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Volume 201, Issue 7
1 October 2018
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ISSN 0022-1767
EISSN 1550-6606

IN THIS ISSUE

In This Issue
J Immunol (2018) 201 (7): 1811–1812.
View articletitled, In This Issue
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IMMUNOLOGY NOTES AND RESOURCES

Flow Cytometry: To Dump or Not To Dump
Maximilian Boesch; Antonio Cosma; Sieghart Sopper
J Immunol (2018) 201 (7): 1813–1815.
View articletitled, Flow Cytometry: To Dump or Not To Dump
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PILLARS OF IMMUNOLOGY

How Superantigens Bind MHC
Luc Van Kaer
J Immunol (2018) 201 (7): 1817–1818.
View articletitled, How Superantigens Bind MHC
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Pillars Article: Three-Dimensional Structure of a Human Class II Histocompatibility Molecule Complexed with Superantigen. Nature. 1994. 368: 711–718
Theodore S. Jardetzky; Jerry H. Brown; Joan C. Gorga; Lawrence J. Stern; Robert G. Urban; Young-in Chi; Cynthia Stauffacher; Jack L. Strominger; Don C. Wiley
J Immunol (2018) 201 (7): 1819–1826.
View articletitled, Pillars Article: Three-Dimensional Structure of a Human Class II Histocompatibility Molecule Complexed with Superantigen. <em>Nature</em>. 1994. 368: 711–718
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BRIEF REVIEWS

Innate T Cells Govern Adipose Tissue Biology
Nelson M. LaMarche; Ayano C. Kohlgruber; Michael B. Brenner
J Immunol (2018) 201 (7): 1827–1834.
View articletitled, Innate T Cells Govern Adipose Tissue Biology
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CUTTING EDGE

Cutting Edge: Elevated Leptin during Diet-Induced Obesity Reduces the Efficacy of Tumor Immunotherapy
Katherine A. Murphy; Britnie R. James; Frances V. Sjaastad; Tamara A. Kucaba; Hyunjoon Kim; Erik L. Brincks; Streamson C. Chua, Jr.; Andrew Wilber; Thomas S. Griffith
J Immunol (2018) 201 (7): 1837–1841.
View articletitled, Cutting Edge: Elevated Leptin during Diet-Induced Obesity Reduces the Efficacy of Tumor Immunotherapy
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ALLERGY AND OTHER HYPERSENSITIVITIES

Testosterone Decreases House Dust Mite–Induced Type 2 and IL-17A–Mediated Airway Inflammation
Hubaida Fuseini; Jeffrey A. Yung; Jacqueline Yvonne Cephus; Jian Zhang; Kasia Goleniewska; Vasiliy V. Polosukhin; R. Stokes Peebles, Jr.; Dawn C. Newcomb
J Immunol (2018) 201 (7): 1843–1854.
View articletitled, Testosterone Decreases House Dust Mite–Induced Type 2 and IL-17A–Mediated Airway Inflammation
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The Canonical but Not the Noncanonical Wnt Pathway Inhibits the Development of Allergic Airway Disease
Hendrik Beckert; Helen Meyer-Martin; Roland Buhl; Christian Taube; Sebastian Reuter
J Immunol (2018) 201 (7): 1855–1864.
View articletitled, The Canonical but Not the Noncanonical Wnt Pathway Inhibits the Development of Allergic Airway Disease
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Differential Influence on Regulatory B Cells by TH2 Cytokines Affects Protection in Allergic Airway Disease
Sophina H. Taitano; Luciën E. P. M. van der Vlugt; Molly M. Shea; Jennifer Yang; Nicholas W. Lukacs; Steven K. Lundy
J Immunol (2018) 201 (7): 1865–1874.
View articletitled, Differential Influence on Regulatory B Cells by T<sub>H</sub>2 Cytokines Affects Protection in Allergic Airway Disease
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ANTIGEN RECOGNITION AND RESPONSES

Cytosolic Processing Governs TAP-Independent Presentation of a Critical Melanoma Antigen
Nathalie Vigneron; Violette Ferrari; Benoît J. Van den Eynde; Peter Cresswell; Ralf M. Leonhardt
J Immunol (2018) 201 (7): 1875–1888.
View articletitled, Cytosolic Processing Governs TAP-Independent Presentation of a Critical Melanoma Antigen
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AUTOIMMUNITY

Nod2 Deficiency Augments Th17 Responses and Exacerbates Autoimmune Arthritis
Ruth J. Napier; Ellen J. Lee; Emily E. Vance; Paige E. Snow; Kimberly A. Samson; Clare E. Dawson; Amy E. Moran; Peter Stenzel; Michael P. Davey; Shimon Sakaguchi; Holly L. Rosenzweig
J Immunol (2018) 201 (7): 1889–1898.
View articletitled, Nod2 Deficiency Augments Th17 Responses and Exacerbates Autoimmune Arthritis
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IL-2–Anti–IL-2 Monoclonal Antibody Immune Complexes Inhibit Collagen-Induced Arthritis by Augmenting Regulatory T Cell Functions
Yuichi Yokoyama; Tsuyoshi Iwasaki; Sachie Kitano; Atsushi Satake; Shosaku Nomura; Tetsuya Furukawa; Kiyoshi Matsui; Hajime Sano
J Immunol (2018) 201 (7): 1899–1906.
View articletitled, IL-2–Anti–IL-2 Monoclonal Antibody Immune Complexes Inhibit Collagen-Induced Arthritis by Augmenting Regulatory T Cell Functions
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A Hypermorphic Nfkbid Allele Contributes to Impaired Thymic Deletion of Autoreactive Diabetogenic CD8+ T Cells in NOD Mice
Maximiliano Presa; Jeremy J. Racine; Jennifer R. Dwyer; Deanna J. Lamont; Jeremy J. Ratiu; Vishal Kumar Sarsani; Yi-Guang Chen; Aron Geurts; Ingo Schmitz; Timothy Stearns; Jennifer Allocco; Harold D. Chapman; David V. Serreze
J Immunol (2018) 201 (7): 1907–1917.
View articletitled, A Hypermorphic <em>Nfkbid</em> Allele Contributes to Impaired Thymic Deletion of Autoreactive Diabetogenic CD8<sup>+</sup> T Cells in NOD Mice
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CLINICAL AND HUMAN IMMUNOLOGY

Activation of NF-κB in Synovium versus Cartilage from Patients with Advanced Knee Osteoarthritis: A Potential Contributor to Inflammatory Aspects of Disease Progression
Aisha S. Ahmed; Per Gedin; Anders Hugo; Georgy Bakalkin; Alkass Kanar; David A. Hart; Henrik Druid; Camilla Svensson; Eva Kosek
J Immunol (2018) 201 (7): 1918–1927.
View articletitled, Activation of NF-κB in Synovium versus Cartilage from Patients with Advanced Knee Osteoarthritis: A Potential Contributor to Inflammatory Aspects of Disease Progression
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Absence of Surface IgD Does Not Impair Naive B Cell Homeostasis or Memory B Cell Formation in IGHD Haploinsufficient Humans
Jana Nechvatalova; Sophinus J. W. Bartol; Zita Chovancova; Louis Boon; Marcela Vlkova; Menno C. van Zelm
J Immunol (2018) 201 (7): 1928–1935.
View articletitled, Absence of Surface IgD Does Not Impair Naive B Cell Homeostasis or Memory B Cell Formation in <em>IGHD</em> Haploinsufficient Humans
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IMMUNE REGULATION

The PGI2 Analog Cicaprost Inhibits IL-33–Induced Th2 Responses, IL-2 Production, and CD25 Expression in Mouse CD4+ T Cells
Weisong Zhou; Jian Zhang; Shinji Toki; Kasia Goleniewska; Marc O. Johnson; Melissa H. Bloodworth; Dawn C. Newcomb; R. Stokes Peebles, Jr.
J Immunol (2018) 201 (7): 1936–1945.
View articletitled, The PGI<sub>2</sub> Analog Cicaprost Inhibits IL-33–Induced Th2 Responses, IL-2 Production, and CD25 Expression in Mouse CD4<sup>+</sup> T Cells
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IMMUNOGENETICS

Characterization of an NLRP1 Inflammasome from Zebrafish Reveals a Unique Sequential Activation Mechanism Underlying Inflammatory Caspases in Ancient Vertebrates
Jiang-yuan Li; Ke Gao; Tong Shao; Dong-dong Fan; Chong-bin Hu; Cen-cen Sun; Wei-ren Dong; Ai-fu Lin; Li-xin Xiang; Jian-zhong Shao
J Immunol (2018) 201 (7): 1946–1966.
View articletitled, Characterization of an NLRP1 Inflammasome from Zebrafish Reveals a Unique Sequential Activation Mechanism Underlying Inflammatory Caspases in Ancient Vertebrates
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IMMUNOTHERAPY AND VACCINES

Activation of Th1 Immunity within the Tumor Microenvironment Is Associated with Clinical Response to Lenalidomide in Chronic Lymphocytic Leukemia
Georg Aue; Clare Sun; Delong Liu; Jae-Hyun Park; Stefania Pittaluga; Xin Tian; Elinor Lee; Susan Soto; Janet Valdez; Irina Maric; Maryalice Stetler-Stevenson; Constance Yuan; Yusuke Nakamura; Pawel Muranski; Adrian Wiestner
J Immunol (2018) 201 (7): 1967–1974.
View articletitled, Activation of Th1 Immunity within the Tumor Microenvironment Is Associated with Clinical Response to Lenalidomide in Chronic Lymphocytic Leukemia
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Three-Dimensional Ameliorated Biologics Elicit Thymic Renewal in Tumor-Bearing Hosts
Yanna Zhang; Huanhuan Yang; Qian Li; Xiaogang Duan; Xia Zhao; Yuquan Wei; Xiancheng Chen
J Immunol (2018) 201 (7): 1975–1983.
View articletitled, Three-Dimensional Ameliorated Biologics Elicit Thymic Renewal in Tumor-Bearing Hosts
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Prime-and-Trap Malaria Vaccination To Generate Protective CD8+ Liver-Resident Memory T Cells
Tayla M. Olsen; Brad C. Stone; Vorada Chuenchob; Sean C. Murphy
J Immunol (2018) 201 (7): 1984–1993.
View articletitled, Prime-and-Trap Malaria Vaccination To Generate Protective CD8<sup>+</sup> Liver-Resident Memory T Cells
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INFECTIOUS DISEASE AND HOST RESPONSE

Impaired Development and Expansion of Germinal Center Follicular Th Cells in Simian Immunodeficiency Virus–Infected Neonatal Macaques
Huanbin Xu; Widade Ziani; Jiasheng Shao; Lara A. Doyle-Meyers; Kasi E. Russell-Lodrigue; Marion S. Ratterree; Ronald S. Veazey; Xiaolei Wang
J Immunol (2018) 201 (7): 1994–2003.
View articletitled, Impaired Development and Expansion of Germinal Center Follicular Th Cells in Simian Immunodeficiency Virus–Infected Neonatal Macaques
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Autocrine IL-10 Signaling Promotes Dendritic Cell Type-2 Activation and Persistence of Murine Cryptococcal Lung Infection
Seagal Teitz-Tennenbaum; Steven P. Viglianti; Jonathan A. Roussey; Stuart M. Levitz; Michal A. Olszewski; John J. Osterholzer
J Immunol (2018) 201 (7): 2004–2015.
View articletitled, Autocrine IL-10 Signaling Promotes Dendritic Cell Type-2 Activation and Persistence of Murine Cryptococcal Lung Infection
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Dysregulated Calcium Homeostasis in Cystic Fibrosis Neutrophils Leads to Deficient Antimicrobial Responses
Frank H. Robledo-Avila; Juan de Dios Ruiz-Rosado; Kenneth L. Brockman; Benjamin T. Kopp; Amal O. Amer; Karen McCoy; Lauren O. Bakaletz; Santiago Partida-Sanchez
J Immunol (2018) 201 (7): 2016–2027.
View articletitled, Dysregulated Calcium Homeostasis in Cystic Fibrosis Neutrophils Leads to Deficient Antimicrobial Responses
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INNATE IMMUNITY AND INFLAMMATION

Human NK Cells Lyse Th2-Polarizing Dendritic Cells via NKp30 and DNAM-1
Katherine Walwyn-Brown; Karolin Guldevall; Mezida Saeed; Daniela Pende; Björn Önfelt; Andrew S. MacDonald; Daniel M. Davis
J Immunol (2018) 201 (7): 2028–2041.
View articletitled, Human NK Cells Lyse Th2-Polarizing Dendritic Cells via NKp30 and DNAM-1
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CSF-1 in Inflammatory and Arthritic Pain Development
Reem Saleh; Ming-Chin Lee; Stella H. Khiew; Cynthia Louis; Andrew J. Fleetwood; Adrian Achuthan; Irmgard Förster; Andrew D. Cook; John A. Hamilton
J Immunol (2018) 201 (7): 2042–2053.
View articletitled, CSF-1 in Inflammatory and Arthritic Pain Development
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PPARγ Deficiency Suppresses the Release of IL-1β and IL-1α in Macrophages via a Type 1 IFN–Dependent Mechanism
Kassandra J. Weber; Madeline Sauer; Li He; Eric Tycksen; Gowri Kalugotla; Babak Razani; Joel D. Schilling
J Immunol (2018) 201 (7): 2054–2069.
View articletitled, PPARγ Deficiency Suppresses the Release of IL-1β and IL-1α in Macrophages via a Type 1 IFN–Dependent Mechanism
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IRAK1 Limits TLR3/4- and IFNAR-Driven IL-27 Production through a STAT1-Dependent Mechanism
Daniela Bruni; Adam Dignam; Susan Dunne; Devlin Wall-Coughlan; Aisling McCrudden; Karen O’Connell; Caitriona Lyons; Christopher McGuigan; Niall Tubridy; Marion P. Butler
J Immunol (2018) 201 (7): 2070–2081.
View articletitled, IRAK1 Limits TLR3/4- and IFNAR-Driven IL-27 Production through a STAT1-Dependent Mechanism
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MOLECULAR AND STRUCTURAL IMMUNOLOGY

Crystal Structure of the Labile Complex of IL-24 with the Extracellular Domains of IL-22R1 and IL-20R2
Jacek Lubkowski; Cem Sonmez; Sergey V. Smirnov; Andriy Anishkin; Sergei V. Kotenko; Alexander Wlodawer
J Immunol (2018) 201 (7): 2082–2093.
View articletitled, Crystal Structure of the Labile Complex of IL-24 with the Extracellular Domains of IL-22R1 and IL-20R2
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Engineering a Single-Agent Cytokine/Antibody Fusion That Selectively Expands Regulatory T Cells for Autoimmune Disease Therapy
Jamie B. Spangler; Eleonora Trotta; Jakub Tomala; Ariana Peck; Tracy A. Young; Christina S. Savvides; Stephanie Silveria; Petra Votavova; Joshua Salafsky; Vijay S. Pande; Marek Kovar; Jeffrey A. Bluestone; K. Christopher Garcia
J Immunol (2018) 201 (7): 2094–2106.
View articletitled, Engineering a Single-Agent Cytokine/Antibody Fusion That Selectively Expands Regulatory T Cells for Autoimmune Disease Therapy
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Sialic Acid Ligand Binding of CD22 and Siglec-G Determines Distinct B Cell Functions but Is Dispensable for B Cell Tolerance Induction
Lamia Özgör; Sarah J. Meyer; Marina Korn; Klara Terörde; Lars Nitschke
J Immunol (2018) 201 (7): 2107–2116.
View articletitled, Sialic Acid Ligand Binding of CD22 and Siglec-G Determines Distinct B Cell Functions but Is Dispensable for B Cell Tolerance Induction
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SYSTEMS IMMUNOLOGY

Differential Induction of IFN-α and Modulation of CD112 and CD54 Expression Govern the Magnitude of NK Cell IFN-γ Response to Influenza A Viruses
Lisa M. Kronstad; Christof Seiler; Rosemary Vergara; Susan P. Holmes; Catherine A. Blish
J Immunol (2018) 201 (7): 2117–2131.
View articletitled, Differential Induction of IFN-α and Modulation of CD112 and CD54 Expression Govern the Magnitude of NK Cell IFN-γ Response to Influenza A Viruses
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Human Lymph Nodes Maintain TCF-1hi Memory T Cells with High Functional Potential and Clonal Diversity throughout Life
Michelle Miron; Brahma V. Kumar; Wenzhao Meng; Tomer Granot; Dustin J. Carpenter; Takashi Senda; Dora Chen; Aaron M. Rosenfeld; Bochao Zhang; Harvey Lerner; Amy L. Friedman; Uri Hershberg; Yufeng Shen; Adeeb Rahman; Eline T. Luning Prak; Donna L. Farber
J Immunol (2018) 201 (7): 2132–2140.
View articletitled, Human Lymph Nodes Maintain TCF-1<sup>hi</sup> Memory T Cells with High Functional Potential and Clonal Diversity throughout Life
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TUMOR IMMUNOLOGY

IL-21 Selectively Protects CD62L+ NKT Cells and Enhances Their Effector Functions for Adoptive Immunotherapy
Ho Ngai; Gengwen Tian; Amy N. Courtney; Soodeh B. Ravari; Linjie Guo; Bin Liu; Jingling Jin; Elise T. Shen; Erica J. Di Pierro; Leonid S. Metelitsa
J Immunol (2018) 201 (7): 2141–2153.
View articletitled, IL-21 Selectively Protects CD62L<sup>+</sup> NKT Cells and Enhances Their Effector Functions for Adoptive Immunotherapy
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Epidermal Growth Factor (EGF) Autocrine Activation of Human Platelets Promotes EGF Receptor–Dependent Oral Squamous Cell Carcinoma Invasion, Migration, and Epithelial Mesenchymal Transition
Rui Chen; Ge Jin; Wei Li; Thomas M. McIntyre
J Immunol (2018) 201 (7): 2154–2164.
View articletitled, Epidermal Growth Factor (EGF) Autocrine Activation of Human Platelets Promotes EGF Receptor–Dependent Oral Squamous Cell Carcinoma Invasion, Migration, and Epithelial Mesenchymal Transition
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miR-143 Regulates Memory T Cell Differentiation by Reprogramming T Cell Metabolism
Tengfei Zhang; Zhen Zhang; Feng Li; Yu Ping; Guohui Qin; Chaoqi Zhang; Yi Zhang
J Immunol (2018) 201 (7): 2165–2175.
View articletitled, miR-143 Regulates Memory T Cell Differentiation by Reprogramming T Cell Metabolism
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NOVEL IMMUNOLOGICAL METHODS

Collateral Damage: What Effect Does Anti-CD4 and Anti-CD8α Antibody–Mediated Depletion Have on Leukocyte Populations?
So Ri Jung; Tamara Suprunenko; Thomas M. Ashhurst; Nicholas J. C. King; Markus J. Hofer
J Immunol (2018) 201 (7): 2176–2186.
View articletitled, Collateral Damage: What Effect Does Anti-CD4 and Anti-CD8α Antibody–Mediated Depletion Have on Leukocyte Populations?
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CORRECTIONS

Correction: Influenza A Virus Negative Strand RNA Is Translated for CD8+ T Cell Immunosurveillance
Heather D. Hickman; Jacqueline W. Mays; James Gibbs; Ivan Kosik; Javier G. Magadán; Kazuyo Takeda; Suman Das; Glennys V. Reynoso; Barbara F. Ngudiankama; JiaJie Wei; John P. Shannon; Daniel McManus; Jonathan W. Yewdell
J Immunol (2018) 201 (7): 2187.
View articletitled, Correction: Influenza A Virus Negative Strand RNA Is Translated for CD8<sup>+</sup> T Cell Immunosurveillance
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  • Cover Image

    Cover Image

    issue cover

    On the cover: Formation of neutrophil extracellular traps in human non–cystic fibrosis neutrophils following infection with Burkholderia cenocepacia. Scanning electron micrograph of fibers of DNA (pseudocolored blue) ejected by neutrophils and trapping B. cenocepacia (pseudocolored red). Robledo-Avila, F. H., J. d. D. Ruiz-Rosado, K. L. Brockman, B. T. Kopp, A. O. Amer, K. McCoy, L. O. Bakaletz, and S. Partida-Sanchez. 2018. Dysregulated calcium homeostasis in cystic fibrosis neutrophils leads to deficient antimicrobial responses. J. Immunol. 201: 2016–2027.

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