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1 April 2017
ISSN 0022-1767
EISSN 1550-6606
In this Issue
IN THIS ISSUE
PILLARS OF IMMUNOLOGY
Pillars Article: Molecular Cloning of cDNA Encoding a Murine Haematopoietic Growth Regulator, Granulocyte—Macrophage Colony Stimulating Factor. Nature. 1984. 309: 763–767
Nicholas M. Gough; Jill Gough; Donald Metcalf; Anne Kelso; Dianne Grail; Nicos A. Nicola; Antony W. Burgess; Ashley R. Dunn
J Immunol (2017) 198 (7): 2522–2526.
BRIEF REVIEWS
Two Strikes and You’re Out? The Pathogenic Interplay of Coinhibitor Deficiency and Lymphopenia-Induced Proliferation
J Immunol (2017) 198 (7): 2534–2541.
ALLERGY AND OTHER HYPERSENSITIVITIES
Expression of IL-22 in the Skin Causes Th2-Biased Immunity, Epidermal Barrier Dysfunction, and Pruritus via Stimulating Epithelial Th2 Cytokines and the GRP Pathway
Hongfei Lou; Jingning Lu; Eun Byul Choi; Min Hee Oh; Mingeum Jeong; Sara Barmettler; Zhou Zhu; Tao Zheng
J Immunol (2017) 198 (7): 2543–2555.
ANTIGEN RECOGNITION AND RESPONSES
The Activating Human NK Cell Receptor KIR2DS2 Recognizes a β2-Microglobulin–Independent Ligand on Cancer Cells
Lavanya Thiruchelvam-Kyle; Sigurd E. Hoelsbrekken; Per C. Saether; Elisabeth Gyllensten Bjørnsen; Daniela Pende; Sigbjørn Fossum; Michael R. Daws; Erik Dissen
J Immunol (2017) 198 (7): 2556–2567.
AUTOIMMUNITY
CD74 Deficiency Mitigates Systemic Lupus Erythematosus–like Autoimmunity and Pathological Findings in Mice
Yi Zhou; Huimei Chen; Li Liu; Xueqing Yu; Galina K. Sukhova; Min Yang; Lijun Zhang; Vasileios C. Kyttaris; George C. Tsokos; Isaac E. Stillman; Takaharu Ichimura; Joseph V. Bonventre; Peter Libby; Guo-Ping Shi
J Immunol (2017) 198 (7): 2568–2577.
Disruption of Pathogenic Cellular Networks by IL-21 Blockade Leads to Disease Amelioration in Murine Lupus
Jin-Young Choi; Abhinav Seth; Michael Kashgarian; Sonia Terrillon; Emma Fung; Lili Huang; Li Chun Wang; Joe Craft
J Immunol (2017) 198 (7): 2578–2588.
Dependence of Glomerulonephritis Induction on Novel Intraglomerular Alternatively Activated Bone Marrow–Derived Macrophages and Mac-1 and PD-L1 in Lupus-Prone NZM2328 Mice
Sun-sang J. Sung; Yan Ge; Chao Dai; Hongyang Wang; Shu Man Fu; Rahul Sharma; Young S. Hahn; Jing Yu; Thu H. Le; Mark D. Okusa; Warren K. Bolton; Jessica R. Lawler
J Immunol (2017) 198 (7): 2589–2601.
BAFF Induces Tertiary Lymphoid Structures and Positions T Cells within the Glomeruli during Lupus Nephritis
J Immunol (2017) 198 (7): 2602–2611.
Activation and Functional Specialization of Regulatory T Cells Lead to the Generation of Foxp3 Instability
J Immunol (2017) 198 (7): 2612–2625.
MicroRNA-15b Suppresses Th17 Differentiation and Is Associated with Pathogenesis of Multiple Sclerosis by Targeting O-GlcNAc Transferase
Ruiqiong Liu; Xiaofeng Ma; Li Chen; Yang Yang; Yi Zeng; Jie Gao; Wei Jiang; Fang Zhang; Daojing Li; Bin Han; Ranran Han; Rongfang Qiu; Wei Huang; Yan Wang; Junwei Hao
J Immunol (2017) 198 (7): 2626–2639.
CLINICAL AND HUMAN IMMUNOLOGY
β2 Glycoprotein I Recognition Drives Th1 Inflammation in Atherosclerotic Plaques of Patients with Primary Antiphospholipid Syndrome
Marisa Benagiano; Maria Gerosa; Jacopo Romagnoli; Michael Mahler; Maria O. Borghi; Alessia Grassi; Chiara Della Bella; Giacomo Emmi; Amedeo Amedei; Elena Silvestri; Lorenzo Emmi; Domenico Prisco; Pier Luigi Meroni; Mario M. D’Elios
J Immunol (2017) 198 (7): 2640–2648.
IMMUNE REGULATION
Metformin Suppresses Systemic Autoimmunity in Roquinsan/san Mice through Inhibiting B Cell Differentiation into Plasma Cells via Regulation of AMPK/mTOR/STAT3
Seon-Yeong Lee; Su-Jin Moon; Eun-Kyung Kim; Hyeon-Beom Seo; Eun-Ji Yang; Hye-Jin Son; Jae-Kyung Kim; Jun-Ki Min; Sung-Hwan Park; Mi-La Cho
J Immunol (2017) 198 (7): 2661–2670.
Antigen Density Dictates Immune Responsiveness following Red Blood Cell Transfusion
Connie M. Arthur; Seema R. Patel; Nicole H. Smith; Ashley Bennett; Nourine A. Kamili; Amanda Mener; Christian Gerner-Smidt; Harold C. Sullivan; J. Scott Hale; Andreas Wieland; Benjamin Youngblood; James C. Zimring; Jeanne E. Hendrickson; Sean R. Stowell
J Immunol (2017) 198 (7): 2671–2680.
IL-13–Mediated Regulation of Learning and Memory
Tiroyaone M. Brombacher; Justin K. Nono; Keisha S. De Gouveia; Nokuthula Makena; Matthew Darby; Jacqueline Womersley; Ousman Tamgue; Frank Brombacher
J Immunol (2017) 198 (7): 2681–2688.
Exopolysaccharide from Bacillus subtilis Induces Anti-Inflammatory M2 Macrophages That Prevent T Cell–Mediated Disease
J Immunol (2017) 198 (7): 2689–2698.
Inducible T Cell Kinase Regulates the Acquisition of Cytolytic Capacity and Degranulation in CD8+ CTLs
J Immunol (2017) 198 (7): 2699–2711.
Epigenetic Component p66a Modulates Myeloid-Derived Suppressor Cells by Modifying STAT3
J Immunol (2017) 198 (7): 2712–2720.
Normal Thymocyte Egress, T Cell Trafficking, and CD4+ T Cell Homeostasis Require Interactions between RGS Proteins and Gαi2
J Immunol (2017) 198 (7): 2721–2734.
Inhibiting Oxidative Phosphorylation In Vivo Restrains Th17 Effector Responses and Ameliorates Murine Colitis
Luigi Franchi; Ivan Monteleone; Ling-Yang Hao; Mark A. Spahr; Wenpu Zhao; Xikui Liu; Kellie Demock; Aditi Kulkarni; Chuck A. Lesch; Brian Sanchez; Laura Carter; Irene Marafini; Xiao Hu; Oksana Mashadova; Min Yuan; John M. Asara; Harinder Singh; Costas A. Lyssiotis; Giovanni Monteleone; Anthony W. Opipari; Gary D. Glick
J Immunol (2017) 198 (7): 2735–2746.
IMMUNE SYSTEM DEVELOPMENT
Roquin Paralogs Differentially Regulate Functional NKT Cell Subsets
Christoph Drees; J. Christoph Vahl; Sabrina Bortoluzzi; Klaus D. Heger; Julius C. Fischer; F. Thomas Wunderlich; Christian Peschel; Marc Schmidt-Supprian
J Immunol (2017) 198 (7): 2747–2759.
IMMUNOTHERAPY AND VACCINES
Novel Adjuvant Based on the Pore-Forming Protein Sticholysin II Encapsulated into Liposomes Effectively Enhances the Antigen-Specific CTL-Mediated Immune Response
Rady J. Laborde; Oraly Sanchez-Ferras; María C. Luzardo; Yoelys Cruz-Leal; Audry Fernández; Circe Mesa; Liliana Oliver; Liem Canet; Liane Abreu-Butin; Catarina V. Nogueira; Mayra Tejuca; Fabiola Pazos; Carlos Álvarez; María E. Alonso; Ieda M. Longo-Maugéri; Michael N. Starnbach; Darren E. Higgins; Luis E. Fernández; María E. Lanio
J Immunol (2017) 198 (7): 2772–2784.
Targeting Influenza Virus Hemagglutinin to Xcr1+ Dendritic Cells in the Absence of Receptor-Mediated Endocytosis Enhances Protective Antibody Responses
Arnar Gudjonsson; Anna Lysén; Sreekumar Balan; Vibeke Sundvold-Gjerstad; Catharina Arnold-Schrauf; Lisa Richter; Espen S. Bækkevold; Marc Dalod; Bjarne Bogen; Even Fossum
J Immunol (2017) 198 (7): 2785–2795.
INFECTIOUS DISEASE AND HOST RESPONSE
Monocytes Are the Predominant Cell Type Associated with Listeria monocytogenes in the Gut, but They Do Not Serve as an Intracellular Growth Niche
J Immunol (2017) 198 (7): 2796–2804.
Rapid and Rigorous IL-17A Production by a Distinct Subpopulation of Effector Memory T Lymphocytes Constitutes a Novel Mechanism of Toxic Shock Syndrome Immunopathology
Peter A. Szabo; Ankur Goswami; Delfina M. Mazzuca; Kyoungok Kim; David B. O’Gorman; David A. Hess; Ian D. Welch; Howard A. Young; Bhagirath Singh; John K. McCormick; S. M. Mansour Haeryfar
J Immunol (2017) 198 (7): 2805–2818.
INNATE IMMUNITY AND INFLAMMATION
Monocyte Subsets Coregulate Inflammatory Responses by Integrated Signaling through TNF and IL-6 at the Endothelial Cell Interface
Myriam Chimen; Clara M. Yates; Helen M. McGettrick; Lewis S. C. Ward; Matthew J. Harrison; Bonita Apta; Lea H. Dib; Beat A. Imhof; Paul Harrison; Gerard B. Nash; G. Ed Rainger
J Immunol (2017) 198 (7): 2834–2843.
DNA Repair Interacts with Autophagy To Regulate Inflammatory Responses to Pulmonary Hyperoxia
Yan Ye; Ping Lin; Weidong Zhang; Shirui Tan; Xikun Zhou; Rongpeng Li; Qinqin Pu; Jonathan L. Koff; Archana Dhasarathy; Feng Ma; Xin Deng; Jianxin Jiang; Min Wu
J Immunol (2017) 198 (7): 2844–2853.
Reactive Oxygen Species–Producing Myeloid Cells Act as a Bone Marrow Niche for Sterile Inflammation–Induced Reactive Granulopoiesis
Haiyan Zhu; Hyun-Jeong Kwak; Peng Liu; Besnik Bajrami; Yuanfu Xu; Shin-Young Park; Cesar Nombela-Arrieta; Subhanjan Mondal; Hiroto Kambara; Hongbo Yu; Li Chai; Leslie E. Silberstein; Tao Cheng; Hongbo R. Luo
J Immunol (2017) 198 (7): 2854–2864.
Local TNFR1 Signaling Licenses Murine Neutrophils for Increased TLR-Dependent Cytokine and Eicosanoid Production
J Immunol (2017) 198 (7): 2865–2875.
Surfactant Protein A Inhibits Growth and Adherence of Uropathogenic Escherichia coli To Protect the Bladder from Infection
Jiro Hashimoto; Motoko Takahashi; Atsushi Saito; Masaki Murata; Yuichiro Kurimura; Chiaki Nishitani; Rina Takamiya; Yasuaki Uehara; Yoshihiro Hasegawa; Yoshiki Hiyama; Norimasa Sawada; Satoshi Takahashi; Naoya Masumori; Yoshio Kuroki; Shigeru Ariki
J Immunol (2017) 198 (7): 2898–2905.
Inhibition of Inflammatory Gene Transcription by IL-10 Is Associated with Rapid Suppression of Lipopolysaccharide-Induced Enhancer Activation
J Immunol (2017) 198 (7): 2906–2915.
Deficiency in IL-1 Receptor Type 2 Aggravates K/BxN Serum Transfer-Induced Arthritis in Mice but Has No Impact on Systemic Inflammatory Responses
Praxedis Martin; Gaby Palmer; Emiliana Rodriguez; Christian Alexander Seemayer; Jennifer Palomo; Dominique Talabot-Ayer; Cem Gabay
J Immunol (2017) 198 (7): 2916–2926.
IL-6 Regulates M2 Polarization and Local Proliferation of Adipose Tissue Macrophages in Obesity
Julia Braune; Ulrike Weyer; Constance Hobusch; Jan Mauer; Jens C. Brüning; Ingo Bechmann; Martin Gericke
J Immunol (2017) 198 (7): 2927–2934.
An Infectious Disease–Associated Il12b Polymorphism Regulates IL-12/23 p40 Transcription Involving Poly(ADP-Ribose) Polymerase 1
J Immunol (2017) 198 (7): 2935–2942.
MOLECULAR AND STRUCTURAL IMMUNOLOGY
Immature Lymphocytes Inhibit Rag1 and Rag2 Transcription and V(D)J Recombination in Response to DNA Double-Strand Breaks
J Immunol (2017) 198 (7): 2943–2956.
TUMOR IMMUNOLOGY
The Ribosomal Protein S19 Suppresses Antitumor Immune Responses via the Complement C5a Receptor 1
Maciej M. Markiewski; Surya Kumari Vadrevu; Sharad K. Sharma; Navin Kumar Chintala; Shanawaz Ghouse; Jun-Hung Cho; David P. Fairlie; Yvonne Paterson; Aristotelis Astrinidis; Magdalena Karbowniczek
J Immunol (2017) 198 (7): 2989–2999.
CORRECTIONS
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Cover Image
Cover Image
On the cover: Confocal microscopy of the thymus of wild-type mice reconstituted with G184S bone marrow previously immunostained for CD3 (blue), CD4 (green), CD8 (red), and UEA1 (white). The section shown is captured from the tiled entire thymus image. Hwang, I.-Y., C. Park, K. Harrison, and J. H. Kehrl. 2017. Normal thymocyte egress, T cell trafficking, and CD4+ T cell homeostasis require interactions between RGS proteins and Gαi2. J. Immunol. 198: 2721–2734.
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