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Volume 201, Issue 12
15 December 2018
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ISSN 0022-1767
EISSN 1550-6606

IN THIS ISSUE

In This Issue
J Immunol (2018) 201 (12): 3477–3478.
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BRIEF REVIEWS

The Goldilocks Zone of Type I IFNs: Lessons from Human Genetics
Justin Taft; Dusan Bogunovic
J Immunol (2018) 201 (12): 3479–3485.
View articletitled, The Goldilocks Zone of Type I IFNs: Lessons from Human Genetics
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CUTTING EDGE

Cutting Edge: Transcriptional Profiling Reveals Multifunctional and Cytotoxic Antiviral Responses of Zika Virus–Specific CD8+ T Cells
Alba Grifoni; Priscilla Costa-Ramos; John Pham; Yuan Tian; Sandy L. Rosales; Grégory Seumois; John Sidney; Aruna D. de Silva; Lakshmanane Premkumar; Matthew H. Collins; Mars Stone; Phillip J. Norris; Claudia M. E. Romero; Anna Durbin; Michael J. Ricciardi; Julie E. Ledgerwood; Aravinda M. de Silva; Michael Busch; Bjoern Peters; Pandurangan Vijayanand; Eva Harris; Andrew K. Falconar; Esper Kallas; Daniela Weiskopf; Alessandro Sette
J Immunol (2018) 201 (12): 3487–3491.
View articletitled, Cutting Edge: Transcriptional Profiling Reveals Multifunctional and Cytotoxic Antiviral Responses of Zika Virus–Specific CD8<sup>+</sup> T Cells
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Cutting Edge: B Cells Expressing Cyclic Citrullinated Peptide–Specific Antigen Receptor Are Tolerized in Normal Conditions
Hisakata Yamada; Tatsuhiko Ozawa; Hiroyuki Kishi; Seiji Okada; Yasuharu Nakashima; Atsushi Muraguchi; Yasunobu Yoshikai
J Immunol (2018) 201 (12): 3492–3496.
View articletitled, Cutting Edge: B Cells Expressing Cyclic Citrullinated Peptide–Specific Antigen Receptor Are Tolerized in Normal Conditions
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Cutting Edge: FHR-1 Binding Impairs Factor H–Mediated Complement Evasion by the Malaria Parasite Plasmodium falciparum
Timo Reiss; Thiago F. de A. Rosa; Katharina Blaesius; Rebecca P. Bobbert; Peter F. Zipfel; Christine Skerka; Gabriele Pradel
J Immunol (2018) 201 (12): 3497–3502.
View articletitled, Cutting Edge: FHR-1 Binding Impairs Factor H–Mediated Complement Evasion by the Malaria Parasite <em>Plasmodium falciparum</em>
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ALLERGY AND OTHER HYPERSENSITIVITIES

TLR-7 Stress Signaling in Differentiating and Mature Eosinophils Is Mediated by the Prolyl Isomerase Pin1
Zhong-Jian Shen; Jie Hu; Venkatesh Kashi; Yury A. Bochkov; James E. Gern; James S. Malter
J Immunol (2018) 201 (12): 3503–3513.
View articletitled, TLR-7 Stress Signaling in Differentiating and Mature Eosinophils Is Mediated by the Prolyl Isomerase Pin1
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AUTOIMMUNITY

Blocking Matrix Metalloproteinase-9 Abrogates Collagen-Induced Arthritis via Inhibiting Dendritic Cell Migration
Juan He; Xing Li; Jian Zhuang; Jiaochan Han; Guihu Luo; Fangyuan Yang; Yan Sun; Pan Liao; Yanping Han; Yi He; Hui Shi; Erwei Sun
J Immunol (2018) 201 (12): 3514–3523.
View articletitled, Blocking Matrix Metalloproteinase-9 Abrogates Collagen-Induced Arthritis via Inhibiting Dendritic Cell Migration
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DRB4*01:01 Has a Distinct Motif and Presents a Proinsulin Epitope That Is Recognized in Subjects with Type 1 Diabetes
Eddie A. James; Laurel Gillette; Ivana Durinovic-Bello; Cate Speake; George P. Bondinas; Antonis K. Moustakas; Carla J. Greenbaum; George K. Papadopoulos; William W. Kwok
J Immunol (2018) 201 (12): 3524–3533.
View articletitled, DRB4*01:01 Has a Distinct Motif and Presents a Proinsulin Epitope That Is Recognized in Subjects with Type 1 Diabetes
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CLINICAL AND HUMAN IMMUNOLOGY

Placenta Specific 8 Suppresses IL-18 Production through Regulation of Autophagy and Is Associated with Adult Still Disease
Seiji Segawa; Yuya Kondo; Yuji Nakai; Akira Iizuka; Shunta Kaneko; Masahiro Yokosawa; Kotona Furuyama; Hiroto Tsuboi; Daisuke Goto; Isao Matsumoto; Takayuki Sumida
J Immunol (2018) 201 (12): 3534–3545.
View articletitled, Placenta Specific 8 Suppresses IL-18 Production through Regulation of Autophagy and Is Associated with Adult Still Disease
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Surveillance of Myelodysplastic Syndrome via Migration Analyses of Blood Neutrophils: A Potential Prognostic Tool
Marc Schuster; Mischa Moeller; Lea Bornemann; Clara Bessen; Charlyn Sobczak; Saskia Schmitz; Laura Witjes; Katja Kruithoff; Christina Kohn; Olga Just; Andrea Kündgen; Noreen Pundt; Benedikt Pelzer; Christophe Ampe; Marleen Van Troys; Arnd Nusch; Rainer Haas; Ulrich Germing; Lennart Martens; Karl-Heinz Jöckel; Matthias Gunzer
J Immunol (2018) 201 (12): 3546–3557.
View articletitled, Surveillance of Myelodysplastic Syndrome via Migration Analyses of Blood Neutrophils: A Potential Prognostic Tool
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IMMUNE REGULATION

Colitis Promotes a Pathological Condition of the Liver in the Absence of Foxp3+ Regulatory T Cells
Franziska Mathies; Niklas Steffens; Doerte Kleinschmidt; Friederike Stuhlmann; Francis J. Huber; Urmi Roy; Thomas Meyer; Marc Luetgehetmann; Mareike von Petersdorff; Oliver Seiz; Johannes Herkel; Christoph Schramm; Richard A. Flavell; Nicola Gagliani; Christian Krebs; Ulf Panzer; Zeinab Abdullah; Till Strowig; Tanja Bedke; Samuel Huber
J Immunol (2018) 201 (12): 3558–3568.
View articletitled, Colitis Promotes a Pathological Condition of the Liver in the Absence of Foxp3<sup>+</sup> Regulatory T Cells
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Nonredundant Roles of IL-21 and IL-4 in the Phased Initiation of Germinal Center B Cells and Subsequent Self-Renewal Transitions
David G. Gonzalez; Christine M. Cote; Jaymin R. Patel; Colin B. Smith; Yuqi Zhang; Kevin M. Nickerson; Tingting Zhang; Steven M. Kerfoot; Ann M. Haberman
J Immunol (2018) 201 (12): 3569–3579.
View articletitled, Nonredundant Roles of IL-21 and IL-4 in the Phased Initiation of Germinal Center B Cells and Subsequent Self-Renewal Transitions
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IMMUNE SYSTEM DEVELOPMENT

Essential Role of Canonical NF-κB Activity in the Development of Stromal Cell Subsets in Secondary Lymphoid Organs
Dana Bogdanova; Arata Takeuchi; Madoka Ozawa; Yasuhiro Kanda; M. Azizur Rahman; Burkhard Ludewig; Tatsuo Kinashi; Tomoya Katakai
J Immunol (2018) 201 (12): 3580–3586.
View articletitled, Essential Role of Canonical NF-κB Activity in the Development of Stromal Cell Subsets in Secondary Lymphoid Organs
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IMMUNOTHERAPY AND VACCINES

Brief Exposure of Skin to Near-Infrared Laser Modulates Mast Cell Function and Augments the Immune Response
Yoshifumi Kimizuka; Wataru Katagiri; Joseph J. Locascio; Ayako Shigeta; Yuri Sasaki; Mai Shibata; Kaitlyn Morse; Ruxandra F. Sîrbulescu; Mizuki Miyatake; Patrick Reeves; Makoto Suematsu; Jeffrey Gelfand; Timothy Brauns; Mark C. Poznansky; Kosuke Tsukada; Satoshi Kashiwagi
J Immunol (2018) 201 (12): 3587–3603.
View articletitled, Brief Exposure of Skin to Near-Infrared Laser Modulates Mast Cell Function and Augments the Immune Response
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Suppression of Th1 Priming by TLR2 Agonists during Cutaneous Immunization Is Mediated by Recruited CCR2+ Monocytes
Christopher T. Johndrow; Michael F. Goldberg; Alison J. Johnson; Tony W. Ng; Shajo Kunnath-Velayudhan; Gregoire Lauvau; Daniel H. Kaplan; Graeme H. Gossel; Ulrich D. Kadolsky; Andrew J. Yates; John Chan; William R. Jacobs, Jr.; Steven A. Porcelli
J Immunol (2018) 201 (12): 3604–3616.
View articletitled, Suppression of Th1 Priming by TLR2 Agonists during Cutaneous Immunization Is Mediated by Recruited CCR2<sup>+</sup> Monocytes
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INFECTIOUS DISEASE AND HOST RESPONSE

Deregulated AUF1 Assists BMP-EZH2–Mediated Delayed Wound Healing during Candida albicans Infection
Kasturi Mahadik; Preeti Yadav; Bharat Bhatt; Riyaz Ahmad Shah; Kithiganahalli Narayanaswamy Balaji
J Immunol (2018) 201 (12): 3617–3629.
View articletitled, Deregulated AUF1 Assists BMP-EZH2–Mediated Delayed Wound Healing during <em>Candida albicans</em> Infection
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Induction of a Long Noncoding RNA Transcript, NR_045064, Promotes Defense Gene Transcription and Facilitates Intestinal Epithelial Cell Responses against Cryptosporidium Infection
Min Li; Ai-Yu Gong; Xin-Tian Zhang; Yang Wang; Nicholas W. Mathy; Gislaine A. Martins; Juliane K. Strauss-Soukup; Xian-Ming Chen
J Immunol (2018) 201 (12): 3630–3640.
View articletitled, Induction of a Long Noncoding RNA Transcript, NR_045064, Promotes Defense Gene Transcription and Facilitates Intestinal Epithelial Cell Responses against <em>Cryptosporidium</em> Infection
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Programming of CD8 T Cell Quantity and Polyfunctionality by Direct IL-1 Signals
Surojit Sarkar; Yevgeniy Yuzefpolskiy; Hanxi Xiao; Florian M. Baumann; Soojin Yim; David J. Lee; Dominik Schenten; Vandana Kalia
J Immunol (2018) 201 (12): 3641–3650.
View articletitled, Programming of CD8 T Cell Quantity and Polyfunctionality by Direct IL-1 Signals
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INNATE IMMUNITY AND INFLAMMATION

Talin1 Methylation Is Required for Neutrophil Infiltration and Lipopolysaccharide-Induced Lethality
Thomas Jun Feng Lim; I-Hsin Su
J Immunol (2018) 201 (12): 3651–3661.
View articletitled, Talin1 Methylation Is Required for Neutrophil Infiltration and Lipopolysaccharide-Induced Lethality
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Gasdermin D Promotes AIM2 Inflammasome Activation and Is Required for Host Protection against Francisella novicida
Qifan Zhu; Min Zheng; Arjun Balakrishnan; Rajendra Karki; Thirumala-Devi Kanneganti
J Immunol (2018) 201 (12): 3662–3668.
View articletitled, Gasdermin D Promotes AIM2 Inflammasome Activation and Is Required for Host Protection against <em>Francisella novicida</em>
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Meteorin-like/Meteorin-β Is a Novel Immunoregulatory Cytokine Associated with Inflammation
Irina Ushach; Gerardo Arrevillaga-Boni; Gina N. Heller; Egest Pone; Marcela Hernandez-Ruiz; Jovani Catalan-Dibene; Peter Hevezi; Albert Zlotnik
J Immunol (2018) 201 (12): 3669–3676.
View articletitled, Meteorin-like/Meteorin-β Is a Novel Immunoregulatory Cytokine Associated with Inflammation
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MOLECULAR AND STRUCTURAL IMMUNOLOGY

The Transcription Factors PU.1 and IRF4 Determine Dendritic Cell–Specific Expression of RALDH2
Takuya Yashiro; Masaki Yamaguchi; Yumi Watanuki; Kazumi Kasakura; Chiharu Nishiyama
J Immunol (2018) 201 (12): 3677–3682.
View articletitled, The Transcription Factors PU.1 and IRF4 Determine Dendritic Cell–Specific Expression of RALDH2
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MUCOSAL IMMUNOLOGY

Indole-3-Pyruvic Acid, an Aryl Hydrocarbon Receptor Activator, Suppresses Experimental Colitis in Mice
Reiji Aoki; Ayako Aoki-Yoshida; Chise Suzuki; Yoshiharu Takayama
J Immunol (2018) 201 (12): 3683–3693.
View articletitled, Indole-3-Pyruvic Acid, an Aryl Hydrocarbon Receptor Activator, Suppresses Experimental Colitis in Mice
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SYSTEMS IMMUNOLOGY

Filtering Next-Generation Sequencing of the Ig Gene Repertoire Data Using Antibody Structural Information
Aleksandr Kovaltsuk; Konrad Krawczyk; Sebastian Kelm; James Snowden; Charlotte M. Deane
J Immunol (2018) 201 (12): 3694–3704.
View articletitled, Filtering Next-Generation Sequencing of the Ig Gene Repertoire Data Using Antibody Structural Information
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The Length Distribution and Multiple Specificity of Naturally Presented HLA-I Ligands
David Gfeller; Philippe Guillaume; Justine Michaux; Hui-Song Pak; Roy T. Daniel; Julien Racle; George Coukos; Michal Bassani-Sternberg
J Immunol (2018) 201 (12): 3705–3716.
View articletitled, The Length Distribution and Multiple Specificity of Naturally Presented HLA-I Ligands
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TRANSPLANTATION

Complement Inhibitor CRIg/FH Ameliorates Renal Ischemia Reperfusion Injury via Activation of PI3K/AKT Signaling
Chao Hu; Long Li; Peipei Ding; Ling Li; Xiaowen Ge; Long Zheng; Xuanchuan Wang; Jina Wang; Weitao Zhang; Na Wang; Hongyu Gu; Fan Zhong; Ming Xu; Ruiming Rong; Tongyu Zhu; Weiguo Hu
J Immunol (2018) 201 (12): 3717–3730.
View articletitled, Complement Inhibitor CRIg/FH Ameliorates Renal Ischemia Reperfusion Injury via Activation of PI3K/AKT Signaling
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Critical Role of Macrophage FcγR Signaling and Reactive Oxygen Species in Alloantibody-Mediated Hepatocyte Rejection
Jason M. Zimmerer; Xin L. Liu; Alecia Blaszczak; Christina L. Avila; Thomas A. Pham; Robert T. Warren; Ginny L. Bumgardner
J Immunol (2018) 201 (12): 3731–3740.
View articletitled, Critical Role of Macrophage FcγR Signaling and Reactive Oxygen Species in Alloantibody-Mediated Hepatocyte Rejection
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TUMOR IMMUNOLOGY

High FcγR Expression on Intratumoral Macrophages Enhances Tumor-Targeting Antibody Therapy
Hreinn Benonisson; Heng Sheng Sow; Cor Breukel; Jill Claassens; Conny Brouwers; Margot M. Linssen; Marieke F. Fransen; Marjolein Sluijter; Ferry Ossendorp; Thorbald van Hall; J. Sjef Verbeek
J Immunol (2018) 201 (12): 3741–3749.
View articletitled, High FcγR Expression on Intratumoral Macrophages Enhances Tumor-Targeting Antibody Therapy
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Sialic Acid–Dependent Inhibition of T Cells by Exosomal Ganglioside GD3 in Ovarian Tumor Microenvironments
Gautam N. Shenoy; Jenni Loyall; Charles S. Berenson; Raymond J. Kelleher, Jr.; Vandana Iyer; Sathy V. Balu-Iyer; Kunle Odunsi; Richard B. Bankert
J Immunol (2018) 201 (12): 3750–3758.
View articletitled, Sialic Acid–Dependent Inhibition of T Cells by Exosomal Ganglioside GD3 in Ovarian Tumor Microenvironments
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CD8α+ Dendritic Cells Dictate Leukemia-Specific CD8+ T Cell Fates
Douglas E. Kline; Brendan W. MacNabb; Xiufen Chen; Wen-Ching Chan; Dominick Fosco; Justin Kline
J Immunol (2018) 201 (12): 3759–3769.
View articletitled, CD8α<sup>+</sup> Dendritic Cells Dictate Leukemia-Specific CD8<sup>+</sup> T Cell Fates
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IL-33 Released in the Liver Inhibits Tumor Growth via Promotion of CD4+ and CD8+ T Cell Responses in Hepatocellular Carcinoma
Ziqi Jin; Lei Lei; Dandan Lin; Yonghao Liu; Yuan Song; Huanle Gong; Ying Zhu; Yu Mei; Bo Hu; Yan Wu; Guangbo Zhang; Haiyan Liu
J Immunol (2018) 201 (12): 3770–3779.
View articletitled, IL-33 Released in the Liver Inhibits Tumor Growth via Promotion of CD4<sup>+</sup> and CD8<sup>+</sup> T Cell Responses in Hepatocellular Carcinoma
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NOVEL IMMUNOLOGICAL METHODS

Predicting Humoral Alloimmunity from Differences in Donor and Recipient HLA Surface Electrostatic Potential
Dermot H. Mallon; Christiane Kling; Matthew Robb; Eva Ellinghaus; J. Andrew Bradley; Craig J. Taylor; Dieter Kabelitz; Vasilis Kosmoliaptsis
J Immunol (2018) 201 (12): 3780–3792.
View articletitled, Predicting Humoral Alloimmunity from Differences in Donor and Recipient HLA Surface Electrostatic Potential
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Myeloid-Specific Deletion of Mcl-1 Yields Severely Neutropenic Mice That Survive and Breed in Homozygous Form
Janka Zsófia Csepregi; Anita Orosz; Erik Zajta; Orsolya Kása; Tamás Németh; Edina Simon; Szabina Fodor; Katalin Csonka; Balázs L. Barátki; Dorottya Kövesdi; You-Wen He; Attila Gácser; Attila Mócsai
J Immunol (2018) 201 (12): 3793–3803.
View articletitled, Myeloid-Specific Deletion of Mcl-1 Yields Severely Neutropenic Mice That Survive and Breed in Homozygous Form
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Multiplexed FluoroSpot for the Analysis of Dengue Virus– and Zika Virus–Specific and Cross-Reactive Memory B Cells
Awadalkareem Adam; Marcia Woda; Sonia Kounlavouth; Alan L. Rothman; Richard G. Jarman; Josephine H. Cox; Julie E. Ledgerwood; Gregory D. Gromowski; Jeffrey R. Currier; Heather Friberg; Anuja Mathew
J Immunol (2018) 201 (12): 3804–3814.
View articletitled, Multiplexed FluoroSpot for the Analysis of Dengue Virus– and Zika Virus–Specific and Cross-Reactive Memory B Cells
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Rapid and Efficient Production of Human Functional Mast Cells through a Three-Dimensional Culture of Adipose Tissue–Derived Stromal Vascular Cells
Jenny Paupert; Eric Espinosa; Nicolas Cenac; Virginie Robert; Patrick Laharrague; Solène M. Evrard; Louis Casteilla; Anne Lorsignol; Béatrice Cousin
J Immunol (2018) 201 (12): 3815–3821.
View articletitled, Rapid and Efficient Production of Human Functional Mast Cells through a Three-Dimensional Culture of Adipose Tissue–Derived Stromal Vascular Cells
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  • Cover Image

    Cover Image

    issue cover

    On the cover: Pocket 4 of HLA-DRB4*01:01 with anchor residue Glu (space-filling). DRB4 residues are in stick form with transparent surfaces colored according to atom charge. This pocket is quite restrictive (favoring Gln/Glu), but in one scenario accepts Trp, allowing presentation of a unique proinsulin epitope. James, E. A., L. Gillette, I. Durinovic-Bello, C. Speake, G. P. Bondinas, A. K. Moustakas, C. J. Greenbaum, G. K. Papadopoulos, and W. W. Kwok. 2018. DRB4*01:01 has a distinct motif and presents a proinsulin epitope that is recognized in subjects with type 1 diabetes. J. Immunol. 201: 3524–3533.

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