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Volume 198, Issue 1
1 January 2017
The Journal of Immunology Cover Image for Volume 198, Issue 1
ISSN 0022-1767
EISSN 1550-6606

IN THIS ISSUE

In This Issue
J Immunol (2017) 198 (1): 1–2.
View articletitled, In This Issue
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PILLARS OF IMMUNOLOGY

Identification of IgE as the Allergy-Associated Ig Isotype
Fred D. Finkelman
J Immunol (2017) 198 (1): 3–4.
View articletitled, Identification of IgE as the Allergy-Associated Ig Isotype
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Pillars Article: Physico-Chemical Properties of Human Reaginic Antibody: IV. Presence of a Unique Immunoglobulin as a Carrier of Reaginic Activity. J. Immunol. 1966. 97: 75–85
Kimishige Ishizaka; Teruko Ishizaka; Margaret M. Hornbrook
J Immunol (2017) 198 (1): 5–15.
View articletitled, Pillars Article: Physico-Chemical Properties of Human Reaginic Antibody: IV. Presence of a Unique Immunoglobulin as a Carrier of Reaginic Activity. <em>J. Immunol.</em> 1966. 97: 75–85
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Pillars Article: Physicochemical Properties of Reaginic Antibody: V. Correlation of Reaginic Activity with γE-Globulin Antibody. J. Immunol. 1966. 97: 840–853
Kimishige Ishizaka; Teruko Ishizaka; Margaret M. Hornbrook
J Immunol (2017) 198 (1): 16–29.
View articletitled, Pillars Article: Physicochemical Properties of Reaginic Antibody: V. Correlation of Reaginic Activity with γE-Globulin Antibody. <em>J. Immunol.</em> 1966. 97: 840–853
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BRIEF REVIEWS

Intratumoral Delivery of Immunotherapy—Act Locally, Think Globally
M. Angela Aznar; Nicola Tinari; Antonio J. Rullán; Alfonso R. Sánchez-Paulete; María E. Rodriguez-Ruiz; Ignacio Melero
J Immunol (2017) 198 (1): 31–39.
View articletitled, Intratumoral Delivery of Immunotherapy—Act Locally, Think Globally
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Immune Reconstitution after Allogeneic Hematopoietic Stem Cell Transplantation: Time To T Up the Thymus
Mohammed S. Chaudhry; Enrico Velardi; Florent Malard; Marcel R. M. van den Brink
J Immunol (2017) 198 (1): 40–46.
View articletitled, Immune Reconstitution after Allogeneic Hematopoietic Stem Cell Transplantation: Time To T Up the Thymus
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The Allostery Model of TCR Regulation
Wolfgang W. A. Schamel; Balbino Alarcon; Thomas Höfer; Susana Minguet
J Immunol (2017) 198 (1): 47–52.
View articletitled, The Allostery Model of TCR Regulation
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CUTTING EDGE

Cutting Edge: Lymphotoxin Signaling Is Essential for Clearance of Salmonella from the Gut Lumen and Generation of Anti-Salmonella Protective Immunity
Joanna A. Wroblewska; Yuan Zhang; Haidong Tang; Xiaohuan Guo; Cathryn Nagler; Yang-Xin Fu
J Immunol (2017) 198 (1): 55–60.
View articletitled, Cutting Edge: Lymphotoxin Signaling Is Essential for Clearance of <em>Salmonella</em> from the Gut Lumen and Generation of Anti-<em>Salmonella</em> Protective Immunity
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ALLERGY AND OTHER HYPERSENSITIVITIES

Dectin-1 Plays an Important Role in House Dust Mite–Induced Allergic Airway Inflammation through the Activation of CD11b+ Dendritic Cells
Takashi Ito; Koichi Hirose; Ayako Norimoto; Tomohiro Tamachi; Masaya Yokota; Aiko Saku; Hiroaki Takatori; Shinobu Saijo; Yoichiro Iwakura; Hiroshi Nakajima
J Immunol (2017) 198 (1): 61–70.
View articletitled, Dectin-1 Plays an Important Role in House Dust Mite–Induced Allergic Airway Inflammation through the Activation of CD11b<sup>+</sup> Dendritic Cells
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Semaphorin 4C Protects against Allergic Inflammation: Requirement of Regulatory CD138+ Plasma Cells
Di Xue; Gabriel N. Kaufman; Marieme Dembele; Marianne Beland; Amir H. Massoud; Barbara C. Mindt; Ryan Fiter; Elizabeth D. Fixman; James G. Martin; Roland H. Friedel; Maziar Divangahi; Jörg H. Fritz; Bruce D. Mazer
J Immunol (2017) 198 (1): 71–81.
View articletitled, Semaphorin 4C Protects against Allergic Inflammation: Requirement of Regulatory CD138<sup>+</sup> Plasma Cells
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AUTOIMMUNITY

Anti-Hinge Antibodies Recognize IgG Subclass– and Protease-Restricted Neoepitopes
Willem J. J. Falkenburg; Dirkjan van Schaardenburg; Pleuni Ooijevaar-de Heer; Michel W. P. Tsang-A-Sjoe; Irene E. M. Bultink; Alexandre E. Voskuyl; Arthur E. H. Bentlage; Gestur Vidarsson; Gertjan Wolbink; Theo Rispens
J Immunol (2017) 198 (1): 82–93.
View articletitled, Anti-Hinge Antibodies Recognize IgG Subclass– and Protease-Restricted Neoepitopes
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CLINICAL AND HUMAN IMMUNOLOGY

Adaptive NKG2C+ NK Cell Response and the Risk of Cytomegalovirus Infection in Kidney Transplant Recipients
Dolores Redondo-Pachón; Marta Crespo; Jose Yélamos; Aura Muntasell; María José Pérez-Sáez; Silvia Pérez-Fernández; Joan Vila; Carlos Vilches; Julio Pascual; Miguel López-Botet
J Immunol (2017) 198 (1): 94–101.
View articletitled, Adaptive NKG2C<sup>+</sup> NK Cell Response and the Risk of Cytomegalovirus Infection in Kidney Transplant Recipients
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T and B Cell Markers in Dried Blood Spots of Neonates with Congenital Cytomegalovirus Infection: B Cell Numbers at Birth Are Associated with Long-Term Outcomes
Roberta Rovito; Marjolein J. Korndewal; Menno C. van Zelm; Dimitrios Ziagkos; Els Wessels; Mirjam van der Burg; Aloys C. M. Kroes; Anton W. Langerak; Ann C. T. M. Vossen
J Immunol (2017) 198 (1): 102–109.
View articletitled, T and B Cell Markers in Dried Blood Spots of Neonates with Congenital Cytomegalovirus Infection: B Cell Numbers at Birth Are Associated with Long-Term Outcomes
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Human Lung Fibroblasts Present Bacterial Antigens to Autologous Lung Th Cells
Andrew J. Hutton; Marta E. Polak; C. Mirella Spalluto; Joshua C. Wallington; Chris Pickard; Karl J. Staples; Jane A. Warner; Tom M. A. Wilkinson
J Immunol (2017) 198 (1): 110–118.
View articletitled, Human Lung Fibroblasts Present Bacterial Antigens to Autologous Lung Th Cells
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IMMUNE REGULATION

IL-35 Suppresses Lipopolysaccharide-Induced Airway Eosinophilia in EBI3-Deficient Mice
Kyosuke Kanai; Ah-Mee Park; Hiroki Yoshida; Ikuo Tsunoda; Osamu Yoshie
J Immunol (2017) 198 (1): 119–127.
View articletitled, IL-35 Suppresses Lipopolysaccharide-Induced Airway Eosinophilia in EBI3-Deficient Mice
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A Proinflammatory Role of Type 2 Innate Lymphoid Cells in Murine Immune-Mediated Hepatitis
Katrin Neumann; Khalil Karimi; Jana Meiners; Ruth Voetlause; Silja Steinmann; Werner Dammermann; Stefan Lüth; Farahnaz Asghari; Claudia Wegscheid; Andrea K. Horst; Gisa Tiegs
J Immunol (2017) 198 (1): 128–137.
View articletitled, A Proinflammatory Role of Type 2 Innate Lymphoid Cells in Murine Immune-Mediated Hepatitis
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Human Regulatory T Cells Mediate Transcriptional Modulation of Dendritic Cell Function
Emily Mavin; Lindsay Nicholson; Syed Rafez Ahmed; Fei Gao; Anne Dickinson; Xiao-nong Wang
J Immunol (2017) 198 (1): 138–146.
View articletitled, Human Regulatory T Cells Mediate Transcriptional Modulation of Dendritic Cell Function
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Sensitivity to Restimulation-Induced Cell Death Is Linked to Glycolytic Metabolism in Human T Cells
Sasha E. Larsen; Abegail Bilenkin; Tatiana N. Tarasenko; Swadhinya Arjunaraja; Jeffrey R. Stinson; Peter J. McGuire; Andrew L. Snow
J Immunol (2017) 198 (1): 147–155.
View articletitled, Sensitivity to Restimulation-Induced Cell Death Is Linked to Glycolytic Metabolism in Human T Cells
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Depletion of Neural Crest–Derived Cells Leads to Reduction in Plasma Noradrenaline and Alters B Lymphopoiesis
Naoki Tsunokuma; Toshiyuki Yamane; Chiaki Matsumoto; Motokazu Tsuneto; Kana Isono; Kyoko Imanaka-Yoshida; Hidetoshi Yamazaki
J Immunol (2017) 198 (1): 156–169.
View articletitled, Depletion of Neural Crest–Derived Cells Leads to Reduction in Plasma Noradrenaline and Alters B Lymphopoiesis
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Homocysteine Activates B Cells via Regulating PKM2-Dependent Metabolic Reprogramming
Jiacheng Deng; Silin Lü; Huiying Liu; Bo Liu; Changtao Jiang; Qingbo Xu; Juan Feng; Xian Wang
J Immunol (2017) 198 (1): 170–183.
View articletitled, Homocysteine Activates B Cells via Regulating PKM2-Dependent Metabolic Reprogramming
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Impairment of CCR6+ and CXCR3+ Th Cell Migration in HIV-1 Infection Is Rescued by Modulating Actin Polymerization
Valentina Cecchinato; Enos Bernasconi; Roberto F. Speck; Michele Proietti; Ulrike Sauermann; Gianluca D’Agostino; Gabriela Danelon; Tanja Rezzonico Jost; Fabio Grassi; Lorenzo Raeli; Franziska Schöni-Affolter; Christiane Stahl-Hennig; Mariagrazia Uguccioni; the Swiss HIV Cohort Study
J Immunol (2017) 198 (1): 184–195.
View articletitled, Impairment of CCR6<sup>+</sup> and CXCR3<sup>+</sup> Th Cell Migration in HIV-1 Infection Is Rescued by Modulating Actin Polymerization
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The Syk–NFAT–IL-2 Pathway in Dendritic Cells Is Required for Optimal Sterile Immunity Elicited by Alum Adjuvants
Hanif Javanmard Khameneh; Adrian W. S. Ho; Roberto Spreafico; Heidi Derks; Hazel Q. Y. Quek; Alessandra Mortellaro
J Immunol (2017) 198 (1): 196–204.
View articletitled, The Syk–NFAT–IL-2 Pathway in Dendritic Cells Is Required for Optimal Sterile Immunity Elicited by Alum Adjuvants
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Conserved Region C Functions To Regulate PD-1 Expression and Subsequent CD8 T Cell Memory
Alexander P. R. Bally; Yan Tang; Joshua T. Lee; Benjamin G. Barwick; Ryan Martinez; Brian D. Evavold; Jeremy M. Boss
J Immunol (2017) 198 (1): 205–217.
View articletitled, Conserved Region C Functions To Regulate PD-1 Expression and Subsequent CD8 T Cell Memory
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OX40 Cooperates with ICOS To Amplify Follicular Th Cell Development and Germinal Center Reactions during Infection
Vikas Tahiliani; Tarun E. Hutchinson; Georges Abboud; Michael Croft; Shahram Salek-Ardakani
J Immunol (2017) 198 (1): 218–228.
View articletitled, OX40 Cooperates with ICOS To Amplify Follicular Th Cell Development and Germinal Center Reactions during Infection
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Human Basophils Modulate Plasma Cell Differentiation and Maturation
Dorothea Dijkstra; Almut Meyer-Bahlburg
J Immunol (2017) 198 (1): 229–238.
View articletitled, Human Basophils Modulate Plasma Cell Differentiation and Maturation
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Immunogenic Dendritic Cell Generation from Pluripotent Stem Cells by Ectopic Expression of Runx3
Erika Takacs; Pal Boto; Emilia Simo; Tamas I. Csuth; Bianka M. Toth; Hadas Raveh-Amit; Attila Pap; Elek G. Kovács; Julianna Kobolak; Szilvia Benkö; Andras Dinnyes; Istvan Szatmari
J Immunol (2017) 198 (1): 239–248.
View articletitled, Immunogenic Dendritic Cell Generation from Pluripotent Stem Cells by Ectopic Expression of <em>Runx3</em>
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Thymic Dendritic Cell Subsets Display Distinct Efficiencies and Mechanisms of Intercellular MHC Transfer
Charles J. Kroger; Nicholas A. Spidale; Bo Wang; Roland Tisch
J Immunol (2017) 198 (1): 249–256.
View articletitled, Thymic Dendritic Cell Subsets Display Distinct Efficiencies and Mechanisms of Intercellular MHC Transfer
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IMMUNE SYSTEM DEVELOPMENT

Temporal Expression of Bim Limits the Development of Agonist-Selected Thymocytes and Skews Their TCRβ Repertoire
Kun-Po Li; Anke Fähnrich; Eron Roy; Carla M. Cuda; H. Leighton Grimes; Harris R. Perlman; Kathrin Kalies; David A. Hildeman
J Immunol (2017) 198 (1): 257–269.
View articletitled, Temporal Expression of Bim Limits the Development of Agonist-Selected Thymocytes and Skews Their TCRβ Repertoire
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IMMUNOGENETICS

IL1R9 Is Evolutionarily Related to IL18BP and May Function as an IL-18 Receptor
Chris S. Booker; David R. Grattan
J Immunol (2017) 198 (1): 270–278.
View articletitled, <em>IL1R9</em> Is Evolutionarily Related to <em>IL18BP</em> and May Function as an IL-18 Receptor
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IMMUNOTHERAPY AND VACCINES

Roles of Aluminum Hydroxide and Monophosphoryl Lipid A Adjuvants in Overcoming CD4+ T Cell Deficiency To Induce Isotype-Switched IgG Antibody Responses and Protection by T-Dependent Influenza Vaccine
Eun-Ju Ko; Young-Tae Lee; Ki-Hye Kim; Youri Lee; Yu-Jin Jung; Min-Chul Kim; Yu-Na Lee; Taeuk Kang; Sang-Moo Kang
J Immunol (2017) 198 (1): 279–291.
View articletitled, Roles of Aluminum Hydroxide and Monophosphoryl Lipid A Adjuvants in Overcoming CD4<sup>+</sup> T Cell Deficiency To Induce Isotype-Switched IgG Antibody Responses and Protection by T-Dependent Influenza Vaccine
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Complement Component 3 Regulates IFN-α Production by Plasmacytoid Dendritic Cells following TLR7 Activation by a Plant Virus–like Nanoparticle
Marie-Ève Lebel; Marie-Pierre Langlois; Jean-François Daudelin; Esther Tarrab; Pierre Savard; Denis Leclerc; Alain Lamarre
J Immunol (2017) 198 (1): 292–299.
View articletitled, Complement Component 3 Regulates IFN-α Production by Plasmacytoid Dendritic Cells following TLR7 Activation by a Plant Virus–like Nanoparticle
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Whole-Killed Blood-Stage Vaccine-Induced Immunity Suppresses the Development of Malaria Parasites in Mosquitoes
Feng Zhu; Taiping Liu; Chenhao Zhao; Xiao Lu; Jian Zhang; Wenyue Xu
J Immunol (2017) 198 (1): 300–307.
View articletitled, Whole-Killed Blood-Stage Vaccine-Induced Immunity Suppresses the Development of Malaria Parasites in Mosquitoes
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Prevention of Vγ9Vδ2 T Cell Activation by a Vγ9Vδ2 TCR Nanobody
Renée C. G. de Bruin; Anita G. M. Stam; Anna Vangone; Paul M. P. van Bergen en Henegouwen; Henk M. W. Verheul; Zsolt Sebestyén; Jürgen Kuball; Alexandre M. J. J. Bonvin; Tanja D. de Gruijl; Hans J. van der Vliet
J Immunol (2017) 198 (1): 308–317.
View articletitled, Prevention of Vγ9Vδ2 T Cell Activation by a Vγ9Vδ2 TCR Nanobody
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INFECTIOUS DISEASE AND HOST RESPONSE

Integrin Cross-Talk Regulates the Human Neutrophil Response to Fungal β-Glucan in the Context of the Extracellular Matrix: A Prominent Role for VLA3 in the Antifungal Response
Courtney M. Johnson; Xian M. O’Brien; Angel S. Byrd; Valentina E. Parisi; Alex J. Loosely; Wei Li; Hadley Witt; Hafeez M. Faridi; Craig T. Lefort; Vineet Gupta; Minsoo Kim; Jonathan S. Reichner
J Immunol (2017) 198 (1): 318–334.
View articletitled, Integrin Cross-Talk Regulates the Human Neutrophil Response to Fungal β-Glucan in the Context of the Extracellular Matrix: A Prominent Role for VLA3 in the Antifungal Response
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CX3CR1+ Cell–Mediated Salmonella Exclusion Protects the Intestinal Mucosa during the Initial Stage of Infection
Angela L. Man; Nadezhda Gicheva; Mari Regoli; Gary Rowley; Giovanna De Cunto; Nikolaus Wellner; Elizabeth Bassity; Massimo Gulisano; Eugenio Bertelli; Claudio Nicoletti
J Immunol (2017) 198 (1): 335–343.
View articletitled, CX<sub>3</sub>CR1<sup>+</sup> Cell–Mediated <em>Salmonella</em> Exclusion Protects the Intestinal Mucosa during the Initial Stage of Infection
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Platelets Mediate Host Defense against Staphylococcus aureus through Direct Bactericidal Activity and by Enhancing Macrophage Activities
Ramadan A. Ali; Leah M. Wuescher; Keith R. Dona; Randall G. Worth
J Immunol (2017) 198 (1): 344–351.
View articletitled, Platelets Mediate Host Defense against <em>Staphylococcus aureus</em> through Direct Bactericidal Activity and by Enhancing Macrophage Activities
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Regulatory T Cells Promote Myositis and Muscle Damage in Toxoplasma gondii Infection
Richard M. Jin; Sarah J. Blair; Jordan Warunek; Reid R. Heffner; Ira J. Blader; Elizabeth A. Wohlfert
J Immunol (2017) 198 (1): 352–362.
View articletitled, Regulatory T Cells Promote Myositis and Muscle Damage in <em>Toxoplasma gondii</em> Infection
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IL-17–Producing Innate and Pathogen-Specific Tissue Resident Memory γδ T Cells Expand in the Lungs of Bordetella pertussis–Infected Mice
Alicja Misiak; Mieszko M. Wilk; Mathilde Raverdeau; Kingston H. G. Mills
J Immunol (2017) 198 (1): 363–374.
View articletitled, IL-17–Producing Innate and Pathogen-Specific Tissue Resident Memory γδ T Cells Expand in the Lungs of <em>Bordetella pertussis</em>–Infected Mice
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Autocrine Type I IFN Signaling in Dendritic Cells Stimulated with Fungal β-Glucans or Lipopolysaccharide Promotes CD8 T Cell Activation
Nargess Hassanzadeh-Kiabi; Alberto Yáñez; Ivy Dang; Gislâine A. Martins; David M. Underhill; Helen S. Goodridge
J Immunol (2017) 198 (1): 375–382.
View articletitled, Autocrine Type I IFN Signaling in Dendritic Cells Stimulated with Fungal β-Glucans or Lipopolysaccharide Promotes CD8 T Cell Activation
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Blocking Virus Replication during Acute Murine Cytomegalovirus Infection Paradoxically Prolongs Antigen Presentation and Increases the CD8+ T Cell Response by Preventing Type I IFN–Dependent Depletion of Dendritic Cells
Christopher P. Loo; Christopher M. Snyder; Ann B. Hill
J Immunol (2017) 198 (1): 383–393.
View articletitled, Blocking Virus Replication during Acute Murine Cytomegalovirus Infection Paradoxically Prolongs Antigen Presentation and Increases the CD8<sup>+</sup> T Cell Response by Preventing Type I IFN–Dependent Depletion of Dendritic Cells
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Pulmonary Dendritic Cell Subsets Shape the Respiratory Syncytial Virus–Specific CD8+ T Cell Immunodominance Hierarchy in Neonates
Allison M. W. Malloy; Tracy J. Ruckwardt; Kaitlyn M. Morabito; Annie W. Lau-Kilby; Barney S. Graham
J Immunol (2017) 198 (1): 394–403.
View articletitled, Pulmonary Dendritic Cell Subsets Shape the Respiratory Syncytial Virus–Specific CD8<sup>+</sup> T Cell Immunodominance Hierarchy in Neonates
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INNATE IMMUNITY AND INFLAMMATION

Myeloid-Specific Gene Deletion of Protein Phosphatase 2A Magnifies MyD88- and TRIF-Dependent Inflammation following Endotoxin Challenge
Lei Sun; Tiffany T. Pham; Timothy T. Cornell; Kelli L. McDonough; Walker M. McHugh; Neal B. Blatt; Mary K. Dahmer; Thomas P. Shanley
J Immunol (2017) 198 (1): 404–416.
View articletitled, Myeloid-Specific Gene Deletion of Protein Phosphatase 2A Magnifies MyD88- and TRIF-Dependent Inflammation following Endotoxin Challenge
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Soluble TNF Regulates TACE via AP-2α Transcription Factor in Mouse Dendritic Cells
Lisheng Ge; Nikola L. Vujanovic
J Immunol (2017) 198 (1): 417–427.
View articletitled, Soluble TNF Regulates TACE via AP-2α Transcription Factor in Mouse Dendritic Cells
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P2Y6 Receptor Antagonist MRS2578 Inhibits Neutrophil Activation and Aggregated Neutrophil Extracellular Trap Formation Induced by Gout-Associated Monosodium Urate Crystals
Payel Sil; Craig P. Hayes; Barbara J. Reaves; Patrick Breen; Shannon Quinn; Jeremy Sokolove; Balázs Rada
J Immunol (2017) 198 (1): 428–442.
View articletitled, P2Y6 Receptor Antagonist MRS2578 Inhibits Neutrophil Activation and Aggregated Neutrophil Extracellular Trap Formation Induced by Gout-Associated Monosodium Urate Crystals
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Uric Acid Crystals Induce Placental Inflammation and Alter Trophoblast Function via an IL-1–Dependent Pathway: Implications for Fetal Growth Restriction
Marie-Eve Brien; Cyntia Duval; Julia Palacios; Ines Boufaied; Andrée-Anne Hudon-Thibeault; Mathieu Nadeau-Vallée; Cathy Vaillancourt; Colin P. Sibley; Vikki M. Abrahams; Rebecca L. Jones; Sylvie Girard
J Immunol (2017) 198 (1): 443–451.
View articletitled, Uric Acid Crystals Induce Placental Inflammation and Alter Trophoblast Function via an IL-1–Dependent Pathway: Implications for Fetal Growth Restriction
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Critical Role of LTB4/BLT1 in IL-23–Induced Synovial Inflammation and Osteoclastogenesis via NF-κB
Laura Bouchareychas; Eva M. Grössinger; Mincheol Kang; Hong Qiu; Iannis E. Adamopoulos
J Immunol (2017) 198 (1): 452–460.
View articletitled, Critical Role of LTB<sub>4</sub>/BLT1 in IL-23–Induced Synovial Inflammation and Osteoclastogenesis via NF-κB
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PGI2 Controls Pulmonary NK Cells That Prevent Airway Sensitization to House Dust Mite Allergen
Bryan Simons; Maria E. Ferrini; Sophia Carvalho; David J. P. Bassett; Zeina Jaffar; Kevan Roberts
J Immunol (2017) 198 (1): 461–471.
View articletitled, PGI<sub>2</sub> Controls Pulmonary NK Cells That Prevent Airway Sensitization to House Dust Mite Allergen
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Complement Protein C1q Enhances Macrophage Foam Cell Survival and Efferocytosis
Marc C. Pulanco; Jason Cosman; Minh-Minh Ho; Jessica Huynh; Karina Fing; Jacqueline Turcu; Deborah A. Fraser
J Immunol (2017) 198 (1): 472–480.
View articletitled, Complement Protein C1q Enhances Macrophage Foam Cell Survival and Efferocytosis
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MUCOSAL IMMUNOLOGY

Distribution and Activation of CD8+ T Cells in the Duodenal Mucosa before and after HIV Seroconversion
Kristina Allers; Andreas Puyskens; Hans-Jörg Epple; Dirk Schürmann; Jörg Hofmann; Verena Moos; Thomas Schneider
J Immunol (2017) 198 (1): 481–491.
View articletitled, Distribution and Activation of CD8<sup>+</sup> T Cells in the Duodenal Mucosa before and after HIV Seroconversion
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Essential Role of mTORC1 in Self-Renewal of Murine Alveolar Macrophages
Wenhai Deng; Jialong Yang; Xingguang Lin; Jinwook Shin; Jimin Gao; Xiao-Ping Zhong
J Immunol (2017) 198 (1): 492–504.
View articletitled, Essential Role of mTORC1 in Self-Renewal of Murine Alveolar Macrophages
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NOVEL IMMUNOLOGICAL METHODS

Accurate Structure Prediction of CDR H3 Loops Enabled by a Novel Structure-Based C-Terminal Constraint
Brian D. Weitzner; Jeffrey J. Gray
J Immunol (2017) 198 (1): 505–515.
View articletitled, Accurate Structure Prediction of CDR H3 Loops Enabled by a Novel Structure-Based C-Terminal Constraint
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Generation of a Novel HLA Class I Transgenic Mouse Model Carrying a Knock-in Mutation at the β2-Microglobulin Locus
Naomoto Harada; Satoshi Fukaya; Hiroshi Wada; Risa Goto; Toshihiro Osada; Akira Gomori; Koichi Ikizawa; Motomu Sakuragi; Nobuyuki Oda
J Immunol (2017) 198 (1): 516–527.
View articletitled, Generation of a Novel HLA Class I Transgenic Mouse Model Carrying a Knock-in Mutation at the β<sub>2</sub>-Microglobulin Locus
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A CD80-Biased CTLA4-Ig Fusion Protein with Superior In Vivo Efficacy by Simultaneous Engineering of Affinity, Selectivity, Stability, and FcRn Binding
Julie Douthwaite; Jacques Moisan; Cyril Privezentzev; Blagoje Soskic; Shereen Sabbah; Suzanne Cohen; Andie Collinson; Elizabeth England; Catherine Huntington; Ben Kemp; Li Zhuang; Suzanne Hudak; D. Gareth Rees; Debbie Goldberg; Chris Barton; Linda Chang; Inna Vainshtein; Meina Liang; Laurie Iciek; Philip Ambery; Mark Peakman; Tristan J. Vaughan; Tim I. M. Tree; David M. Sansom; Michael A. Bowen; Ralph R. Minter; Lutz Jermutus
J Immunol (2017) 198 (1): 528–537.
View articletitled, A CD80-Biased CTLA4-Ig Fusion Protein with Superior In Vivo Efficacy by Simultaneous Engineering of Affinity, Selectivity, Stability, and FcRn Binding
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    On the cover: Representative image of a histologic skin section from an in vitro human graft-versus-host disease skin explant model demonstrating that allogeneic T cells primed by regulatory T cell–treated dendritic cells are unable to mediate cutaneous graft-versus-host reactions. Mavin, E., L. Nicholson, S. R. Ahmed, F. Gao, A. Dickinson, and X. Wang. 2017. Human regulatory T cells mediate transcriptional modulation of dendritic cell function. J. Immunol. 198: 138–146.

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  • Online ISSN 1550-6606
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