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Issues
15 February 2017
ISSN 0022-1767
EISSN 1550-6606
In this Issue
IN THIS ISSUE
TRANSLATING IMMUNOLOGY
Natalizumab for Multiple Sclerosis: A Case in Point for the Impact of Translational Neuroimmunology
J Immunol (2017) 198 (4): 1381–1386.
BRIEF REVIEWS
Efferocytosis Signaling in the Regulation of Macrophage Inflammatory Responses
J Immunol (2017) 198 (4): 1387–1394.
Contact, Collaboration, and Conflict: Signal Integration of Syk-Coupled C-Type Lectin Receptors
J Immunol (2017) 198 (4): 1403–1414.
CUTTING EDGE
Cutting Edge: Human CD49e− NK Cells Are Tissue Resident in the Liver
Han Xian Aw Yeang; Sytse J. Piersma; Yiing Lin; Liping Yang; Olga N. Malkova; Cathrine Miner; Alexander S. Krupnick; William C. Chapman; Wayne M. Yokoyama
J Immunol (2017) 198 (4): 1417–1422.
AUTOIMMUNITY
Functional Conversion and Dominance of γδ T Subset in Mouse Experimental Autoimmune Uveitis
J Immunol (2017) 198 (4): 1429–1438.
PRMT5-Selective Inhibitors Suppress Inflammatory T Cell Responses and Experimental Autoimmune Encephalomyelitis
Lindsay M. Webb; Stephanie A. Amici; Kyle A. Jablonski; Himanshu Savardekar; Amanda R. Panfil; Linsen Li; Wei Zhou; Kevin Peine; Vrajesh Karkhanis; Eric M. Bachelder; Kristy M. Ainslie; Patrick L. Green; Chenglong Li; Robert A. Baiocchi; Mireia Guerau-de-Arellano
J Immunol (2017) 198 (4): 1439–1451.
CLINICAL AND HUMAN IMMUNOLOGY
The Clonal Invariant NKT Cell Repertoire in People with Type 1 Diabetes Is Characterized by a Loss of Clones Expressing High-Affinity TCRs
Anna S. Tocheva; Salah Mansour; Tristan G. H. Holt; Samuel Jones; Andrew Chancellor; Joseph P. Sanderson; Efrem Eren; Tim J. Elliott; Richard I. G. Holt; Stephan D. Gadola
J Immunol (2017) 198 (4): 1452–1459.
Dysregulation of B Cell Repertoire Formation in Myasthenia Gravis Patients Revealed through Deep Sequencing
Jason A. Vander Heiden; Panos Stathopoulos; Julian Q. Zhou; Luan Chen; Tamara J. Gilbert; Christopher R. Bolen; Richard J. Barohn; Mazen M. Dimachkie; Emma Ciafaloni; Teresa J. Broering; Francois Vigneault; Richard J. Nowak; Steven H. Kleinstein; Kevin C. O’Connor
J Immunol (2017) 198 (4): 1460–1473.
IMMUNE REGULATION
Oncostatin M Suppresses Activation of IL-17/Th17 via SOCS3 Regulation in CD4+ T Cells
Hye-Jin Son; Seung Hoon Lee; Seon-Yeong Lee; Eun-Kyung Kim; Eun-Ji Yang; Jae-Kyung Kim; Hyeon-Beom Seo; Sung-Hwan Park; Mi-La Cho
J Immunol (2017) 198 (4): 1484–1491.
NKG2D Promotes B1a Cell Development and Protection against Bacterial Infection
Maja Lenartić; Vedrana Jelenčić; Biljana Zafirova; Mateja Ožanič; Valentina Marečić; Slaven Jurković; Veronika Sexl; Marina Šantić; Felix M. Wensveen; Bojan Polić
J Immunol (2017) 198 (4): 1531–1542.
IMMUNE SYSTEM DEVELOPMENT
Human Blood CD1c+ Dendritic Cells Encompass CD5high and CD5low Subsets That Differ Significantly in Phenotype, Gene Expression, and Functions
Xiangyun Yin; Haisheng Yu; Xiaoyang Jin; Jingyun Li; Hao Guo; Quanxing Shi; Zhao Yin; Yong Xu; Xuefei Wang; Rong Liu; Shouli Wang; Liguo Zhang
J Immunol (2017) 198 (4): 1553–1564.
IMMUNOTHERAPY AND VACCINES
Effective Combination of Innate and Adaptive Immunotherapeutic Approaches in a Mouse Melanoma Model
Alexander L. Rakhmilevich; Mildred Felder; Lauren Lever; Jacob Slowinski; Kayla Rasmussen; Anna Hoefges; Tyler J. Van De Voort; Hans Loibner; Alan J. Korman; Stephen D. Gillies; Paul M. Sondel
J Immunol (2017) 198 (4): 1575–1584.
Monoclonal Antibodies against Epidermal Growth Factor Receptor Acquire an Ability To Kill Tumor Cells through Complement Activation by Mutations That Selectively Facilitate the Hexamerization of IgG on Opsonized Cells
Annalina Tammen; Stefanie Derer; Ralf Schwanbeck; Thies Rösner; Anna Kretschmer; Frank J. Beurskens; Janine Schuurman; Paul W. H. I. Parren; Thomas Valerius
J Immunol (2017) 198 (4): 1585–1594.
A New RNA-Based Adjuvant Enhances Virus-Specific Vaccine Responses by Locally Triggering TLR- and RLH-Dependent Effects
Annett Ziegler; Claudia Soldner; Stefan Lienenklaus; Julia Spanier; Stephanie Trittel; Peggy Riese; Thomas Kramps; Siegfried Weiss; Regina Heidenreich; Edith Jasny; Carlos A. Guzmán; Karl-Josef Kallen; Mariola Fotin-Mleczek; Ulrich Kalinke
J Immunol (2017) 198 (4): 1595–1605.
INFECTIOUS DISEASE AND HOST RESPONSE
Steroid Receptor Coactivator 3 Contributes to Host Defense against Enteric Bacteria by Recruiting Neutrophils via Upregulation of CXCL2 Expression
Wenbo Chen; Xuqiang Lu; Yuan Chen; Ming Li; Pingli Mo; Zhangwei Tong; Wei Wang; Wei Wan; Guoqiang Su; Jianming Xu; Chundong Yu
J Immunol (2017) 198 (4): 1606–1615.
Widespread Virus Replication in Alveoli Drives Acute Respiratory Distress Syndrome in Aerosolized H5N1 Influenza Infection of Macaques
Elizabeth R. Wonderlich; Zachary D. Swan; Stephanie J. Bissel; Amy L. Hartman; Jonathan P. Carney; Katherine J. O’Malley; Adebimpe O. Obadan; Jefferson Santos; Reagan Walker; Timothy J. Sturgeon; Lonnie J. Frye, Jr.; Pauline Maiello; Charles A. Scanga; Jennifer D. Bowling; Anthea L. Bouwer; Parichat A. Duangkhae; Clayton A. Wiley; JoAnne L. Flynn; Jieru Wang; Kelly S. Cole; Daniel R. Perez; Douglas S. Reed; Simon M. Barratt-Boyes
J Immunol (2017) 198 (4): 1616–1626.
Different Lymphocyte Populations Direct Dichotomous Eosinophil or Neutrophil Responses to Pulmonary Cryptococcus Infection
J Immunol (2017) 198 (4): 1627–1637.
INNATE IMMUNITY AND INFLAMMATION
DNA-Containing Exosomes Derived from Cancer Cells Treated with Topotecan Activate a STING-Dependent Pathway and Reinforce Antitumor Immunity
Yuichi Kitai; Takumi Kawasaki; Takuya Sueyoshi; Kouji Kobiyama; Ken J. Ishii; Jian Zou; Shizuo Akira; Tadashi Matsuda; Taro Kawai
J Immunol (2017) 198 (4): 1649–1659.
BLT1 Mediates Bleomycin-Induced Lung Fibrosis Independently of Neutrophils and CD4+ T Cells
J Immunol (2017) 198 (4): 1673–1684.
MOLECULAR AND STRUCTURAL IMMUNOLOGY
A B Cell Epitope Peptide Derived from the Major Grass Pollen Allergen Phl p 1 Boosts Allergen-Specific Secondary Antibody Responses without Allergen-Specific T Cell Help
Meena Narayanan; Raphaela Freidl; Margarete Focke-Tejkl; Ulrike Baranyi; Thomas Wekerle; Rudolf Valenta; Birgit Linhart
J Immunol (2017) 198 (4): 1685–1695.
MUCOSAL IMMUNOLOGY
Subclinical Herpes Simplex Virus Type 1 Infections Provide Site-Specific Resistance to an Unrelated Pathogen
J Immunol (2017) 198 (4): 1706–1717.
TRANSPLANTATION
Intravital Imaging of Neutrophil Recruitment Reveals the Efficacy of FPR1 Blockade in Hepatic Ischemia-Reperfusion Injury
Masaki Honda; Takayuki Takeichi; Shintaro Hashimoto; Daiki Yoshii; Kaori Isono; Shintaro Hayashida; Yuki Ohya; Hidekazu Yamamoto; Yasuhiko Sugawara; Yukihiro Inomata
J Immunol (2017) 198 (4): 1718–1728.
TUMOR IMMUNOLOGY
CD8+ T Cells That Coexpress RORγt and T-bet Are Functionally Impaired and Expand in Patients with Distal Bile Duct Cancer
Stalin Chellappa; Harald Hugenschmidt; Morten Hagness; Saranya Subramani; Espen Melum; Pål Dag Line; Knut-Jørgen Labori; Gro Wiedswang; Kjetil Taskén; Einar Martin Aandahl
J Immunol (2017) 198 (4): 1729–1739.
Ibrutinib Therapy Increases T Cell Repertoire Diversity in Patients with Chronic Lymphocytic Leukemia
Qingsong Yin; Mariela Sivina; Harlan Robins; Erik Yusko; Marissa Vignali; Susan O’Brien; Michael J. Keating; Alessandra Ferrajoli; Zeev Estrov; Nitin Jain; William G. Wierda; Jan A. Burger
J Immunol (2017) 198 (4): 1740–1747.
NOVEL IMMUNOLOGICAL METHODS
An Integrated Workflow To Assess Technical and Biological Variability of Cell Population Frequencies in Human Peripheral Blood by Flow Cytometry
Julie G. Burel; Yu Qian; Cecilia Lindestam Arlehamn; Daniela Weiskopf; Jose Zapardiel-Gonzalo; Randy Taplitz; Robert H. Gilman; Mayuko Saito; Aruna D. de Silva; Pandurangan Vijayanand; Richard H. Scheuermann; Alessandro Sette; Bjoern Peters
J Immunol (2017) 198 (4): 1748–1758.
CORRECTIONS
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Cover Image
Cover Image
![issue cover]()
On the cover: Immunomodulatory PRMT5 inhibitor HLCL65 binding to PRMT5 enzyme. Docked HLCL65 molecule is represented in green. PRMT5's α-helix, β-sheets, and turns are colored pink, yellow and grey, respectively. S-adenosyl methionine analog is shown in orange, and histone H4 peptide with substrate Arg3 residue is shown in cyan. Webb, L. M., S. A. Amici, K. A. Jablonski, H. Savardekar, A. R. Panfil, L. Li, W. Zhou, K. Peine, V. Karkhanis, E. M. Bachelder, K. M. Ainslie, P. L. Green, C. Li, R. A. Baiocchi, and M. Guerau-de-Arellano. 2017. PRMT5 selective inhibitors suppress inflammatory T cell responses and experimental autoimmune encephalomyelitis. J. Immunol. 197: 1439–1451.
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