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1 March 2016
ISSN 0022-1767
EISSN 1550-6606
In this Issue
IN THIS ISSUE
PILLARS OF IMMUNOLOGY
Pillars Article: Coreceptor Reversal in the Thymus: Signaled CD4+8+ Thymocytes Initially Terminate CD8 Transcription Even When Differentiating into CD8+ T Cells. Immunity. 2000. 13: 59–71
Enrico Brugnera; Avinash Bhandoola; Ricardo Cibotti; Qing Yu; Terry I. Guinter; Yoshio Yamashita; Susan O. Sharrow; Alfred Singer
J Immunol (2016) 196 (5): 1985–1997.
CUTTING EDGE
Cutting Edge: Expression of IRF8 in Gastric Epithelial Cells Confers Protective Innate Immunity against Helicobacter pylori Infection
Ming Yan; Hongsheng Wang; Jiafang Sun; Wei Liao; Peng Li; Yin Zhu; Chengfu Xu; Jungsoo Joo; Yan Sun; Sadia Abbasi; Alexander Kovalchuk; Nonghua Lv; Warren J. Leonard; Herbert C. Morse, III
J Immunol (2016) 196 (5): 1999–2003.
Cutting Edge: Critical Role of Glycolysis in Human Plasmacytoid Dendritic Cell Antiviral Responses
J Immunol (2016) 196 (5): 2004–2009.
Cutting Edge: Regulatory T Cells Facilitate Cutaneous Wound Healing
Audrey Nosbaum; Nicolas Prevel; Hong-An Truong; Pooja Mehta; Monika Ettinger; Tiffany C. Scharschmidt; Niwa H. Ali; Mariela L. Pauli; Abul K. Abbas; Michael D. Rosenblum
J Immunol (2016) 196 (5): 2010–2014.
ALLERGY AND OTHER HYPERSENSITIVITIES
Clusterin Modulates Allergic Airway Inflammation by Attenuating CCL20-Mediated Dendritic Cell Recruitment
Gyong Hwa Hong; Hyouk-Soo Kwon; Keun-Ai Moon; So Young Park; Sunjoo Park; Kyoung Young Lee; Eun Hee Ha; Tae-Bum Kim; Hee-Bom Moon; Heung Kyu Lee; You Sook Cho
J Immunol (2016) 196 (5): 2021–2030.
AUTOIMMUNITY
Despite Increased Type 1 IFN, Autoimmune Nonobese Diabetic Mice Display Impaired Dendritic Cell Response to CpG and Decreased Nuclear Localization of IFN-Activated STAT1
M. Jubayer Rahman; Gwendoline Rahir; Matthew B. Dong; Yongge Zhao; Kameron B. Rodrigues; Chie Hotta-Iwamura; Ye Chen; Alan Guerrero; Kristin V. Tarbell
J Immunol (2016) 196 (5): 2031–2040.
Overlapping IgG4 Responses to Self- and Environmental Antigens in Endemic Pemphigus Foliaceus
Ye Qian; Joseph S. Jeong; Jian Ye; Bim Dang; Maha Abdeladhim; Valeria Aoki; Gunter Hans-Filhio; Evandro A. Rivitti; Jesus G. Valenzuela; Luis A. Diaz
J Immunol (2016) 196 (5): 2041–2050.
CLINICAL AND HUMAN IMMUNOLOGY
Anti-C1q Autoantibodies from Systemic Lupus Erythematosus Patients Induce a Proinflammatory Phenotype in Macrophages
J Immunol (2016) 196 (5): 2063–2074.
LLT1 and CD161 Expression in Human Germinal Centers Promotes B Cell Activation and CXCR4 Downregulation
Alba Llibre; Constantino López-Macías; Teresa Marafioti; Hema Mehta; Amy Partridge; Carina Kanzig; Felice Rivellese; Jacob D. Galson; Lucy J. Walker; Paul Milne; Rodney E. Phillips; Dominic F. Kelly; Gordon J. Freeman; Mohey Eldin El Shikh; Paul Klenerman; Christian B. Willberg
J Immunol (2016) 196 (5): 2085–2094.
IMMUNE REGULATION
Treatment of Uveitis by In Situ Administration of Ex Vivo–Activated Polyclonal Regulatory T Cells
Sylvie Grégoire; Céline Terrada; Gaelle H. Martin; Gwladys Fourcade; Audrey Baeyens; Gilles Marodon; Sylvain Fisson; Fabienne Billiard; Bruno Lucas; Ramin Tadayoni; Francine Béhar-Cohen; Béatrice Levacher; Anne Galy; Phuc LeHoang; David Klatzmann; Bahram Bodaghi; Benoît L. Salomon
J Immunol (2016) 196 (5): 2109–2118.
Vitamin C Facilitates Demethylation of the Foxp3 Enhancer in a Tet-Dependent Manner
J Immunol (2016) 196 (5): 2119–2131.
Ptpn22 Modifies Regulatory T Cell Homeostasis via GITR Upregulation
J Immunol (2016) 196 (5): 2145–2152.
A Context-Dependent Role for IL-21 in Modulating the Differentiation, Distribution, and Abundance of Effector and Memory CD8 T Cell Subsets
J Immunol (2016) 196 (5): 2153–2166.
Yeast-Derived Particulate β-Glucan Treatment Subverts the Suppression of Myeloid-Derived Suppressor Cells (MDSC) by Inducing Polymorphonuclear MDSC Apoptosis and Monocytic MDSC Differentiation to APC in Cancer
Sabrin H. Albeituni; Chuanlin Ding; Min Liu; Xiaoling Hu; Fengling Luo; Goetz Kloecker; Michael Bousamra, II; Huang-ge Zhang; Jun Yan
J Immunol (2016) 196 (5): 2167–2180.
IMMUNE SYSTEM DEVELOPMENT
INFECTIOUS DISEASE AND HOST RESPONSE
Extensive CD4 and CD8 T Cell Cross-Reactivity between Alphaherpesviruses
Lichen Jing; Kerry J. Laing; Lichun Dong; Ronnie M. Russell; Russell S. Barlow; Juergen G. Haas; Meena S. Ramchandani; Christine Johnston; Soren Buus; Alec J. Redwood; Katie D. White; Simon A. Mallal; Elizabeth J. Phillips; Christine M. Posavad; Anna Wald; David M. Koelle
J Immunol (2016) 196 (5): 2205–2218.
PcpA Promotes Higher Levels of Infection and Modulates Recruitment of Myeloid-Derived Suppressor Cells during Pneumococcal Pneumonia
Melissa M. Walker; Lea Novak; Rebecca Widener; James Aaron Grubbs; Janice King; Joanetha Y. Hale; Martina M. Ochs; Lisa E. Myers; David E. Briles; Jessy Deshane
J Immunol (2016) 196 (5): 2239–2248.
Chronic Gastrointestinal Nematode Infection Mutes Immune Responses to Mycobacterial Infection Distal to the Gut
Katja Obieglo; Xiaogang Feng; Vishnu Priya Bollampalli; Isabel Dellacasa-Lindberg; Cajsa Classon; Markus Österblad; Helena Helmby; James P. Hewitson; Rick M. Maizels; Antonio Gigliotti Rothfuchs; Susanne Nylén
J Immunol (2016) 196 (5): 2262–2271.
MicroRNA-30c Modulates Type I IFN Responses To Facilitate Porcine Reproductive and Respiratory Syndrome Virus Infection by Targeting JAK1
J Immunol (2016) 196 (5): 2272–2282.
Hepatitis C Virus–Induced Myeloid-Derived Suppressor Cells Suppress NK Cell IFN-γ Production by Altering Cellular Metabolism via Arginase-1
J Immunol (2016) 196 (5): 2283–2292.
INNATE IMMUNITY AND INFLAMMATION
Subclinical-Dose Endotoxin Sustains Low-Grade Inflammation and Exacerbates Steatohepatitis in High-Fat Diet–Fed Mice
J Immunol (2016) 196 (5): 2300–2308.
Molecular Basis of the Functional Differences between Soluble Human Versus Murine MD-2: Role of Val135 in Transfer of Lipopolysaccharide from CD14 to MD-2
Jožica Vašl; Alja Oblak; Tina T. Peternelj; Javier Klett; Sonsoles Martín-Santamaría; Theresa L. Gioannini; Jerrold P. Weiss; Roman Jerala
J Immunol (2016) 196 (5): 2309–2318.
MOLECULAR AND STRUCTURAL IMMUNOLOGY
The MHC Class I Cancer-Associated Neoepitope Trh4 Linked with Impaired Peptide Processing Induces a Unique Noncanonical TCR Conformer
Ida Hafstrand; Elien M. Doorduijn; Adil Doganay Duru; Jeremie Buratto; Claudia Cunha Oliveira; Tatyana Sandalova; Thorbald van Hall; Adnane Achour
J Immunol (2016) 196 (5): 2327–2334.
Survival of Igα-Deficient Mature B Cells Requires BAFF-R Function
Ella Levit-Zerdoun; Martin Becker; Roland Pohlmeyer; Isabel Wilhelm; Palash Chandra Maity; Klaus Rajewsky; Michael Reth; Elias Hobeika
J Immunol (2016) 196 (5): 2348–2360.
HB-EGF–Promoted Airway Smooth Muscle Cells and Their Progenitor Migration Contribute to Airway Smooth Muscle Remodeling in Asthmatic Mouse
J Immunol (2016) 196 (5): 2361–2367.
MUCOSAL IMMUNOLOGY
Eotaxin-Rich Proangiogenic Hematopoietic Progenitor Cells and CCR3+ Endothelium in the Atopic Asthmatic Response
Kewal Asosingh; Amit Vasanji; Aaron Tipton; Kimberly Queisser; Nicholas Wanner; Allison Janocha; Deepa Grandon; Bela Anand-Apte; Marc E. Rothenberg; Raed Dweik; Serpil C. Erzurum
J Immunol (2016) 196 (5): 2377–2387.
Chronically Elevated Levels of Short-Chain Fatty Acids Induce T Cell–Mediated Ureteritis and Hydronephrosis
J Immunol (2016) 196 (5): 2388–2400.
Enhancement of Microbiota in Healthy Macaques Results in Beneficial Modulation of Mucosal and Systemic Immune Function
Jennifer A. Manuzak; Tiffany Hensley-McBain; Alexander S. Zevin; Charlene Miller; Rafael Cubas; Brian Agricola; Jill Gile; Laura Richert-Spuhler; Gabriela Patilea; Jacob D. Estes; Stanley Langevin; R. Keith Reeves; Elias K. Haddad; Nichole R. Klatt
J Immunol (2016) 196 (5): 2401–2409.
TUMOR IMMUNOLOGY
Intratumorally Establishing Type 2 Innate Lymphoid Cells Blocks Tumor Growth
Juyang Kim; Wonyoung Kim; U J. Moon; Hyun J. Kim; Hye-Jeong Choi; Jeong-Im Sin; Neung H. Park; Hong R. Cho; Byungsuk Kwon
J Immunol (2016) 196 (5): 2410–2423.
CORRECTIONS
Correction: Ozone Inhalation Promotes CX3CR1-Dependent Maturation of Resident Lung Macrophages That Limit Oxidative Stress and Inflammation
Robert M. Tighe; Zhuowei Li; Erin N. Potts; Sarah Frush; Ningshan Liu; Michael D. Gunn; W. Michael Foster; Paul W. Noble; John W. Hollingsworth
J Immunol (2016) 196 (5): 2424.
Correction: Hyaluronan Fragments Contribute to the Ozone-Primed Immune Response to Lipopolysaccharide
J Immunol (2016) 196 (5): 2426.
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Cover Image
Cover Image
On the cover: The C-type lectin-like CD161 protein is expressed on follicular dendritic cells (FDC), shown by immunofluorescent staining of frozen human tonsils. The CNA.42 clone was used as an FDC marker and the IMG14F1F11 clone was used for CD161 staining. Llibre, A., C. López-Macías, T. Marafioti, H. Mehta, A. Partridge, C. Kanzig, F. Rivellese, J. D. Galson, L. J. Walker, P. Milne, R. E. Phillips, D. F. Kelly, G. J. Freeman, M. E. El Shikh, P. Klenerman, and C. B. Willberg. 2016. LLT1 and CD161 expression in human germinal centers promotes B cell activation and CXCR4 downregulation. J. Immunol. 196: 2085–2094.
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