Cover Image

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On the cover: Location of RORγt⁺ and RORγt⁻ γδ T cells within peripheral lymph nodes from mice. Representative immunofluorescence TCRγδ (red), CD169 (blue) and RORγt-GFP (green) staining of fixed peripheral lymph node slices (maxillary lymph node is shown here). RORγt⁺ γδ T cells appear in yellow. Audemard-Verger, A., M. Rivière, A. Durand, E. Peranzoni, V. Guichard, P. Hamon, N. Bonilla, T. Guilbert, A. Boissonnas, C. Auffray, G. Eberl, B. Lucas, and B. Martin. 2017. Macrophages induce long-term trapping of γδ T cells with innate-like properties within secondary lymphoid organs in the steady state. J. Immunol. 199: 1998–2007.
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IN THIS ISSUE

In This Issue

BRIEF REVIEWS

Cytokine-Mediated Regulation of Human Lymphocyte Development and Function: Insights from Primary Immunodeficiencies

CUTTING EDGE

Cutting Edge: 2B4-Mediated Coinhibition of CD4⁺ T Cells Underlies Mortality in Experimental Sepsis

Cutting Edge: IL-2–Induced Expression of the Amino Acid Transporters SLC1A5 and CD98 Is a Prerequisite for NKG2D-Mediated Activation of Human NK Cells

Cutting Edge: Murine NK Cells Degranulate and Retain Cytotoxic Function without Store-Operated Calcium Entry

AUTOIMMUNITY

IFN-α Negatively Regulates the Expression of Endothelial Nitric Oxide Synthase and Nitric Oxide Production: Implications for Systemic Lupus Erythematosus

Notch Balances Th17 and Induced Regulatory T Cell Functions in Dendritic Cells by Regulating Aldh1a2 Expression

IMMUNE REGULATION

Macrophages Induce Long-Term Trapping of γδ T Cells with Innate-like Properties within Secondary Lymphoid Organs in the Steady State

Lamtor1 Is Critically Required for CD4⁺ T Cell Proliferation and Regulatory T Cell Suppressive Function

PD-L2 Regulates B-1 Cell Antibody Production against Phosphorylcholine through an IL-5–Dependent Mechanism

IMMUNOGENETICS

α3-Deletion Isoform of HLA-A11 Modulates Cytotoxicity of NK Cells: Correlations with HIV-1 Infection of Cells

INFECTIOUS DISEASE AND HOST RESPONSE

Resolvin D1 Improves the Resolution of Inflammation via Activating NF-κB p50/p50–Mediated Cyclooxygenase-2 Expression in Acute Respiratory Distress Syndrome

Dectin-1 Activation during Leishmania amazonensis Phagocytosis Prompts Syk-Dependent Reactive Oxygen Species Production To Trigger Inflammasome Assembly and Restriction of Parasite Replication

HIV-1 Infection Is Associated with Depletion and Functional Impairment of Mycobacterium tuberculosis–Specific CD4 T Cells in Individuals with Latent Tuberculosis Infection

Erythroid Suppressor Cells Compromise Neonatal Immune Response against Bordetella pertussis

INNATE IMMUNITY AND INFLAMMATION

The Lipid Kinase PIKfyve Coordinates the Neutrophil Immune Response through the Activation of the Rac GTPase

Extracellular MicroRNAs Induce Potent Innate Immune Responses via TLR7/MyD88-Dependent Mechanisms

DOCK8 Drives Src-Dependent NK Cell Effector Function

Integrin-Linked Kinase Expression in Myeloid Cells Promotes Inflammatory Signaling during Experimental Colitis

IL-33 Signaling Regulates Innate IL-17A and IL-22 Production via Suppression of Prostaglandin E₂ during Lung Fungal Infection

Oxidized Low-Density Lipoprotein Loading of Macrophages Downregulates TLR-Induced Proinflammatory Responses in a Gene-Specific and Temporal Manner through Transcriptional Control

MOLECULAR AND STRUCTURAL IMMUNOLOGY

Analysis of Factor D Isoforms in Malpuech–Michels–Mingarelli–Carnevale Patients Highlights the Role of MASP-3 as a Maturase in the Alternative Pathway of Complement

SYSTEMS IMMUNOLOGY

Deep Immune Profiling of an Arginine-Enriched Nutritional Intervention in Patients Undergoing Surgery

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IN THIS ISSUE

BRIEF REVIEWS

CUTTING EDGE

AUTOIMMUNITY

IMMUNE REGULATION

IMMUNOGENETICS

INFECTIOUS DISEASE AND HOST RESPONSE

INNATE IMMUNITY AND INFLAMMATION

MOLECULAR AND STRUCTURAL IMMUNOLOGY

SYSTEMS IMMUNOLOGY

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