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Issues
1 September 2016
ISSN 0022-1767
EISSN 1550-6606
In this Issue
IN THIS ISSUE
PILLARS OF IMMUNOLOGY
BRIEF REVIEWS
ALLERGY AND OTHER HYPERSENSITIVITIES
In Vivo Expansion of Endogenous Regulatory T Cell Populations Induces Long-Term Suppression of Contact Hypersensitivity
Asmaa El Beidaq; Christopher W. M. Link; Katharina Hofmann; Britta Frehse; Karin Hartmann; Katja Bieber; Stefan F. Martin; Ralf J. Ludwig; Rudolf A. Manz
J Immunol (2016) 197 (5): 1567–1576.
Prostaglandin I2 Suppresses Proinflammatory Chemokine Expression, CD4 T Cell Activation, and STAT6-Independent Allergic Lung Inflammation
Weisong Zhou; Jian Zhang; Kasia Goleniewska; Daniel E. Dulek; Shinji Toki; Dawn C. Newcomb; Jacqueline Y. Cephus; Robert D. Collins; Pingsheng Wu; Mark R. Boothby; R. Stokes Peebles, Jr.
J Immunol (2016) 197 (5): 1577–1586.
ANTIGEN RECOGNITION AND RESPONSES
FcγRIIB-Independent Mechanisms Controlling Membrane Localization of the Inhibitory Phosphatase SHIP in Human B Cells
J Immunol (2016) 197 (5): 1587–1596.
Heparan Sulfate Proteoglycans Promote Telomerase Internalization and MHC Class II Presentation on Dendritic Cells
Jeanne Galaine; Guillaume Kellermann; Yves Guillaume; Romain Boidot; Emilie Picard; Romain Loyon; Lise Queiroz; Laura Boullerot; Laurent Beziaud; Marine Jary; Laura Mansi; Claire André; Lydie Lethier; Evelyne Ségal-Bendirdjian; Christophe Borg; Yann Godet; Olivier Adotévi
J Immunol (2016) 197 (5): 1597–1608.
AUTOIMMUNITY
Clonal Characteristics of Circulating B Lymphocyte Repertoire in Primary Biliary Cholangitis
Yan-guo Tan; Yu-qi Wang; Ming Zhang; Ying-xin Han; Chun-yang Huang; Hai-ping Zhang; Zhuo-min Li; Xiao-lei Wu; Xiao-feng Wang; Yan Dong; Hong-mei Zhu; Shi-da Zhu; Hong-mei Li; Ning Li; Hui-ping Yan; Zu-hua Gao
J Immunol (2016) 197 (5): 1609–1620.
Involvement of NK Cells and NKp30 Pathway in Antisynthetase Syndrome
Baptiste Hervier; Mikaël Perez; Yves Allenbach; Hervé Devilliers; Fleur Cohen; Yurdagül Uzunhan; Hanane Ouakrim; Karim Dorgham; Jean-François Méritet; Elisabeth Longchampt; Werner Stenzel; Isabelle Cremer; Olivier Benveniste; Vincent Vieillard
J Immunol (2016) 197 (5): 1621–1630.
CLINICAL AND HUMAN IMMUNOLOGY
Targeting T Cell Bioenergetics by Modulating P-Glycoprotein Selectively Depletes Alloreactive T Cells To Prevent Graft-versus-Host Disease
Zachariah A. McIver; Jason M. Grayson; Benjamin N. Coe; Jacqueline E. Hill; Gregory A. Schamerhorn; Tymish Y. Ohulchanskyy; Michelle K. Linder; Kellie S. Davies; Roy S. Weiner; Michael R. Detty
J Immunol (2016) 197 (5): 1631–1641.
Accelerated Loss of TCR Repertoire Diversity in Common Variable Immunodeficiency
Gabriel K. Wong; David Millar; Sarah Penny; James M. Heather; Punam Mistry; Nico Buettner; Jane Bryon; Aarnoud P. Huissoon; Mark Cobbold
J Immunol (2016) 197 (5): 1642–1649.
IMMUNE REGULATION
Plasmacytoid Dendritic Cells Die by the CD8 T Cell–Dependent Perforin Pathway during Acute Nonviral Inflammation
J Immunol (2016) 197 (5): 1672–1682.
Mst1 Kinase Regulates the Actin-Bundling Protein L-Plastin To Promote T Cell Migration
Xiaolu Xu; Xinxin Wang; Elizabeth M. Todd; Emily R. Jaeger; Jennifer L. Vella; Olivia L. Mooren; Yunfeng Feng; Jiancheng Hu; John A. Cooper; Sharon Celeste Morley; Yina H. Huang
J Immunol (2016) 197 (5): 1683–1691.
YY1 Regulates the Germinal Center Reaction by Inhibiting Apoptosis
J Immunol (2016) 197 (5): 1699–1707.
In Vivo Expansion of Activated Foxp3+ Regulatory T Cells and Establishment of a Type 2 Immune Response upon IL-33 Treatment Protect against Experimental Arthritis
Jérôme Biton; Sara Khaleghparast Athari; Allan Thiolat; François Santinon; Delphine Lemeiter; Roxane Hervé; Laure Delavallée; Anais Levescot; Stéphane Roga; Patrice Decker; Jean-Philippe Girard; André Herbelin; Marie-Christophe Boissier; Natacha Bessis
J Immunol (2016) 197 (5): 1708–1719.
Uricase Inhibits Nitrogen Dioxide–Promoted Allergic Sensitization to Inhaled Ovalbumin Independent of Uric Acid Catabolism
Jennifer L. Ather; Edward J. Burgess; Laura R. Hoyt; Matthew J. Randall; Mridul K. Mandal; Dwight E. Matthews; Jonathan E. Boyson; Matthew E. Poynter
J Immunol (2016) 197 (5): 1720–1732.
IMMUNE SYSTEM DEVELOPMENT
IMMUNOTHERAPY AND VACCINES
Antibodies That Efficiently Form Hexamers upon Antigen Binding Can Induce Complement-Dependent Cytotoxicity under Complement-Limiting Conditions
Erika M. Cook; Margaret A. Lindorfer; Hilma van der Horst; Simone Oostindie; Frank J. Beurskens; Janine Schuurman; Clive S. Zent; Richard Burack; Paul W. H. I. Parren; Ronald P. Taylor
J Immunol (2016) 197 (5): 1762–1775.
INFECTIOUS DISEASE AND HOST RESPONSE
Mucosal Inducible NO Synthase–Producing IgA+ Plasma Cells in Helicobacter pylori–Infected Patients
Laura Neumann; Mattea Mueller; Verena Moos; Frank Heller; Thomas F. Meyer; Christoph Loddenkemper; Christian Bojarski; Michael Fehlings; Thomas Doerner; Kristina Allers; Toni Aebischer; Ralf Ignatius; Thomas Schneider
J Immunol (2016) 197 (5): 1801–1808.
Immediate Dysfunction of Vaccine-Elicited CD8+ T Cells Primed in the Absence of CD4+ T Cells
Nicholas M. Provine; Rafael A. Larocca; Malika Aid; Pablo Penaloza-MacMaster; Alexander Badamchi-Zadeh; Erica N. Borducchi; Kathleen B. Yates; Peter Abbink; Marinela Kirilova; David Ng’ang’a; Jonathan Bramson; W. Nicholas Haining; Dan H. Barouch
J Immunol (2016) 197 (5): 1809–1822.
Induction of Th1-Biased T Follicular Helper (Tfh) Cells in Lymphoid Tissues during Chronic Simian Immunodeficiency Virus Infection Defines Functionally Distinct Germinal Center Tfh Cells
Vijayakumar Velu; Geetha Hanna Mylvaganam; Sailaja Gangadhara; Jung Joo Hong; Smita S. Iyer; Sanjeev Gumber; Chris C. Ibegbu; Francois Villinger; Rama Rao Amara
J Immunol (2016) 197 (5): 1832–1842.
Innate Invariant NKT Cell Recognition of HIV-1–Infected Dendritic Cells Is an Early Detection Mechanism Targeted by Viral Immune Evasion
Dominic Paquin-Proulx; Anna Gibbs; Susanna M. Bächle; Antonio Checa; Andrea Introini; Edwin Leeansyah; Craig E. Wheelock; Douglas F. Nixon; Kristina Broliden; Annelie Tjernlund; Markus Moll; Johan K. Sandberg
J Immunol (2016) 197 (5): 1843–1851.
Lack of IL-1 Receptor–Associated Kinase-4 Leads to Defective Th1 Cell Responses and Renders Mice Susceptible to Mycobacterial Infection
Fábio V. Marinho; Júlia S. Fahel; Charles A. Scanga; Marco Tulio R. Gomes; Gabriela Guimarães; Gabrielle R. M. Carvalho; Stefanny V. Morales; André Báfica; Sergio Costa Oliveira
J Immunol (2016) 197 (5): 1852–1863.
Critical Role of IL-22/IL22-RA1 Signaling in Pneumococcal Pneumonia
J Immunol (2016) 197 (5): 1877–1883.
INNATE IMMUNITY AND INFLAMMATION
Prolonged PD1 Expression on Neonatal Vδ2 Lymphocytes Dampens Proinflammatory Responses: Role of Epigenetic Regulation
Haoting Hsu; Sarah Boudova; Godfrey Mvula; Titus H. Divala; Randy G. Mungwira; Christopher Harman; Miriam K. Laufer; C. David Pauza; Cristiana Cairo
J Immunol (2016) 197 (5): 1884–1892.
Zebrafish IRF1, IRF3, and IRF7 Differentially Regulate IFNΦ1 and IFNΦ3 Expression through Assembly of Homo- or Heteroprotein Complexes
J Immunol (2016) 197 (5): 1893–1904.
DNA Sensing via TLR-9 Constitutes a Major Innate Immunity Pathway Activated during Erythema Nodosum Leprosum
André A. Dias; Camila O. Silva; João Pedro S. Santos; Leonardo R. Batista-Silva; Chyntia Carolina D. Acosta; Amanda N. B. Fontes; Roberta O. Pinheiro; Flávio A. Lara; Alice M. Machado; José Augusto C. Nery; Euzenir N. Sarno; Geraldo M. B. Pereira; Maria Cristina V. Pessolani
J Immunol (2016) 197 (5): 1905–1913.
The Repair of Skeletal Muscle Requires Iron Recycling through Macrophage Ferroportin
Gianfranca Corna; Imma Caserta; Antonella Monno; Pietro Apostoli; Angelo A. Manfredi; Clara Camaschella; Patrizia Rovere-Querini
J Immunol (2016) 197 (5): 1914–1925.
MOLECULAR AND STRUCTURAL IMMUNOLOGY
Extensive Citrullination Promotes Immunogenicity of HSP90 through Protein Unfolding and Exposure of Cryptic Epitopes
Timothy S. Travers; Lisa Harlow; Ivan O. Rosas; Bernadette R. Gochuico; Ted R. Mikuls; Sanjoy K. Bhattacharya; Carlos J. Camacho; Dana P. Ascherman
J Immunol (2016) 197 (5): 1926–1936.
Identification of Stage-Specific Surface Markers in Early B Cell Development Provides Novel Tools for Identification of Progenitor Populations
J Immunol (2016) 197 (5): 1937–1944.
Pyk2 Controls Integrin-Dependent CTL Migration through Regulation of De-Adhesion
J Immunol (2016) 197 (5): 1945–1956.
MUCOSAL IMMUNOLOGY
Bimodal Expansion of the Lymphatic Vessels Is Regulated by the Sequential Expression of IL-7 and Lymphotoxin α1β2 in Newly Formed Tertiary Lymphoid Structures
Saba Nayar; Joana Campos; Ming May Chung; Leyre Navarro-Núñez; Menka Chachlani; Nathalie Steinthal; David H. Gardner; Philip Rankin; Thomas Cloake; Jorge H. Caamaño; Helen M. McGettrick; Steve P. Watson; Sanjiv Luther; Christopher D. Buckley; Francesca Barone
J Immunol (2016) 197 (5): 1957–1967.
β8 Integrin Expression and Activation of TGF-β by Intestinal Dendritic Cells Are Determined by Both Tissue Microenvironment and Cell Lineage
Mathilde Boucard-Jourdin; David Kugler; Marie-Laure Endale Ahanda; Sébastien This; Jaime De Calisto; Ailiang Zhang; J. Rodrigo Mora; Lynda M. Stuart; John Savill; Adam Lacy-Hulbert; Helena Paidassi
J Immunol (2016) 197 (5): 1968–1978.
First Membrane Proximal External Region–Specific Anti-HIV1 Broadly Neutralizing Monoclonal IgA1 Presenting Short CDRH3 and Low Somatic Mutations
Fahd Benjelloun; Zeliha Oruc; Nicole Thielens; Bernard Verrier; Gael Champier; Nadine Vincent; Nicolas Rochereau; Alexandre Girard; Fabienne Jospin; Blandine Chanut; Christian Genin; Michel Cogné; Stephane Paul
J Immunol (2016) 197 (5): 1979–1988.
SYSTEMS IMMUNOLOGY
Changes in Gene Expression during G-CSF–Induced Emergency Granulopoiesis in Humans
Corinna C. Pedersen; Rehannah Borup; Anne Fischer-Nielsen; Helena Mora-Jensen; Anna Fossum; Jack B. Cowland; Niels Borregaard
J Immunol (2016) 197 (5): 1989–1999.
TRANSPLANTATION
TUMOR IMMUNOLOGY
Chemoattractant Receptors BLT1 and CXCR3 Regulate Antitumor Immunity by Facilitating CD8+ T Cell Migration into Tumors
J Immunol (2016) 197 (5): 2016–2026.
NOVEL IMMUNOLOGICAL METHODS
CORRECTIONS
Correction: LFA-1/ICAM-1 Ligation in Human T Cells Promotes Th1 Polarization through a GSK3β Signaling–Dependent Notch Pathway
Navin K. Verma; M. H. U. Turabe Fazil; Seow Theng Ong; Madhavi Latha S. Chalasani; Jian Hui Low; Amuthavalli Kottaiswamy; Praseetha P; Atish Kizhakeyil; Sunil Kumar; Aditya K. Panda; Michael Freeley; Sinead M. Smith; Bernhard O. Boehm; Dermot Kelleher
J Immunol (2016) 197 (5): 2039–2040.
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Cover Image
Cover Image
On the cover: Histologic section of an ear of a C57BL/6 mouse infected for 5 wk with Leishmania major parasites and stained with Masson’s trichrome showing a robust inflammatory infiltrate associated with dermal vascular remodeling and dilated vessels containing RBCs. Weinkopff, T., C. Konradt, D. A. Christian, D. E. Discher, C. A. Hunter, and P. Scott. 2016. Leishmania major infection–induced VEGF-A/VEGFR-2 signaling promotes lymphangiogenesis that controls disease. J. Immunol. 197: 1823–1831.
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