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Volume 200, Issue 3
1 February 2018
The Journal of Immunology Cover Image for Volume 200, Issue 3
ISSN 0022-1767
EISSN 1550-6606

IN THIS ISSUE

In This Issue
J Immunol (2018) 200 (3): 883–884.
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PILLARS OF IMMUNOLOGY

Dendritic Cells on the Way to Glory
Sebastian Amigorena
J Immunol (2018) 200 (3): 885–886.
View articletitled, Dendritic Cells on the Way to Glory
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Pillars Article: Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor α. J. Exp. Med. 1994. 179:1109–1118
Federica Sallusto; Antonio Lanzavecchia
J Immunol (2018) 200 (3): 887–896.
View articletitled, Pillars Article: Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor α. <em>J. Exp. Med.</em> 1994. 179:1109–1118
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BRIEF REVIEWS

The Hypoxia–Adenosine Link during Intestinal Inflammation
Jessica L. Bowser; Luan H. Phan; Holger K. Eltzschig
J Immunol (2018) 200 (3): 897–907.
View articletitled, The Hypoxia–Adenosine Link during Intestinal Inflammation
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CUTTING EDGE

Cutting Edge: Low-Affinity TCRs Support Regulatory T Cell Function in Autoimmunity
Maran L. Sprouse; Ivan Shevchenko; Marissa A. Scavuzzo; Faith Joseph; Thomas Lee; Samuel Blum; Malgorzata Borowiak; Matthew L. Bettini; Maria Bettini
J Immunol (2018) 200 (3): 909–914.
View articletitled, Cutting Edge: Low-Affinity TCRs Support Regulatory T Cell Function in Autoimmunity
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ALLERGY AND OTHER HYPERSENSITIVITIES

Type 2 Cysteinyl Leukotriene Receptors Drive IL-33–Dependent Type 2 Immunopathology and Aspirin Sensitivity
Tao Liu; Nora A. Barrett; Yoshihide Kanaoka; Eri Yoshimoto; Denise Garofalo; Haley Cirka; Chunli Feng; Joshua A. Boyce
J Immunol (2018) 200 (3): 915–927.
View articletitled, Type 2 Cysteinyl Leukotriene Receptors Drive IL-33–Dependent Type 2 Immunopathology and Aspirin Sensitivity
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ANTIGEN RECOGNITION AND RESPONSES

Inhibition of the Deubiquitinase Usp14 Diminishes Direct MHC Class I Antigen Presentation
Amy L. Palmer; Annemieke de Jong; Yves Leestemaker; Paul P. Geurink; Ruud H. Wijdeven; Huib Ovaa; Brian P. Dolan
J Immunol (2018) 200 (3): 928–936.
View articletitled, Inhibition of the Deubiquitinase Usp14 Diminishes Direct MHC Class I Antigen Presentation
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B Cell–Intrinsic MyD88 Signaling Promotes Initial Cell Proliferation and Differentiation To Enhance the Germinal Center Response to a Virus-like Particle
Meijie Tian; Zhaolin Hua; Sheng Hong; Zhimin Zhang; Can Liu; Lin Lin; Jiaorong Chen; Wei Zhang; Xuyu Zhou; Fuping Zhang; Anthony L. DeFranco; Baidong Hou
J Immunol (2018) 200 (3): 937–948.
View articletitled, B Cell–Intrinsic MyD88 Signaling Promotes Initial Cell Proliferation and Differentiation To Enhance the Germinal Center Response to a Virus-like Particle
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Murine Red Blood Cells Lack Ligands for B Cell Siglecs, Allowing Strong Activation by Erythrocyte Surface Antigens
Fernando Spiller; Corwin M. Nycholat; Chika Kikuchi; James C. Paulson; Matthew S. Macauley
J Immunol (2018) 200 (3): 949–956.
View articletitled, Murine Red Blood Cells Lack Ligands for B Cell Siglecs, Allowing Strong Activation by Erythrocyte Surface Antigens
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AUTOIMMUNITY

Antibody-Mediated Neutralization of uPA Proteolytic Function Reduces Disease Progression in Mouse Arthritis Models
Kasper Almholt; Josephine B. Hebsgaard; Anneline Nansen; Christina Andersson; Jesper Pass; Birgitte Rønø; Peter Thygesen; Hermann Pelzer; Mette Loftager; Ida K. Lund; Gunilla Høyer-Hansen; Thomas Frisch; Claus H. Jensen; Kristian S. Otte; Niels H. Søe; Else M. Bartels; Martin Andersen; Henning Bliddal; Pernille A. Usher
J Immunol (2018) 200 (3): 957–965.
View articletitled, Antibody-Mediated Neutralization of uPA Proteolytic Function Reduces Disease Progression in Mouse Arthritis Models
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GM-CSF Promotes Chronic Disability in Experimental Autoimmune Encephalomyelitis by Altering the Composition of Central Nervous System–Infiltrating Cells, but Is Dispensable for Disease Induction
Patrick C. Duncker; Joshua S. Stoolman; Amanda K. Huber; Benjamin M. Segal
J Immunol (2018) 200 (3): 966–973.
View articletitled, GM-CSF Promotes Chronic Disability in Experimental Autoimmune Encephalomyelitis by Altering the Composition of Central Nervous System–Infiltrating Cells, but Is Dispensable for Disease Induction
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Production of IL-17 by MAIT Cells Is Increased in Multiple Sclerosis and Is Associated with IL-7 Receptor Expression
Anne Willing; Jan Jäger; Stefanie Reinhardt; Nina Kursawe; Manuel A. Friese
J Immunol (2018) 200 (3): 974–982.
View articletitled, Production of IL-17 by MAIT Cells Is Increased in Multiple Sclerosis and Is Associated with IL-7 Receptor Expression
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IMMUNE REGULATION

Select Clr-g Expression on Activated Dendritic Cells Facilitates Cognate Interaction with a Minor Subset of Splenic NK Cells Expressing the Inhibitory Nkrp1g Receptor
Miriam E. Friede; Stefan Leibelt; Diana Dudziak; Alexander Steinle
J Immunol (2018) 200 (3): 983–996.
View articletitled, Select Clr-g Expression on Activated Dendritic Cells Facilitates Cognate Interaction with a Minor Subset of Splenic NK Cells Expressing the Inhibitory Nkrp1g Receptor
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Novel TCR-Mediated Mechanisms of Notch Activation and Signaling
Martin Peter Steinbuck; Ksenia Arakcheeva; Susan Winandy
J Immunol (2018) 200 (3): 997–1007.
View articletitled, Novel TCR-Mediated Mechanisms of Notch Activation and Signaling
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Human M2 Macrophages Limit NK Cell Effector Functions through Secretion of TGF-β and Engagement of CD85j
Sol Y. Nuñez; Andrea Ziblat; Florencia Secchiari; Nicolás I. Torres; Jessica M. Sierra; Ximena L. Raffo Iraolagoitia; Romina E. Araya; Carolina I. Domaica; Mercedes B. Fuertes; Norberto W. Zwirner
J Immunol (2018) 200 (3): 1008–1015.
View articletitled, Human M2 Macrophages Limit NK Cell Effector Functions through Secretion of TGF-β and Engagement of CD85j
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Deficiency of the AIM2–ASC Signal Uncovers the STING-Driven Overreactive Response of Type I IFN and Reciprocal Depression of Protective IFN-γ Immunity in Mycobacterial Infection
Shanshan Yan; Hongbo Shen; Qiaoshi Lian; Wenlong Jin; Ronghua Zhang; Xuan Lin; Wangpeng Gu; Xiaoyu Sun; Guangxun Meng; Zhigang Tian; Zheng W. Chen; Bing Sun
J Immunol (2018) 200 (3): 1016–1026.
View articletitled, Deficiency of the AIM2–ASC Signal Uncovers the STING-Driven Overreactive Response of Type I IFN and Reciprocal Depression of Protective IFN-γ Immunity in Mycobacterial Infection
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IL-4–Induced Gene 1: A Negative Immune Checkpoint Controlling B Cell Differentiation and Activation
Lloyd Bod; Laetitia Douguet; Cédric Auffray; Renée Lengagne; Fériel Bekkat; Elena Rondeau; Valérie Molinier-Frenkel; Flavia Castellano; Yolande Richard; Armelle Prévost-Blondel
J Immunol (2018) 200 (3): 1027–1038.
View articletitled, IL-4–Induced Gene 1: A Negative Immune Checkpoint Controlling B Cell Differentiation and Activation
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EZH2 Represses the B Cell Transcriptional Program and Regulates Antibody-Secreting Cell Metabolism and Antibody Production
Muyao Guo; Madeline J. Price; Dillon G. Patterson; Benjamin G. Barwick; Robert R. Haines; Anna K. Kania; John E. Bradley; Troy D. Randall; Jeremy M. Boss; Christopher D. Scharer
J Immunol (2018) 200 (3): 1039–1052.
View articletitled, EZH2 Represses the B Cell Transcriptional Program and Regulates Antibody-Secreting Cell Metabolism and Antibody Production
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IMMUNE SYSTEM DEVELOPMENT

A Cellular MicroRNA Facilitates Regulatory T Lymphocyte Development by Targeting the FOXP3 Promoter TATA-Box Motif
Yiwen Zhang; Weiwei Liu; Yingshi Chen; Jun Liu; Kang Wu; Lishi Su; Wanying Zhang; Yawen Jiang; Xu Zhang; Yijun Zhang; Chao Liu; Liang Tao; Bingfeng Liu; Hui Zhang
J Immunol (2018) 200 (3): 1053–1063.
View articletitled, A Cellular MicroRNA Facilitates Regulatory T Lymphocyte Development by Targeting the <em>FOXP3</em> Promoter TATA-Box Motif
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Newly Generated CD4+ T Cells Acquire Metabolic Quiescence after Thymic Egress
Shusong Zhang; Xinwei Zhang; Ke Wang; Xi Xu; Mingyang Li; Jun Zhang; Yan Zhang; Jie Hao; Xiuyuan Sun; Yingyu Chen; Xiaohui Liu; Yingjun Chang; Rong Jin; Hounan Wu; Qing Ge
J Immunol (2018) 200 (3): 1064–1077.
View articletitled, Newly Generated CD4<sup>+</sup> T Cells Acquire Metabolic Quiescence after Thymic Egress
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Identification of a Multipotent Progenitor Population in the Spleen That Is Regulated by NR4A1
Melanie D. Mumau; Ashley N. Vanderbeck; Elizabeth D. Lynch; Sophia B. Golec; Stephen G. Emerson; Jennifer A. Punt
J Immunol (2018) 200 (3): 1078–1087.
View articletitled, Identification of a Multipotent Progenitor Population in the Spleen That Is Regulated by NR4A1
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IMMUNOTHERAPY AND VACCINES

Comparison of T Cell Activities Mediated by Human TCRs and CARs That Use the Same Recognition Domains
Daniel T. Harris; Marlies V. Hager; Sheena N. Smith; Qi Cai; Jennifer D. Stone; Philipp Kruger; Melissa Lever; Omer Dushek; Thomas M. Schmitt; Philip D. Greenberg; David M. Kranz
J Immunol (2018) 200 (3): 1088–1100.
View articletitled, Comparison of T Cell Activities Mediated by Human TCRs and CARs That Use the Same Recognition Domains
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INFECTIOUS DISEASE AND HOST RESPONSE

Intestinal Inflammation-Mediated Clearance of Amebic Parasites Is Dependent on IFN-γ
Chikako Shimokawa; Masachika Senba; Seiki Kobayashi; Mihoko Kikuchi; Seiji Obi; Alex Olia; Shinjiro Hamano; Hajime Hisaeda
J Immunol (2018) 200 (3): 1101–1109.
View articletitled, Intestinal Inflammation-Mediated Clearance of Amebic Parasites Is Dependent on IFN-γ
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Both HIV-Infected and Uninfected Cells Express TRAILshort, Which Confers TRAIL Resistance upon Bystander Cells within the Microenvironment
Zilin Nie; Fatma Aboulnasr; Sekar Natesampillai; Stephen P. Burke; Ashton Krogman; Gary D. Bren; Thomas D. Y. Chung; Jeff R. Anderson; Michele K. Smart; David J. Katzmann; Govindarajan Rajagopalan; Nathan W. Cummins; Andrew D. Badley
J Immunol (2018) 200 (3): 1110–1123.
View articletitled, Both HIV-Infected and Uninfected Cells Express TRAILshort, Which Confers TRAIL Resistance upon Bystander Cells within the Microenvironment
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Memory T Cell Proliferation before Hepatitis C Virus Therapy Predicts Antiviral Immune Responses and Treatment Success
Gema Méndez-Lagares; Ding Lu; Connie Chen; Norah Terrault; Mark R. Segal; Mandana Khalili; Alexander Monto; Hui Shen; M. Michele Manos; Lewis L. Lanier; James C. Ryan; Joseph M. McCune; Dennis J. Hartigan-O’Connor
J Immunol (2018) 200 (3): 1124–1132.
View articletitled, Memory T Cell Proliferation before Hepatitis C Virus Therapy Predicts Antiviral Immune Responses and Treatment Success
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The Chemokine Receptor CXCR3 Promotes CD8+ T Cell Accumulation in Uninfected Salivary Glands but Is Not Necessary after Murine Cytomegalovirus Infection
Sofia Caldeira-Dantas; Thomas Furmanak; Corinne Smith; Michael Quinn; Leyla Y. Teos; Adam Ertel; Drishya Kurup; Mayank Tandon; Ilias Alevizos; Christopher M. Snyder
J Immunol (2018) 200 (3): 1133–1145.
View articletitled, The Chemokine Receptor CXCR3 Promotes CD8<sup>+</sup> T Cell Accumulation in Uninfected Salivary Glands but Is Not Necessary after Murine Cytomegalovirus Infection
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INNATE IMMUNITY AND INFLAMMATION

Human NK Cells Downregulate Zap70 and Syk in Response to Prolonged Activation or DNA Damage
Jason L. Pugh; Neda Nemat-Gorgani; Paul J. Norman; Lisbeth A. Guethlein; Peter Parham
J Immunol (2018) 200 (3): 1146–1158.
View articletitled, Human NK Cells Downregulate Zap70 and Syk in Response to Prolonged Activation or DNA Damage
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ATP Evokes Ca2+ Responses and CXCL5 Secretion via P2X4 Receptor Activation in Human Monocyte-Derived Macrophages
Janice A. Layhadi; Jeremy Turner; David Crossman; Samuel J. Fountain
J Immunol (2018) 200 (3): 1159–1168.
View articletitled, ATP Evokes Ca<sup>2+</sup> Responses and CXCL5 Secretion via P2X<sub>4</sub> Receptor Activation in Human Monocyte-Derived Macrophages
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The STAT3–IL-10–IL-6 Pathway Is a Novel Regulator of Macrophage Efferocytosis and Phenotypic Conversion in Sterile Liver Injury
Lara Campana; Philip J. Starkey Lewis; Antonella Pellicoro; Rebecca L. Aucott; Janet Man; Eoghan O’Duibhir; Sarah E. Mok; Sofia Ferreira-Gonzalez; Eilidh Livingstone; Stephen N. Greenhalgh; Katherine L. Hull; Timothy J. Kendall; Douglas Vernimmen; Neil C. Henderson; Luke Boulter; Christopher D. Gregory; Yi Feng; Stephen M. Anderton; Stuart J. Forbes; John P. Iredale
J Immunol (2018) 200 (3): 1169–1187.
View articletitled, The STAT3–IL-10–IL-6 Pathway Is a Novel Regulator of Macrophage Efferocytosis and Phenotypic Conversion in Sterile Liver Injury
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Nlrp12 Mediates Adverse Neutrophil Recruitment during Influenza Virus Infection
Emma E. Hornick; Balaji Banoth; Ann M. Miller; Zeb R. Zacharias; Nidhi Jain; Mary E. Wilson; Katherine N. Gibson-Corley; Kevin L. Legge; Gail A. Bishop; Fayyaz S. Sutterwala; Suzanne L. Cassel
J Immunol (2018) 200 (3): 1188–1197.
View articletitled, Nlrp12 Mediates Adverse Neutrophil Recruitment during Influenza Virus Infection
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MOLECULAR AND STRUCTURAL IMMUNOLOGY

The p38-MK2/3 Module Is Critical for IL-33–Induced Signaling and Cytokine Production in Dendritic Cells
Christiane Göpfert; Nico Andreas; Franziska Weber; Norman Häfner; Tatiana Yakovleva; Matthias Gaestel; Thomas Kamradt; Sebastian Drube
J Immunol (2018) 200 (3): 1198–1206.
View articletitled, The p38-MK2/3 Module Is Critical for IL-33–Induced Signaling and Cytokine Production in Dendritic Cells
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TUMOR IMMUNOLOGY

ILT3.Fc–CD166 Interaction Induces Inactivation of p70 S6 Kinase and Inhibits Tumor Cell Growth
Zheng Xu; Chih-Chao Chang; Muyang Li; Qing-Yin Zhang; Elena-Rodica M. Vasilescu; Vivette D’Agati; Aristidis Floratos; George Vlad; Nicole Suciu-Foca
J Immunol (2018) 200 (3): 1207–1219.
View articletitled, ILT3.Fc–CD166 Interaction Induces Inactivation of p70 S6 Kinase and Inhibits Tumor Cell Growth
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NOVEL IMMUNOLOGICAL METHODS

Extracellular Lactate: A Novel Measure of T Cell Proliferation
James T. Grist; Lorna B. Jarvis; Zoya Georgieva; Sara Thompson; Harpreet Kaur Sandhu; Keith Burling; Ashley Clarke; Sarah Jackson; Mark Wills; Ferdia A. Gallagher; Joanne L. Jones
J Immunol (2018) 200 (3): 1220–1226.
View articletitled, Extracellular Lactate: A Novel Measure of T Cell Proliferation
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CORRECTIONS

Correction: The Adaptor 3BP2 Is Required for KIT Receptor Expression and Human Mast Cell Survival
Erola Ainsua-Enrich; Eva Serrano-Candelas; Damiana Álvarez-Errico; César Picado; Joan Sayós; Juan Rivera; Margarita Martín
J Immunol (2018) 200 (3): 1227.
View articletitled, Correction: The Adaptor 3BP2 Is Required for KIT Receptor Expression and Human Mast Cell Survival
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  • Online ISSN 1550-6606
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