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Volume 201, Issue 11
1 December 2018
Issue Cover
ISSN 0022-1767
EISSN 1550-6606

IN MEMORIAM

Kimishige Ishizaka, M.D., Ph.D. (AAI ’58), December 3, 1925 to July 6, 2018
Gina Kirchweger; Elise Lamar; Mitchell Kronenberg
J Immunol (2018) 201 (11): 3143–3144.
View articletitled, Kimishige Ishizaka, M.D., Ph.D. (AAI ’58), December 3, 1925 to July 6, 2018
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IN THIS ISSUE

In This Issue
J Immunol (2018) 201 (11): 3145–3146.
View articletitled, In This Issue
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PILLARS OF IMMUNOLOGY

Opening the Black Box of Immunosuppression
Mark H. Kaplan
J Immunol (2018) 201 (11): 3147–3148.
View articletitled, Opening the Black Box of Immunosuppression
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Pillars Article: Cyclosporin A Specifically Inhibits Function of Nuclear Proteins Involved in T Cell Activation. Science. 1989. 246: 1617–1620
Elizabeth A. Emmel; Cornelis L. Verweij; David B. Durand; Kay M. Higgins; Elizabeth Lacy; Gerald R. Crabtree
J Immunol (2018) 201 (11): 3149–3152.
View articletitled, Pillars Article: Cyclosporin A Specifically Inhibits Function of Nuclear Proteins Involved in T Cell Activation. <em>Science</em>. 1989. 246: 1617–1620
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BRIEF REVIEWS

IL-17 in Renal Immunity and Autoimmunity
Partha S. Biswas
J Immunol (2018) 201 (11): 3153–3159.
View articletitled, IL-17 in Renal Immunity and Autoimmunity
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CUTTING EDGE

Cutting Edge: Human Vagus Produces Specialized Proresolving Mediators of Inflammation with Electrical Stimulation Reducing Proinflammatory Eicosanoids
Charles N. Serhan; Xavier de la Rosa; Charlotte C. Jouvene
J Immunol (2018) 201 (11): 3161–3165.
View articletitled, Cutting Edge: Human Vagus Produces Specialized Proresolving Mediators of Inflammation with Electrical Stimulation Reducing Proinflammatory Eicosanoids
Supplementary data
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ANTIGEN RECOGNITION AND RESPONSES

Divergent TCR-Initiated Calcium Signals Govern Recruitment versus Activation of Human Alloreactive Effector Memory T Cells by Endothelial Cells
Thomas D. Manes; Vivian Wang; Jordan S. Pober
J Immunol (2018) 201 (11): 3167–3174.
View articletitled, Divergent TCR-Initiated Calcium Signals Govern Recruitment versus Activation of Human Alloreactive Effector Memory T Cells by Endothelial Cells
Supplementary data
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AUTOIMMUNITY

Calcium-Sensing Receptor Autoantibodies in Patients with Autoimmune Polyendocrine Syndrome Type 1: Epitopes, Specificity, Functional Affinity, IgG Subclass, and Effects on Receptor Activity
Mahmoud Habibullah; Julie A. Porter; Nicolas Kluger; Annamari Ranki; Kai J. E. Krohn; Maria L. Brandi; Edward M. Brown; Anthony P. Weetman; E. Helen Kemp
J Immunol (2018) 201 (11): 3175–3183.
View articletitled, Calcium-Sensing Receptor Autoantibodies in Patients with Autoimmune Polyendocrine Syndrome Type 1: Epitopes, Specificity, Functional Affinity, IgG Subclass, and Effects on Receptor Activity
Supplementary data
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Sublytic C5b-9 Induces IL-23 and IL-36a Production by Glomerular Mesangial Cells via PCAF-Mediated KLF4 Acetylation in Rat Thy-1 Nephritis
Jing Zhang; Mengxiao Xie; Lu Xia; Tianyi Yu; Fengxia He; Chenhui Zhao; Wen Qiu; Dan Zhao; Yu Liu; Yajuan Gong; Chunyan Yao; Longfei Liu; Yingwei Wang
J Immunol (2018) 201 (11): 3184–3198.
View articletitled, Sublytic C5b-9 Induces IL-23 and IL-36a Production by Glomerular Mesangial Cells via PCAF-Mediated KLF4 Acetylation in Rat Thy-1 Nephritis
Supplementary data
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FcγRIIb on B Cells and Myeloid Cells Modulates B Cell Activation and Autoantibody Responses via Different but Synergistic Pathways in Lupus-Prone Yaa Mice
Qingshun Lin; Mareki Ohtsuji; Hirofumi Amano; Hiromichi Tsurui; Norihiro Tada; Ryota Sato; Hidehiro Fukuyama; Hiroyuki Nishimura; J. Sjef Verbeek; Sachiko Hirose
J Immunol (2018) 201 (11): 3199–3210.
View articletitled, FcγRIIb on B Cells and Myeloid Cells Modulates B Cell Activation and Autoantibody Responses via Different but Synergistic Pathways in Lupus-Prone <em>Yaa</em> Mice
Supplementary data
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Seropositivity and Antibody Profiling of Patients Are Dramatically Impacted by the Features of Peptides Used as Immunosorbents: A Lesson from Anti–Citrullinated Protein/Peptide Antibody
Martin Cornillet; Fruzsina Babos; Anna Magyar; Mireille Sebbag; Evelyne Verrouil; Ferenc Hudecz; Guy Serre; Leonor Nogueira
J Immunol (2018) 201 (11): 3211–3217.
View articletitled, Seropositivity and Antibody Profiling of Patients Are Dramatically Impacted by the Features of Peptides Used as Immunosorbents: A Lesson from Anti–Citrullinated Protein/Peptide Antibody
Supplementary data
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Estrogen Signaling in Bystander Foxp3neg CD4+ T Cells Suppresses Cognate Th17 Differentiation in Trans and Protects from Central Nervous System Autoimmunity
Laure Garnier; Sophie Laffont; Karine Lélu; Nir Yogev; Ari Waisman; Jean-Charles Guéry
J Immunol (2018) 201 (11): 3218–3228.
View articletitled, Estrogen Signaling in Bystander Foxp3<sup>neg</sup> CD4<sup>+</sup> T Cells Suppresses Cognate Th17 Differentiation in <em>Trans</em> and Protects from Central Nervous System Autoimmunity
Supplementary data
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Targeted Diet Modification Reduces Multiple Sclerosis–like Disease in Adult Marmoset Monkeys from an Outbred Colony
Yolanda S. Kap; Carien Bus-Spoor; Nikki van Driel; Marissa L. Dubbelaar; Corien Grit; Susanne M. Kooistra; Zahra C. Fagrouch; Ernst J. Verschoor; Jan Bauer; Bart J. L. Eggen; Hermie J. M. Harmsen; Jon D. Laman; Bert A. ’t Hart
J Immunol (2018) 201 (11): 3229–3243.
View articletitled, Targeted Diet Modification Reduces Multiple Sclerosis–like Disease in Adult Marmoset Monkeys from an Outbred Colony
Supplementary data
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Aire Controls in Trans the Production of Medullary Thymic Epithelial Cells Expressing Ly-6C/Ly-6G
Junko Morimoto; Yumiko Nishikawa; Takumi Kakimoto; Kohei Furutani; Naoki Kihara; Minoru Matsumoto; Koichi Tsuneyama; Yuko Kozono; Haruo Kozono; Katsuto Hozumi; Kazuyoshi Hosomichi; Hitoshi Nishijima; Mitsuru Matsumoto
J Immunol (2018) 201 (11): 3244–3257.
View articletitled, Aire Controls in <em>Trans</em> the Production of Medullary Thymic Epithelial Cells Expressing Ly-6C/Ly-6G
Supplementary data
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Integrated B Cell, Toll-like, and BAFF Receptor Signals Promote Autoantibody Production by Transitional B Cells
Samuel W. Du; Holly M. Jacobs; Tanvi Arkatkar; David J. Rawlings; Shaun W. Jackson
J Immunol (2018) 201 (11): 3258–3268.
View articletitled, Integrated B Cell, Toll-like, and BAFF Receptor Signals Promote Autoantibody Production by Transitional B Cells
Supplementary data
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CLINICAL AND HUMAN IMMUNOLOGY

T Regulatory Cell Subpopulations Associated with Recent Ultraviolet Radiation Exposure in a Skin Cancer Screening Cohort
Rebecca S. Hesterberg; Rossybelle P. Amorrortu; Yayi Zhao; Shalaka Hampras; Afua A. Akuffo; Neil Fenske; Basil Cherpelis; Juliana Balliu; Laxmi Vijayan; Pearlie K. Epling-Burnette; Dana E. Rollison
J Immunol (2018) 201 (11): 3269–3281.
View articletitled, T Regulatory Cell Subpopulations Associated with Recent Ultraviolet Radiation Exposure in a Skin Cancer Screening Cohort
Supplementary data
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IMMUNE REGULATION

Limited Phenotypic and Functional Plasticity of Influenza Virus–Specific Memory CD8+ T Cells during Activation in an Alternative Cytokine Environment
Kim L. Harland; Annette Fox; Simone Nüssing; Luca Hensen; Katherine Kedzierska; Stephen J. Turner; Anne Kelso
J Immunol (2018) 201 (11): 3282–3293.
View articletitled, Limited Phenotypic and Functional Plasticity of Influenza Virus–Specific Memory CD8<sup>+</sup> T Cells during Activation in an Alternative Cytokine Environment
Supplementary data
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Increased Mitochondrial Biogenesis and Reactive Oxygen Species Production Accompany Prolonged CD4+ T Cell Activation
Billur Akkaya; Alexander S. Roesler; Pietro Miozzo; Brandon P. Theall; Jafar Al Souz; Margery G. Smelkinson; Juraj Kabat; Javier Traba; Michael N. Sack; Joseph A. Brzostowski; Mirna Pena; David W. Dorward; Susan K. Pierce; Munir Akkaya
J Immunol (2018) 201 (11): 3294–3306.
View articletitled, Increased Mitochondrial Biogenesis and Reactive Oxygen Species Production Accompany Prolonged CD4<sup>+</sup> T Cell Activation
Supplementary data
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Loss of Canonical Notch Signaling Affects Multiple Steps in NK Cell Development in Mice
Patricia Chaves; Alya Zriwil; Lilian Wittmann; Hanane Boukarabila; Claudia Peitzsch; Sten Eirik W. Jacobsen; Ewa Sitnicka
J Immunol (2018) 201 (11): 3307–3319.
View articletitled, Loss of Canonical Notch Signaling Affects Multiple Steps in NK Cell Development in Mice
Supplementary data
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IMMUNE SYSTEM DEVELOPMENT

Thymic Epithelial Cell Support of Thymopoiesis Does Not Require Klotho
Yan Xing; Michelle J. Smith; Christine A. Goetz; Ron T. McElmurry; Sarah L. Parker; Dullei Min; Georg A. Hollander; Kenneth I. Weinberg; Jakub Tolar; Heather E. Stefanski; Bruce R. Blazar
J Immunol (2018) 201 (11): 3320–3328.
View articletitled, Thymic Epithelial Cell Support of Thymopoiesis Does Not Require <em>Klotho</em>
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IMMUNOGENETICS

Unique Composition of Intronless and Intron-Containing Type I IFNs in the Tibetan Frog Nanorana parkeri Provides New Evidence To Support Independent Retroposition Hypothesis for Type I IFN Genes in Amphibians
Zhen Gan; Yue Cong Yang; Shan Nan Chen; Jing Hou; Zubair Ahmed Laghari; Bei Huang; Nan Li; Pin Nie
J Immunol (2018) 201 (11): 3329–3342.
View articletitled, Unique Composition of Intronless and Intron-Containing Type I IFNs in the Tibetan Frog <em>Nanorana parkeri</em> Provides New Evidence To Support Independent Retroposition Hypothesis for Type I IFN Genes in Amphibians
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IMMUNOTHERAPY AND VACCINES

Lipoxin B4 Enhances Human Memory B Cell Antibody Production via Upregulating Cyclooxygenase-2 Expression
Nina Kim; Katie L. Lannan; Thomas H. Thatcher; Stephen J. Pollock; Collynn F. Woeller; Richard P. Phipps
J Immunol (2018) 201 (11): 3343–3351.
View articletitled, Lipoxin B<sub>4</sub> Enhances Human Memory B Cell Antibody Production via Upregulating Cyclooxygenase-2 Expression
Supplementary data
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INFECTIOUS DISEASE AND HOST RESPONSE

Aeroallergens Exacerbate Histoplasma capsulatum Infection
Chelsea L. Bueter; George S. Deepe, Jr.
J Immunol (2018) 201 (11): 3352–3361.
View articletitled, Aeroallergens Exacerbate <em>Histoplasma capsulatum</em> Infection
Supplementary data
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Distinct Roles for CD4+ Foxp3+ Regulatory T Cells and IL-10–Mediated Immunoregulatory Mechanisms during Experimental Visceral Leishmaniasis Caused by Leishmania donovani
Patrick T. Bunn; Marcela Montes de Oca; Fabian de Labastida Rivera; Rajiv Kumar; Susanna S. Ng; Chelsea L. Edwards; Rebecca J. Faleiro; Meru Sheel; Fiona H. Amante; Teija C. M. Frame; Werner Muller; Ashraful Haque; Jude E. Uzonna; Geoffrey R. Hill; Christian R. Engwerda
J Immunol (2018) 201 (11): 3362–3372.
View articletitled, Distinct Roles for CD4<sup>+</sup> Foxp3<sup>+</sup> Regulatory T Cells and IL-10–Mediated Immunoregulatory Mechanisms during Experimental Visceral Leishmaniasis Caused by <em>Leishmania donovani</em>
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INNATE IMMUNITY AND INFLAMMATION

ABIN2 Function Is Required To Suppress DSS-Induced Colitis by a Tpl2-Independent Mechanism
Sambit K. Nanda; Tsunehisa Nagamori; Mark Windheim; Sylvia Amu; Gabriella Aviello; Janet Patterson-Kane; J. Simon C. Arthur; Steven C. Ley; Padraic Fallon; Philip Cohen
J Immunol (2018) 201 (11): 3373–3382.
View articletitled, ABIN2 Function Is Required To Suppress DSS-Induced Colitis by a Tpl2-Independent Mechanism
Supplementary data
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Computationally Designed Bispecific MD2/CD14 Binding Peptides Show TLR4 Agonist Activity
Amit Michaeli; Shaul Mezan; Andreas Kühbacher; Doris Finkelmeier; Maayan Elias; Maria Zatsepin; Steven G. Reed; Malcolm S. Duthie; Steffen Rupp; Immanuel Lerner; Anke Burger-Kentischer
J Immunol (2018) 201 (11): 3383–3391.
View articletitled, Computationally Designed Bispecific MD2/CD14 Binding Peptides Show TLR4 Agonist Activity
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Circulating Plasma Extracellular Vesicles from Septic Mice Induce Inflammation via MicroRNA- and TLR7-Dependent Mechanisms
Jinjin Xu; Yan Feng; Anjana Jeyaram; Steven M. Jay; Lin Zou; Wei Chao
J Immunol (2018) 201 (11): 3392–3400.
View articletitled, Circulating Plasma Extracellular Vesicles from Septic Mice Induce Inflammation via MicroRNA- and TLR7-Dependent Mechanisms
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Innate Lymphoid Cells Have Decreased HLA-DR Expression but Retain Their Responsiveness to TLR Ligands during Sepsis
David Cruz-Zárate; Graciela Libier Cabrera-Rivera; Bibiana Patricia Ruiz-Sánchez; Jeanet Serafín-López; Rommel Chacón-Salinas; Constantino López-Macías; Armando Isibasi; Humberto Gallegos-Pérez; Marco Antonio León-Gutiérrez; Eduardo Ferat-Osorio; Lourdes Arriaga-Pizano; Iris Estrada-García; Isabel Wong-Baeza
J Immunol (2018) 201 (11): 3401–3410.
View articletitled, Innate Lymphoid Cells Have Decreased HLA-DR Expression but Retain Their Responsiveness to TLR Ligands during Sepsis
Supplementary data
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Consequences of Hypoxia for the Pulmonary Alveolar Epithelial Cell Innate Immune Response
Anne Sturrock; Diana Woller; Andrew Freeman; Karl Sanders; Robert Paine, III
J Immunol (2018) 201 (11): 3411–3420.
View articletitled, Consequences of Hypoxia for the Pulmonary Alveolar Epithelial Cell Innate Immune Response
Supplementary data
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MOLECULAR AND STRUCTURAL IMMUNOLOGY

TRAF2 Deficiency in B Cells Impairs CD40-Induced Isotype Switching That Can Be Rescued by Restoring NF-κB1 Activation
Rachel A. Woolaver; Xiaoguang Wang; Yonatan Dollin; Ping Xie; Jing H. Wang; Zhangguo Chen
J Immunol (2018) 201 (11): 3421–3430.
View articletitled, TRAF2 Deficiency in B Cells Impairs CD40-Induced Isotype Switching That Can Be Rescued by Restoring NF-κB1 Activation
Supplementary data
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TAOK3 Regulates Canonical TCR Signaling by Preventing Early SHP-1–Mediated Inactivation of LCK
João V. S. Ormonde; Zhigang Li; Camille Stegen; Joaquín Madrenas
J Immunol (2018) 201 (11): 3431–3442.
View articletitled, TAOK3 Regulates Canonical TCR Signaling by Preventing Early SHP-1–Mediated Inactivation of LCK
Supplementary data
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TRANSPLANTATION

Mitochondrial Deacetylase SIRT3 Plays an Important Role in Donor T Cell Responses after Experimental Allogeneic Hematopoietic Transplantation
Tomomi Toubai; Hiroya Tamaki; Daniel C. Peltier; Corinne Rossi; Katherine Oravecz-Wilson; Chen Liu; Cynthia Zajac; Julia Wu; Yaping Sun; Hideaki Fujiwara; Israel Henig; Stephanie Kim; David B. Lombard; Pavan Reddy
J Immunol (2018) 201 (11): 3443–3455.
View articletitled, Mitochondrial Deacetylase SIRT3 Plays an Important Role in Donor T Cell Responses after Experimental Allogeneic Hematopoietic Transplantation
Supplementary data
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TUMOR IMMUNOLOGY

Type 2 Innate Lymphoid Cells Impede IL-33–Mediated Tumor Suppression
Alan Long; Donye Dominguez; Lei Qin; Siqi Chen; Jie Fan; Minghui Zhang; Deyu Fang; Yi Zhang; Timothy M. Kuzel; Bin Zhang
J Immunol (2018) 201 (11): 3456–3464.
View articletitled, Type 2 Innate Lymphoid Cells Impede IL-33–Mediated Tumor Suppression
Supplementary data
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NOVEL IMMUNOLOGICAL METHODS

High-Throughput Single-Cell Sequencing of both TCR-β Alleles
Tomonori Hosoya; Hongyang Li; Chia-Jui Ku; Qingqing Wu; Yuanfang Guan; James Douglas Engel
J Immunol (2018) 201 (11): 3465–3470.
View articletitled, High-Throughput Single-Cell Sequencing of both <em>TCR-β</em> Alleles
Supplementary data
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CORRECTIONS

Correction: Nasopharyngeal Exposure to Streptococcus pneumoniae Induces Extended Age-Dependent Protection against Pulmonary Infection Mediated by Antibodies and CD138+ Cells
Elsa N. Bou Ghanem; Nang H. Tin Maung; Nalat Siwapornchai; Aaron E. Goodwin; Stacie Clark; Ernesto J. Muñoz-Elías; Andrew Camilli; Rachel M. Gerstein; John M. Leong
J Immunol (2018) 201 (11): 3471.
View articletitled, Correction: Nasopharyngeal Exposure to <em>Streptococcus pneumoniae</em> Induces Extended Age-Dependent Protection against Pulmonary Infection Mediated by Antibodies and CD138<sup>+</sup> Cells
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Correction: Regulation of the DNA Repair Complex during Somatic Hypermutation and Class-Switch Recombination
Anjani Kumar; Anshu Priya; Tanzeel Ahmed; Christine Grundström; Neema Negi; Thomas Grundström
J Immunol (2018) 201 (11): 3472–3473.
View articletitled, Correction: Regulation of the DNA Repair Complex during Somatic Hypermutation and Class-Switch Recombination
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  • Cover Image

    Cover Image

    issue cover

    On the cover: The binding model of LPS to CD14 showed a conformational shift which was used to form structure-based artificial intelligence ligand discovery. In depth studies of protein conformations allows the ab initio (“from scratch”) discovery of novel molecules, in this case CD14 and MD2 bispecific peptides. Michaeli, A., S. Mezan, A. Kühbacher, D. Finkelmeier, M. Elias, M. Zatsepin, S. G. Reed, M. S. Duthie, S. Rupp, I. Lerner, A. Burger-Kentischer. 2018. Computationally designed bispecific MD2/CD14 binding peptides show TLR4 agonist activity. J. Immunol. 201: 3383–3391.

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