Cover Image

Cover Image

On the cover: Lymphatic endothelial cell expression of programmed death ligand 1 (PD-L1) increases after viral infection. Shown is a murine lymph node section from 5 d after s.c. vaccinia viral infection. The 7-μm section was stained with anti–Lyve-1 (red) to visualize lymphatics and anti–PD-L1 (green) to visualize PD-L1 expression. Lucas, E. D., J. M. Finlon, M. A. Burchill, M. K. McCarthy, T. E. Morrison, T. M. Colpitts, and B. A. J. Tamburini. 2018. Type 1 IFN and PD-L1 coordinate lymphatic endothelial cell expansion and contraction during an inflammatory immune response. J. Immunol. 201: 1735–1747.
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IN THIS ISSUE

In This Issue

TRANSLATING IMMUNOLOGY

Discovery of the IL-23/IL-17 Signaling Pathway and the Treatment of Psoriasis

BRIEF REVIEWS

The Intestinal Virome and Immunity

CUTTING EDGE

Cutting Edge: Glycolytic Metabolism and Mitochondrial Metabolism Are Uncoupled in Antigen-Activated CD8⁺ Recent Thymic Emigrants

Cutting Edge: Proper Orientation of CTCF Sites in Cer Is Required for Normal Jκ-Distal and Jκ-Proximal Vκ Gene Usage

Cutting Edge: Dysregulated CARD9 Signaling in Neutrophils Drives Inflammation in a Mouse Model of Neutrophilic Dermatoses

Cutting Edge: IL-1R1 Mediates Host Resistance to Mycobacterium tuberculosis by Trans-Protection of Infected Cells

ALLERGY AND OTHER HYPERSENSITIVITIES

Syndecan-1 Regulates Psoriasiform Dermatitis by Controlling Homeostasis of IL-17–Producing γδ T Cells

CLINICAL AND HUMAN IMMUNOLOGY

Identification and Analysis of Islet Antigen–Specific CD8⁺ T Cells with T Cell Libraries

IMMUNE REGULATION

SAMHD1 Posttranscriptionally Controls the Expression of Foxp3 and Helios in Human T Regulatory Cells

IMMUNE SYSTEM DEVELOPMENT

ERK Signaling Controls Innate-like CD8⁺ T Cell Differentiation via the ELK4 (SAP-1) and ELK1 Transcription Factors

Progression from the Common Lymphoid Progenitor to B/Myeloid PreproB and ProB Precursors during B Lymphopoiesis Requires C/EBPα

INFECTIOUS DISEASE AND HOST RESPONSE

The Phagocyte Oxidase Controls Tolerance to Mycobacterium tuberculosis Infection

CBLB Constrains Inactivated Vaccine–Induced CD8⁺ T Cell Responses and Immunity against Lethal Fungal Pneumonia

INNATE IMMUNITY AND INFLAMMATION

Glatiramer Acetate Enhances Myeloid-Derived Suppressor Cell Function via Recognition of Paired Ig-like Receptor B

Type 1 IFN and PD-L1 Coordinate Lymphatic Endothelial Cell Expansion and Contraction during an Inflammatory Immune Response

A Fundamental Role of Myh9 for Neutrophil Migration in Innate Immunity

MOLECULAR AND STRUCTURAL IMMUNOLOGY

Nucleotide Composition of Human Ig Nontemplated Regions Depends on Trimming of the Flanking Gene Segments, and Terminal Deoxynucleotidyl Transferase Favors Adding Cytosine, Not Guanosine, in Most VDJ Rearrangements

MUCOSAL IMMUNOLOGY

Airway Epithelial Cell Peroxisome Proliferator–Activated Receptor γ Regulates Inflammation and Mucin Expression in Allergic Airway Disease

SYSTEMS IMMUNOLOGY

Conventional Dendritic Cells Impair Recovery after Myocardial Infarction

NOVEL IMMUNOLOGICAL METHODS

Subsets of CD4⁺, CD8⁺, and CD25^hi Lymphocytes Are in General Not Influenced by Isolation and Long-Term Cryopreservation

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IN THIS ISSUE

TRANSLATING IMMUNOLOGY

BRIEF REVIEWS

CUTTING EDGE

ALLERGY AND OTHER HYPERSENSITIVITIES

CLINICAL AND HUMAN IMMUNOLOGY

IMMUNE REGULATION

IMMUNE SYSTEM DEVELOPMENT

INFECTIOUS DISEASE AND HOST RESPONSE

INNATE IMMUNITY AND INFLAMMATION

MOLECULAR AND STRUCTURAL IMMUNOLOGY

MUCOSAL IMMUNOLOGY

SYSTEMS IMMUNOLOGY

NOVEL IMMUNOLOGICAL METHODS

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