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Volume 200, Issue 7
1 April 2018
Issue Cover
ISSN 0022-1767
EISSN 1550-6606

IN THIS ISSUE

In This Issue
J Immunol (2018) 200 (7): 2227–2228.
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PILLARS OF IMMUNOLOGY

NKG2D–MICA Interaction: A Paradigm Shift in Innate Recognition
Mathieu Bléry; Eric Vivier
J Immunol (2018) 200 (7): 2229–2230.
View articletitled, NKG2D–MICA Interaction: A Paradigm Shift in Innate Recognition
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Pillars Article: Activation of NK Cells and T Cells by NKG2D, a Receptor for Stress-Inducible MICA. Science. 1999. 285: 727–729
Stefan Bauer; Veronika Groh; Jun Wu; Alexander Steinle; Joseph H. Phillips; Lewis L. Lanier; Thomas Spies
J Immunol (2018) 200 (7): 2231–2233.
View articletitled, Pillars Article: Activation of NK Cells and T Cells by NKG2D, a Receptor for Stress-Inducible MICA. <em>Science</em>. 1999. 285: 727–729
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BRIEF REVIEWS

Development, Homeostasis, and Functions of Intestinal Intraepithelial Lymphocytes
Luc Van Kaer; Danyvid Olivares-Villagómez
J Immunol (2018) 200 (7): 2235–2244.
View articletitled, Development, Homeostasis, and Functions of Intestinal Intraepithelial Lymphocytes
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CUTTING EDGE

Cutting Edge: A New Player in the Alternative Complement Pathway, MASP-1 Is Essential for LPS-Induced, but Not for Zymosan-Induced, Alternative Pathway Activation
Katalin Paréj; Andrea Kocsis; Csenge Enyingi; Ráhel Dani; Gábor Oroszlán; László Beinrohr; József Dobó; Péter Závodszky; Gábor Pál; Péter Gál
J Immunol (2018) 200 (7): 2247–2252.
View articletitled, Cutting Edge: A New Player in the Alternative Complement Pathway, MASP-1 Is Essential for LPS-Induced, but Not for Zymosan-Induced, Alternative Pathway Activation
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ALLERGY AND OTHER HYPERSENSITIVITIES

Elevated Expression of IL-33 and TSLP in the Airways of Human Asthmatics In Vivo: A Potential Biomarker of Severe Refractory Disease
Yan Li; Wei Wang; Zhe Lv; Yun Li; Yan Chen; Kewu Huang; Chris J. Corrigan; Sun Ying
J Immunol (2018) 200 (7): 2253–2262.
View articletitled, Elevated Expression of IL-33 and TSLP in the Airways of Human Asthmatics In Vivo: A Potential Biomarker of Severe Refractory Disease
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ANTIGEN RECOGNITION AND RESPONSES

Peptide–MHC Class I Tetramers Can Fail To Detect Relevant Functional T Cell Clonotypes and Underestimate Antigen-Reactive T Cell Populations
Cristina Rius; Meriem Attaf; Katie Tungatt; Valentina Bianchi; Mateusz Legut; Amandine Bovay; Marco Donia; Per thor Straten; Mark Peakman; Inge Marie Svane; Sascha Ott; Tom Connor; Barbara Szomolay; Garry Dolton; Andrew K. Sewell
J Immunol (2018) 200 (7): 2263–2279.
View articletitled, Peptide–MHC Class I Tetramers Can Fail To Detect Relevant Functional T Cell Clonotypes and Underestimate Antigen-Reactive T Cell Populations
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AUTOIMMUNITY

FHR5 Binds to Laminins, Uses Separate C3b and Surface-Binding Sites, and Activates Complement on Malondialdehyde-Acetaldehyde Surfaces
Ramona B. Rudnick; Qian Chen; Emma Diletta Stea; Andrea Hartmann; Nikolina Papac-Milicevic; Fermin Person; Michael Wiesener; Christoph J. Binder; Thorsten Wiech; Christine Skerka; Peter F. Zipfel
J Immunol (2018) 200 (7): 2280–2290.
View articletitled, FHR5 Binds to Laminins, Uses Separate C3b and Surface-Binding Sites, and Activates Complement on Malondialdehyde-Acetaldehyde Surfaces
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CLINICAL AND HUMAN IMMUNOLOGY

Human Binge Alcohol Intake Inhibits TLR4–MyD88 and TLR4–TRIF Responses but Not the TLR3–TRIF Pathway: HspA1A and PP1 Play Selective Regulatory Roles
Sujatha Muralidharan; Arlene Lim; Donna Catalano; Pranoti Mandrekar
J Immunol (2018) 200 (7): 2291–2303.
View articletitled, Human Binge Alcohol Intake Inhibits TLR4–MyD88 and TLR4–TRIF Responses but Not the TLR3–TRIF Pathway: HspA1A and PP1 Play Selective Regulatory Roles
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The PI3Kδ-Selective Inhibitor Idelalisib Minimally Interferes with Immune Effector Function Mediated by Rituximab or Obinutuzumab and Significantly Augments B Cell Depletion In Vivo
Adam Palazzo; Sylvia Herter; Laura Grosmaire; Randy Jones; Christian R. Frey; Florian Limani; Marina Bacac; Pablo Umana; Robert J. Oldham; Michael J. E. Marshall; Kerry L. Cox; Anna H. Turaj; Mark S. Cragg; Christian Klein; Matthew J. Carter; Stacey Tannheimer
J Immunol (2018) 200 (7): 2304–2312.
View articletitled, The PI3Kδ-Selective Inhibitor Idelalisib Minimally Interferes with Immune Effector Function Mediated by Rituximab or Obinutuzumab and Significantly Augments B Cell Depletion In Vivo
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IMMUNE REGULATION

Reciprocal Regulation of Glycolysis-Driven Th17 Pathogenicity and Regulatory T Cell Stability by Cdc42
Khalid W. Kalim; Jun-Qi Yang; Yuan Li; Yan Meng; Yi Zheng; Fukun Guo
J Immunol (2018) 200 (7): 2313–2326.
View articletitled, Reciprocal Regulation of Glycolysis-Driven Th17 Pathogenicity and Regulatory T Cell Stability by Cdc42
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A Novel Biological Role for Peptidyl-Arginine Deiminases: Citrullination of Cathelicidin LL-37 Controls the Immunostimulatory Potential of Cell-Free DNA
Alicia Wong; Danuta Bryzek; Ewelina Dobosz; Carsten Scavenius; Pavel Svoboda; Maria Rapala-Kozik; Adam Lesner; Ivo Frydrych; Jan Enghild; Piotr Mydel; Jan Pohl; Paul R. Thompson; Jan Potempa; Joanna Koziel
J Immunol (2018) 200 (7): 2327–2340.
View articletitled, A Novel Biological Role for Peptidyl-Arginine Deiminases: Citrullination of Cathelicidin LL-37 Controls the Immunostimulatory Potential of Cell-Free DNA
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TLR2 Stimulation Strengthens Intrahepatic Myeloid-Derived Cell-Mediated T Cell Tolerance through Inducing Kupffer Cell Expansion and IL-10 Production
Jia Liu; Qing Yu; Weimin Wu; Xuan Huang; Ruth Broering; Melanie Werner; Michael Roggendorf; Dongliang Yang; Mengji Lu
J Immunol (2018) 200 (7): 2341–2351.
View articletitled, TLR2 Stimulation Strengthens Intrahepatic Myeloid-Derived Cell-Mediated T Cell Tolerance through Inducing Kupffer Cell Expansion and IL-10 Production
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IMMUNE SYSTEM DEVELOPMENT

Bruton’s Tyrosine Kinase Is Not Essential for B Cell Survival beyond Early Developmental Stages
Lindsay E. Nyhoff; Emily S. Clark; Bridgette L. Barron; Rachel H. Bonami; Wasif N. Khan; Peggy L. Kendall
J Immunol (2018) 200 (7): 2352–2361.
View articletitled, Bruton’s Tyrosine Kinase Is Not Essential for B Cell Survival beyond Early Developmental Stages
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The Alternative NF-κB Pathway in Regulatory T Cell Homeostasis and Suppressive Function
Yenkel Grinberg-Bleyer; Rachel Caron; John J. Seeley; Nilushi S. De Silva; Christian W. Schindler; Matthew S. Hayden; Ulf Klein; Sankar Ghosh
J Immunol (2018) 200 (7): 2362–2371.
View articletitled, The Alternative NF-κB Pathway in Regulatory T Cell Homeostasis and Suppressive Function
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IMMUNOGENETICS

HLA Class II–Triggered Signaling Cascades Cause Endothelial Cell Proliferation and Migration: Relevance to Antibody-Mediated Transplant Rejection
Yi-Ping Jin; Nicole M. Valenzuela; Xiaohai Zhang; Enrique Rozengurt; Elaine F. Reed
J Immunol (2018) 200 (7): 2372–2390.
View articletitled, HLA Class II–Triggered Signaling Cascades Cause Endothelial Cell Proliferation and Migration: Relevance to Antibody-Mediated Transplant Rejection
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INFECTIOUS DISEASE AND HOST RESPONSE

Inflammatory Monocytes Drive Influenza A Virus–Mediated Lung Injury in Juvenile Mice
Bria M. Coates; Kelly L. Staricha; Clarissa M. Koch; Yuan Cheng; Dale K. Shumaker; G. R. Scott Budinger; Harris Perlman; Alexander V. Misharin; Karen M. Ridge
J Immunol (2018) 200 (7): 2391–2404.
View articletitled, Inflammatory Monocytes Drive Influenza A Virus–Mediated Lung Injury in Juvenile Mice
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IL-12+IL-18 Cosignaling in Human Macrophages and Lung Epithelial Cells Activates Cathelicidin and Autophagy, Inhibiting Intracellular Mycobacterial Growth
Rui Yang; Enzhuo Yang; Ling Shen; Robert L. Modlin; Hongbo Shen; Zheng W. Chen
J Immunol (2018) 200 (7): 2405–2417.
View articletitled, IL-12+IL-18 Cosignaling in Human Macrophages and Lung Epithelial Cells Activates Cathelicidin and Autophagy, Inhibiting Intracellular Mycobacterial Growth
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Septic Shock Shapes B Cell Response toward an Exhausted-like/Immunoregulatory Profile in Patients
Claude-Alexandre Gustave; Morgane Gossez; Julie Demaret; Thomas Rimmelé; Alain Lepape; Christophe Malcus; Françoise Poitevin-Later; Laurent Jallades; Julien Textoris; Guillaume Monneret; Fabienne Venet
J Immunol (2018) 200 (7): 2418–2425.
View articletitled, Septic Shock Shapes B Cell Response toward an Exhausted-like/Immunoregulatory Profile in Patients
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INNATE IMMUNITY AND INFLAMMATION

αMβ2 Is Antiatherogenic in Female but Not Male Mice
Dorota Szpak; Lahoucine Izem; Dmitriy Verbovetskiy; Dmitry A. Soloviev; Valentin P. Yakubenko; Elzbieta Pluskota
J Immunol (2018) 200 (7): 2426–2438.
View articletitled, α<sub>M</sub>β<sub>2</sub> Is Antiatherogenic in Female but Not Male Mice
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PARP14 Controls the Nuclear Accumulation of a Subset of Type I IFN–Inducible Proteins
Greta Caprara; Elena Prosperini; Viviana Piccolo; Gianluca Sigismondo; Alessia Melacarne; Alessandro Cuomo; Mark Boothby; Maria Rescigno; Tiziana Bonaldi; Gioacchino Natoli
J Immunol (2018) 200 (7): 2439–2454.
View articletitled, PARP14 Controls the Nuclear Accumulation of a Subset of Type I IFN–Inducible Proteins
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MOLECULAR AND STRUCTURAL IMMUNOLOGY

c-Src–Dependent and –Independent Functions of Matk in Osteoclasts and Osteoblasts
Jung Ha Kim; Kabsun Kim; Inyoung Kim; Semun Seong; Nacksung Kim
J Immunol (2018) 200 (7): 2455–2463.
View articletitled, c-Src–Dependent and –Independent Functions of Matk in Osteoclasts and Osteoblasts
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Statistical Validation of Rare Complement Variants Provides Insights into the Molecular Basis of Atypical Hemolytic Uremic Syndrome and C3 Glomerulopathy
Amy J. Osborne; Matteo Breno; Nicolo Ghiringhelli Borsa; Fengxiao Bu; Véronique Frémeaux-Bacchi; Daniel P. Gale; Lambertus P. van den Heuvel; David Kavanagh; Marina Noris; Sheila Pinto; Pavithra M. Rallapalli; Giuseppe Remuzzi; Santiago Rodríguez de Cordoba; Angela Ruiz; Richard J. H. Smith; Paula Vieira-Martins; Elena Volokhina; Valerie Wilson; Timothy H. J. Goodship; Stephen J. Perkins
J Immunol (2018) 200 (7): 2464–2478.
View articletitled, Statistical Validation of Rare Complement Variants Provides Insights into the Molecular Basis of Atypical Hemolytic Uremic Syndrome and C3 Glomerulopathy
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TRANSPLANTATION

Blockade of Host β2-Adrenergic Receptor Enhances Graft-versus-Tumor Effect through Modulating APCs
Hemn Mohammadpour; Rachel O’Neil; Jingxin Qiu; Philip L. McCarthy; Elizabeth A. Repasky; Xuefang Cao
J Immunol (2018) 200 (7): 2479–2488.
View articletitled, Blockade of Host β2-Adrenergic Receptor Enhances Graft-versus-Tumor Effect through Modulating APCs
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NOVEL IMMUNOLOGICAL METHODS

Highly Efficient and Versatile Plasmid-Based Gene Editing in Primary T Cells
Mara Kornete; Romina Marone; Lukas T. Jeker
J Immunol (2018) 200 (7): 2489–2501.
View articletitled, Highly Efficient and Versatile Plasmid-Based Gene Editing in Primary T Cells
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CORRECTIONS

Correction: Green Tea Polyphenol EGCG Upregulates Tollip Expression by Suppressing Elf-1 Expression
Motofumi Kumazoe; Mai Yamashita; Yuki Nakamura; Kanako Takamatsu; Jaehoon Bae; Shuya Yamashita; Shuhei Yamada; Hiroaki Onda; Takashi Nojiri; Kenji Kangawa; Hirofumi Tachibana
J Immunol (2018) 200 (7): 2502–2504.
View articletitled, Correction: Green Tea Polyphenol EGCG Upregulates Tollip Expression by Suppressing Elf-1 Expression
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Correction: B Cells Drive Autoimmunity in Mice with CD28-Deficient Regulatory T Cells
Ruan Zhang; Peter T. Sage; Kelsey Finn; Alexandria Huynh; Bruce R. Blazar; Francesco Marangoni; Thorsten R. Mempel; Arlene H. Sharpe; Laurence A. Turka
J Immunol (2018) 200 (7): 2505–2506.
View articletitled, Correction: B Cells Drive Autoimmunity in Mice with CD28-Deficient Regulatory T Cells
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Correction: A Fusion Protein Encoding the Second Extracellular Domain of CCR5 Arrests Chemokine-Induced Cosignaling and Effectively Suppresses Ongoing Experimental Autoimmune Encephalomyelitis
Yair Sapir; Alon Vitenshtein; Yiftah Barsheshet; Yaniv Zohar; Gizi Wildbaum; Nathan Karin
J Immunol (2018) 200 (7): 2507–2508.
View articletitled, Correction: A Fusion Protein Encoding the Second Extracellular Domain of CCR5 Arrests Chemokine-Induced Cosignaling and Effectively Suppresses Ongoing Experimental Autoimmune Encephalomyelitis
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Correction: Predominant Expression of CCL2 at the Tumor Site of Prostate Cancer Patients Directs a Selective Loss of Immunological Tolerance to CCL2 That Could Be Amplified in a Beneficial Manner
Liat Izhak; Gizi Wildbaum; Uri Weinberg; Yuval Shaked; Jennifer Alami; Daniel Dumont; Boris Friedman; Avi Stein; Nathan Karin
J Immunol (2018) 200 (7): 2509–2510.
View articletitled, Correction: Predominant Expression of CCL2 at the Tumor Site of Prostate Cancer Patients Directs a Selective Loss of Immunological Tolerance to CCL2 That Could Be Amplified in a Beneficial Manner
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  • Cover Image

    Cover Image

    issue cover

    On the cover: Deletion of nfkb2 in Foxp3+ regulatory T cells (Tregs) results in impaired Treg homeostasis, altered suppressive function, and systemic inflammation. However, concomitant ablation of relb in nfkb2-deleted Treg cells restores suppressive function and, as revealed here by histopathological analysis of colon sections, rescues the intestinal inflammation. Grinberg-Bleyer, Y., R. Caron, J. J. Seeley, N. S. De Silva, C. W. Schindler, M. S. Hayden, U. Klein, and S. Ghosh. 2018. The alternative NF-κB pathway in regulatory T cell homeostasis and suppressive function. J. Immunol. 200: 2362–2371.

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