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Volume 197, Issue 12
15 December 2016
Issue Cover
ISSN 0022-1767
EISSN 1550-6606

IN THIS ISSUE

In This Issue
J Immunol (2016) 197 (12): 4507–4508.
View articletitled, In This Issue
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BRIEF REVIEWS

Biogenesis and Transcriptional Regulation of Long Noncoding RNAs in the Human Immune System
Charles F. Spurlock, III; Philip S. Crooke, III; Thomas M. Aune
J Immunol (2016) 197 (12): 4509–4517.
View articletitled, Biogenesis and Transcriptional Regulation of Long Noncoding RNAs in the Human Immune System
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The Impact of Established Immunoregulatory Networks on Vaccine Efficacy and the Development of Immunity to Malaria
Marcela Montes de Oca; Michael F. Good; James S. McCarthy; Christian R. Engwerda
J Immunol (2016) 197 (12): 4518–4526.
View articletitled, The Impact of Established Immunoregulatory Networks on Vaccine Efficacy and the Development of Immunity to Malaria
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CUTTING EDGE

Cutting Edge: BAFF Overexpression Reduces Atherosclerosis via TACI-Dependent B Cell Activation
Shaun W. Jackson; Nicole E. Scharping; Holly M. Jacobs; Shari Wang; Alan Chait; David J. Rawlings
J Immunol (2016) 197 (12): 4529–4534.
View articletitled, Cutting Edge: BAFF Overexpression Reduces Atherosclerosis via TACI-Dependent B Cell Activation
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Cutting Edge: T Regulatory Cell Depletion Reactivates Latent Simian Immunodeficiency Virus (SIV) in Controller Macaques While Boosting SIV-Specific T Lymphocytes
Tianyu He; Egidio Brocca-Cofano; Benjamin B. Policicchio; Ranjit Sivanandham; Rajeev Gautam; Kevin D. Raehtz; Cuiling Xu; Ivona Pandrea; Cristian Apetrei
J Immunol (2016) 197 (12): 4535–4539.
View articletitled, Cutting Edge: T Regulatory Cell Depletion Reactivates Latent Simian Immunodeficiency Virus (SIV) in Controller Macaques While Boosting SIV-Specific T Lymphocytes
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ALLERGY AND OTHER HYPERSENSITIVITIES

STAT6 Regulates the Development of Eosinophilic versus Neutrophilic Asthma in Response to Alternaria alternata
Andrea C. Valladao; Charles W. Frevert; Lisa K. Koch; Daniel J. Campbell; Steven F. Ziegler
J Immunol (2016) 197 (12): 4541–4551.
View articletitled, STAT6 Regulates the Development of Eosinophilic versus Neutrophilic Asthma in Response to <em>Alternaria alternata</em>
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AUTOIMMUNITY

IgA Complexes in Plasma and Synovial Fluid of Patients with Rheumatoid Arthritis Induce Neutrophil Extracellular Traps via FcαRI
Esil Aleyd; Marjon Al; Cornelis W. Tuk; Conny J. van der Laken; Marjolein van Egmond
J Immunol (2016) 197 (12): 4552–4559.
View articletitled, IgA Complexes in Plasma and Synovial Fluid of Patients with Rheumatoid Arthritis Induce Neutrophil Extracellular Traps via FcαRI
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Critical Differences between Induced and Spontaneous Mouse Models of Graves’ Disease with Implications for Antigen-Specific Immunotherapy in Humans
Basil Rapoport; Bianca Banuelos; Holly A. Aliesky; Nicole Hartwig Trier; Sandra M. McLachlan
J Immunol (2016) 197 (12): 4560–4568.
View articletitled, Critical Differences between Induced and Spontaneous Mouse Models of Graves’ Disease with Implications for Antigen-Specific Immunotherapy in Humans
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Characterization of the Syk-Dependent T Cell Signaling Response to an Altered Peptide
Jeoung-Eun Park; Jeffrey A. Rotondo; David L. Cullins; David D. Brand; Ae-Kyung Yi; John M. Stuart; Andrew H. Kang; Linda K. Myers
J Immunol (2016) 197 (12): 4569–4575.
View articletitled, Characterization of the Syk-Dependent T Cell Signaling Response to an Altered Peptide
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Age-Associated B Cells with Proinflammatory Characteristics Are Expanded in a Proportion of Multiple Sclerosis Patients
Nele Claes; Judith Fraussen; Marjan Vanheusden; Niels Hellings; Piet Stinissen; Bart Van Wijmeersch; Raymond Hupperts; Veerle Somers
J Immunol (2016) 197 (12): 4576–4583.
View articletitled, Age-Associated B Cells with Proinflammatory Characteristics Are Expanded in a Proportion of Multiple Sclerosis Patients
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CLINICAL AND HUMAN IMMUNOLOGY

CD8αβ+ γδ T Cells: A Novel T Cell Subset with a Potential Role in Inflammatory Bowel Disease
Mohammad Kadivar; Julia Petersson; Lena Svensson; Jan Marsal
J Immunol (2016) 197 (12): 4584–4592.
View articletitled, CD8αβ<sup>+</sup> γδ T Cells: A Novel T Cell Subset with a Potential Role in Inflammatory Bowel Disease
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First-in-Human Study in Healthy Subjects with FR104, a Pegylated Monoclonal Antibody Fragment Antagonist of CD28
Nicolas Poirier; Gilles Blancho; Maryvonne Hiance; Caroline Mary; Tim Van Assche; Jos Lempoels; Steven Ramael; Weirong Wang; Virginie Thepenier; Cecile Braudeau; Nina Salabert; Regis Josien; Ian Anderson; Ian Gourley; Jean-Paul Soulillou; Didier Coquoz; Bernard Vanhove
J Immunol (2016) 197 (12): 4593–4602.
View articletitled, First-in-Human Study in Healthy Subjects with FR104, a Pegylated Monoclonal Antibody Fragment Antagonist of CD28
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Diversity of Antiviral IgG Effector Activities Observed in HIV-Infected and Vaccinated Subjects
Yunda Huang; Guido Ferrari; Galit Alter; Donald N. Forthal; John C. Kappes; George K. Lewis; J. Christopher Love; Bhavesh Borate; Linda Harris; Kelli Greene; Hongmei Gao; Tran B. Phan; Gary Landucci; Brittany A. Goods; Karen G. Dowell; Hao D. Cheng; Chris Bailey-Kellogg; David C. Montefiori; Margaret E. Ackerman
J Immunol (2016) 197 (12): 4603–4612.
View articletitled, Diversity of Antiviral IgG Effector Activities Observed in HIV-Infected and Vaccinated Subjects
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IMMUNE REGULATION

The Analysis of CD83 Expression on Human Immune Cells Identifies a Unique CD83+-Activated T Cell Population
Xinsheng Ju; Pablo A. Silveira; Wei-Hsun Hsu; Zehra Elgundi; Renz Alingcastre; Nirupama D. Verma; Phillip D. Fromm; Jennifer L. Hsu; Christian Bryant; Ziduo Li; Fiona Kupresanin; Tsun-Ho Lo; Candice Clarke; Kenneth Lee; Helen McGuire; Barbara Fazekas de St. Groth; Stephen R. Larsen; John Gibson; Kenneth F. Bradstock; Georgina J. Clark; Derek N. J. Hart
J Immunol (2016) 197 (12): 4613–4625.
View articletitled, The Analysis of CD83 Expression on Human Immune Cells Identifies a Unique CD83<sup>+</sup>-Activated T Cell Population
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Overexpression of Soluble Fas Ligand following Adeno-Associated Virus Gene Therapy Prevents Retinal Ganglion Cell Death in Chronic and Acute Murine Models of Glaucoma
Anitha Krishnan; Fei Fei; Alexander Jones; Patricia Busto; Ann Marshak-Rothstein; Bruce R. Ksander; Meredith Gregory-Ksander
J Immunol (2016) 197 (12): 4626–4638.
View articletitled, Overexpression of Soluble Fas Ligand following Adeno-Associated Virus Gene Therapy Prevents Retinal Ganglion Cell Death in Chronic and Acute Murine Models of Glaucoma
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The Nuclear Receptor AhR Controls Bone Homeostasis by Regulating Osteoclast Differentiation via the RANK/c-Fos Signaling Axis
Takashi Izawa; Rieko Arakaki; Hiroki Mori; Takaaki Tsunematsu; Yasusei Kudo; Eiji Tanaka; Naozumi Ishimaru
J Immunol (2016) 197 (12): 4639–4650.
View articletitled, The Nuclear Receptor AhR Controls Bone Homeostasis by Regulating Osteoclast Differentiation via the RANK/c-Fos Signaling Axis
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Dendritic Cell KLF2 Expression Regulates T Cell Activation and Proatherogenic Immune Responses
Noah Alberts-Grill; Daniel Engelbertsen; Dexiu Bu; Amanda Foks; Nir Grabie; Jan M. Herter; Felicia Kuperwaser; Tao Chen; Gina Destefano; Petr Jarolim; Andrew H. Lichtman
J Immunol (2016) 197 (12): 4651–4662.
View articletitled, Dendritic Cell KLF2 Expression Regulates T Cell Activation and Proatherogenic Immune Responses
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IMMUNOTHERAPY AND VACCINES

HIV-1 Envelope Mimicry of Host Enzyme Kynureninase Does Not Disrupt Tryptophan Metabolism
Todd Bradley; Guang Yang; Olga Ilkayeva; T. Matt Holl; Ruijun Zhang; Jinsong Zhang; Sampa Santra; Christopher B. Fox; Steve G. Reed; Robert Parks; Cindy M. Bowman; Hilary Bouton-Verville; Laura L. Sutherland; Richard M. Scearce; Nathan Vandergrift; Thomas B. Kepler; M. Anthony Moody; Hua-Xin Liao; S. Munir Alam; Roger McLendon; Jeffrey I. Everitt; Christopher B. Newgard; Laurent Verkoczy; Garnett Kelsoe; Barton F. Haynes
J Immunol (2016) 197 (12): 4663–4673.
View articletitled, HIV-1 Envelope Mimicry of Host Enzyme Kynureninase Does Not Disrupt Tryptophan Metabolism
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Mechanisms of Acute Toxicity in NKG2D Chimeric Antigen Receptor T Cell–Treated Mice
Marie-Louise Sentman; Joana M. Murad; W. James Cook; Ming-Ru Wu; Jake Reder; Susanne H. Baumeister; Glenn Dranoff; Michael W. Fanger; Charles L. Sentman
J Immunol (2016) 197 (12): 4674–4685.
View articletitled, Mechanisms of Acute Toxicity in NKG2D Chimeric Antigen Receptor T Cell–Treated Mice
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INFECTIOUS DISEASE AND HOST RESPONSE

Mucosal and Systemic γδ+ T Cells Associated with Control of Simian Immunodeficiency Virus Infection
Iskra Tuero; David Venzon; Marjorie Robert-Guroff
J Immunol (2016) 197 (12): 4686–4695.
View articletitled, Mucosal and Systemic γδ<sup>+</sup> T Cells Associated with Control of Simian Immunodeficiency Virus Infection
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Identification of an Activating Chicken Ig-like Receptor Recognizing Avian Influenza Viruses
Christine A. Jansen; Daphne A. van Haarlem; Beatrice Sperling; Peter J. van Kooten; Erik de Vries; Birgit C. Viertlboeck; Lonneke Vervelde; Thomas W. Göbel
J Immunol (2016) 197 (12): 4696–4703.
View articletitled, Identification of an Activating Chicken Ig-like Receptor Recognizing Avian Influenza Viruses
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Duck Tembusu Virus Nonstructural Protein 1 Antagonizes IFN-β Signaling Pathways by Targeting VISA
Junyong Wang; Cao-Qi Lei; Yanhong Ji; Hongbo Zhou; Yujie Ren; Qianqian Peng; Yan Zeng; Yane Jia; Jinying Ge; Bo Zhong; Yu Li; Jianzhong Wei; Hong-Bing Shu; Qiyun Zhu
J Immunol (2016) 197 (12): 4704–4713.
View articletitled, Duck Tembusu Virus Nonstructural Protein 1 Antagonizes IFN-β Signaling Pathways by Targeting VISA
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Type I IFN Inhibits Alternative Macrophage Activation during Mycobacterium tuberculosis Infection and Leads to Enhanced Protection in the Absence of IFN-γ Signaling
Lúcia Moreira-Teixeira; Jeremy Sousa; Finlay W. McNab; Egídio Torrado; Filipa Cardoso; Henrique Machado; Flávia Castro; Vânia Cardoso; Joana Gaifem; Xuemei Wu; Rui Appelberg; António Gil Castro; Anne O’Garra; Margarida Saraiva
J Immunol (2016) 197 (12): 4714–4726.
View articletitled, Type I IFN Inhibits Alternative Macrophage Activation during <em>Mycobacterium tuberculosis</em> Infection and Leads to Enhanced Protection in the Absence of IFN-γ Signaling
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CD36-Mediated Uptake of Surfactant Lipids by Human Macrophages Promotes Intracellular Growth of Mycobacterium tuberculosis
Claire E. Dodd; Charlie J. Pyle; Rebecca Glowinski; Murugesan V. S. Rajaram; Larry S. Schlesinger
J Immunol (2016) 197 (12): 4727–4735.
View articletitled, CD36-Mediated Uptake of Surfactant Lipids by Human Macrophages Promotes Intracellular Growth of <em>Mycobacterium tuberculosis</em>
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INNATE IMMUNITY AND INFLAMMATION

Zebrafish foxo3b Negatively Regulates Antiviral Response through Suppressing the Transactivity of irf3 and irf7
Xing Liu; Xiaolian Cai; Dawei Zhang; Chenxi Xu; Wuhan Xiao
J Immunol (2016) 197 (12): 4736–4749.
View articletitled, Zebrafish <em>foxo3b</em> Negatively Regulates Antiviral Response through Suppressing the Transactivity of <em>irf3</em> and <em>irf7</em>
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Identification and Function of Fibrocytes in Skeletal Muscle Injury Repair and Muscular Dystrophy
Xingyu Wang; Wanming Zhao; Richard M. Ransohoff; Lan Zhou
J Immunol (2016) 197 (12): 4750–4761.
View articletitled, Identification and Function of Fibrocytes in Skeletal Muscle Injury Repair and Muscular Dystrophy
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Obeticholic Acid Protects against Lipopolysaccharide-Induced Fetal Death and Intrauterine Growth Restriction through Its Anti-Inflammatory Activity
Yuan-Hua Chen; Xiao-Guang Hu; Yan Zhou; Zhen Yu; Lin Fu; Gui-Bin Zhang; Qing-Li Bo; Hua Wang; Cheng Zhang; De-Xiang Xu
J Immunol (2016) 197 (12): 4762–4770.
View articletitled, Obeticholic Acid Protects against Lipopolysaccharide-Induced Fetal Death and Intrauterine Growth Restriction through Its Anti-Inflammatory Activity
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PTPN22 Is a Critical Regulator of Fcγ Receptor–Mediated Neutrophil Activation
Sonja Vermeren; Katherine Miles; Julia Y. Chu; Donald Salter; Rose Zamoyska; Mohini Gray
J Immunol (2016) 197 (12): 4771–4779.
View articletitled, PTPN22 Is a Critical Regulator of Fcγ Receptor–Mediated Neutrophil Activation
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Rac2 Functions in Both Neutrophils and Macrophages To Mediate Motility and Host Defense in Larval Zebrafish
Emily E. Rosowski; Qing Deng; Nancy P. Keller; Anna Huttenlocher
J Immunol (2016) 197 (12): 4780–4790.
View articletitled, Rac2 Functions in Both Neutrophils and Macrophages To Mediate Motility and Host Defense in Larval Zebrafish
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Characterization and Transcriptomic Analysis of Porcine Blood Conventional and Plasmacytoid Dendritic Cells Reveals Striking Species-Specific Differences
Gael Auray; Irene Keller; Sylvie Python; Markus Gerber; Remy Bruggmann; Nicolas Ruggli; Artur Summerfield
J Immunol (2016) 197 (12): 4791–4806.
View articletitled, Characterization and Transcriptomic Analysis of Porcine Blood Conventional and Plasmacytoid Dendritic Cells Reveals Striking Species-Specific Differences
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MOLECULAR AND STRUCTURAL IMMUNOLOGY

Low Constitutive Cell Surface Expression of HLA-B Is Caused by a Posttranslational Mechanism Involving Glu180 and Arg239
Christoffer Dellgren; Vanessa A. C. Ekwelum; Maria Ormhøj; Nicole Pallesen; Julie Knudsen; Jan O. Nehlin; Torben Barington
J Immunol (2016) 197 (12): 4807–4816.
View articletitled, Low Constitutive Cell Surface Expression of HLA-B Is Caused by a Posttranslational Mechanism Involving Glu<sup>180</sup> and Arg<sup>239</sup>
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SYSTEMS IMMUNOLOGY

Early Whole Blood Transcriptional Signatures Are Associated with Severity of Lung Inflammation in Cynomolgus Macaques with Mycobacterium tuberculosis Infection
Hannah P. Gideon; Jason A. Skinner; Nicole Baldwin; JoAnne L. Flynn; Philana Ling Lin
J Immunol (2016) 197 (12): 4817–4828.
View articletitled, Early Whole Blood Transcriptional Signatures Are Associated with Severity of Lung Inflammation in Cynomolgus Macaques with <em>Mycobacterium tuberculosis</em> Infection
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TUMOR IMMUNOLOGY

Type I CD20 Antibodies Recruit the B Cell Receptor for Complement-Dependent Lysis of Malignant B Cells
Patrick J. Engelberts; Marleen Voorhorst; Janine Schuurman; Tom van Meerten; Joost M. Bakker; Tom Vink; Wendy J. M. Mackus; Esther C. W. Breij; Stefanie Derer; Thomas Valerius; Jan G. J. van de Winkel; Paul W. H. I. Parren; Frank J. Beurskens
J Immunol (2016) 197 (12): 4829–4837.
View articletitled, Type I CD20 Antibodies Recruit the B Cell Receptor for Complement-Dependent Lysis of Malignant B Cells
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NOVEL IMMUNOLOGICAL METHODS

Generation of Immunity against Pathogens via Single-Domain Antibody–Antigen Constructs
Joao N. Duarte; Juan J. Cragnolini; Lee Kim Swee; Angelina M. Bilate; Justin Bader; Jessica R. Ingram; Ali Rashidfarrokhi; Tao Fang; Ariën Schiepers; Leo Hanke; Hidde L. Ploegh
J Immunol (2016) 197 (12): 4838–4847.
View articletitled, Generation of Immunity against Pathogens via Single-Domain Antibody–Antigen Constructs
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Novel E2 Glycoprotein Tetramer Detects Hepatitis C Virus–Specific Memory B Cells
Maude Boisvert; Wanrui Zhang; Elizabeth J. Elrod; Nicole F. Bernard; Jean-Pierre Villeneuve; Julie Bruneau; Joseph Marcotrigiano; Naglaa H. Shoukry; Arash Grakoui
J Immunol (2016) 197 (12): 4848–4858.
View articletitled, Novel E2 Glycoprotein Tetramer Detects Hepatitis C Virus–Specific Memory B Cells
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LETTERS OF RETRACTION

Retraction: Regulation of Tumor Cell Sensitivity to TRAIL-Induced Apoptosis by the Metastatic Suppressor Raf Kinase Inhibitor Protein via Yin Yang 1 Inhibition and Death Receptor 5 Up-Regulation
J Immunol (2016) 197 (12): 4859.
View articletitled, Retraction: Regulation of Tumor Cell Sensitivity to TRAIL-Induced Apoptosis by the Metastatic Suppressor Raf Kinase Inhibitor Protein via Yin Yang 1 Inhibition and Death Receptor 5 Up-Regulation
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Retraction: Inhibition of Yin Yang 1-Dependent Repressor Activity of DR5 Transcription and Expression by the Novel Proteasome Inhibitor NPI-0052 Contributes to its TRAIL-Enhanced Apoptosis in Cancer Cells
J Immunol (2016) 197 (12): 4860.
View articletitled, Retraction: Inhibition of Yin Yang 1-Dependent Repressor Activity of DR5 Transcription and Expression by the Novel Proteasome Inhibitor NPI-0052 Contributes to its TRAIL-Enhanced Apoptosis in Cancer Cells
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CORRECTIONS

Correction: In This Issue
J Immunol (2016) 197 (12): 4861.
View articletitled, Correction: In This Issue
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  • Cover Image

    Cover Image

    issue cover

    On the cover: Image shows Oil Red O–stained atheroma within aortic root section from Western diet–fed Apoe−/−.BAFF-Tg.Taci−/− mouse. Whereas transgenic BAFF overexpression markedly reduced atherosclerosis in Apoe−/−.BAFF-Tg mice, atheroma formation was restored by Taci deletion demonstrating that excess BAFF protects against atherosclerosis in a TACI-dependent manner. Jackson S. W., N. E. Scharping, H. M. Jacobs, S. Wang, A. Chait, and D. J. Rawlings. Cutting Edge: BAFF overexpression reduces atherosclerosis via TACI-dependent B cell activation. 2016. J. Immunol. 197: 4529–4534.

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