis
Eduardo Huarte; SangMu Jun; Agnieszka Rynda-Apple; Sara Golden; Larissa Jackiw; Carol Hoffman; Massimo Maddaloni; David W. Pascual
J Immunol (2016) 196 (12): 5036–5046.
View articletitled, Regulatory T Cell Dysfunction Acquiesces to BTLA<sup>+</sup> Regulatory B Cells Subsequent to Oral Intervention in Experimental Autoimmune Encephalomyelitis
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INFECTIOUS DISEASE AND HOST RESPONSE

M-CSF Mediates Host Defense during Bacterial Pneumonia by Promoting the Survival of Lung and Liver Mononuclear Phagocytes
Alexandra Bettina; Zhimin Zhang; Kathryn Michels; R. Elaine Cagnina; Isaah S. Vincent; Marie D. Burdick; Alexandra Kadl; Borna Mehrad
J Immunol (2016) 196 (12): 5047–5055.
View articletitled, M-CSF Mediates Host Defense during Bacterial Pneumonia by Promoting the Survival of Lung and Liver Mononuclear Phagocytes
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RIPK1 and PGAM5 Control Leishmania Replication through Distinct Mechanisms
Nivea Farias Luz; Sakthi Balaji; Kendi Okuda; Aline Silva Barreto; John Bertin; Peter J. Gough; Ricardo Gazzinelli; Roque P. Almeida; Marcelo T. Bozza; Valeria M. Borges; Francis Ka-Ming Chan
J Immunol (2016) 196 (12): 5056–5063.
View articletitled, RIPK1 and PGAM5 Control <em>Leishmania</em> Replication through Distinct Mechanisms
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INNATE IMMUNITY AND INFLAMMATION

Cholesterol Crystals Activate the Lectin Complement Pathway via Ficolin-2 and Mannose-Binding Lectin: Implications for the Progression of Atherosclerosis
Katrine Pilely; Anne Rosbjerg; Ninette Genster; Peter Gal; Gábor Pál; Bente Halvorsen; Sverre Holm; Pål Aukrust; Siril Skaret Bakke; Bjørnar Sporsheim; Ingunn Nervik; Nathalie Niyonzima; Emil D. Bartels; Gregory L. Stahl; Tom Eirik Mollnes; Terje Espevik; Peter Garred
J Immunol (2016) 196 (12): 5064–5074.
View articletitled, Cholesterol Crystals Activate the Lectin Complement Pathway via Ficolin-2 and Mannose-Binding Lectin: Implications for the Progression of Atherosclerosis
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Protein Tyrosine Kinase Fyn Regulates TLR4-Elicited Responses on Mast Cells Controlling the Function of a PP2A-PKCα/β Signaling Node Leading to TNF Secretion
Alejandro Martín-Ávila; Jaciel Medina-Tamayo; Alfredo Ibarra-Sánchez; Genaro Vázquez-Victorio; Jorge Iván Castillo-Arellano; Alma Cristal Hernández-Mondragón; Juan Rivera; Iris K. Madera-Salcedo; Ulrich Blank; Marina Macías-Silva; Claudia González-Espinosa
J Immunol (2016) 196 (12): 5075–5088.
View articletitled, Protein Tyrosine Kinase Fyn Regulates TLR4-Elicited Responses on Mast Cells Controlling the Function of a PP2A-PKCα/β Signaling Node Leading to TNF Secretion
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Correction of MFG-E8 Resolves Inflammation and Promotes Cutaneous Wound Healing in Diabetes
Amitava Das; Subhadip Ghatak; Mithun Sinha; Scott Chaffee; Noha S. Ahmed; Narasimham L. Parinandi; Eric S. Wohleb; John F. Sheridan; Chandan K. Sen; Sashwati Roy
J Immunol (2016) 196 (12): 5089–5100.
View articletitled, Correction of MFG-E8 Resolves Inflammation and Promotes Cutaneous Wound Healing in Diabetes
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LSm14A Plays a Critical Role in Antiviral Immune Responses by Regulating MITA Level in a Cell-Specific Manner
Tian-Tian Liu; Qing Yang; Mi Li; Bo Zhong; Yong Ran; Li-Li Liu; Yan Yang; Yan-Yi Wang; Hong-Bing Shu
J Immunol (2016) 196 (12): 5101–5111.
View articletitled, LSm14A Plays a Critical Role in Antiviral Immune Responses by Regulating MITA Level in a Cell-Specific Manner
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Alveolar Epithelial Cell–Derived Prostaglandin E2 Serves as a Request Signal for Macrophage Secretion of Suppressor of Cytokine Signaling 3 during Innate Inflammation
Jennifer M. Speth; Emilie Bourdonnay; Loka Raghu Kumar Penke; Peter Mancuso; Bethany B. Moore; Jason B. Weinberg; Marc Peters-Golden
J Immunol (2016) 196 (12): 5112–5120.
View articletitled, Alveolar Epithelial Cell–Derived Prostaglandin E<sub>2</sub> Serves as a Request Signal for Macrophage Secretion of Suppressor of Cytokine Signaling 3 during Innate Inflammation
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Nod1 Limits Colitis-Associated Tumorigenesis by Regulating IFN-γ Production
Yu Zhan; Sergey S. Seregin; Jiachen Chen; Grace Y. Chen
J Immunol (2016) 196 (12): 5121–5129.
View articletitled, Nod1 Limits Colitis-Associated Tumorigenesis by Regulating IFN-γ Production
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Experimental Anti-Inflammatory Drug Semapimod Inhibits TLR Signaling by Targeting the TLR Chaperone gp96
Jin Wang; Anatoly V. Grishin; Henri R. Ford
J Immunol (2016) 196 (12): 5130–5137.
View articletitled, Experimental Anti-Inflammatory Drug Semapimod Inhibits TLR Signaling by Targeting the TLR Chaperone gp96
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MOLECULAR AND STRUCTURAL IMMUNOLOGY

Multiple IgH Isotypes Including IgD, Subclasses of IgM, and IgY Are Expressed in the Common Ancestors of Modern Birds
Binyue Han; Hui Yuan; Tao Wang; Bo Li; Li Ma; Shuyang Yu; Tian Huang; Yan Li; Dongming Fang; Xiaoli Chen; Yongsi Wang; Si Qiu; Ying Guo; Jing Fei; Liming Ren; Qiang Pan-Hammarström; Lennart Hammarström; Jun Wang; Jian Wang; Yong Hou; Qingjie Pan; Xun Xu; Yaofeng Zhao
J Immunol (2016) 196 (12): 5138–5147.
View articletitled, Multiple IgH Isotypes Including IgD, Subclasses of IgM, and IgY Are Expressed in the Common Ancestors of Modern Birds
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MUCOSAL IMMUNOLOGY

Vitamin A Controls the Presence of RORγ+ Innate Lymphoid Cells and Lymphoid Tissue in the Small Intestine
Gera Goverse; Carlos Labao-Almeida; Manuela Ferreira; Rosalie Molenaar; Sigrid Wahlen; Tanja Konijn; Jasper Koning; Henrique Veiga-Fernandes; Reina E. Mebius
J Immunol (2016) 196 (12): 5148–5155.
View articletitled, Vitamin A Controls the Presence of RORγ<sup>+</sup> Innate Lymphoid Cells and Lymphoid Tissue in the Small Intestine
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TUMOR IMMUNOLOGY

Regulation of Complement-Dependent Cytotoxicity by MicroRNAs miR-200b, miR-200c, and miR-217
Yaron Hillman; Niv Mazkereth; Luba Farberov; Noam Shomron; Zvi Fishelson
J Immunol (2016) 196 (12): 5156–5165.
View articletitled, Regulation of Complement-Dependent Cytotoxicity by MicroRNAs miR-200b, miR-200c, and miR-217
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  • Cover Image

    Cover Image

    issue cover

    On the cover: Fluorescence micrograph of day 5 wound section from ROSA-LysM mice. ROSAmT/mG is a two-color fluorescent Cre reporter allele, expressing cell membrane–localized red fluorescence in widespread cells and tissues prior to Cre recombinase exposure. When bred with LysMcre animals, all cells of myeloid origin express GFP. Das, A., S. Ghatak, M. Sinha, S. Chaffee, N. S. Ahmed, N. L. Parinandi, E. S. Wohleb, J. F. Sheridan, C. K. Sen, and S. Roy. 2016. Correction of MFG-E8 resolves inflammation and promotes cutaneous wound healing in diabetes. J. Immunol. 196: 5089–5100.

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  • Online ISSN 1550-6606
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