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Volume 199, Issue 1
1 July 2017
Issue Cover
ISSN 0022-1767
EISSN 1550-6606

IN THIS ISSUE

In This Issue
J Immunol (2017) 199 (1): 1–2.
View articletitled, In This Issue
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PILLARS OF IMMUNOLOGY

Access Guide to Antigen Receptor Genes
Ranjan Sen
J Immunol (2017) 199 (1): 3–4.
View articletitled, Access Guide to Antigen Receptor Genes
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Pillars Article: A Role for Histone Acetylation in the Developmental Regulation of V(D)J Recombination. Science. 2000. 287: 495-498
Michelle Taylor McMurry; Michael S. Krangel
J Immunol (2017) 199 (1): 5–8.
View articletitled, Pillars Article: A Role for Histone Acetylation in the Developmental Regulation of V(D)J Recombination. <em>Science</em>. 2000. 287: 495-498
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BRIEF REVIEWS

Inducing Mucosal IgA: A Challenge for Vaccine Adjuvants and Delivery Systems
Prosper N. Boyaka
J Immunol (2017) 199 (1): 9–16.
View articletitled, Inducing Mucosal IgA: A Challenge for Vaccine Adjuvants and Delivery Systems
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Macrophage-Mediated Inflammation in Normal and Diabetic Wound Healing
Anna E. Boniakowski; Andrew S. Kimball; Benjamin N. Jacobs; Steven L. Kunkel; Katherine A. Gallagher
J Immunol (2017) 199 (1): 17–24.
View articletitled, Macrophage-Mediated Inflammation in Normal and Diabetic Wound Healing
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CUTTING EDGE

Cutting Edge: Origins, Recruitment, and Regulation of CD11c+ Cells in Inflamed Islets of Autoimmune Diabetes Mice
Joanna E. Klementowicz; Ashley E. Mahne; Allyson Spence; Vinh Nguyen; Ansuman T. Satpathy; Kenneth M. Murphy; Qizhi Tang
J Immunol (2017) 199 (1): 27–32.
View articletitled, Cutting Edge: Origins, Recruitment, and Regulation of CD11c<sup>+</sup> Cells in Inflamed Islets of Autoimmune Diabetes Mice
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Cutting Edge: Dual TCRα Expression Poses an Autoimmune Hazard by Limiting Regulatory T Cell Generation
Nathaniel J. Schuldt; Jennifer L. Auger; Justin A. Spanier; Tijana Martinov; Elise R. Breed; Brian T. Fife; Kristin A. Hogquist; Bryce A. Binstadt
J Immunol (2017) 199 (1): 33–38.
View articletitled, Cutting Edge: Dual TCRα Expression Poses an Autoimmune Hazard by Limiting Regulatory T Cell Generation
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ALLERGY AND OTHER HYPERSENSITIVITIES

Aeroallergens Induce Reactive Oxygen Species Production and DNA Damage and Dampen Antioxidant Responses in Bronchial Epithelial Cells
Tze Khee Chan; W. S. Daniel Tan; Hong Yong Peh; W. S. Fred Wong
J Immunol (2017) 199 (1): 39–47.
View articletitled, Aeroallergens Induce Reactive Oxygen Species Production and DNA Damage and Dampen Antioxidant Responses in Bronchial Epithelial Cells
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Airway Epithelial Cells Are Crucial Targets of Glucocorticoids in a Mouse Model of Allergic Asthma
Carina Klaßen; Anna Karabinskaya; Lien Dejager; Sabine Vettorazzi; Justine Van Moorleghem; Fred Lühder; Sebastiaan H. Meijsing; Jan P. Tuckermann; Hanibal Bohnenberger; Claude Libert; Holger M. Reichardt
J Immunol (2017) 199 (1): 48–61.
View articletitled, Airway Epithelial Cells Are Crucial Targets of Glucocorticoids in a Mouse Model of Allergic Asthma
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Occludin Expression in Epidermal γδ T Cells in Response to Epidermal Stress Causes Them To Migrate into Draining Lymph Nodes
Takahito Saito; Michihiro Yano; Yutaro Ohki; Michio Tomura; Naoko Nakano
J Immunol (2017) 199 (1): 62–71.
View articletitled, Occludin Expression in Epidermal γδ T Cells in Response to Epidermal Stress Causes Them To Migrate into Draining Lymph Nodes
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AUTOIMMUNITY

Critical Role of P2Y12 Receptor in Regulation of Th17 Differentiation and Experimental Autoimmune Encephalomyelitis Pathogenesis
Chaoyan Qin; Jinfeng Zhou; Yuan Gao; Weiming Lai; Cuixia Yang; Yingying Cai; Shuai Chen; Changsheng Du
J Immunol (2017) 199 (1): 72–81.
View articletitled, Critical Role of P2Y<sub>12</sub> Receptor in Regulation of Th17 Differentiation and Experimental Autoimmune Encephalomyelitis Pathogenesis
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A Novel α9 Integrin Ligand, XCL1/Lymphotactin, Is Involved in the Development of Murine Models of Autoimmune Diseases
Naoki Matsumoto; Shigeyuki Kon; Takuya Nakatsuru; Tomoe Miyashita; Kyosuke Inui; Kodai Saitoh; Yuichi Kitai; Ryuta Muromoto; Jun-ichi Kashiwakura; Toshimitsu Uede; Tadashi Matsuda
J Immunol (2017) 199 (1): 82–90.
View articletitled, A Novel α9 Integrin Ligand, XCL1/Lymphotactin, Is Involved in the Development of Murine Models of Autoimmune Diseases
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Antigen-Specific T Cell Analysis Reveals That Active Immune Responses to β Cell Antigens Are Focused on a Unique Set of Epitopes
Junbao Yang; Xiaomin Wen; Hengyu Xu; Nadia Torres-Chinn; Cate Speake; Carla J. Greenbaum; Gerald T. Nepom; William W. Kwok
J Immunol (2017) 199 (1): 91–96.
View articletitled, Antigen-Specific T Cell Analysis Reveals That Active Immune Responses to β Cell Antigens Are Focused on a Unique Set of Epitopes
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CLINICAL AND HUMAN IMMUNOLOGY

Autoreactivity to Sulfatide by Human Invariant NKT Cells
Annelein M. Stax; Jessica Tuengel; Enrico Girardi; Naoki Kitano; Lenka L. Allan; Victor Liu; Dongjun Zheng; William J. Panenka; Joren Guillaume; Chi-Huey Wong; Serge van Calenbergh; Dirk M. Zajonc; Peter van den Elzen
J Immunol (2017) 199 (1): 97–106.
View articletitled, Autoreactivity to Sulfatide by Human Invariant NKT Cells
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Controlled Human Malaria Infection Leads to Long-Lasting Changes in Innate and Innate-like Lymphocyte Populations
Maxmillian Mpina; Nicholas J. Maurice; Masanao Yajima; Chloe K. Slichter; Hannah W. Miller; Mukta Dutta; M. Juliana McElrath; Kenneth D. Stuart; Stephen C. De Rosa; John P. McNevin; Peter S. Linsley; Salim Abdulla; Marcel Tanner; Stephen L. Hoffman; Raphael Gottardo; Claudia A. Daubenberger; Martin Prlic
J Immunol (2017) 199 (1): 107–118.
View articletitled, Controlled Human Malaria Infection Leads to Long-Lasting Changes in Innate and Innate-like Lymphocyte Populations
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IMMUNE REGULATION

Viral RNA–Unprimed Rig-I Restrains Stat3 Activation in the Modulation of Regulatory T Cell/Th17 Cell Balance
Hui Yang; He-Zhou Guo; Xian-Yang Li; Jian Lin; Wu Zhang; Jun-Mei Zhao; Hong-Xin Zhang; Sai-Juan Chen; Zhu Chen; Jiang Zhu
J Immunol (2017) 199 (1): 119–128.
View articletitled, Viral RNA–Unprimed Rig-I Restrains Stat3 Activation in the Modulation of Regulatory T Cell/Th17 Cell Balance
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T Cells Deficient in the Tyrosine Phosphatase SHP-1 Resist Suppression by Regulatory T Cells
Emily R. Mercadante; Ulrike M. Lorenz
J Immunol (2017) 199 (1): 129–137.
View articletitled, T Cells Deficient in the Tyrosine Phosphatase SHP-1 Resist Suppression by Regulatory T Cells
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Physiologic Thymic Involution Underlies Age-Dependent Accumulation of Senescence-Associated CD4+ T Cells
Kyosuke Sato; Aiko Kato; Miho Sekai; Yoko Hamazaki; Nagahiro Minato
J Immunol (2017) 199 (1): 138–148.
View articletitled, Physiologic Thymic Involution Underlies Age-Dependent Accumulation of Senescence-Associated CD4<sup>+</sup> T Cells
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SOCS1 Is a Key Molecule That Prevents Regulatory T Cell Plasticity under Inflammatory Conditions
Reiko Takahashi; Hiroko Nakatsukasa; Shunichi Shiozawa; Akihiko Yoshimura
J Immunol (2017) 199 (1): 149–158.
View articletitled, SOCS1 Is a Key Molecule That Prevents Regulatory T Cell Plasticity under Inflammatory Conditions
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Monoclonal Invariant NKT (iNKT) Cell Mice Reveal a Role for Both Tissue of Origin and the TCR in Development of iNKT Functional Subsets
Eleanor Clancy-Thompson; Gui Zhen Chen; Paul M. Tyler; Mariah M. Servos; Marta Barisa; Patrick J. Brennan; Hidde L. Ploegh; Stephanie K. Dougan
J Immunol (2017) 199 (1): 159–171.
View articletitled, Monoclonal Invariant NKT (iNKT) Cell Mice Reveal a Role for Both Tissue of Origin and the TCR in Development of iNKT Functional Subsets
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IMMUNE SYSTEM DEVELOPMENT

The Influence of MHC Class II on B Cell Defects Induced by Invariant Chain/CD74 N-Terminal Fragments
Janna Schneppenheim; Ann-Christine Loock; Susann Hüttl; Michaela Schweizer; Renate Lüllmann-Rauch; Hans-Heinrich Oberg; Philipp Arnold; Christian H. K. Lehmann; Diana Dudziak; Dieter Kabelitz; Ralph Lucius; Ana-Maria Lennon-Duménil; Paul Saftig; Bernd Schröder
J Immunol (2017) 199 (1): 172–185.
View articletitled, The Influence of MHC Class II on B Cell Defects Induced by Invariant Chain/CD74 N-Terminal Fragments
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IMMUNOTHERAPY AND VACCINES

Bolstering the Number and Function of HSV-1–Specific CD8+ Effector Memory T Cells and Tissue-Resident Memory T Cells in Latently Infected Trigeminal Ganglia Reduces Recurrent Ocular Herpes Infection and Disease
Arif A. Khan; Ruchi Srivastava; Aziz A. Chentoufi; Elizabeth Kritzer; Sravya Chilukuri; Sumit Garg; David C. Yu; Hawa Vahed; Lei Huang; Sabrina A. Syed; Julie N. Furness; Tien T. Tran; Nesburn B. Anthony; Christine E. McLaren; John Sidney; Alessandro Sette; Randolph J. Noelle; Lbachir BenMohamed
J Immunol (2017) 199 (1): 186–203.
View articletitled, Bolstering the Number and Function of HSV-1–Specific CD8<sup>+</sup> Effector Memory T Cells and Tissue-Resident Memory T Cells in Latently Infected Trigeminal Ganglia Reduces Recurrent Ocular Herpes Infection and Disease
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Enhanced Effector Functions Due to Antibody Defucosylation Depend on the Effector Cell Fcγ Receptor Profile
Christine W. Bruggeman; Gillian Dekkers; Arthur E. H. Bentlage; Louise W. Treffers; Sietse Q. Nagelkerke; Suzanne Lissenberg-Thunnissen; Carolien A. M. Koeleman; Manfred Wuhrer; Timo K. van den Berg; Theo Rispens; Gestur Vidarsson; Taco W. Kuijpers
J Immunol (2017) 199 (1): 204–211.
View articletitled, Enhanced Effector Functions Due to Antibody Defucosylation Depend on the Effector Cell Fcγ Receptor Profile
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INFECTIOUS DISEASE AND HOST RESPONSE

Heme Oxygenase-1 Modulates Human Respiratory Syncytial Virus Replication and Lung Pathogenesis during Infection
Janyra A. Espinoza; Miguel A. León; Pablo F. Céspedes; Roberto S. Gómez; Gisela Canedo-Marroquín; Sebastían A. Riquelme; Francisco J. Salazar-Echegarai; Phillipe Blancou; Thomas Simon; Ignacio Anegon; Margarita K. Lay; Pablo A. González; Claudia A. Riedel; Susan M. Bueno; Alexis M. Kalergis
J Immunol (2017) 199 (1): 212–223.
View articletitled, Heme Oxygenase-1 Modulates Human Respiratory Syncytial Virus Replication and Lung Pathogenesis during Infection
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The Role of Shed PrPc in the Neuropathogenesis of HIV Infection
Bezawit W. Megra; Eliseo A. Eugenin; Joan W. Berman
J Immunol (2017) 199 (1): 224–232.
View articletitled, The Role of Shed PrP<sup>c</sup> in the Neuropathogenesis of HIV Infection
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Lung CD4 Tissue-Resident Memory T Cells Mediate Adaptive Immunity Induced by Previous Infection of Mice with Bordetella pertussis
Mieszko M. Wilk; Alicja Misiak; Róisín M. McManus; Aideen C. Allen; Marina A. Lynch; Kingston H. G. Mills
J Immunol (2017) 199 (1): 233–243.
View articletitled, Lung CD4 Tissue-Resident Memory T Cells Mediate Adaptive Immunity Induced by Previous Infection of Mice with <em>Bordetella pertussis</em>
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T Follicular Helper Cell–Derived IL-4 Is Required for IgE Production during Intestinal Helminth Infection
Alexandre P. Meli; Ghislaine Fontés; Cindy Leung Soo; Irah L. King
J Immunol (2017) 199 (1): 244–252.
View articletitled, T Follicular Helper Cell–Derived IL-4 Is Required for IgE Production during Intestinal Helminth Infection
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INNATE IMMUNITY AND INFLAMMATION

CXCL4 Exposure Potentiates TLR-Driven Polarization of Human Monocyte-Derived Dendritic Cells and Increases Stimulation of T Cells
Sandra C. Silva-Cardoso; Alsya J. Affandi; Lotte Spel; Marta Cossu; Joel A. G. van Roon; Marianne Boes; Timothy R. D. J. Radstake
J Immunol (2017) 199 (1): 253–262.
View articletitled, CXCL4 Exposure Potentiates TLR-Driven Polarization of Human Monocyte-Derived Dendritic Cells and Increases Stimulation of T Cells
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SLC46 Family Transporters Facilitate Cytosolic Innate Immune Recognition of Monomeric Peptidoglycans
Donggi Paik; Amanda Monahan; Daniel R. Caffrey; Roland Elling; William E. Goldman; Neal Silverman
J Immunol (2017) 199 (1): 263–270.
View articletitled, SLC46 Family Transporters Facilitate Cytosolic Innate Immune Recognition of Monomeric Peptidoglycans
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Golgi-Associated Protein Kinase C-ε Is Delivered to Phagocytic Cups: Role of Phosphatidylinositol 4-Phosphate
Cheryl M. Hanes; Anna E. D’Amico; Takehiko Ueyama; Alexander C. Wong; Xuexin Zhang; W. Frederick Hynes; Margarida M. Barroso; Nathaniel C. Cady; Mohamed Trebak; Naoaki Saito; Michelle R. Lennartz
J Immunol (2017) 199 (1): 271–277.
View articletitled, Golgi-Associated Protein Kinase C-ε Is Delivered to Phagocytic Cups: Role of Phosphatidylinositol 4-Phosphate
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TLR-Induced Murine Dendritic Cell (DC) Activation Requires DC-Intrinsic Complement
Joong-Hyuk Sheen; Michael G. Strainic; Jinbo Liu; Weijia Zhang; Zhengzi Yi; M. Edward Medof; Peter S. Heeger
J Immunol (2017) 199 (1): 278–291.
View articletitled, TLR-Induced Murine Dendritic Cell (DC) Activation Requires DC-Intrinsic Complement
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MOLECULAR AND STRUCTURAL IMMUNOLOGY

FHR-1 Binds to C-Reactive Protein and Enhances Rather than Inhibits Complement Activation
Ádám I. Csincsi; Zsóka Szabó; Zsófia Bánlaki; Barbara Uzonyi; Marcell Cserhalmi; Éva Kárpáti; Agustín Tortajada; Joseph J. E. Caesar; Zoltán Prohászka; T. Sakari Jokiranta; Susan M. Lea; Santiago Rodríguez de Córdoba; Mihály Józsi
J Immunol (2017) 199 (1): 292–303.
View articletitled, FHR-1 Binds to C-Reactive Protein and Enhances Rather than Inhibits Complement Activation
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MUCOSAL IMMUNOLOGY

IL-6 Signaling Regulates Small Intestinal Crypt Homeostasis
Victoria Jeffery; Andrew J. Goldson; Jack R. Dainty; Marcello Chieppa; Anastasia Sobolewski
J Immunol (2017) 199 (1): 304–311.
View articletitled, IL-6 Signaling Regulates Small Intestinal Crypt Homeostasis
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Selective Induction of Homeostatic Th17 Cells in the Murine Intestine by Cholera Toxin Interacting with the Microbiota
Qing Zhao; Stacey N. Harbour; Raivo Kolde; Isabel J. Latorre; Hein M. Tun; Trenton R. Schoeb; Henrietta Turner; James J. Moon; Ehsan Khafipour; Ramnik J. Xavier; Casey T. Weaver; Charles O. Elson
J Immunol (2017) 199 (1): 312–322.
View articletitled, Selective Induction of Homeostatic Th17 Cells in the Murine Intestine by Cholera Toxin Interacting with the Microbiota
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SYSTEMS IMMUNOLOGY

Single-Cell RNA Sequencing Reveals Expanded Clones of Islet Antigen-Reactive CD4+ T Cells in Peripheral Blood of Subjects with Type 1 Diabetes
Karen Cerosaletti; Fariba Barahmand-pour-Whitman; Junbao Yang; Hannah A. DeBerg; Matthew J. Dufort; Sara A. Murray; Elisabeth Israelsson; Cate Speake; Vivian H. Gersuk; James A. Eddy; Helena Reijonen; Carla J. Greenbaum; William W. Kwok; Erik Wambre; Martin Prlic; Raphael Gottardo; Gerald T. Nepom; Peter S. Linsley
J Immunol (2017) 199 (1): 323–335.
View articletitled, Single-Cell RNA Sequencing Reveals Expanded Clones of Islet Antigen-Reactive CD4<sup>+</sup> T Cells in Peripheral Blood of Subjects with Type 1 Diabetes
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TRANSPLANTATION

Host-Derived CD70 Suppresses Murine Graft-versus-Host Disease by Limiting Donor T Cell Expansion and Effector Function
Nicholas D. Leigh; Rachel E. O’Neill; Wei Du; Chuan Chen; Jingxin Qiu; Jonathan D. Ashwell; Philip L. McCarthy; George L. Chen; Xuefang Cao
J Immunol (2017) 199 (1): 336–347.
View articletitled, Host-Derived CD70 Suppresses Murine Graft-versus-Host Disease by Limiting Donor T Cell Expansion and Effector Function
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NOVEL IMMUNOLOGICAL METHODS

Comprehensive Approach for Identifying the T Cell Subset Origin of CD3 and CD28 Antibody–Activated Chimeric Antigen Receptor–Modified T Cells
Michael Schmueck-Henneresse; Bilal Omer; Thomas Shum; Haruko Tashiro; Maksim Mamonkin; Natalia Lapteva; Sandhya Sharma; Lisa Rollins; Gianpietro Dotti; Petra Reinke; Hans-Dieter Volk; Cliona M. Rooney
J Immunol (2017) 199 (1): 348–362.
View articletitled, Comprehensive Approach for Identifying the T Cell Subset Origin of CD3 and CD28 Antibody–Activated Chimeric Antigen Receptor–Modified T Cells
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LETTERS OF RETRACTION

Retraction: Adora2b Adenosine Receptor Signaling Protects during Acute Kidney Injury via Inhibition of Neutrophil-Dependent TNF-α Release
J Immunol (2017) 199 (1): 363.
View articletitled, Retraction: Adora2b Adenosine Receptor Signaling Protects during Acute Kidney Injury via Inhibition of Neutrophil-Dependent TNF-α Release
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  • Cover Image

    Cover Image

    issue cover

    On the cover: Mice with an inducible deletion of the glucocorticoid receptor in alveolar type 2 cells were immunized and challenged with OVA to induce allergic airway inflammation. Leukocyte infiltration into the lung, bronchoconstriction and enhanced mucus production (Muc5B stained in brown) in mutant mice largely failed to resolve after dexamethasone treatment. Klaßen, C., A. Karabinskaya, L. Dejager, S. Vettorazzi, J. Van Moorleghem, F. Lühder, S. H. Meijsing, J. P. Tuckermann, H. Bohnenberger, C. Libert, and H. M. Reichardt. 2017. Airway epithelial cells are crucial targets of glucocorticoids in a mouse model of allergic asthma. J. Immunol. 199: 48–61.

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