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Volume 197, Issue 6
15 September 2016
Issue Cover
ISSN 0022-1767
EISSN 1550-6606

IN THIS ISSUE

In This Issue
J Immunol (2016) 197 (6): 2043–2044.
View articletitled, In This Issue
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TRANSLATING IMMUNOLOGY

Costimulation Blockade in Autoimmunity and Transplantation: The CD28 Pathway
Andrew B. Adams; Mandy L. Ford; Christian P. Larsen
J Immunol (2016) 197 (6): 2045–2050.
View articletitled, Costimulation Blockade in Autoimmunity and Transplantation: The CD28 Pathway
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BRIEF REVIEWS

Novel Evasion Mechanisms of the Classical Complement Pathway
Brandon L. Garcia; Seline A. Zwarthoff; Suzan H. M. Rooijakkers; Brian V. Geisbrecht
J Immunol (2016) 197 (6): 2051–2060.
View articletitled, Novel Evasion Mechanisms of the Classical Complement Pathway
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CUTTING EDGE

Cutting Edge: Marginal Zone Macrophages Regulate Antigen Transport by B Cells to the Follicle in the Spleen via CD21
Kajsa E. Prokopec; Anna-Maria Georgoudaki; Silke Sohn; Fredrik Wermeling; Hans Grönlund; Emma Lindh; Michael C. Carroll; Mikael C. I. Karlsson
J Immunol (2016) 197 (6): 2063–2068.
View articletitled, Cutting Edge: Marginal Zone Macrophages Regulate Antigen Transport by B Cells to the Follicle in the Spleen via CD21
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ALLERGY AND OTHER HYPERSENSITIVITIES

Leukotriene B4 Receptor 2 Is Critical for the Synthesis of Vascular Endothelial Growth Factor in Allergen-Stimulated Mast Cells
A-Jin Lee; MyungJa Ro; Jae-Hong Kim
J Immunol (2016) 197 (6): 2069–2078.
View articletitled, Leukotriene B<sub>4</sub> Receptor 2 Is Critical for the Synthesis of Vascular Endothelial Growth Factor in Allergen-Stimulated Mast Cells
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ANTIGEN RECOGNITION AND RESPONSES

Adhesion- and Degranulation-Promoting Adapter Protein Promotes CD8 T Cell Differentiation and Resident Memory Formation and Function during an Acute Infection
Jessica K. Fiege; Lalit K. Beura; Brandon J. Burbach; Yoji Shimizu
J Immunol (2016) 197 (6): 2079–2089.
View articletitled, Adhesion- and Degranulation-Promoting Adapter Protein Promotes CD8 T Cell Differentiation and Resident Memory Formation and Function during an Acute Infection
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Dynein Separately Partners with NDE1 and Dynactin To Orchestrate T Cell Focused Secretion
Shubhankar Nath; Laura Christian; Sarah Youngsun Tan; Sanghee Ki; Lauren I. R. Ehrlich; Martin Poenie
J Immunol (2016) 197 (6): 2090–2101.
View articletitled, Dynein Separately Partners with NDE1 and Dynactin To Orchestrate T Cell Focused Secretion
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Diverse HLA-I Peptide Repertoires of the APC Lines MUTZ3-Derived Immature and Mature Dendritic Cells and THP1-Derived Macrophages
Lydon Wainaina Nyambura; Saulius Jarmalavicius; Renato Brito Baleeiro; Peter Walden
J Immunol (2016) 197 (6): 2102–2109.
View articletitled, Diverse HLA-I Peptide Repertoires of the APC Lines MUTZ3-Derived Immature and Mature Dendritic Cells and THP1-Derived Macrophages
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AUTOIMMUNITY

TLR Tolerance as a Treatment for Central Nervous System Autoimmunity
Emily J. Anstadt; Mai Fujiwara; Nicholas Wasko; Frank Nichols; Robert B. Clark
J Immunol (2016) 197 (6): 2110–2118.
View articletitled, TLR Tolerance as a Treatment for Central Nervous System Autoimmunity
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New Murine Model of Early Onset Autoimmune Thyroid Disease/Hypothyroidism and Autoimmune Exocrinopathy of the Salivary Gland
Timothy Daniel Kayes; Gary A. Weisman; Jean M. Camden; Lucas T. Woods; Cole Bredehoeft; Edward F. Downey; James Cole; Helen Braley-Mullen
J Immunol (2016) 197 (6): 2119–2130.
View articletitled, New Murine Model of Early Onset Autoimmune Thyroid Disease/Hypothyroidism and Autoimmune Exocrinopathy of the Salivary Gland
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IL-35 Decelerates the Inflammatory Process by Regulating Inflammatory Cytokine Secretion and M1/M2 Macrophage Ratio in Psoriasis
Junfeng Zhang; Yi Lin; Chunlei Li; Xiaomei Zhang; Lin Cheng; Lei Dai; Youcui Wang; Fangfang Wang; Gang Shi; Yiming Li; Qianmei Yang; Xueliang Cui; Yi Liu; Huiling Wang; Shuang Zhang; Yang Yang; Rong Xiang; Jiong Li; Dechao Yu; Yuquan Wei; Hongxin Deng
J Immunol (2016) 197 (6): 2131–2144.
View articletitled, IL-35 Decelerates the Inflammatory Process by Regulating Inflammatory Cytokine Secretion and M1/M2 Macrophage Ratio in Psoriasis
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Transient Expression of Transgenic IL-12 in Mouse Liver Triggers Unremitting Inflammation Mimicking Human Autoimmune Hepatitis
Irene Gil-Farina; Marianna Di Scala; Eduardo Salido; Esperanza López-Franco; Estefania Rodríguez-García; Mercedes Blasi; Juana Merino; Rafael Aldabe; Jesús Prieto; Gloria Gonzalez-Aseguinolaza
J Immunol (2016) 197 (6): 2145–2156.
View articletitled, Transient Expression of Transgenic IL-12 in Mouse Liver Triggers Unremitting Inflammation Mimicking Human Autoimmune Hepatitis
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Loss of Trex1 in Dendritic Cells Is Sufficient To Trigger Systemic Autoimmunity
Katrin Peschke; Martin Achleitner; Kathrin Frenzel; Alexander Gerbaulet; Servi Remzi Ada; Nicolas Zeller; Stefan Lienenklaus; Mathias Lesche; Claire Poulet; Ronald Naumann; Andreas Dahl; Ursula Ravens; Claudia Günther; Werner Müller; Klaus-Peter Knobeloch; Marco Prinz; Axel Roers; Rayk Behrendt
J Immunol (2016) 197 (6): 2157–2166.
View articletitled, Loss of Trex1 in Dendritic Cells Is Sufficient To Trigger Systemic Autoimmunity
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Essential Requirement for IFN Regulatory Factor 7 in Autoantibody Production but Not Development of Nephritis in Murine Lupus
Fumi Miyagawa; Yutaka Tagaya; Keiko Ozato; Hideo Asada
J Immunol (2016) 197 (6): 2167–2176.
View articletitled, Essential Requirement for IFN Regulatory Factor 7 in Autoantibody Production but Not Development of Nephritis in Murine Lupus
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Osteopontin in Spontaneous Germinal Centers Inhibits Apoptotic Cell Engulfment and Promotes Anti-Nuclear Antibody Production in Lupus-Prone Mice
Keiko Sakamoto; Yuji Fukushima; Koyu Ito; Michiyuki Matsuda; Shigekazu Nagata; Nagahiro Minato; Masakazu Hattori
J Immunol (2016) 197 (6): 2177–2186.
View articletitled, Osteopontin in Spontaneous Germinal Centers Inhibits Apoptotic Cell Engulfment and Promotes Anti-Nuclear Antibody Production in Lupus-Prone Mice
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Opposing Roles of Tyrosine Kinase Receptors Mer and Axl Determine Clinical Outcomes in Experimental Immune-Mediated Nephritis
Yuxuan Zhen; Stephen O. Priest; Wen-Hai Shao
J Immunol (2016) 197 (6): 2187–2194.
View articletitled, Opposing Roles of Tyrosine Kinase Receptors Mer and Axl Determine Clinical Outcomes in Experimental Immune-Mediated Nephritis
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CLINICAL AND HUMAN IMMUNOLOGY

Unconventional Human T Cells Accumulate at the Site of Infection in Response to Microbial Ligands and Induce Local Tissue Remodeling
Anna Rita Liuzzi; Ann Kift-Morgan; Melisa Lopez-Anton; Ida M. Friberg; Jingjing Zhang; Amy C. Brook; Gareth W. Roberts; Kieron L. Donovan; Chantal S. Colmont; Mark A. Toleman; Timothy Bowen; David W. Johnson; Nicholas Topley; Bernhard Moser; Donald J. Fraser; Matthias Eberl
J Immunol (2016) 197 (6): 2195–2207.
View articletitled, Unconventional Human T Cells Accumulate at the Site of Infection in Response to Microbial Ligands and Induce Local Tissue Remodeling
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IMMUNE REGULATION

Regulatory T Cell Numbers in Inflamed Skin Are Controlled by Local Inflammatory Cues That Upregulate CD25 and Facilitate Antigen-Driven Local Proliferation
Alison C. Billroth-MacLurg; Jill Ford; Alexander Rosenberg; Jim Miller; Deborah J. Fowell
J Immunol (2016) 197 (6): 2208–2218.
View articletitled, Regulatory T Cell Numbers in Inflamed Skin Are Controlled by Local Inflammatory Cues That Upregulate CD25 and Facilitate Antigen-Driven Local Proliferation
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MicroRNA-17 Suppresses TNF-α Signaling by Interfering with TRAF2 and cIAP2 Association in Rheumatoid Arthritis Synovial Fibroblasts
Nahid Akhtar; Anil Kumar Singh; Salahuddin Ahmed
J Immunol (2016) 197 (6): 2219–2228.
View articletitled, MicroRNA-17 Suppresses TNF-α Signaling by Interfering with TRAF2 and cIAP2 Association in Rheumatoid Arthritis Synovial Fibroblasts
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Folate Receptor β Regulates Integrin CD11b/CD18 Adhesion of a Macrophage Subset to Collagen
Christian Machacek; Verena Supper; Vladimir Leksa; Goran Mitulovic; Andreas Spittler; Karel Drbal; Miloslav Suchanek; Anna Ohradanova-Repic; Hannes Stockinger
J Immunol (2016) 197 (6): 2229–2238.
View articletitled, Folate Receptor β Regulates Integrin CD11b/CD18 Adhesion of a Macrophage Subset to Collagen
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IMMUNE SYSTEM DEVELOPMENT

IL-36–Induced Toxicity in Neonatal Mice Involves TNF-α Production by Liver Myeloid Cells
Jennifer Palomo; Beatris Mastelic-Gavillet; Estelle Woldt; Sabina Troccaz; Emiliana Rodriguez; Gaby Palmer; Claire-Anne Siegrist; Cem Gabay
J Immunol (2016) 197 (6): 2239–2249.
View articletitled, IL-36–Induced Toxicity in Neonatal Mice Involves TNF-α Production by Liver Myeloid Cells
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Conditional Disruption of Raptor Reveals an Essential Role for mTORC1 in B Cell Development, Survival, and Metabolism
Terri N. Iwata; Julita A. Ramírez; Mark Tsang; Heon Park; Daciana H. Margineantu; David M. Hockenbery; Brian M. Iritani
J Immunol (2016) 197 (6): 2250–2260.
View articletitled, Conditional Disruption of Raptor Reveals an Essential Role for mTORC1 in B Cell Development, Survival, and Metabolism
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lck-Driven Cre Expression Alters T Cell Development in the Thymus and the Frequencies and Functions of Peripheral T Cell Subsets
Berit Carow; Yu Gao; Jonathan Coquet; Marie Reilly; Martin E. Rottenberg
J Immunol (2016) 197 (6): 2261–2268.
View articletitled, <em>lck</em>-Driven Cre Expression Alters T Cell Development in the Thymus and the Frequencies and Functions of Peripheral T Cell Subsets
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A Histone Methyltransferase ESET Is Critical for T Cell Development
Shoichi Takikita; Ryunosuke Muro; Toshiyuki Takai; Takeshi Otsubo; Yuki I. Kawamura; Taeko Dohi; Hiroyo Oda; Masayuki Kitajima; Kenshiro Oshima; Masahira Hattori; Takaho A. Endo; Tetsuro Toyoda; John Weis; Yoichi Shinkai; Harumi Suzuki
J Immunol (2016) 197 (6): 2269–2279.
View articletitled, A Histone Methyltransferase ESET Is Critical for T Cell Development
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Rpl22 Loss Selectively Impairs αβ T Cell Development by Dysregulating Endoplasmic Reticulum Stress Signaling
Nehal R. Solanki; Jason E. Stadanlick; Yong Zhang; Ann-Cecile Duc; Sang-Yun Lee; Jens Peter Holst Lauritsen; Zhiqiang Zhang; David L. Wiest
J Immunol (2016) 197 (6): 2280–2289.
View articletitled, Rpl22 Loss Selectively Impairs αβ T Cell Development by Dysregulating Endoplasmic Reticulum Stress Signaling
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Maternal Milk T Cells Drive Development of Transgenerational Th1 Immunity in Offspring Thymus
Mrinal K. Ghosh; Virginia Nguyen; H. Konrad Muller; Ameae M. Walker
J Immunol (2016) 197 (6): 2290–2296.
View articletitled, Maternal Milk T Cells Drive Development of Transgenerational Th1 Immunity in Offspring Thymus
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A Csf1r-EGFP Transgene Provides a Novel Marker for Monocyte Subsets in Sheep
Clare Pridans; Gemma M. Davis; Kristin A. Sauter; Zofia M. Lisowski; Yolanda Corripio-Miyar; Anna Raper; Lucas Lefevre; Rachel Young; Mary E. McCulloch; Simon Lillico; Elspeth Milne; Bruce Whitelaw; David A. Hume
J Immunol (2016) 197 (6): 2297–2305.
View articletitled, A <em>Csf1r</em>-EGFP Transgene Provides a Novel Marker for Monocyte Subsets in Sheep
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IMMUNOGENETICS

Diversified Anchoring Features the Peptide Presentation of DLA-88*50801: First Structural Insight into Domestic Dog MHC Class I
Jin Xiao; Wangzhen Xiang; Yan Chai; Joel Haywood; Jianxun Qi; Limin Ba; Peng Qi; Ming Wang; Jun Liu; George F. Gao
J Immunol (2016) 197 (6): 2306–2315.
View articletitled, Diversified Anchoring Features the Peptide Presentation of DLA-88*50801: First Structural Insight into Domestic Dog MHC Class I
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IMMUNOTHERAPY AND VACCINES

B Cell Responses Associated with Vaccine-Induced Delayed SIVmac251 Acquisition in Female Rhesus Macaques
Venkatramanan Mohanram; Thorsten Demberg; Thomas Musich; Iskra Tuero; Diego A. Vargas-Inchaustegui; Leia Miller-Novak; David Venzon; Marjorie Robert-Guroff
J Immunol (2016) 197 (6): 2316–2324.
View articletitled, B Cell Responses Associated with Vaccine-Induced Delayed SIV<sub>mac251</sub> Acquisition in Female Rhesus Macaques
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INFECTIOUS DISEASE AND HOST RESPONSE

Expansion and Protection by a Virus-Specific NK Cell Subset Lacking Expression of the Inhibitory NKR-P1B Receptor during Murine Cytomegalovirus Infection
Mir Munir A. Rahim; Andrew Wight; Ahmad Bakur Mahmoud; Oscar A. Aguilar; Seung-Hwan Lee; Silvia M. Vidal; James R. Carlyle; Andrew P. Makrigiannis
J Immunol (2016) 197 (6): 2325–2337.
View articletitled, Expansion and Protection by a Virus-Specific NK Cell Subset Lacking Expression of the Inhibitory NKR-P1B Receptor during Murine Cytomegalovirus Infection
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Herpesvirus-Associated Lymphadenitis Distorts Fibroblastic Reticular Cell Microarchitecture and Attenuates CD8 T Cell Responses to Neurotropic Infection in Mice Lacking the STING-IFNα/β Defense Pathways
Derek J. Royer; Christopher D. Conrady; Daniel J. J. Carr
J Immunol (2016) 197 (6): 2338–2352.
View articletitled, Herpesvirus-Associated Lymphadenitis Distorts Fibroblastic Reticular Cell Microarchitecture and Attenuates CD8 T Cell Responses to Neurotropic Infection in Mice Lacking the STING-IFNα/β Defense Pathways
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INNATE IMMUNITY AND INFLAMMATION

Complement Destabilizes Cardiomyocyte Function In Vivo after Polymicrobial Sepsis and In Vitro
Miriam Kalbitz; Fatemeh Fattahi; Todd J. Herron; Jamison J. Grailer; Lawrence Jajou; Hope Lu; Markus Huber-Lang; Firas S. Zetoune; J. Vidya Sarma; Sharlene M. Day; Mark W. Russell; José Jalife; Peter A. Ward
J Immunol (2016) 197 (6): 2353–2361.
View articletitled, Complement Destabilizes Cardiomyocyte Function In Vivo after Polymicrobial Sepsis and In Vitro
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Resolvin D3 Is Dysregulated in Arthritis and Reduces Arthritic Inflammation
Hildur H. Arnardottir; Jesmond Dalli; Lucy V. Norling; Romain A. Colas; Mauro Perretti; Charles N. Serhan
J Immunol (2016) 197 (6): 2362–2368.
View articletitled, Resolvin D3 Is Dysregulated in Arthritis and Reduces Arthritic Inflammation
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Soluble IL-6 Receptor and IL-27 Subunit p28 Protein Complex Mediate the Antiviral Response through the Type III IFN Pathway
Xiaodan Yang; Hua Hao; Zhangchuan Xia; Gang Xu; Zhongying Cao; Xueyuan Chen; Shi Liu; Ying Zhu
J Immunol (2016) 197 (6): 2369–2381.
View articletitled, Soluble IL-6 Receptor and IL-27 Subunit p28 Protein Complex Mediate the Antiviral Response through the Type III IFN Pathway
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Charon Mediates Immune Deficiency–Driven PARP-1–Dependent Immune Responses in Drosophila
Yingbiao Ji; Colin Thomas; Nikita Tulin; Niraj Lodhi; Ernest Boamah; Vladimir Kolenko; Alexei V. Tulin
J Immunol (2016) 197 (6): 2382–2389.
View articletitled, Charon Mediates Immune Deficiency–Driven PARP-1–Dependent Immune Responses in <em>Drosophila</em>
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Blood-Borne Lipopolysaccharide Is Rapidly Eliminated by Liver Sinusoidal Endothelial Cells via High-Density Lipoprotein
Zhili Yao; Jessica M. Mates; Alana M. Cheplowitz; Lindsay P. Hammer; Andrei Maiseyeu; Gary S. Phillips; Mark D. Wewers; Murugesan V. S. Rajaram; John M. Robinson; Clark L. Anderson; Latha P. Ganesan
J Immunol (2016) 197 (6): 2390–2399.
View articletitled, Blood-Borne Lipopolysaccharide Is Rapidly Eliminated by Liver Sinusoidal Endothelial Cells via High-Density Lipoprotein
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IL-17 Promotes Neutrophil-Mediated Immunity by Activating Microvascular Pericytes and Not Endothelium
Rebecca Liu; Holly M. Lauridsen; Robert A. Amezquita; Richard W. Pierce; Dan Jane-wit; Caodi Fang; Amanda S. Pellowe; Nancy C. Kirkiles-Smith; Anjelica L. Gonzalez; Jordan S. Pober
J Immunol (2016) 197 (6): 2400–2408.
View articletitled, IL-17 Promotes Neutrophil-Mediated Immunity by Activating Microvascular Pericytes and Not Endothelium
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TLR2 Activation Limits Rhinovirus-Stimulated CXCL-10 by Attenuating IRAK-1–Dependent IL-33 Receptor Signaling in Human Bronchial Epithelial Cells
Shyamala Ganesan; Duc Pham; Yaxun Jing; Mohammad Farazuddin; Magdalena H. Hudy; Benjamin Unger; Adam T. Comstock; David Proud; Adam S. Lauring; Uma S. Sajjan
J Immunol (2016) 197 (6): 2409–2420.
View articletitled, TLR2 Activation Limits Rhinovirus-Stimulated CXCL-10 by Attenuating IRAK-1–Dependent IL-33 Receptor Signaling in Human Bronchial Epithelial Cells
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Efficacy and Pharmacology of the NLRP3 Inflammasome Inhibitor CP-456,773 (CRID3) in Murine Models of Dermal and Pulmonary Inflammation
Michael J. Primiano; Bruce A. Lefker; Michael R. Bowman; Andrea G. Bree; Cedric Hubeau; Paul D. Bonin; Matthew Mangan; Ken Dower; Brian G. Monks; Leah Cushing; Stephen Wang; Julia Guzova; Aiping Jiao; Lih-Ling Lin; Eicke Latz; David Hepworth; J. Perry Hall
J Immunol (2016) 197 (6): 2421–2433.
View articletitled, Efficacy and Pharmacology of the NLRP3 Inflammasome Inhibitor CP-456,773 (CRID3) in Murine Models of Dermal and Pulmonary Inflammation
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IL-12 Signals through the TCR To Support CD8 Innate Immune Responses
Nicholas P. Goplen; Vikas Saxena; Karin M. Knudson; Adam G. Schrum; Diana Gil; Mark A. Daniels; Rose Zamoyska; Emma Teixeiro
J Immunol (2016) 197 (6): 2434–2443.
View articletitled, IL-12 Signals through the TCR To Support CD8 Innate Immune Responses
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Local Microenvironment Controls the Compartmentalization of NK Cell Responses during Systemic Inflammation in Mice
Orhan Rasid; Ioana Sonya Ciulean; Catherine Fitting; Noelle Doyen; Jean-Marc Cavaillon
J Immunol (2016) 197 (6): 2444–2454.
View articletitled, Local Microenvironment Controls the Compartmentalization of NK Cell Responses during Systemic Inflammation in Mice
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Human Invariant NKT Cells Induce IL-1β Secretion by Peripheral Blood Monocytes via a P2X7-Independent Pathway
Laura E. Felley; Akshat Sharma; Erin Theisen; James C. Romero-Masters; John-Demian Sauer; Jenny E. Gumperz
J Immunol (2016) 197 (6): 2455–2464.
View articletitled, Human Invariant NKT Cells Induce IL-1β Secretion by Peripheral Blood Monocytes via a P2X<sub>7</sub>-Independent Pathway
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MOLECULAR AND STRUCTURAL IMMUNOLOGY

The ETS Family Transcription Factors Etv5 and PU.1 Function in Parallel To Promote Th9 Cell Development
Byunghee Koh; Matthew M. Hufford; Duy Pham; Matthew R. Olson; Tong Wu; Rukhsana Jabeen; Xin Sun; Mark H. Kaplan
J Immunol (2016) 197 (6): 2465–2472.
View articletitled, The ETS Family Transcription Factors Etv5 and PU.1 Function in Parallel To Promote Th9 Cell Development
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Endocytosis of Cytotoxic Granules Is Essential for Multiple Killing of Target Cells by T Lymphocytes
Hsin-Fang Chang; Hawraa Bzeih; Claudia Schirra; Praneeth Chitirala; Mahantappa Halimani; Emmanuelle Cordat; Elmar Krause; Jens Rettig; Varsha Pattu
J Immunol (2016) 197 (6): 2473–2484.
View articletitled, Endocytosis of Cytotoxic Granules Is Essential for Multiple Killing of Target Cells by T Lymphocytes
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MUCOSAL IMMUNOLOGY

NFIL3 Expression Distinguishes Tissue-Resident NK Cells and Conventional NK-like Cells in the Mouse Submandibular Glands
Timothy K. Erick; Courtney K. Anderson; Emma C. Reilly; Jack R. Wands; Laurent Brossay
J Immunol (2016) 197 (6): 2485–2491.
View articletitled, NFIL3 Expression Distinguishes Tissue-Resident NK Cells and Conventional NK-like Cells in the Mouse Submandibular Glands
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SYSTEMS IMMUNOLOGY

Unsupervised HLA Peptidome Deconvolution Improves Ligand Prediction Accuracy and Predicts Cooperative Effects in Peptide–HLA Interactions
Michal Bassani-Sternberg; David Gfeller
J Immunol (2016) 197 (6): 2492–2499.
View articletitled, Unsupervised HLA Peptidome Deconvolution Improves Ligand Prediction Accuracy and Predicts Cooperative Effects in Peptide–HLA Interactions
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Systems Analysis of the Complement-Induced Priming Phase of Liver Regeneration
Jun S. Min; Robert A. DeAngelis; Edimara S. Reis; Shakti Gupta; Mano R. Maurya; Charles Evans; Arun Das; Charles Burant; John D. Lambris; Shankar Subramaniam
J Immunol (2016) 197 (6): 2500–2508.
View articletitled, Systems Analysis of the Complement-Induced Priming Phase of Liver Regeneration
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TUMOR IMMUNOLOGY

Immunotherapy Expands and Maintains the Function of High-Affinity Tumor-Infiltrating CD8 T Cells In Situ
Amy E. Moran; Fanny Polesso; Andrew D. Weinberg
J Immunol (2016) 197 (6): 2509–2521.
View articletitled, Immunotherapy Expands and Maintains the Function of High-Affinity Tumor-Infiltrating CD8 T Cells In Situ
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Functional Differences between IgM and IgD Signaling in Chronic Lymphocytic Leukemia
Elisa ten Hacken; Mariela Sivina; Ekaterina Kim; Susan O’Brien; William G. Wierda; Alessandra Ferrajoli; Zeev Estrov; Michael J. Keating; Thomas Oellerich; Cristina Scielzo; Paolo Ghia; Federico Caligaris-Cappio; Jan A. Burger
J Immunol (2016) 197 (6): 2522–2531.
View articletitled, Functional Differences between IgM and IgD Signaling in Chronic Lymphocytic Leukemia
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Suppression of Glut1 and Glucose Metabolism by Decreased Akt/mTORC1 Signaling Drives T Cell Impairment in B Cell Leukemia
Peter J. Siska; Gerritje J. W. van der Windt; Rigel J. Kishton; Sivan Cohen; William Eisner; Nancie J. MacIver; Arnon P. Kater; J. Brice Weinberg; Jeffrey C. Rathmell
J Immunol (2016) 197 (6): 2532–2540.
View articletitled, Suppression of Glut1 and Glucose Metabolism by Decreased Akt/mTORC1 Signaling Drives T Cell Impairment in B Cell Leukemia
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MAGE-C2–Specific TCRs Combined with Epigenetic Drug-Enhanced Antigenicity Yield Robust and Tumor-Selective T Cell Responses
Andre Kunert; Mandy van Brakel; Sabine van Steenbergen-Langeveld; Marvin da Silva; Pierre G. Coulie; Cor Lamers; Stefan Sleijfer; Reno Debets
J Immunol (2016) 197 (6): 2541–2552.
View articletitled, MAGE-C2–Specific TCRs Combined with Epigenetic Drug-Enhanced Antigenicity Yield Robust and Tumor-Selective T Cell Responses
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  • Cover Image

    Cover Image

    issue cover

    On the cover: Representative image of an immunofluorescently labeled spleen section 24 h after anti-MARCO Ab treatment showing marginal zone macrophages (SIGN-R1+, blue) and marginal zone B cells (B220+, red) situated outside the metallophilic macrophages (MOMA-1+, green) lining the marginal sinus and follicular B cells (B220+, red). Prokopec, K. E., A.-M. Georgoudaki, S. Sohn, F. Wermeling, H. Grönlund, E. Lindh, M. C. Carroll, and M. C. I. Karlsson. 2016. Cutting edge: marginal zone macrophages regulate antigen transport by B cells to the follicle in the spleen via CD21. J. Immunol. 197: 2063–2068.

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